HIV co-infection in HTLV-1 carriers in Spain
Por:
de Mendoza, C, Caballero, E, Aguilera, A, Benito, R, Macia, D, Garcia-Costa, J, Soriano, V, Rodriguez, C, Vera, M, del Romero, J, Marcaida, G, Ocete, MD, Caballero, E, Molina, I, Aguilera, A, Rodriguez-Calvino, JJ, Navarro, D, Rivero, C, Vilarino, MD, Benito, R, Algarate, S, Gil, J, de Lejarazu, RO, Rojo, S, Eiros, JM, San Miguel, A, Manzardo, C, Mira, JM, Garcia, J, Paz, I, Poveda, E, Calderon, E, Escudero, D, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Martin, AM, Ramos, JM, Gimeno, A, Gutierrez, F, Rodriguez, JC, Sanchez, V, Gomez-Hernando, C, Cilla, G, Perez-Trallero, E, Lopez-Aldeguer, J, Fernandez-Pereira, L, Niubo, J, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Cifuentes, C, Raya, C, Gonzalez-Praetorius, A, Perez, JL, Penaranda, M, Hernaez-Crespo, S, Montejo, JM, Roc, L, Martinez-Sapina, A, Viciana, I, Cabezas, T, Lozano, A, Fernandez, JM, Garcia-Bermejo, I, Gaspar, G, Garcia, R, Gorgolas, M, Vegas, C, Blas, J, Miralles, P, Valeiro, M, Aldamiz, T, Margall, N, Guardia, C, do Pico, E, Polo, I, Aguinaga, A, Ezpeleta, C, Sauleda, S, Piron, M, Gonzalez, R, Barea, L, Jimenez, A, Blanco, L, Suarez, A, Rodriguez-Avial, I, Perez-Rivilla, A, Parra, P, Fernandez, M, Fernandez-Alonso, M, Reina, G, Trevino, A, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, de Mendoza, C, Barreiro, P, Soriano, V, Corral, O, Gomez-Gallego, F, Perez, S, Morano, L
Publicada:
1 jun 2019
Resumen:
Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain.
Methods: A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection.
Results: Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia).
HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection.
Conclusion: HIV coinfection is infrequent (< 5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.
Filiaciones:
de Mendoza, C:
Puerta de Hierro Res Inst, Madrid, Spain
Univ Hosp, Madrid, Spain
CEU San Pablo Univ, Microbiol Dept, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Caballero, E:
Hosp Valle De Hebron, Barcelona, Spain
Hosp Vall dHebro, Barcelona, Spain
Aguilera, A:
Complexo Hosp Univ, Santiago, Spain
Hosp Conxo CHUS, Santiago, Chile
Benito, R:
Hosp Clin Lozano Blesa, Zaragoza, Spain
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Macia, D:
Hosp Son Llatzer, Mallorca, Spain
Garcia-Costa, J:
Complejo Hosp Univ, Orense, Spain
Soriano, V:
UNIR Hlth Sci Sch & Med Ctr, Madrid, Spain
UNIR Hlth Sci Sch, Madrid, Spain
Rodriguez, C:
Ctr Sanitario Sandoval, Madrid, Spain
Vera, M:
Ctr Sanitario Sandoval, Madrid, Spain
del Romero, J:
Ctr Sanitario Sandoval, Madrid, Spain
Marcaida, G:
Hosp Gen Univ, Valencia, Spain
Ocete, MD:
Hosp Gen Univ, Valencia, Spain
Caballero, E:
Hosp Valle De Hebron, Barcelona, Spain
Hosp Vall dHebro, Barcelona, Spain
Molina, I:
Hosp Vall dHebro, Barcelona, Spain
Aguilera, A:
Complexo Hosp Univ, Santiago, Spain
Hosp Conxo CHUS, Santiago, Chile
Rodriguez-Calvino, JJ:
Hosp Conxo CHUS, Santiago, Chile
Navarro, D:
Hosp Conxo CHUS, Santiago, Chile
Rivero, C:
Hosp Conxo CHUS, Santiago, Chile
Vilarino, MD:
Hosp Conxo CHUS, Santiago, Chile
Benito, R:
Hosp Clin Lozano Blesa, Zaragoza, Spain
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Algarate, S:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Gil, J:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
de Lejarazu, RO:
Hosp Clin Univ, Valladolid, Spain
Rojo, S:
Hosp Clin Univ, Valladolid, Spain
Eiros, JM:
Hosp Rio Hortega, Valladolid, Spain
San Miguel, A:
Hosp Rio Hortega, Valladolid, Spain
Manzardo, C:
Hosp Clin IDIBAPS, Barcelona, Spain
Mira, JM:
Hosp Clin IDIBAPS, Barcelona, Spain
Garcia, J:
Hosp Cristal Pinor, Orense, Spain
Paz, I:
Hosp Cristal Pinor, Orense, Spain
Poveda, E:
INIBIC Complejo Hosp Univ, La Coruna, Spain
Calderon, E:
Hosp Virgen del Rocio, Seville, Spain
CIBERESP, Seville, Spain
Escudero, D:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Trigo, M:
Complejo Hosp, Pontevedra, Spain
Diz, J:
Complejo Hosp, Pontevedra, Spain
Garcia-Campello, M:
Complejo Hosp, Pontevedra, Spain
Rodriguez-Iglesias, M:
Hosp Univ, Puerto Real, Spain
Hernandez-Betancor, A:
Hosp Insular Hosp Univ, Las Palmas Gran Canaria, Spain
Martin, AM:
Hosp Insular Hosp Univ, Las Palmas Gran Canaria, Spain
Ramos, JM:
Hosp Univ, Alicante, Spain
Gimeno, A:
Hosp Univ, Alicante, Spain
Gutierrez, F:
Hosp Gen, Elche, Spain
Rodriguez, JC:
Hosp Gen, Elche, Spain
Sanchez, V:
Hosp Gen, Elche, Spain
Gomez-Hernando, C:
Complejo Hosp Virgen de la Salud, Toledo, Spain
Cilla, G:
Hosp Donostia, San Sebastian, Spain
Perez-Trallero, E:
Hosp Donostia, San Sebastian, Spain
Lopez-Aldeguer, J:
Hosp La Fe, Valencia, Spain
Fernandez-Pereira, L:
Hosp San Pedro de Alcantara, Caceres, Spain
Niubo, J:
Ciudad Sanitaria Bellvitge, Barcelona, Spain
Hernandez, M:
Hosp Univ La Laguna, Tenerife, Spain
Lopez-Lirola, AM:
Hosp Univ La Laguna, Tenerife, Spain
Gomez-Sirvent, JL:
Hosp Univ La Laguna, Tenerife, Spain
Force, L:
Hosp Gen, Mataro, Spain
Cifuentes, C:
Hosp Son Llatzer, Palma De Mallorca, Spain
Raya, C:
Hosp Bierzo, Ponferrada, Spain
Gonzalez-Praetorius, A:
Hosp Meixoeiro, Vigo, Spain
Perez, JL:
Hosp Bierzo, Ponferrada, Spain
Penaranda, M:
Hosp Bierzo, Ponferrada, Spain
Hernaez-Crespo, S:
Hosp Basurto, Bilbao, Spain
Montejo, JM:
Hosp Cruces, Bilbao, Spain
Roc, L:
Hosp Miguel Servet, Zaragoza, Spain
Martinez-Sapina, A:
Hosp Miguel Servet, Zaragoza, Spain
Viciana, I:
Hosp Virgen de la Victoria, Malaga, Spain
Cabezas, T:
Hosp Poniente, Almeria, Spain
Lozano, A:
Hosp Poniente, Almeria, Spain
Fernandez, JM:
Hosp Poniente, Almeria, Spain
Garcia-Bermejo, I:
Hosp Univ, Getafe, Spain
Gaspar, G:
Hosp Univ, Getafe, Spain
Garcia, R:
Fdn Jimenez Diaz, Madrid, Spain
Gorgolas, M:
Fdn Jimenez Diaz, Madrid, Spain
Vegas, C:
Fdn Jimenez Diaz, Madrid, Spain
Blas, J:
Fdn Jimenez Diaz, Madrid, Spain
Miralles, P:
Hosp Gregorio Maranon, Madrid, Spain
Valeiro, M:
Hosp Gregorio Maranon, Madrid, Spain
Aldamiz, T:
Hosp Gregorio Maranon, Madrid, Spain
Margall, N:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Guardia, C:
ICS, Barcelona, Spain
do Pico, E:
ICS, Barcelona, Spain
Polo, I:
Complejo Hosp Navarra, Pamplona, Spain
Aguinaga, A:
Complejo Hosp Navarra, Pamplona, Spain
Ezpeleta, C:
Complejo Hosp Navarra, Pamplona, Spain
Sauleda, S:
Banco Sangre & Tejidos, Barcelona, Spain
Piron, M:
Banco Sangre & Tejidos, Barcelona, Spain
Gonzalez, R:
Ctr Transfus, Madrid, Spain
Barea, L:
Ctr Transfus, Madrid, Spain
Jimenez, A:
Ctr Hemoterapia & Hemodonac Castilla & Leon, Valladolid, Spain
Blanco, L:
Ctr Hemoterapia & Hemodonac Castilla & Leon, Valladolid, Spain
Suarez, A:
Hosp Clin San Carlos, Madrid, Spain
Rodriguez-Avial, I:
Hosp Clin San Carlos, Madrid, Spain
Perez-Rivilla, A:
Hosp Univ 12 Octubre, Madrid, Spain
Parra, P:
Hosp Univ 12 Octubre, Madrid, Spain
Fernandez, M:
Hosp Univ 12 Octubre, Madrid, Spain
Fernandez-Alonso, M:
Clin Univ, Pamplona, Spain
Reina, G:
Clin Univ, Pamplona, Spain
Trevino, A:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Requena, S:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Benitez-Gutierrez, L:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Cuervas-Mons, V:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
de Mendoza, C:
Puerta de Hierro Res Inst, Madrid, Spain
Univ Hosp, Madrid, Spain
CEU San Pablo Univ, Microbiol Dept, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Barreiro, P:
La Paz Univ Hosp, Madrid, Spain
Soriano, V:
UNIR Hlth Sci Sch & Med Ctr, Madrid, Spain
UNIR Hlth Sci Sch, Madrid, Spain
Corral, O:
UNIR Hlth Sci Sch, Madrid, Spain
Gomez-Gallego, F:
UNIR Hlth Sci Sch, Madrid, Spain
Perez, S:
Hosp Meixoeiro, Vigo, Spain
Morano, L:
Hosp Meixoeiro, Vigo, Spain
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