Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial (August, 10.1038/s41591-021-01455-x, 2021)

Por: Dam, T, Golbe, LI, Hoglinger, GU, Grundman, M, Yang, LL, Tidemann-Miller, B, Kupferman, J, Harper, K, Kamisoglu, K, Wald, MJ, Graham, DL, Gedney, L, O'Gorman, J, Haeberlein, SB, Aiba, I, Antonini, A, Apetauerova, D, Azulay, JP, Martinez, EB, Bang, J, Barone, P, Barrett, M, Bega, D, Berg, D, Corrales, KB, Bordelon, Y, Boxer, AL, Brandt, M, Brueggemann, N, Castelnovo, G, Ceravolo, R, Chuang, RD, Chung, SJ, Church, A, Corvol, JC, Cudia, P, Dale, M, Defebvre, L, Drapier, S, Driver-Dunckley, ED, Ebersbach, G, Eggert, KM, Ellenbogen, A, Eusebio, A, Evans, AH, Fedorova, N, Finger, E, Foubert-Samier, A, Ghosh, B, Golbe, L, Perez, FG, Grossman, M, Hall, D, Hamada, K, Hasegawa, K, Hoeglinger, G, Honig, L, Houghton, D, Huang, XM, Isaacson, S, Koh, S, Bojarski, JK, Lang, ANE, Leigh, PN, Litvan, I, Lozano, JJL, Moreno, JLLS, Ludolph, AC, Piudo, MRL, Torres, IM, McFarland, N, Meissner, W, Mestre, T, Rivera, PM, Molho, E, Mollenhauer, B, Morris, HR, Murata, M, Obi, T, Magne, FO, O'Suilleabhain, P, Pahwa, R, Pantelyat, A, Pavese, N, Pokhabov, D, Prudlo, J, Rodriguez-Porcel, F, Rowe, J, Savitt, J, Schnitzler, A, Schulz, JB, Seppi, K, Shah, BI, Shill, H, Shprecher, D, Stamelou, M, Steiger, M, Takahashi, Y, Takigawa, H, Tartaglia, C, Toenges, L, Truong, D, Tse, W, Tuite, P, Volc, D, Wills, AMA, Woitalla, D, Xie, T, Yuasa, T, Zauber, SE, Zesiewicz, T

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Publicada: 1 nov 2023 Ahead of Print: 1 oct 2022

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Filiaciones:
Aiba, I:
 Higashinagoya Natl Hosp, Natl Hosp Org, Dept Neurol, Nagoya, Aichi, Japan

Antonini, A:
 San Camillo Hosp IRCCS, Venice Lido, Italy

Apetauerova, D:
 Lahey Hosp & Med Ctr, Burlington, MA USA

Azulay, JP:
 AP HM, Marseille, France

Martinez, EB:
 Hosp Gen Cataluna, Barcelona, Spain

Bang, J:
 Johns Hopkins Univ, Baltimore, MD USA

Barone, P:
 Univ Salerno, AOU San Giovanni di Dio & Ruggi dAragona, Salerno, Italy

Barrett, M:
 Univ Virginia Hlth Syst, Charlottesville, VA USA

Bega, D:
 Northwestern Univ, Chicago, IL 60611 USA

Berg, D:
 UKSH Campus Kiel, Kiel, Germany

Corrales, KB:
 Hosp De Cruces, Baracaldo, Spain

Bordelon, Y:
 Univ Calif Los Angeles, Los Angeles, CA USA

Boxer, AL:
 Univ Calif San Francisco, Dept Neurol, Mem & Aging Ctr, San Francisco, CA USA

Brandt, M:
 Univ Klinikum Carl Gustav Carus Dresden, Dresden, Germany

Brueggemann, N:
 Univ Hosp Schleswig Holstein, Lubeck, Germany

Castelnovo, G:
 Hop Univ Caremeau, CHU Nimes, Nimes, France

Ceravolo, R:
 Univ Hosp Pisa, Pisa, Italy

Chuang, RD:
 Swedish Hlth Serv, Seattle, WA USA

Chung, SJ:
 Asan Med Ctr, Seoul, South Korea

Church, A:
 Aneurin Bevan Univ, St Woolos Hosp, Hlth Board Clin Res & Innovat Ctr, Newport, Shrops, England

Corvol, JC:
 Sorbonne Univ, Hop Pitie Salpetriere, AP HP, INSERM,CNRS,Inst Cerveau,Paris Brain Inst,ICM, Paris, France

Cudia, P:
 San Camillo Hosp IRCCS, Venice Lido, Italy

Dale, M:
 Med Univ South Carolina, Charleston, SC 29425 USA

Defebvre, L:
 Hop Roger Salengro, Ctr Hosp Reg Univ Lille, Lille, France

Drapier, S:
 Hop Pontchaillou, CHU Rennes, Rennes, France

Driver-Dunckley, ED:
 Mayo Clin Arizona, Scottsdale, AZ USA

Ebersbach, G:
 Movement Disorders Clin, Beelitz, Germany

Eggert, KM:
 Philipps Univ Marburg, Marburg, Germany

Ellenbogen, A:
 QUEST Res Inst, Farmington, MI USA

Eusebio, A:
 AP HM, Marseille, France

Evans, AH:
 Royal Melbourne Hosp RMH Flemington Neurol North, North Melbourne, Australia

Fedorova, N:
 Russian Med Acad Postgrad Educ, Moscow, Russia

Finger, E:
 Parkwood Inst, London, ON, Canada

Foubert-Samier, A:
 IMNC Hop Pellegrin, CHU Bordeaux, Parkinson Expert Ctr, Bordeaux, France

Ghosh, B:
 Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England

Golbe, L:
 Rutgers Robert Wood Johnson Med Sch, New Brunswick, NJ USA

Perez, FG:
 Hosp Gen Univ Gregorio Maranon, Madrid, Spain

Grossman, M:
 Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA

Hall, D:
 Rush Univ, Med Ctr, Chicago, IL 60612 USA

Hamada, K:
 Shinsapporo Neurosurg Hosp, Sapporo, Hokkaido, Japan

Hasegawa, K:
 Sagamihara Natl Hosp, Natl Hosp Org, Sagamihara, Kanagawa, Japan

Hoeglinger, G:
 Tech Univ Munich, Dept Neurol, Munich, Germany

Honig, L:
 Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, 630 W 168th St, New York, NY 10032 USA

Houghton, D:
 Ochsner Med Ctr, New Orleans, LA USA

Huang, XM:
 Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA

Isaacson, S:
 Parkinsons Dis & Movement Disorder Ctr Boca Raton, Boca Raton, FL USA

Koh, S:
 Korea Univ, Guro Hosp, Seoul, South Korea

Bojarski, JK:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Lang, ANE:
 Toronto Western Hosp, Parkinsons Dis & Rossy PSP Ctr, Edmond J Safra Program, Toronto, ON, Canada

 Univ Toronto, Toronto, ON, Canada

Leigh, PN:
 Trafford Ctr Biomed Res, Brighton & Sussex Med Sch, Brighton, E Sussex, England

Litvan, I:
 Univ Calif San Diego, Parkinson & Other Movement Disorders Ctr, San Diego, CA 92103 USA

Lozano, JJL:
 Clin Ruber Int, Madrid, Spain

Moreno, JLLS:
 Hosp Univ Ramon & Cajal, Madrid, Spain

Ludolph, AC:
 Univ & Rehabil Kliniken Ulm, Ulm, Germany

Piudo, MRL:
 Clin Univ Navarra, Pamplona, Spain

Torres, IM:
 Hosp La Fe, Valencia, Spain

McFarland, N:
 Univ Florida, Ctr Movement Disorders & Neurorestorat, Gainesville, FL USA

Meissner, W:
 IMNC Hop Pellegrin, CHU Bordeaux, Parkinson Expert Ctr, Bordeaux, France

Mestre, T:
 Univ Ottawa, Ottawa Hosp Civ Campus, Ottawa, ON, Canada

Rivera, PM:
 Hosp Univ Virgen del Rocio, Seville, Spain

Molho, E:
 Albany Med Coll, Albany, NY 12208 USA

Mollenhauer, B:
 Paracelsus Elena Klin Kassel, Kassel, Germany

Morris, HR:
 Natl Hosp Neurol & Neurosurg, London, England

Murata, M:
 Musashi Hosp, Kodaira, Tokyo, Japan

Obi, T:
 Natl Hosp Org, Shizuoka Inst Epilepsy & Neurol Disorders, Shizuoka, Japan

Magne, FO:
 Hop Purpan, Batiment Pierre Paul Riquet, Toulouse, France

O'Suilleabhain, P:
 Univ Texas Southwestern Med Ctr Dallas, Clin Ctr Movement Disorders, Dallas, TX 75390 USA

Pahwa, R:
 Univ Kansas, Med Ctr, Parkinsons Dis & Movement Disorder Ctr, Kansas City, KS 66103 USA

Pantelyat, A:
 Johns Hopkins Univ, Baltimore, MD USA

Pavese, N:
 Newcastle Upon Tyne Hosp NHS Fdn Trust Campus Age, Newcastle Upon Tyne, Tyne & Wear, England

Pokhabov, D:
 Fed Med Biol Agcy, Fed Siberian Sci Clin Ctr, Fed State Budgetary Inst, Krasnoyarsk, Russia

Prudlo, J:
 Univ Med Rostock, Univ Rostock, Rostock, Germany

Rodriguez-Porcel, F:
 Med Univ South Carolina, Charleston, SC 29425 USA

Rowe, J:
 Univ Cambridge, Cambridge, England

Savitt, J:
 Univ Maryland, Sch Med, Baltimore, MD 21201 USA

Schnitzler, A:
 Univ Hosp Dusseldorf, Ctr Movement Disorders & Neuromodulat, Dusseldorf, Germany

Schulz, JB:
 Uniklin RWTH Aachen, Med Klin 3, Aachen, Germany

Seppi, K:
 Med Univ Innsbruck, Innsbruck, Austria

Shah, BI:
 Univ Virginia Hlth Syst, Charlottesville, VA USA

Shill, H:
 St Josephs Hosp, Barrow Neurol Clin, Phoenix, AZ USA

Shprecher, D:
 Banner Sun Hlth Res Inst, Sun City, AZ USA

Stamelou, M:
 Hygeia Hosp, Maroussi, Greece

Steiger, M:
 Walton Ctr NHS Fdn Trust, Liverpool, Merseyside, England

Takahashi, Y:
 Musashi Hosp, Kodaira, Tokyo, Japan

Takigawa, H:
 Tottori Univ Hosp, Yonago, Tottori, Japan

Tartaglia, C:
 Univ Hlth Network, Toronto Western Hosp, Movement Disorders Ctr, Toronto, ON, Canada

Toenges, L:
 St Josef Hosp Bochum, Kardiol Studienambulanz, Bochum, Germany

Truong, D:
 Parkinsons & Movement Disorder Inst, Fountain Valley, CA USA

Tse, W:
 Mt Sinai Movement Disorders Ctr, New York, NY USA

Tuite, P:
 Univ Minnesota, Med Ctr, Fairview Neurol Clin, Minneapolis, MN 55455 USA

Volc, D:
 Prosenex Ambulatoriumsbetriebs GmbH Studienzentru, Vienna, Austria

Wills, AMA:
 Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA

Woitalla, D:
 St Josefs Hosp, Essen, Germany

Xie, T:
 Univ Chicago Med, Ctr Parkinsons Dis & Movement Disorders, Chicago, IL USA

Yuasa, T:
 Kamagaya Gen Hosp, Kamagaya, Japan

Zauber, SE:
 Indiana Univ Hlth Phys Neurol Indianapolis, Indianapolis, IN USA

Zesiewicz, T:
 Univ S Florida, Morsani Coll Med, Tampa, FL 33620 USA