Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
Por:
Tack, J, Stanghellini, V, Mearin, F, Yiannakou, Y, Layer, P, Coffin, B, Simren, M, Mackinnon, J, Wiseman, G, Marciniak, A, Bouchoucha, Ducrotte, Macaigne, Mion, Schneider, Le Sidanier, Tardy, Zerbib, Andresen, Bischoff, Jander, Jung, Krammer, Langhorst, Omankowsky, Schiefke, Steuer, Van der Voort, Von Arnim, Annese, Cuomo, De Angelis, Di Mario, Di Stefano, Ferrini, Gasbarrini, Giaccobe, Marchi, Marzio, Repici, Savarino, Angos, Berdier, Brotons, Caballero-Plasencia, Clave, Fort, Garcia, Gomez, Martinez, Perello, Rey, Sanchez-Antolin, Serra, Tantina, Toran, Ekesbo, Hellstrom, Kjellstrom, Lindberg, Walter, Arebi, Bridger, Butt, Emmanuel, Eugenicos, Kaushik, Millar, Sanders, Whorwell
Publicada:
7 may 2019
Resumen:
BackgroundIrritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK).MethodsAn observational, one year retrospective-prospective (6months each) study of patients diagnosed in the last five years with IBS-C (Rome III criteria) and moderate to severe disease at inclusion (IBS Symptom Severity Scale score175). The primary objective was to assess the direct cost to European healthcare systems.ResultsFive hundred twenty-five patients were included, 60% (range: 43.1-78.8%) suffered from severe IBS-C. During follow-up 11.1-24.0% of patients had a hospitalisation/emergency room (ER) visit, median stay range: 1.5-12.0days and 41.1-90.4% took prescription drugs for IBS-C. 21.4-50.8% of employed patients took sick leave (mean: 11.6-64.1days). The mean annual direct cost to the healthcare systems was Euro937.1- Euro2108.0. The total direct cost (combined costs to healthcare systems and patient) for IBS-C was Euro1421.7-Euro2487.1.ConclusionsIBS-C is not a life-threatening condition; however, it has large impact on healthcare systems and society. Direct and indirect costs for moderate to severe IBS-C were high with the largest direct cost driver being hospitalisations/ER visits.
Filiaciones:
Tack, J:
Univ Hosp Gasthuisberg, Leuven, Belgium
Univ Leuven, Herestr 49, B-3000 Leuven, Belgium
Stanghellini, V:
Univ Hosp S Orsola, Bologna, Italy
Mearin, F:
Ctr Med Teknon, Barcelona, Spain
Yiannakou, Y:
Cty Durham & Darlington NHS Trust, Durham, England
Layer, P:
Israelitic Hosp, Hamburg, Germany
Coffin, B:
Louis Mourier Hosp, AP HP, Colombes, France
Paris Diderot Univ, Paris, France
Simren, M:
Sahlgrens Univ Hosp, Gothenburg, Sweden
Mackinnon, J:
TFS Develop SL, Barcelona, Spain
Wiseman, G:
Allergan Int, Marlow, Bucks, England
Marciniak, A:
Allergan Int, Marlow, Bucks, England
Bouchoucha:
Hop Avicenne, Bobigny, France
Ducrotte:
Hop Charles Nicolle, Rouen, France
Macaigne:
Hop Lagny, Lagny, France
Mion:
Hop Edouard Herriot, Lyon, France
Le Sidanier:
Hop Dupuytren, Limoges, France
Zerbib:
Hop St Andre, Bordeaux, Germany
Andresen:
Israelitic Hosp, Hamburg, Germany
Bischoff:
Univ Hohenheim, Stuttgart, Germany
Jander:
Arzt Innere Med, Neuotting, Germany
Jung:
Praxis Dr Thomas Jung, Deggingen, Germany
Krammer:
Enddarmzentrum Mannheim, Mannheim, Germany
Langhorst:
Kiiniken Essen Mitte, Essen, Germany
Omankowsky:
Praxis Dr S Omankowsky, Berlin, Germany
Schiefke:
Eurogastro, Leipzig, Germany
Steuer:
Praxis Dr Steuer, Hemsbach, Germany
Van der Voort:
Martin Luther Krankenhausbetrieb, Berlin, Germany
Von Arnim:
Univ Klinikum Magdeburg, Klin Gastroenterol & Hepatol, Magdeburg, Italy
Annese:
Careggi Univ, Florence, Italy
Cuomo:
Univ Napoli Federico II, Naples, Italy
De Angelis:
Univ Parma, Parma, Italy
Di Mario:
Osped S Maria di Ca Foncello, Treviso, Italy
Di Stefano:
Policlin San Matteo, Pavia, Italy
Ferrini:
F Renzetti Hosp, Lanciano, Italy
Gasbarrini:
Catholic Univ, Gemelli Hosp Rome, Rome, Italy
Giaccobe:
Univ Messina, Messina, Italy
Marchi:
Univ Pisa, Pisa, Italy
Marzio:
Univ Pescara, Pescara, Italy
Repici:
Humanitas Hosp IRCS, Milan, Italy
Savarino:
Univ Genoa, Genoa, Spain
Angos:
Clin Univ Navarra, Pamplona, Spain
Berdier:
CAP Vallcarca St Gervasi, Barcelona, Spain
Brotons:
CAP Sardenya, Barcelona, Spain
Caballero-Plasencia:
Clin Dr Caballero, Granada, Spain
Clave:
Hosp Mataro, Mataro, Spain
Fort:
Hosp Dr Josep Trueta, Girona, Spain
Garcia:
Hosp Univ Tajo, Madrid, Spain
Gomez:
Hosp USP Sagrado Corazon, Seville, Spain
Martinez:
Hosp St Joan Reus, Reus, Spain
Perello:
Hosp Viladecans, Viladecans, Spain
Rey:
Hosp Clin San Carlos, Madrid, Spain
Sanchez-Antolin:
Hosp Univ Rio Hortega, Valladolid, Spain
Serra:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Tantina:
CAP Centelles, Centelles, Spain
Toran:
CAP Mareseme, Mataro, Sweden
Ekesbo:
Capio Citykliniken Malmo, Malmo, Sweden
Hellstrom:
Lakarhuset Hotorget City, Stockholm, Sweden
Kjellstrom:
Aleris Specialistvard Sabbatsberg, Stockholm, Sweden
Lindberg:
Karolinska Inst, Stockholm, Sweden
Walter:
Linkoping Univ, Linkoping, Sweden
Arebi:
St Marks Hosp, Harrow, Middx, England
Bridger:
Dorset Cty Hosp, Dorchester, England
Butt:
South Tyneside NHS Fdn Trust, South Shields, England
Emmanuel:
Univ Coll Hosp, London, England
Eugenicos:
Western Gen Hosp, Edinburgh, Midlothian, Scotland
Kaushik:
Royal Blackburn Hosp, Blackburn, Lancs, England
Millar:
North Middlesex Univ Hosp NHS Trust, London, England
Sanders:
Royal Hallamshire Hosp, Sheffield, S Yorkshire, England
Whorwell:
Wythenshawe Hosp, Manchester, Lancs, England
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