Identification of regulatory variants associated with genetic susceptibility to meningococcal disease
Por:
Borghini, L, Png, E, Binder, A, Wright, VJ, Pinnock, E, de Groot, R, Hazelzet, J, Emonts, M, Van der Flier, M, Schlapbach, LJ, Anderson, S, Secka, F, Salas, A, Fink, C, Carrol, ED, Pollard, AJ, Coin, LJ, Kuijpers, TW, Martinon-Torres, F, Zenz, W, Levin, M, Hibberd, ML, Davila, S, Gormley, S, Hamilton, S, Herberg, J, Hourmat, B, Hoggart, C, Kaforou, M, Sancho-Shimizu, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Bokhandi, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Cratev, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Gonzalez, FA, Barral-Arca, R, Cebey-Lopez, M, Curras-Tuala, MJ, Garcia, N, Vicente, LG, Gomez-Carballa, A, Rial, JG, Beiroa, AG, Grande, AJ, Iglesias, PL, Santos, AEM, Martinon-Torres, N, Sanchez, JMM, Perez, BM, Pacheco, PO, Pardo-Seco, J, Pischedda, S, Calle, IR, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Fernandez, SS, Silva, MDP, Vega, A, Reyes, SB, Leon, MCL, Mingorance, AN, Barrios, XG, Vergara, EO, Torre, AC, Vivanco, A, Fernandez, R, Sanchez, FG, Forte, MS, Rojo, P, Contreras, JR, Palacios, A, Navarro, M, Alvarez, CA, Lozano, MJ, Carreras, E, Sanagustin, SB, Neth, O, Padilla, MDM, Tato, LMP, Guillen, S, Silveira, LF, Moreno, D, van Furth, AMT, van der Flier, M, Boeddha, NP, Driessen, GJA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Berger, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Paulus, S, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Agbeko, R, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Saidykhan, M, Cole, F, Thomas, G, Antonio, M, Walcher, W, Geishofer, G, Klobassa, D, Martin, M, Pfurtscheller, K, Reiter, K, Rodl, S, Zobel, G, Zohrer, B, Topke, B, Fucik, P, Gabriel, M, Penzien, JM, Diab, G, Miething, R, Deeg, KH, Hammer, J, Varnholt, V, Schmidt, A, Bindl, L, Sillaber, U, Huemer, C, Meier, P, Simic-Schleicher, G, Markart, M, Pfau, E, Broede, H, Ausserer, B, Kalhoff, H, Arpe, V, Schweitzer-Krantz, S, Kasper, JM, Loranth, K, Bittrich, HJ, Simma, B, Klinge, J, Fedlmaier, M, Weigand, N, Herting, E, Grube, R, Fusch, C, Gruber, A, Schimmel, U, Knaufer-Schiefer, S, Lassig, W, Hennenberger, A, von der Wense, A, Tillmann, R, Schwarick, J, Sitzmann, FC, Streif, W, Muller, H, Kurnik, P, Groneck, P, Weiss, U, Groblacher-Roth, H, Bensch, J, Moser, R, Schwarz, R, Lenz, K, Hofmann, T, Gopel, W, Schulz, D, Berger, T, Hauser, E, Forster, KM, Peters, J, Nicolai, TH, Kumlien, B, Beckmann, R, Seitz, C, Huseman, D, Schurmann, R, Ta, VH, Weikmann, E, Evert, W, Hautz, J, Seidenberg, J, Wocko, L, Luigs, P, Reiter, HL, Quietzach, J, Konig, M, Herrmann, J, Mitter, H, Seidler, E, Maak, B, Sperl, W, Zwiauer, K, Meissl, M, Koch, R, Cremer, M, Breuer, HA, Gorke, W, Nossal, R, Pernice, W, Brangenberg, R, Salzer, HR, Koch, H, Schaller, G, Paky, F, Strasser, F, Eitelberger, F, Sontheimer, D, Lischka, A, Kronberger, M, Dilch, A, Scheibenpflug, C, Bruckner, R, Mahler, K, Runge, K, Kunze, W, Schermann, P
Publicada:
6 may 2019
Resumen:
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA- a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngea I epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes.
Filiaciones:
Borghini, L:
Genome Inst Singapore, Human Genet, Singapore, Singapore
Genome Inst Singapore, Infect dis, Singapore, Singapore
Png, E:
Genome Inst Singapore, Infect dis, Singapore, Singapore
Binder, A:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Wright, VJ:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Pinnock, E:
Univ Warwick, Micropathol Ltd, Warwick, England
de Groot, R:
Radboud Univ Nijmegen, Dept Pediat, Med Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands
Hazelzet, J:
Univ Med Ctr, Erasmus Med Ctr, Dept Pediat, Sophia Childrens Hosp, Rotterdam, Netherlands
Emonts, M:
Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Tyne Hosp Fdn Trust, Great North Childrens Hosp, Paediat Infect Dis & Immunol Dept, Newcastle Upon Tyne, Tyne & Wear, England
Van der Flier, M:
Radboud Univ Nijmegen, Dept Pediat, Med Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands
Schlapbach, LJ:
Univ Queensland, Fac Med, Brisbane, Qld, Australia
Univ Queensland, Mater Res Inst, Paediat Crit Care Res Grp, Brisbane, Qld, Australia
Lady Cilento Childrens Hosp, Paediat Intens Care Unit, Brisbane, Qld, Australia
Univ Bern, Bern Univ Hosp, Dept Pediat, Inselspital, Bern, Switzerland
Anderson, S:
Med Res Council Unit Gambia, Banjul, Gambia
Secka, F:
Med Res Council Unit Gambia, Banjul, Gambia
Salas, A:
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat PatolOx & Ciencias Forenses, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPoB Res Grp, Galicia, Spain
Fink, C:
Univ Warwick, Micropathol Ltd, Warwick, England
Carrol, ED:
Univ Liverpool, Inst Infect & Global Hlth, Liverpool, Merseyside, England
Pollard, AJ:
Univ Oxford, Dept Pediat, Oxford Vaccine Grp, Oxford, England
NIHR Oxford Biomed Res Ctr, Oxford, England
Coin, LJ:
Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
Kuijpers, TW:
Emma Childrens Hosp Acad, Div Pediat Hematol, Immunol & Infect Dis, Med Ctr, Amsterdam, Netherlands
Martinon-Torres, F:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Zenz, W:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Levin, M:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Hibberd, ML:
Genome Inst Singapore, Infect dis, Singapore, Singapore
London Sch Hyg & Trop Med, Infect & Trop Dis, London, England
Davila, S:
Genome Inst Singapore, Human Genet, Singapore, Singapore
Singhlth Duke NUS Inst Precis Med PRISM, Singapore, Singapore
Duke NUS Med Sch, Singapore, Singapore
Gormley, S:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Hamilton, S:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Herberg, J:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Hourmat, B:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Hoggart, C:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Kaforou, M:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Sancho-Shimizu, V:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Abdulla, A:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Agapow, P:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Bartlett, M:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Bellos, E:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Eleftherohorinou, H:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Galassini, R:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Inwald, D:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Mashbat, M:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Menikou, S:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Mustafa, S:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Nadel, S:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Rahman, R:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Thakker, C:
Imperial Coll London, Dept Med, Div Infect Dis, Sect Paediat, London, England
Bokhandi, S:
Poole Hosp NHS Fdn Trust, Poole, Dorset, England
Power, S:
Poole Hosp NHS Fdn Trust, Poole, Dorset, England
Barham, H:
Poole Hosp NHS Fdn Trust, Poole, Dorset, England
Pathan, N:
Cambridge Univ Hosp NHS Trust, Cambridge, England
Ridout, J:
Cambridge Univ Hosp NHS Trust, Cambridge, England
White, D:
Cambridge Univ Hosp NHS Trust, Cambridge, England
Thurston, S:
Cambridge Univ Hosp NHS Trust, Cambridge, England
Faust, S:
Univ Hosp Southampton, Southampton, Hants, England
Patel, S:
Univ Hosp Southampton, Southampton, Hants, England
McCorkell, J:
Univ Hosp Southampton, Southampton, Hants, England
Davies, P:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Cratev, L:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Navarra, H:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Carter, S:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Ramaiah, R:
Univ Hosp Leicester NHS Trust, Leicester, Leics, England
Patel, R:
Univ Hosp Leicester NHS Trust, Leicester, Leics, England
Tuffrey, C:
Portsmouth Hosp NHS Trust, London, England
Gribbin, A:
Portsmouth Hosp NHS Trust, London, England
McCready, S:
Portsmouth Hosp NHS Trust, London, England
Peters, M:
Portsmouth Hosp NHS Trust, London, England
Hardy, K:
Portsmouth Hosp NHS Trust, London, England
Standing, F:
Portsmouth Hosp NHS Trust, London, England
O'Neill, L:
Portsmouth Hosp NHS Trust, London, England
Abelake, E:
Portsmouth Hosp NHS Trust, London, England
Deep, A:
Kings Coll Hosp NHS Fdn Trust, London, England
Nsirim, E:
Kings Coll Hosp NHS Fdn Trust, London, England
Willis, L:
Univ Oxford, Dept Pediat, Oxford Vaccine Grp, Oxford, England
NIHR Oxford Biomed Res Ctr, Oxford, England
Young, Z:
Univ Oxford, Dept Pediat, Oxford Vaccine Grp, Oxford, England
NIHR Oxford Biomed Res Ctr, Oxford, England
Royad, C:
Kettering Gen Hosp NHS Fdn Trust, Kettering, England
White, S:
Kettering Gen Hosp NHS Fdn Trust, Kettering, England
Fortune, PM:
Cent Manchester NHS Trust, Manchester, Lancs, England
Hudnott, P:
Cent Manchester NHS Trust, Manchester, Lancs, England
Gonzalez, FA:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Barral-Arca, R:
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat PatolOx & Ciencias Forenses, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPoB Res Grp, Galicia, Spain
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Cebey-Lopez, M:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Curras-Tuala, MJ:
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat PatolOx & Ciencias Forenses, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPoB Res Grp, Galicia, Spain
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Garcia, N:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Vicente, LG:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Gomez-Carballa, A:
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat PatolOx & Ciencias Forenses, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPoB Res Grp, Galicia, Spain
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Rial, JG:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Beiroa, AG:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Grande, AJ:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Iglesias, PL:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Santos, AEM:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Martinon-Torres, N:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Sanchez, JMM:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Perez, BM:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Pacheco, PO:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Pardo-Seco, J:
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat PatolOx & Ciencias Forenses, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPoB Res Grp, Galicia, Spain
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Pischedda, S:
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat PatolOx & Ciencias Forenses, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPoB Res Grp, Galicia, Spain
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Calle, IR:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Rodriguez-Tenreiro, C:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Redondo-Collazo, L:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Fernandez, SS:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Silva, MDP:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Vega, A:
Hosp Clin Univ Santiago, Translat Pediat & Infect Dis, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, GENVIP Res Grp, Galicia, Spain
Univ Santiago Compostela, Fdn Publ Galega Med Xenom, Inst Invest Sanitarias IDIS, Serv Galego Saude SERGAS,CIBERER, Santiago De Compostela, Spain
Univ Santiago Compostela, Ctr Invest Biomed Red Enfermedades Raras, Grp Med Xenom, Santiago De Compostela, Spain
Reyes, SB:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Leon, MCL:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Mingorance, AN:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Barrios, XG:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Vergara, EO:
Hosp Donostia, San Sebastian, Spain
Torre, AC:
Hosp Univ Cent Asturias, Asturias, Spain
Vivanco, A:
Hosp Univ Cent Asturias, Asturias, Spain
Fernandez, R:
Hosp Univ Cent Asturias, Asturias, Spain
Sanchez, FG:
Complejo Hosp Torrecardenas, Almeria, Spain
Forte, MS:
Complejo Hosp Torrecardenas, Almeria, Spain
Rojo, P:
Hosp Univ 12 Octubre, Madrid, Spain
Contreras, JR:
Hosp Univ 12 Octubre, Madrid, Spain
Palacios, A:
Hosp Univ 12 Octubre, Madrid, Spain
Navarro, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Alvarez, CA:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Lozano, MJ:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Carreras, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Sanagustin, SB:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Neth, O:
Hosp Univ Virgen Rodo, Seville, Spain
Padilla, MDM:
Complejo Hosp Jaen, Jaen, Spain
Tato, LMP:
Hosp Univ Getafe, Madrid, Spain
Guillen, S:
Hosp Univ Getafe, Madrid, Spain
Silveira, LF:
Hosp Univ & Politecn La Fe, Valencia, Spain
Moreno, D:
Hosp Reg Univ Carlos Haya, Malaga, Spain
van Furth, AMT:
Vrije Univ Univ, Med Ctr, Amsterdam, Netherlands
van der Flier, M:
Radboud Univ Nijmegen, Dept Pediat, Med Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands
Boeddha, NP:
Univ Med Ctr, Erasmus Med Ctr, Dept Pediat, Sophia Childrens Hosp, Rotterdam, Netherlands
Driessen, GJA:
Univ Med Ctr, Erasmus Med Ctr, Dept Pediat, Sophia Childrens Hosp, Rotterdam, Netherlands
Pajkrt, D:
Emma Childrens Hosp Acad, Div Pediat Hematol, Immunol & Infect Dis, Med Ctr, Amsterdam, Netherlands
Sanders, EAM:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Utrecht, Netherlands
van de Beek, D:
Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands
van der Ende, A:
Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands
Philipsen, HLA:
Radboud Univ Nijmegen, Dept Pediat, Med Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands
Adeel, AOA:
Kennemer Gasthuis, Haarlem, Netherlands
Breukels, MA:
Elkerliek Hosp, Helmond, Netherlands
Brinkman, DMC:
Alrijne Hosp, Leiderdorp, Netherlands
de Korte, CCMM:
Beatrix Hosp, Gorinchem, Netherlands
de Vries, E:
Jeroen Bosch Hosp, Shertogenbosch, Netherlands
de Waal, WJ:
Diakonessen Hosp, Utrecht, Netherlands
Dekkers, R:
Maasziekenhuis Pantein, Boxmeer, Netherlands
Dings-Lammertink, A:
Gelre Hosp, Zutphen, Netherlands
Doedens, RA:
Martini Hosp, Groningen, Netherlands
Donker, AE:
Maxima Med Ctr, Veldhoven, Netherlands
Dousma, M:
Gemini Hosp, Den Helder, Netherlands
Faber, TE:
Med Ctr Leeuwarden, Leeuwarden, Netherlands
Gerrits, GPJM:
Canisius Wilhelmina Hosp, Nijmegen, Netherlands
Gerver, JAM:
Rode Kruis Hosp, Beverwijk, Netherlands
Heidema, J:
St Antonius Hosp, Nieuwegein, Netherlands
Homan-van der Veen, J:
Deventer Hosp, Deventer, Netherlands
Jacobs, MAM:
Slingeland Hosp, Doetinchem, Netherlands
Jansen, NJG:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Utrecht, Netherlands
Kawczynski, P:
Refaja Hosp, Stadskanaal, Netherlands
Klucovska, K:
Bethesda Hosp, Hoogeveen, Netherlands
Kneyber, MCJ:
Univ Med Ctr Groningen, Beatrix Childrens Hosp, Groningen, Netherlands
Koopman-Keemink, Y:
Juliana Childrens Hosp, Naga Hosp, The Hague, Netherlands
Langenhorst, VJ:
Isala Hosp, Zwolle, Netherlands
Leusink, J:
Bernhoven Hosp, Uden, Netherlands
Loza, BF:
VieCuri Med Ctr, Venlo, Netherlands
Merth, IT:
Ziekenhuisgrp Twente, Almelo Hengelo, Netherlands
Miedema, CJ:
Catharina Hosp, Eindhoven, Netherlands
Neeleman, C:
Radboud Univ Nijmegen, Dept Pediat, Med Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands
Noordzij, JG:
Reinier Graaf Gasthuis, Delft, Netherlands
Obihara, CC:
ETZ Elisabeth, Tilburg, Netherlands
van Overbeek-van Gils, ALT:
Scheper Hosp, Emmen, Netherlands
Poortman, GH:
St Jansdal Hosp, Hardewijk, Netherlands
Potgieter, ST:
Laurentius Hosp, Roermond, Netherlands
Potjewijd, J:
Isala Diaconessenhuis, Meppel, Netherlands
Rosias, PPR:
Zuyderland Med Ctr, Sittard Geleen, Netherlands
Sprong, T:
Canisius Wilhelmina Hosp, Nijmegen, Netherlands
ten Tussher, GW:
Westfriesgasthuis, Hoorn, Netherlands
Thio, BJ:
Med Spectrum Twente, Enschede, Netherlands
Tramper-Stranders, GA:
St Franciscus Gasthuis, Rotterdam, Netherlands
van Deuren, M:
Radboud Univ Nijmegen, Dept Pediat, Med Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands
van der Meer, H:
Vrije Univ Univ, Med Ctr, Amsterdam, Netherlands
van Kuppevelt, AJM:
Streekziekenhuis Koningin Beatrix, Winterswijk, Netherlands
van Wermeskerken, AM:
Flevo Hosp, Almere, Netherlands
Verwijs, WA:
Zuwe Hofpoort Hosp, Woerden, Netherlands
Wolfs, TFW:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Utrecht, Netherlands
Agyeman, P:
Univ Bern, Bern Univ Hosp, Dept Pediat, Inselspital, Bern, Switzerland
Aebi, C:
Univ Bern, Bern Univ Hosp, Dept Pediat, Inselspital, Bern, Switzerland
Berger, C:
Univ Bern, Bern Univ Hosp, Dept Pediat, Inselspital, Bern, Switzerland
Univ Childrens Hosp Zurich, Div Infect Dis, Zurich, Switzerland
Univ Childrens Hosp Zurich, Hosp Epidemiol, Zurich, Switzerland
Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland
Giannoni, E:
Lausanne Univ Hosp, Serv Neonatol, Lausanne, Switzerland
Lausanne Univ Hosp, Infect Dis Serv, Lausanne, Switzerland
Stocker, M:
Childrens Hosp Lucerne, Dept Pediat, Luzern, Switzerland
Posfay-Barbe, KM:
Univ Hosp Geneva, Childrens Hosp Geneva, Pediat Infect Dis Unit, Geneva, Switzerland
Heininger, U:
Univ Basel Childrens Hosp, Infect Dis & Vaccinol, Basel, Switzerland
Univ Kinderspital Beider Basel, Abt Infektiol, Basel, Switzerland
Bernhard-Stirnemann, S:
Childrens Hosp Aarau, Aarau, Switzerland
Niederer-Loher, A:
Childrens Hosp Eastern Switzerland, Div Infect Dis, St Gallen, Switzerland
Childrens Hosp Eastern Switzerland, Hosp Epidemiol, St Gallen, Switzerland
Kahlert, C:
Childrens Hosp Eastern Switzerland, Div Infect Dis, St Gallen, Switzerland
Childrens Hosp Eastern Switzerland, Hosp Epidemiol, St Gallen, Switzerland
Hasters, P:
Univ Hosp Zurich, Dept Neonatol, Zurich, Switzerland
Relly, C:
Univ Childrens Hosp Zurich, Div Infect Dis, Zurich, Switzerland
Univ Childrens Hosp Zurich, Hosp Epidemiol, Zurich, Switzerland
Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland
Baer, W:
Childrens Hosp Chur, Chur, Switzerland
Paulus, S:
Alder Hey Childrens Hosp, Dept Infect Dis, Eaton Rd, Liverpool, Merseyside, England
Frederick, H:
Alder Hey Childrens Hosp, Dept Infect Dis, Eaton Rd, Liverpool, Merseyside, England
Jennings, R:
Alder Hey Childrens Hosp, Dept Infect Dis, Eaton Rd, Liverpool, Merseyside, England
Johnston, J:
Alder Hey Childrens Hosp, Dept Infect Dis, Eaton Rd, Liverpool, Merseyside, England
Kenwright, R:
Alder Hey Childrens Hosp, Dept Infect Dis, Eaton Rd, Liverpool, Merseyside, England
Agbeko, R:
Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Tyne Hosp Fdn Trust, Great North Childrens Hosp, Paediat Intens Care Unit, Newcastle Upon Tyne, Tyne & Wear, England
Bojang, K:
Med Res Council Unit Gambia, Banjul, Gambia
Sarr, I:
Med Res Council Unit Gambia, Banjul, Gambia
Kebbeh, N:
Med Res Council Unit Gambia, Banjul, Gambia
Sey, G:
Med Res Council Unit Gambia, Banjul, Gambia
Saidykhan, M:
Med Res Council Unit Gambia, Banjul, Gambia
Cole, F:
Med Res Council Unit Gambia, Banjul, Gambia
Thomas, G:
Med Res Council Unit Gambia, Banjul, Gambia
Antonio, M:
Med Res Council Unit Gambia, Banjul, Gambia
Walcher, W:
Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria
Geishofer, G:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Klobassa, D:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Martin, M:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Pfurtscheller, K:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Reiter, K:
Kinderklin LMU Munchen Dr von Haunerschen Kinders, Munich, Germany
Rodl, S:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Zobel, G:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Zohrer, B:
Med Univ Graz, Dept Gen Pediat, Graz, Austria
Topke, B:
Ostalb Klinikum, Aalen, Germany
Fucik, P:
Krankenhaus Amstetten, Amstetten, Austria
Gabriel, M:
Klinikum Aschaffenburg, Aschaffenburg, Germany
Penzien, JM:
Zentralklinikum Kinderkliniken, Augsburg, Germany
Diab, G:
Kreiskrankenhaus Bad Hersfeld, Bad Hersfeld, Germany
Miething, R:
Diakonie Krankenhaus, Bad Kreuznach, Germany
Deeg, KH:
Klinikum Bamberg, Bamberg, Germany
Hammer, J:
Univ Kinderspital Beider Basel, Padiatr Intensivmed, Basel, Switzerland
Varnholt, V:
Univ Klinikum Charite, Campus Virchow Klinikum, Berlin, Germany
Schmidt, A:
St Agnes Hosp, Bocholt, Germany
Bindl, L:
Rheinische Friedrich Wilhelms Univ, Bonn, Germany
Sillaber, U:
Landeskrankenhaus Bregenz, Abt Innere Med, Bregenz, Austria
Huemer, C:
Landeskrankenhaus Bregenz, Abt Kinderheilkunde, Bregenz, Austria
Meier, P:
Zentralkrankenhaus Links Weser, Bremen, Germany
Simic-Schleicher, G:
Zentralkrankenhaus Bremen Nord, Bremen, Germany
Markart, M:
Osped Bressanone, Brixen, Italy
Pfau, E:
DRK Krankenhaus Chemnitz Rabenstein, Chemnitz, Germany
Broede, H:
Klinikum Lippe Detmold GmbH, Detmold, Germany
Ausserer, B:
Krankenhaus Dornbirn, Dornbirn, Austria
Kalhoff, H:
Stadt Kliniken Dortmund, Dortmund, Germany
Arpe, V:
St Marien Hosp Duren Birkesdorf, Duren, Germany
Schweitzer-Krantz, S:
Evangel Krankenhaus, Dusseldorf, Germany
Kasper, JM:
St Georg Klinikum Eisenach gGmbH, Eisenach, Germany
Loranth, K:
Krankenhaus Barmherzigen Bruder, Eisenstadt, Austria
Bittrich, HJ:
Helios Klinikum Erfurt, Erfurt, Germany
Simma, B:
Landeskrankenhaus Feldkirch, Feldkirch, Austria
Klinge, J:
Klinikum Furth, Furth, Germany
Fedlmaier, M:
Klinikum Garm Partenkirchen, Garmisch Partenkirchen, Germany
Weigand, N:
Klinikum Justus Liebig Uni O, Giessen, Germany
Herting, E:
Georg August Univ Kinderklin, Gottingen, Germany
Grube, R:
Univ Klin Neurol, Graz, Austria
Fusch, C:
Klinikum Ernst Moritz Arndt Univ, Greifswald, Germany
Gruber, A:
Krankenhaus Schulschwestern Grieskirchen, Grieskirchen, Germany
Schimmel, U:
Allg Krankenhaus Hagen GmbH, Hagen, Germany
Knaufer-Schiefer, S:
Ohrekreis Klinikum, Haldensleben, Germany
Lassig, W:
Stadt Krankenhaus Martha Maria Halle Dolau gGmbH, Halle, Germany
Hennenberger, A:
Kinderkrankenhaus Wilhelmstift, Hamburg, Germany
von der Wense, A:
Altonaer Kinderkrankenhaus, Hamburg, Germany
Tillmann, R:
Klinikum Kreis Herford, Herford, Germany
Schwarick, J:
Kreiskrankenhaus Herzberg, Herzberg, Germany
Sitzmann, FC:
Univ Klin Kinder & Jugendmed, Homburg Saar, Germany
Streif, W:
Univ Klin Kinder & Jugendheilkunde Innsbruck, Innsbruck, Austria
Muller, H:
Klin Robert Weixler Str, Kempten, Germany
Kurnik, P:
Landeskrankenhaus Klagenfurt, Klagenfurt, Austria
Groneck, P:
Kinderklin Stadt Koln, Cologne, Germany
Weiss, U:
Achenbach Kreiskrankenhaus, Konigs Wusterhause, Germany
Groblacher-Roth, H:
Landeskrankenhaus Krems a d Donau, Krems Ad Donau, Austria
Bensch, J:
Vinzentius Krankenhaus, Landau, Germany
Moser, R:
Landeskrankenhaus Leoben, Leoben, Austria
Schwarz, R:
Landes Kinderklin Linz, Linz, Austria
Lenz, K:
Konventhosp Barmherzigen Bruder, Linz, Austria
Hofmann, T:
Evangel Krankenhaus, Lippstadt, Germany
Gopel, W:
Med Univ Lubeck, Lubeck, Germany
Schulz, D:
Stadt Klinikum Luneburg, Luneburg, Germany
Berger, T:
Kantonspital Luzern, Luzern, Switzerland
Hauser, E:
Landeskrankenhaus Modling, Modling, Austria
Forster, KM:
Stadt Krankenhaus Harlaching, Munich, Germany
Peters, J:
Kinderklin TU Munchen, Munich, Germany
Nicolai, TH:
Kinderklin Dr v Haunerschen Kinderspital, Munich, Germany
Kumlien, B:
Kinderklin Dritten Ordens, Munich, Germany
Beckmann, R:
Dietrich Bonhoeffer Klinikum, Neubrandenburg, Germany
Seitz, C:
FEK Friedrich Ebert Krankenhaus Neumunster GmbH, Neumunster, Germany
Huseman, D:
Ruppiner Kliniken GmbH, Neuruppin, Germany
Schurmann, R:
Stadt Kliniken Neuss Lukaskrankenhaus GmbH, Neuss, Germany
Ta, VH:
Evangel Krankenhaus, Oberhausen, Germany
Weikmann, E:
Landeskrankenhaus Oberwart, Oberwart, Austria
Evert, W:
Stadt Kliniken Offenbach, Offenbach, Germany
Hautz, J:
Klinikum Offenburg, Offenburg, Germany
Seidenberg, J:
Elisabeth Kinderkrankenhaus, Oldenburg, Germany
Wocko, L:
Krankenhaus Oranienburg, Oranienburg, Germany
Luigs, P:
St Vincenz Krankenhaus Frauen Kinderklin, Paderborn, Germany
Reiter, HL:
Klin Kinder & Jugendl Stadt Klinikum, Pforzheim, Germany
Quietzach, J:
Vogtland Klinikum Plauen GmbH, Plauen, Germany
Konig, M:
Oerschwaben Klin gGmbH, Ravensburg, Germany
Herrmann, J:
Kreiskrankenhaus Rendsburg, Rendsburg, Germany
Mitter, H:
Krankenhaus Barmherzigen Schwestern Ried, Ried, Austria
Krankenhaus Barmherzigen Schwestern Ried, Innkreis, Austria
Seidler, E:
Kreiskrankenhaus Obergoltzsch Rodew, Rodewisch, Germany
Maak, B:
Thuringen Klin Georgius Agr gGmbH, Saalfeld, Germany
Sperl, W:
Landeskrankenanstalten Salzburg, Salzburg, Austria
Zwiauer, K:
Landesklinikum Sankt Polten, Sankt Polten, Austria
Meissl, M:
Landeskrankenhaus Scharding, Scharding, Austria
Koch, R:
Leopoldina Krankenhaus, Schweinfurt, Germany
Cremer, M:
DRK Kinderklin Siegen, Siegen, Germany
Breuer, HA:
Stadt Klinikum Solingen, Solingen, Germany
Gorke, W:
Johanniter Kinderklin, Stendal, Germany
Nossal, R:
Olga Hosp Stuttgart, Stuttgart, Germany
Pernice, W:
Kreiskrankenhaus Torgau, Torgau, Germany
Brangenberg, R:
Klinikum Traunstein, Traunstein, Germany
Salzer, HR:
Landeskrankenhaus Tulin, Tulin, Austria
Koch, H:
St Marien Hosp, Vechta, Germany
Schaller, G:
Landeskrankenhaus Villach, Villach, Austria
Paky, F:
Landeskrankenhaus Vocklabruck, Vocklabruck, Austria
Strasser, F:
Klinikum Weiden, Weiden, Germany
Eitelberger, F:
Krankenhaus Barmherzigen Schwestern v Heiligen Kr, Wels, Austria
Sontheimer, D:
Harz Klinikum Wernigerode GmbH, Wernigerode, Germany
Lischka, A:
Wilhelminenspital Wien, Vienna, Austria
Kronberger, M:
St Anna Childrens Hosp, Vienna, Austria
Dilch, A:
Gottfried Preyersches Kinderspital Stadt Wien, Vienna, Austria
Scheibenpflug, C:
Donauspital SMZ Ost Stadt Wien, Vienna, Austria
Bruckner, R:
Krankenhaus Wiener Neustadt, Wiener Neustadt, Austria
Mahler, K:
St Elizabeth Hosp, Wittlich, Germany
Runge, K:
Zentrum Kinder & Jugendmed, Wuppertal, Germany
Kunze, W:
Krankenhaus Muldentalkreis Wurzen, Wurzen, Germany
Schermann, P:
Krankenhaus Zwettl, Zwettl, Austria
Green Published, Green Accepted, gold
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