Stroke genetics informs drug discovery and risk prediction across ancestries
Por:
Mishra, A, Malik, R, Hachiya, T, Jurgenson, T, Namba, S, Posner, DC, Kamanu, FK, Koido, M, Shi, MY, He, YY, Georgakis, MK, Caro, I, Krebs, K, Liaw, YC, Vaura, FC, Lin, K, Winsvold, BS, Srinivasasainagendra, V, Parodi, L, Bae, HJ, Chauhan, G, Chong, MCR, Tomppo, L, Akinyemi, R, Roshchupkin, GV, Habib, N, Jee, YH, Thomassen, JQ, Abedi, V, Carcel-Marquez, J, Nygaard, M, Leonard, HL, Yang, CJ, Yonova-Doing, E, Knol, MJ, Lewis, AJ, Judy, RL, Ago, T, Amouyel, P, Armstrong, ND, Bakker, MK, Bartz, TM, Bennett, DA, Bordes, C, Borte, S, Cain, A, Ridker, PM, Cho, K, Chen, ZM, Cruchaga, C, Cole, JW, Endres, M, Hata, J, He, J, Ho, YL, Havulinna, AS, Hopewell, JC, Hyacinth, HI, Inouye, M, Jacob, MA, Jeon, CE, Jern, C, Kamouchi, M, Keene, KL, Kitazono, T, Kittner, SJ, Konuma, T, Kumar, A, Lacaze, P, Launer, LJ, Lee, KJ, Lepik, K, Li, J, Li, LM, Manichaikul, A, Markus, HS, Marston, NA, Meitinger, T, Mitchell, BD, Montellano, FA, Morisaki, T, Mosley, TH, Nalls, MA, O'Donnell, MJ, Okada, Y, Ovbiagele, B, Peters, A, Psaty, BM, Rich, SS, Rosand, J, Sabatine, MS, Sacco, RL, Saleheen, D, Sandset, EC, Salomaa, V, Sasaki, M, Satizabal, CL, Schmidt, CO, Shimizu, A, Smith, NL, Sloane, KL, Sutoh, Y, Sun, YV, Tanno, K, Tiedt, S, Tatlisumak, T, Torres-Aguila, NP, Tiwari, HK, Tregouet, DA, Trompet, S, Tuladhar, AM, Tybjaerg-Hansen, A, Vibo, R, Wiggins, KL, Wennberg, P, Woo, D, Wilson, PWF, Xu, HC, Yang, Q, Yoon, K, Bis, JC, Lee, JM, Cheng, YC, Meschia, JF, Chen, WM, Sale, MM, Zonderman, AB, Evans, MK, Wilson, JG, Correa, A, Traylor, M, Lewis, CM, Carty, CL, Reiner, A, Langefeld, CD, Yaffe, K, Liu, YM, Lange, LA, Furie, KL, Arnett, DK, Benavente, OR, Grewal, RP, Peddareddygari, LR, Kooperberg, C, Lindstrom, S, Wang, L, Smith, EN, Gordon, W, Vlieg, AV, de Andrade, M, Brody, JA, Pattee, JW, Haessler, J, Suchon, P, Chen, MH, Frazer, KA, Turman, C, Germain, M, MacDonald, J, Braekkan, SK, Armasu, SM, Pankratz, N, Giulianini, F, Puurunen, MK, Ibrahim, M, Heckbert, SR, Bammler, TK, McCauley, BM, Pankow, JS, Reiner, AP, Deleuze, JF, O'Donnell, CJ, Kim, J, McKnight, B, Kraft, P, Hansen, JB, Rosendaal, FR, Heit, JA, Tang, WH, Morange, PE, Johnson, AD, Kabrhel, C, van Dijk, EJ, Koudstaal, PJ, Luijckx, GJ, van Oostenbrugge, RJ, Visser, MC, Wermer, MJH, Kappelle, LJ, Esko, T, Metspalu, A, Magi, R, Nelis, M, Levi, CR, Maguire, J, Jimenez-Conde, J, Sharma, P, Sudlow, CLM, Rannikmae, K, Schmidt, R, Slowik, A, Pera, J, Thijs, VNS, Lindgren, AG, Ilinca, A, Melander, O, Engstrom, G, Rexrode, KM, Rothwell, PM, Stanne, TM, Johnson, JA, Danesh, J, Butterworth, AS, Heitsch, L, Boncoraglio, GB, Kubo, M, Pezzini, A, Rolfs, A, Weir, D, Jackson, RD, Ross, OA, Lemmons, R, Soderholm, M, Cushman, M, Jood, K, McDonough, CW, Bell, S, Linkohr, B, Lee, TH, Putaala, J, Lopez, OL, Jian, XQ, Schminke, U, Cullell, N, Ibanez, L, Krupinski, J, Lioutas, V, Matsuda, K, Montaner, J, Muino, E, Roquer, J, Sarnowski, C, Sattar, N, Sibolt, G, Teumer, A, Rutten-Jacobs, L, Kanai, M, Giese, AK, Gretarsdottir, S, Rost, NS, Yusuf, S, Almgren, P, Ay, H, Bevan, S, Brown, RD, Carrera, C, Buring, JE, Chen, WM, Cotlarciuc, I, de Bakker, PIW, DeStefano, AL, den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gustafsson, S, Hassan, A, Holliday, EG, Howard, G, Hsu, FC, Ingelsson, E, Harris, TB, Kissela, BM, Kleindorfer, DO, Langenberg, C, Lemmens, R, Leys, D, Lin, WY, Lorentzen, E, Magnusson, PK, McArdle, PF, Pulit, SL, Rice, K, Sakaue, S, Sapkota, BR, Tanislav, C, Thorleifsson, G, Thorsteinsdottir, U, Tzourio, C, van Duijn, CM, Walters, M, Wareham, NJ, Amin, N, Aparicio, HJ, Attia, J, Berr, C, Bustamante, M, Caso, V, Choi, SH, Chowhan, A, Dartigues, JF, Delavaran, H, Dorr, M, Ford, I, Gurpreet, WS, Hamsten, A, Hozawa, A, Ingelsson, M, Iwasaki, M, Kaffashian, S, Kalra, L, Kjartansson, O, Kloss, M, Labovitz, DL, Laurie, CC, Li, LN, Lind, L, Lindgren, CM, Makoto, H, Minegishi, N, Morris, AP, Muller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, EA, Pedersen, NL, Perola, M, Jousilahti, P, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribases, M, Romero, JR, Rudd, AG, Sarin, AP, Sarju, R, Satoh, M, Sawada, N, Sigurdsson, A, Smith, A, Stine, OC, Stott, DJ, Strauch, K, Takai, T, Tanaka, H, Touze, E, Tsugane, S, Uitterlinden, AG, Valdimarsson, EM, van der Lee, SJ, Wakai, K, Williams, SR, Wolfe, CDA, Wong, QN, Yamaji, T, Sanghera, DK, Stefansson, K, Taylor, KD, Martinez-Majander, N, Sobue, K, Soriano-Tarraga, C, Volzke, H, Akpa, O, Sarfo, FS, Akpalu, A, Obiako, R, Wahab, K, Osaigbovo, G, Owolabi, L, Komolafe, M, Jenkins, C, Arulogun, O, Ogbole, G, Adeoye, AM, Akinyemi, J, Agunloye, A, Fakunle, AG, Uvere, E, Olalere, A, Adebajo, OJ, Chen, JS, Clarke, R, Collins, R, Guo, Y, Wang, C, Lv, J, Peto, R, Chen, YP, Fairhurst-Hunter, Z, Hill, M, Pozarickij, A, Schmidt, D, Stevens, B, Turnbull, I, Yu, CQ, Le Grand, Q, Ferreira, LE, Nagai, A, Murakami, Y, Geerlings, MI, Gasca, NC, Gudnason, V, van Vugt, M, Gottesman, RF, Shiroma, EJ, Sigurdsson, S, Ghanbari, M, Boerwinkle, E, Beiser, AS, Fongang, B, Wang, RQ, Ikram, MK, Volker, U, de Jager, PL, de Cid, R, Nordestgaard, BG, Sargurupremraj, M, Verma, SS, de Laat, KF, van Norden, AGW, de Kort, PL, Vermeer, SE, Brouwers, PJAM, Gons, RAR, Nederkoorn, PJ, den Heijer, T, van Dijk, GW, van Rooij, FGW, Aamodt, AH, Skogholt, AH, Brumpton, BM, Willer, CJ, Heuch, I, Hagen, K, Fritsche, LG, Pedersen, LM, Gabrielsen, ME, Ellekjaer, H, Zhou, W, Martinsen, AE, Kristoffersen, ES, Nielsen, JB, Hveem, K, Thomas, LF, Kleinschnitz, C, Frantz, S, Ungethum, K, Gallego-Fabrega, C, Lledos, M, Llucia-Carol, L, Sobrino, T, Campos, F, Castillo, J, Freijo, M, Arenillas, JF, Obach, V, Alvarez-Sabin, J, Molina, CA, Ribo, M, Munoz-Narbona, L, Lopez-Cancio, E, Millan, M, Diaz-Navarro, R, Vives-Bauza, C, Serrano-Heras, G, Segura, T, Delgado, P, Dhar, R, Delgado-Mederos, R, Prats-Sanchez, L, Camps-Renom, P, Blay, N, Sumoy, L, Marti-Fabregas, J, Schnohr, P, Jensen, GB, Benn, M, Afzal, S, Kamstrup, PR, van Setten, J, van der Laan, SW, Vonk, JMJ, Kim, BJ, Curtze, S, Tiainen, M, Kinnunen, J, Menon, V, Sung, YJ, Yang, CR, Saillour-Glenisson, F, Gravel, S, Onland-Moret, NC, Heath, AK, Millwood, IY, Gieger, C, Ninomiya, T, Grabe, HJ, Jukema, JW, Rissanen, IL, Strbian, D, Kim, YJ, Chen, PH, Mayerhofer, E, Howson, JMM, Irvin, MR, Adams, H, Wassertheil-Smoller, S, Christensen, K, Ikram, MA, Rundek, T, Worrall, BB, Lathrop, GM, Riaz, M, Simonsick, EM, Korv, J, Franca, PHC, Zand, R, Prasad, K, Frikke-Schmidt, R, de Leeuw, FE, Liman, T, Haeusler, KG, Ruigrok, YM, Heuschmann, PU, Longstreth, WT, Jung, KJ, Bastarache, L, Pare, G, Damrauer, SM, Chasman, DI, Rotter, JI, Anderson, CD, Zwart, JA, Niiranen, TJ, Fornage, M, Liaw, YP, Seshadri, S, Fernandez-Cadenas, I, Walters, RG, Ruff, CT, Owolabi, MO, Huffman, JE, Milani, L, Kamatani, Y, Dichgans, M, Debette, S
Publicada:
3 nov 2022
Ahead of Print:
1 sep 2022
Resumen:
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
Filiaciones:
Mishra, A:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Malik, R:
Univ Hosp, Inst Stroke & Dementia Res, ISD, LMU Munich, Munich, Germany
Hachiya, T:
Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan
Jurgenson, T:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Univ Tartu, Inst Math & Stat, Tartu, Estonia
Namba, S:
Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Japan
Posner, DC:
VA Boston Healthcare Syst, Massachusetts Vet Epidmiol Res & Informat Ctr, MAVERIC, Boston, MA USA
Kamanu, FK:
TIMI Study Grp, Boston, MA USA
Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA
Koido, M:
Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo, Japan
Univ Tokyo, Grad Sch Frontier Sci, Lab Complex Trait Genom, Tokyo, Japan
Shi, MY:
Univ Tokyo, Grad Sch Frontier Sci, Lab Complex Trait Genom, Tokyo, Japan
He, YY:
Univ Tokyo, Grad Sch Frontier Sci, Lab Complex Trait Genom, Tokyo, Japan
Georgakis, MK:
Univ Hosp, Inst Stroke & Dementia Res, ISD, LMU Munich, Munich, Germany
Massachusetts Gen Hosp, Ctr Gen Med, Boston, MA USA
Harvard & Massachusetts Inst Technol, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Caro, I:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Krebs, K:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Liaw, YC:
Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Clin Genome Sequencing, Tokyo, Japan
Chung Shan Med Univ, Dept Publ Hlth, Taichung, Taiwan
Chung Shan Med Univ, Inst Publ Hlth, Taichung, Taiwan
Vaura, FC:
Univ Turku, Dept Internal Med, Turku, Finland
Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Turku, Finland
Lin, K:
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Winsvold, BS:
Oslo Univ Hosp, Dept Res & Innovat, Div Clin Neurosci, Oslo, Norway
Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Oslo Univ Hosp, Dept Neurol, Oslo, Norway
Srinivasasainagendra, V:
Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL USA
Parodi, L:
Massachusetts Gen Hosp, Ctr Gen Med, Boston, MA USA
Harvard & Massachusetts Inst Technol, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Bae, HJ:
Seoul Natl Univ, Coll Med, Seoul Natl Univ Bundang Hosp, Dept Neurol, Seongnam, South Korea
Seoul Natl Univ, Coll Med, Seoul Natl Univ Bundang Hosp, Cerebrovasc Dis Ctr, Seongnam, South Korea
Chauhan, G:
Rajendra Inst Med Sci, Ranchi, India
Chong, MCR:
David Braley Cardiac Vasc & Stroke Res Inst, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada
McMaster Univ, Michael G DeGroote Sch Med, Dept Pathol & Mol Med, Hamilton, ON, Canada
Tomppo, L:
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
Univ Helsinki, Helsinki, Finland
Akinyemi, R:
Univ Ibadan, Coll Med, Ctr Genom & Precis Med, Ibadan, Nigeria
Univ Ibadan, Neurosci & Ageing Res Unit, Coll Med, Inst Adv Med Res & Training, Ibadan, Nigeria
Roshchupkin, GV:
Erasmus MC, Dept Epidmiol, Univ Med Ctr Rotterdam, Rotterdam, Netherlands
Erasmus MC, Dept Radiol & Nucl Med, Univ Med Ctr Rotterdam, Rotterdam, Netherlands
Habib, N:
Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, Jerusalem, Israel
Jee, YH:
Harvard TH Chan Sch Publ Hlth, Dept Epidmiol, Boston, MA USA
Thomassen, JQ:
Copenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark
Abedi, V:
Weis Ctr Res, Dept Mol & Funct Genom, Geisinger Hlth Syst, Danville, VA USA
Penn State Univ, Coll Med, Dept Publ Hlth Sci, State Coll, PA USA
Carcel-Marquez, J:
Biomed Res Inst Sant Pau IIB Sant Pau, Stroke Pharmacogen & Genet Lab, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Nygaard, M:
Univ Southern Denmark, Dept Publ Hlth, Danish Twin Registry, Odense, Denmark
Odense Univ Hosp, Dept Clin Genet, Odense, Denmark
Leonard, HL:
Ctr Alzheimers & Related Dementias, Natl Inst Hlth, Bethesda, MD USA
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Data Tecnica Int, Glen Echo, MD USA
Yang, CJ:
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA
Yonova-Doing, E:
Univ Cambridge, British Heart Fdn Cardiovasc Epidemiol Unit, Dept Publ Hlth & Primary Care, Cambridge, England
Novo Nordisk Res Centre Oxford, Dept Genet, Oxford, England
Knol, MJ:
Erasmus MC, Dept Epidmiol, Univ Med Ctr Rotterdam, Rotterdam, Netherlands
Lewis, AJ:
Vanderbilt Univ, Dept Biomed Informat, Med Ctr, Nashville, TN USA
Judy, RL:
Univ Penn, Dept Surg, Philadelphia, PA USA
Ago, T:
Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan
Amouyel, P:
Univ Lille, INSERM U1167, RID AGE, LabEx DISTALZ,Risk Factors & Mol Determinants Agi, Lille, France
CHU Lille, Publ Hlth Dept, Lille, France
Inst Pasteur, Lille, France
Armstrong, ND:
Univ Alabama Birmingham, Dept Epidmiol, Birmingham, AL USA
Bakker, MK:
Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands
Bartz, TM:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Univ Washington, Dept Biostat, Seattle, WA USA
Bennett, DA:
Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL USA
Bordes, C:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Borte, S:
Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway
Oslo Univ Hosp, Div Clin Neurosci, Dept Res & Innovat, Res Commun Unit Musculoskeletal Hlth FORMI, Oslo, Norway
Cain, A:
Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, Jerusalem, Israel
Ridker, PM:
Brigham & Womens Hosp, Div Prevent Med, Boston, MA USA
Harvard Med Sch, Boston, MA 02115 USA
Cho, K:
VA Boston Healthcare Syst, Massachusetts Vet Epidmiol Res & Informat Ctr, MAVERIC, Boston, MA USA
Chen, ZM:
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Univ Oxford, MRC Populat Hlth Res Unit, Oxford, England
Cruchaga, C:
Washington Univ, Dept Psychiat, Sch Med, St Louis, MO USA
Washington Univ, NeuroGenom & Informat Ctr, Sch Med, St Louis, MO USA
Cole, JW:
VA Maryland Hlth Care Syst, Baltimore, MD USA
Univ Maryland, Dept Neurol, Sch Med, Baltimore, MD USA
Endres, M:
Charite Univ Med Berlin, Klin Hochschulambulanz Neurol, Berlin, Germany
Ctr Stroke Res Berlin, Berlin, Germany
German Ctr Neurodegenerat Dis DZNE, Partner Site Berlin, Berlin, Germany
German Centre Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany
Hata, J:
Kyushu Univ, Grad Sch Med Sci, Dept Epidmiol & Publ Hlth, Fukuoka, Japan
He, J:
Vanderbilt Univ, Dept Biomed Informat, Med Ctr, Nashville, TN USA
Ho, YL:
VA Boston Healthcare Syst, Massachusetts Vet Epidmiol Res & Informat Ctr, MAVERIC, Boston, MA USA
Havulinna, AS:
Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Inst Mol Med Finland, FIMM, HiLIFE, Helsinki, Finland
Hopewell, JC:
Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv & Epidemiol Studies Unit CTSU, Oxford, England
Hyacinth, HI:
Univ Cincinnati, Dept Neurol & Rehabil Med, Coll Med, Cincinnati, OH USA
Inouye, M:
Univ Cambridge, British Heart Fdn Cardiovasc Epidemiol Unit, Dept Publ Hlth & Primary Care, Cambridge, England
Univ Cambridge, Dept Public Hlth & Primary Care, Cambridge Baker Syst Genom Initiative, Cambridge, England
Baker Heart & Diabet Inst, Cambridge Baker Syst Genom Initiat, Melbourne, Vic, Australia
Wellcome Genome Campus & Univ Cambridge, Hlth Data Res UK Cambridge, Cambridge, England
Univ Cambridge, British Heart Fdn Ctr Res Excellence, Cambridge, England
Jacob, MA:
Radboud Univ Nijmegen, Donders Ctr Med Neurosci, Dept Neurol, Med Ctr, Nijmegen, Netherlands
Jeon, CE:
Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA
Jern, C:
Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Lab Med, Gothenburg, Sweden
Sahlgrens Univ Hosp, Dept Clin Genet & Genom, Gothenburg, Sweden
Kamouchi, M:
Kyushu Univ, Grad Sch Med Sci, Dept Hlth Care Adm & Management, Fukuoka, Japan
Keene, KL:
East Carolina Univ, Brody Sch Med, Dept Biol, Ctr Hlth Dispar, Greenville, NC USA
Kitazono, T:
Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan
Kittner, SJ:
Univ Maryland, Dept Neurol, Sch Med, Baltimore, MD USA
VA Maryland Hlth Care Syst, Dept Neurol, Baltimore, MD USA
VA Maryland Hlth Care Syst, Geriatr Res & Educ Clin Ctr, Baltimore, MD USA
Konuma, T:
Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Japan
Kumar, A:
Rajendra Inst Med Sci, Ranchi, India
Lacaze, P:
Monash Univ, Sch Publ Hlth & Prevent Med, Dept Epidmiol & Prevent Med, Melbourne, Vic, Australia
Launer, LJ:
Natl Inst Aging, Intramural Res Program, NIH, Baltimore, MD USA
Lee, KJ:
Korea Univ Guro Hosp, Dept Neurol, Seoul, South Korea
Lepik, K:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland
Swiss Inst Bioinformat, Lausanne, Switzerland
Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland
Li, J:
Weis Ctr Res, Dept Mol & Funct Genom, Geisinger Hlth Syst, Danville, VA USA
Li, LM:
Peking Univ, Sch Publ Hlth, Dept Epidmiol & Biostat, Hlth Sci Ctr, Beijing, Peoples R China
Manichaikul, A:
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Markus, HS:
Univ Cambridge, Dept Clinical Neurosci, Stroke Res Grp, Cambridge, England
Marston, NA:
TIMI Study Grp, Boston, MA USA
Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA
Meitinger, T:
Tech Univ Munich, Inst Human Genet, Munich, Germany
German Res Ctr Environm Hlth, Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany
Carl von Ossietzky Univ Oldenburg, Klin Neurol, Oldenburg, Germany
Mitchell, BD:
Univ Maryland, Dept Med, Sch Med, Baltimore, MD USA
Baltimore Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD USA
Montellano, FA:
Univ Wurzburg, Inst Clin Epidmiol & Biometry, Wurzburg, Germany
Univ Hosp Wurzburg, Dept Neurol, Wurzburg, Germany
Morisaki, T:
Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo, Japan
Mosley, TH:
Univ Mississippi, MIND Ctr, Med Ctr, Jackson, MS USA
Nalls, MA:
Ctr Alzheimers & Related Dementias, Natl Inst Hlth, Bethesda, MD USA
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Data Tecnica Int, Glen Echo, MD USA
O'Donnell, MJ:
NUI Galway, Coll Med Nursing & Hlth Sci, Galway, Ireland
Okada, Y:
Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Japan
Univ Tokyo, Grad Sch Med, Dept Genome Informat, Tokyo, Japan
RIKEN Ctr Integrat Med Sci, Lab Syst Genet, Yokohama, Japan
Osaka Univ, Lab Stat Immunol Immunol Frontier Res Ctr WPI IFR, Suita, Osaka, Japan
Osaka Univ, Inst Open & Transdisciplinary Res Initiat, Integrated Frontier Res Med Sci Div, Suita, Osaka, Japan
Osaka Univ, Ctr Infect Dis Educ & Res, CiDER, Suita, Osaka, Japan
Ovbiagele, B:
Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA USA
Peters, A:
German Res Ctr Environm Hlth, Inst Epidmiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
Ludwig Maximilian Univ Munich, Inst Med Informat Proc Biometry & Epidmiol, Munich, Germany
German Ctr Cardiovasc Res DZHK, partner site Munich, Munich, Germany
Psaty, BM:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Univ Washington, Dept Epidmiol, Seattle, WA USA
Univ Washington, Dept Hlth Syst & Populat Hlth, Seattle, WA USA
Rich, SS:
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Rosand, J:
Massachusetts Gen Hosp, Ctr Gen Med, Boston, MA USA
Harvard & Massachusetts Inst Technol, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Massachusetts Gen Hosp, McCance Ctr Brain Hlth, Boston, MA USA
Sabatine, MS:
TIMI Study Grp, Boston, MA USA
Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA
Sacco, RL:
Univ Miami, Dept Neurol, Miller Sch Med, Miami, FL USA
Evelyn F McKnight Brain Inst, Gainesville, FL USA
Saleheen, D:
Columbia Univ, Dept Med, Div Cardiol, New York, NY USA
Sandset, EC:
Oslo Univ Hosp, Dept Neurol, Stroke Unit, Oslo, Norway
Norwegian Air Ambulance Fdn, Res & Dev, Oslo, Norway
Salomaa, V:
Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Sasaki, M:
Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan
Satizabal, CL:
Univ Texas Hlth Sci Ctr, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Schmidt, CO:
Univ Med Greifswald, Inst Community Med, SHIP KEF, Greifswald, Germany
Shimizu, A:
Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan
Smith, NL:
Univ Washington, Dept Epidmiol, Seattle, WA USA
Kaiser Permanente Washington Hlth Res Inst, Kaiser Permanente Washington, Seattle, WA USA
Seattle Epidmiol Res & Informat Ctr, Dept Vet Affairs Off Res & Dev, Seattle, WA USA
Sloane, KL:
Univ Penn, Dept Neurol, Philadelphia, PA USA
Sutoh, Y:
Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan
Sun, YV:
Atlanta VA Hlth Care Syst, Decatur, GA USA
Emory Univ, Dept Epidmiol, Rollins Sch Publ Hlth, Atlanta, GA USA
Tanno, K:
Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan
Tiedt, S:
Univ Hosp, Inst Stroke & Dementia Res, ISD, LMU Munich, Munich, Germany
Tatlisumak, T:
Sahlgrenska Unvier Hosp, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden
Torres-Aguila, NP:
Biomed Res Inst Sant Pau IIB Sant Pau, Stroke Pharmacogen & Genet Lab, Barcelona, Spain
Tiwari, HK:
Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL USA
Tregouet, DA:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Trompet, S:
Leiden Univ, Dept Internal Med, Sect Gerontol & Geriatr, Med Ctr, Leiden, Netherlands
Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands
Tuladhar, AM:
Radboud Univ Nijmegen, Donders Ctr Med Neurosci, Dept Neurol, Med Ctr, Nijmegen, Netherlands
Tybjaerg-Hansen, A:
Copenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Vibo, R:
Univ Tartu, Dept Neurol & Neurosurg, Tartu, Estonia
Wiggins, KL:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Wennberg, P:
Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden
Woo, D:
Univ Cincinnati, Dept Neurol & Rehabil Med, Coll Med, Cincinnati, OH USA
Wilson, PWF:
Atlanta VA Hlth Care Syst, Decatur, GA USA
Emory Univ, Dept Med, Div Cardiovasc Dis, Sch Med, Atlanta, GA USA
Xu, HC:
Univ Maryland, Dept Med, Sch Med, Baltimore, MD USA
Yang, Q:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA USA
Yoon, K:
Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea
Bis, JC:
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Univ Washington, Dept Epidmiol, Seattle, WA USA
Cheng, YC:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Peddareddygari, LR:
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Kooperberg, C:
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
de Andrade, M:
Univ Washington, Dept Epidmiol, Seattle, WA USA
Pankratz, N:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Univ Washington, Dept Biostat, Seattle, WA USA
Brigham & Womens Hosp, Div Prevent Med, Boston, MA USA
Univ Washington, Dept Epidmiol, Seattle, WA USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Kaiser Permanente Washington Hlth Res Inst, Kaiser Permanente Washington, Seattle, WA USA
Inst Translat Gen & Populat Sciences, Lundquist Inst BioMed Innovat Harbor, UCLA Med Ctr, Dept Pediat, Torrance, CA USA
Heckbert, SR:
Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Pankow, JS:
Univ Washington, Dept Epidmiol, Seattle, WA USA
Deleuze, JF:
Univ Washington, Dept Epidmiol, Seattle, WA USA
McKnight, B:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Rosendaal, FR:
Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Tang, WH:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Kabrhel, C:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
van Oostenbrugge, RJ:
Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Visser, MC:
Brigham & Womens Hosp, Div Prevent Med, Boston, MA USA
Wermer, MJH:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Esko, T:
Univ Washington, Dept Epidmiol, Seattle, WA USA
Kaiser Permanente Washington Hlth Res Inst, Kaiser Permanente Washington, Seattle, WA USA
Magi, R:
Inst Translat Gen & Populat Sciences, Lundquist Inst BioMed Innovat Harbor, UCLA Med Ctr, Dept Pediat, Torrance, CA USA
Levi, CR:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Jimenez-Conde, J:
Univ Washington, Dept Biostat, Seattle, WA USA
Thijs, VNS:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Ilinca, A:
Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands
Radboud Univ Nijmegen, Donders Ctr Med Neurosci, Dept Neurol, Med Ctr, Nijmegen, Netherlands
Rexrode, KM:
Radboud Univ Nijmegen, Donders Ctr Med Neurosci, Dept Neurol, Med Ctr, Nijmegen, Netherlands
Boncoraglio, GB:
Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands
Kubo, M:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Jackson, RD:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Ross, OA:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Lemmons, R:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Soderholm, M:
Univ Tartu, Inst Genom, Estonian Genome Centre, Tartu, Estonia
Putaala, J:
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
Univ Helsinki, Helsinki, Finland
Univ Alabama Birmingham, Dept Epidmiol, Birmingham, AL USA
Radboud Univ Nijmegen, Donders Ctr Med Neurosci, Dept Neurol, Med Ctr, Nijmegen, Netherlands
Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Lab Med, Gothenburg, Sweden
Univ Cambridge, Dept Clinical Neurosci, Stroke Res Grp, Cambridge, England
German Res Ctr Environm Hlth, Inst Epidmiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
Rutten-Jacobs, L:
Univ Alabama Birmingham, Dept Epidmiol, Birmingham, AL USA
Yusuf, S:
Radboud Univ Nijmegen, Donders Ctr Med Neurosci, Dept Neurol, Med Ctr, Nijmegen, Netherlands
Lemmens, R:
Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Lab Med, Gothenburg, Sweden
Attia, J:
Univ Cambridge, Dept Clinical Neurosci, Stroke Res Grp, Cambridge, England
Bustamante, M:
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
Univ Helsinki, Helsinki, Finland
Caso, V:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan
Massachusetts Gen Hosp, Ctr Gen Med, Boston, MA USA
Harvard & Massachusetts Inst Technol, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Clin Genome Sequencing, Tokyo, Japan
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL USA
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
Univ Helsinki, Helsinki, Finland
Erasmus MC, Dept Epidmiol, Univ Med Ctr Rotterdam, Rotterdam, Netherlands
Biomed Res Inst Sant Pau IIB Sant Pau, Stroke Pharmacogen & Genet Lab, Barcelona, Spain
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Vanderbilt Univ, Dept Biomed Informat, Med Ctr, Nashville, TN USA
Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands
Univ Washington, Dept Biostat, Seattle, WA USA
Brigham & Womens Hosp, Div Prevent Med, Boston, MA USA
Harvard Med Sch, Boston, MA 02115 USA
Washington Univ, Dept Psychiat, Sch Med, St Louis, MO USA
Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidmiol, Utrecht, Netherlands
Univ Iceland, Fac Med, Reykjavik, Iceland
Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Inst Mol Med Finland, FIMM, HiLIFE, Helsinki, Finland
Univ Cincinnati, Dept Neurol & Rehabil Med, Coll Med, Cincinnati, OH USA
Univ Cambridge, Dept Clinical Neurosci, Stroke Res Grp, Cambridge, England
Univ Maryland, Dept Med, Sch Med, Baltimore, MD USA
German Ctr Cardiovasc Res DZHK, partner site Munich, Munich, Germany
Massachusetts Gen Hosp, McCance Ctr Brain Hlth, Boston, MA USA
Univ Texas Hlth Sci Ctr, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Univ Med Greifswald, Inst Community Med, SHIP KEF, Greifswald, Germany
Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA USA
Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark
Inst Translat Gen & Populat Sciences, Lundquist Inst BioMed Innovat Harbor, UCLA Med Ctr, Dept Pediat, Torrance, CA USA
Brigham & Women's Hosp, Dept Neurol, Boston, MA USA
Boston Univ, Dept Neurol, Sch Med, Boston, MA USA
Sobue, K:
Massachusetts Gen Hosp, Ctr Gen Med, Boston, MA USA
Harvard & Massachusetts Inst Technol, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Massachusetts Gen Hosp, McCance Ctr Brain Hlth, Boston, MA USA
Brigham & Women's Hosp, Dept Neurol, Boston, MA USA
Ogbole, G:
Univ Texas Hlth Sci Ctr, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Wang, C:
Biomed Res Inst Sant Pau IIB Sant Pau, Stroke Pharmacogen & Genet Lab, Barcelona, Spain
Peto, R:
Washington Univ, Dept Psychiat, Sch Med, St Louis, MO USA
Fairhurst-Hunter, Z:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Hill, M:
Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Clin Genome Sequencing, Tokyo, Japan
Schmidt, D:
Biomed Res Inst Sant Pau IIB Sant Pau, Stroke Pharmacogen & Genet Lab, Barcelona, Spain
Le Grand, Q:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
Univ Helsinki, Helsinki, Finland
Ferreira, LE:
Univ Regiao Joinville, Dept Med, Postgrad Program Hlth & Environm, Santa Catarina, Brazil
Univ Regiao Joinville, Joinville Stroke Biobank, Santa Catarina, Brazil
Univ Med Greifswald, Inst Community Med, SHIP KEF, Greifswald, Germany
Nagai, A:
Univ Cambridge, Dept Clinical Neurosci, Stroke Res Grp, Cambridge, England
Geerlings, MI:
Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidmiol, Utrecht, Netherlands
Gasca, NC:
Univ Washington, Dept Biostat, Seattle, WA USA
Gudnason, V:
Iceland Heart Assoc, Kopavogur, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
van Vugt, M:
Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
Beiser, AS:
Brigham & Womens Hosp, Div Prevent Med, Boston, MA USA
Harvard Med Sch, Boston, MA 02115 USA
German Res Ctr Environm Hlth, Inst Epidmiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
Fongang, B:
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Volker, U:
Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidmiol, Utrecht, Netherlands
de Jager, PL:
Harvard & Massachusetts Inst Technol, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Columbia Univ, Ctr Translat & Computat Neuroimmunol, Dept Neurol, Med Ctr, New York, NY USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA USA
de Cid, R:
Germans Trias & Pujol Res Inst IGTP, GenomesForLife GCAT Lab Grp, Badalona, Spain
Nordestgaard, BG:
Copenhagen Univ Hosp Herlev & Gentofte, Dept Clin Biochem, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Sargurupremraj, M:
Harvard & Massachusetts Inst Technol, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Univ Texas Hlth Sci Ctr, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Verma, SS:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA
de Kort, PL:
Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL USA
den Heijer, T:
Univ Cincinnati, Dept Neurol & Rehabil Med, Coll Med, Cincinnati, OH USA
van Dijk, GW:
Univ Cincinnati, Dept Neurol & Rehabil Med, Coll Med, Cincinnati, OH USA
Pedersen, LM:
Univ Maryland, Dept Med, Sch Med, Baltimore, MD USA
Gabrielsen, ME:
Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands
Martinsen, AE:
Univ Washington, Dept Biostat, Seattle, WA USA
Llucia-Carol, L:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Sobrino, T:
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Erasmus MC, Dept Epidmiol, Univ Med Ctr Rotterdam, Rotterdam, Netherlands
Freijo, M:
Erasmus MC, Dept Epidmiol, Univ Med Ctr Rotterdam, Rotterdam, Netherlands
Arenillas, JF:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Boston Univ, Dept Neurol, Sch Med, Boston, MA USA
Alvarez-Sabin, J:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA USA
Lopez-Cancio, E:
Vanderbilt Univ, Dept Biomed Informat, Med Ctr, Nashville, TN USA
Millan, M:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Boston Univ, Dept Neurol, Sch Med, Boston, MA USA
Diaz-Navarro, R:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Jensen, GB:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
van der Laan, SW:
Univ Washington, Dept Biostat, Seattle, WA USA
Sung, YJ:
German Ctr Cardiovasc Res DZHK, partner site Munich, Munich, Germany
Onland-Moret, NC:
Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidmiol, Utrecht, Netherlands
Heath, AK:
Imperial Coll London, Sch Public Hlth, Dept Epidemiol & Biostat, London, England
Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Millwood, IY:
Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Gieger, C:
German Res Ctr Environm Hlth, Inst Epidmiol, Res Unit Mol Epidmiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
Grabe, HJ:
Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany
German Ctr Neurodegenerat Dis, DZNE, Rostock, Germany
Jukema, JW:
Netherlands Heart Inst, Utrecht, Netherlands
LUMC, Einthoven Lab Expt Vasc Med, Leiden, Netherlands
Strbian, D:
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Boston Univ, Dept Neurol, Sch Med, Boston, MA USA
Chen, PH:
Inst Mol Med Finland, FIMM, HiLIFE, Helsinki, Finland
Univ Texas Hlth Sci Ctr, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Irvin, MR:
Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Univ Washington, Dept Epidmiol, Seattle, WA USA
Adams, H:
Erasmus MC, Dept Radiol & Nucl Med, Dept Clin Genet, Rotterdam, Netherlands
Univ Adolfo Ibanez, Latin Amer Brain Hlth BrainLat, Santiago, Chile
Wassertheil-Smoller, S:
Albert Einstein Coll Med, Dept Epidmiol & Populat Hlth, New York, NY USA
Christensen, K:
Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark
Worrall, BB:
Univ Virginia, Dept Neurol, Charlottesville, VA USA
Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA
Lathrop, GM:
McGill Genome Ctr, Montreal, PQ, Canada
Simonsick, EM:
Natl Inst Aging, Translat Gerontol Branch, Longitudinal Studies Sect, Baltimore, MD USA
Zand, R:
Geisinger Neuroscience Inst, Geisinger Hlth Syst, Danville, PA USA
Penn State Univ, Coll Med, Dept Neurol, State Coll, PA USA
Prasad, K:
Erasmus MC, Dept Epidmiol, Univ Med Ctr Rotterdam, Rotterdam, Netherlands
Liman, T:
Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark
Ruigrok, YM:
Univ Washington, Dept Biostat, Seattle, WA USA
Heuschmann, PU:
Univ Hosp Wurzburg, Comprehens Heart Failure Ctr, Wurzburg, Germany
Univ Hosp Wurzburg, Clin Trial Ctr, Wurzburg, Germany
Longstreth, WT:
Univ Washington, Dept Neurol, Seattle, WA USA
Jung, KJ:
Yonsei Univ, Inst Hlth Promot, Grad Sch Publ Hlth, Seoul, South Korea
Pare, G:
Univ Iceland, Fac Med, Reykjavik, Iceland
McMaster Univ, Dept Hlth Res Methods, Evidence & Impact, Hamilton, ON, Canada
Populat Hlth Res Inst, Vasc & Stroke Res Inst, David Braley Cardiac, Hamilton, ON, Canada
Damrauer, SM:
Univ Penn, Dept Surg, Dept Genet, Philadelphia, PA USA
Corporal Michael Crescenz VA Med Ctr, Philadelphia, PA USA
Inst Translat Gen & Populat Sciences, Lundquist Inst BioMed Innovat Harbor, UCLA Med Ctr, Dept Pediat, Torrance, CA USA
Chasman, DI:
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
Univ Helsinki, Helsinki, Finland
Rotter, JI:
Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan
Inst Translat Gen & Populat Sciences, Lundquist Inst BioMed Innovat Harbor, UCLA Med Ctr, Dept Pediat, Torrance, CA USA
Anderson, CD:
Brigham & Women's Hosp, Dept Neurol, Boston, MA USA
Zwart, JA:
Univ Med Greifswald, Inst Community Med, SHIP KEF, Greifswald, Germany
Niiranen, TJ:
Univ Ibadan, Coll Med, Ctr Genom & Precis Med, Ibadan, Nigeria
Turku Univ Hosp, Div Med, Turku, Finland
Univ Ibadan, Dept Med, Ibadan, Nigeria
Fornage, M:
Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, McGovern Med Sch, Houston, TX USA
Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX USA
Liaw, YP:
Chung Shan Med Univ Hosp, Dept Med Imaging, Taichung, Taiwan
Dichgans, M:
Univ Hosp, Inst Stroke & Dementia Res, ISD, LMU Munich, Munich, Germany
Munich Cluster Syst Neurol, Munich, Germany
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Debette, S:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
CHU Bordeaux, Inst Neurodegenerat Dis, Dept Neurol, Bordeaux, France
Green Published, Green Submitted, hybrid
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