Epidemiology of congenital Chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015
Por:
Martin-Nalda, A, Cebollero, A, Carrascon, A, Moreira, A, Requena-Mendez, A, Soto, AT, Martin, A, Ballester, A, Bragulat, A, Soligo, A, Bastarras, AV, Paya, A, Soriano-Arandes, A, Sorni, A, Calvo, A, Mur, A, Colomer, A, Carral, B, Trevino, B, Guarch, B, Orta, C, Rodrigo, C, Galles, C, Garrido, C, Molina, C, Mora, C, Munoz, C, Marti, C, Sanjose, C, Guardia, C, Cortes, C, Gutierrez, C, Martinez, C, Riera, C, Soler, C, Gonzalez, D, Guix, D, Mir, ES, Padilla, E, Sulleiro, E, Llurba, E, Del Amo, E, Moliner, E, Esteba, EP, Coll, E, Rodriguez, E, Monaco, E, Munoz, E, Freixas, E, Dopico, E, Sarda, E, Ballester, F, Gomez, F, Barranco, F, Ripoll, F, Fargas, FJ, Falguera, G, Fernandez-Rivas, G, Ginovart, G, Navarro, G, Garcia-Pardo, G, Lorenzo, G, Ouaarab, H, Caubet, I, Claveria, I, Sanfeliu, I, Molina, I, Blanch, J, Marti, JA, Farre, J, Gascon, J, Costa, J, Prat, JGI, Fulquet, J, Jove, JP, Armengol, J, Riera, JC, Villar, J, Torrent, LS, De La Torre, L, Delgado, L, Valerio, L, Montsant, L, Basile, L, Mayol, L, Valls, ME, Vives, MA, Sauca, MG, Coll, M, Pinazo, MJ, Ferri, MJ, Vidal, MJ, Villegas, ML, Anquela, MAS, Monsonis, M, Blasco, MP, Perez-Moreno, MO, Sabates, MC, Mendez, M, Navarro, M, Urcola, M, Lora, M, Navarro, M, Almirall, M, Arasa, M, Alaball, MV, Carulla, M, Jane, M, Ribell-Bachs, M, Abella, M, Gallego, M, Prat, N, Rius, N, Bosh, NP, Garcia, P, Araujo, P, Sole, P, Ciruela, P, Villalobos, P, Almirall, R, Diaz, R, Puigarnau, R, Serra, R, Diez, R, Bosch, ST, Franch, S, Vega, S, Mani, SG, Juncosa, T, Pineda, V, Fumado, V, Urquizu, X
Publicada:
27 jun 2019
Resumen:
Background: Chagas disease is endemic in Latin America and affects 8 million people worldwide. In 2010, Catalonia introduced systematic public health surveillance to detect and treat congenital Chagas disease. Aim: The objective was to evaluate the health outcomes of the congenital Chagas disease screening programme during the first 6 years (2010-2015) after its introduction in Catalonia. Methods: In a surveillance system, we screened pregnant women and newborns and other children of positive mothers, and treated Chagas-positive newborns and children. Diagnosis was confirmed for pregnant women and children with two positive serological tests and for newborns with microhaematocrit and/or PCR at birth or serology at age 9 months. Results: From 2010 to 2015, the estimated screening coverage rate increased from 68.4% to 88.6%. In this period, 33,469 pregnant women were tested for Trypanosoma cruzi and 937 positive cases were diagnosed. The overall prevalence was 2.8 cases per loo pregnancies per year (15.8 in Bolivian women). We followed 82.8% of newborns until serological testing at age 9-12 months and 28 were diagnosed with Chagas disease (congenital transmission rate: 4.17%). Of 518 siblings, 178 (34.3%) were tested and 14 (7.8%) were positive for T. cruzi. Having other children with Chagas disease and the heart clinical form of Chagas disease were maternal risk factors associated with congenital T. cruzi infection (p < 0.05). Conclusion: The increased screening coverage rate indicates consolidation of the programme in Catalonia. The rate of Chagas disease congenital transmission in Catalonia is in accordance with the range in non-endemic countries.
Filiaciones:
Martin-Nalda, A:
UAB, VHIR, HUVH, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona, Spain
Cebollero, A:
Consorci Lab Intercomarcal, CLILAB Diagnost, Barcelona, Spain
Carrascon, A:
ICS, ASSIR Izquierdo Barcelona Ciudad, Barcelona, Spain
Moreira, A:
Hosp St Joan de Deu Martorell, Barcelona, Spain
Requena-Mendez, A:
Univ Barcelona, Hosp Clin, Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, ISGlobal, Barcelona, Spain
Soto, AT:
Hosp Residencia St Camil, Barcelona, Spain
Martin, A:
Hosp Univ Vall dHebron, Barcelona, Spain
Ballester, A:
Corp Salut Maresme & Selva, Barcelona, Spain
Bragulat, A:
Hosp Cerdanya, Puigcerda, Spain
Soligo, A:
ASSIR Consorci Sanitari Terrassa, Terrassa, Spain
Bastarras, AV:
Consorci Hosp Vic, Vic, Spain
Paya, A:
Hosp Mar, Barcelona, Spain
Soriano-Arandes, A:
Hosp Univ Vall dHebron, Barcelona, Spain
Sorni, A:
Hosp Verge Cinta Tortosa, Tortosa, Spain
Calvo, A:
Hosp Clin Barcelona, Barcelona, Spain
Mur, A:
Hosp Mar, Barcelona, Spain
Colomer, A:
Consorci Hosp Vic, Vic, Spain
Carral, B:
ICS, ASSIR Baix Llobregat Litoral, Barcelona, Spain
Trevino, B:
Hosp Univ Vall dHebron, Unitat Salut Int Drassanes, Barcelona, Spain
Guarch, B:
Hosp Univ Dr Josep Trueta Girona, Girona, Spain
Orta, C:
Hosp Comarcal Alt Penedes, Vilafranca Del Penedes, Spain
Rodrigo, C:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Galles, C:
Corp Salut Maresme & Selva, Calella, Spain
Garrido, C:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Molina, C:
Hosp Joan XXIII Tarragona, Tarragona, Spain
Mora, C:
Hosp Figueres, Figueres, Spain
Munoz, C:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Marti, C:
Hosp Gen Granollers, Granollers, Spain
Sanjose, C:
Consorcio Lab Intercomarcal, CLILAB Diagnost, Barcelona, Spain
Guardia, C:
Lab Barcelones Nord & Valles Oriental, Barcelona, Spain
Cortes, C:
Hosp Gen LHospitalet, Barcelona, Spain
Gutierrez, C:
Hosp Univ Joan XXIII Tarragona, Tarragona, Spain
Martinez, C:
ICS, ASSIR Barcelona Ciutat, Barcelona, Spain
Riera, C:
Univ Barcelona, Fac Farm, Barcelona, Spain
Soler, C:
Hosp Santa Caterina, Salt, Spain
Gonzalez, D:
ICS Camp Tarragona, CAP Rambla Nova, Tarragona, Spain
Guix, D:
ICS, ASSIR Granollers, Granollers, Spain
Mir, ES:
Hosp Arnau Vilanova, IRBLleida, Lleida, Spain
Padilla, E:
Lab Referencia Catalunya, Catalunya, Spain
Sulleiro, E:
UAB, HUVH, PROSICS Barcelona, Dept Microbiol, Barcelona, Spain
Hosp Univ Vall dHebron, Barcelona, Spain
Llurba, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Del Amo, E:
ICS, ASSIR Litoral Barcelona Ciudad, Barcelona, Spain
Moliner, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Esteba, EP:
AIE, Ctr Analit Terrassa, Catlab, Viladecavalls, Spain
Coll, E:
ASSIR Hosp Mutua Terrassa, ICS, Terrassa, Spain
Rodriguez, E:
Hosp Gen LHospitalet, Barcelona, Spain
Monaco, E:
Hosp Residencia St Camil, Barcelona, Spain
Munoz, E:
Hosp Cerdanya, Puigcerda, Spain
Freixas, E:
ICS, ASSIR LHospitalet, Barcelona, Spain
Dopico, E:
Lab Clin LHospitalet, Barcelona, Spain
Sarda, E:
ICS, ASSIR Muntanya Barcelona Ciudad, Barcelona, Spain
Ballester, F:
Hosp Univ St Joan Reus, Reus, Spain
Gomez, F:
Hosp Joan XXIII Tarragona, Tarragona, Spain
Barranco, F:
Hosp Cerdanya, Puigcerda, Spain
Ripoll, F:
Hosp Santa Caterina, Salt, Spain
Fargas, FJ:
ICS, ASSIR Camp Tarragona, Tarragona, Spain
Falguera, G:
ICS, ASSIR Direccio Atencio Primaria Metropolitana Nor, Sabadell, Spain
Fernandez-Rivas, G:
Hosp Badalona Germans Trias & Pujol, Dept Microbiol, Clin Lab North Metropolitan Area, Barcelona, Spain
Ginovart, G:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Navarro, G:
Hosp Univ Parc Tauli, Sabadell, Spain
Garcia-Pardo, G:
Hosp Joan XXIII Tarragona, Tarragona, Spain
Lorenzo, G:
Hosp Mollet del Valles, Mollet Del Valles, Spain
Ouaarab, H:
Hosp Univ Vall dHebron, Unitat Salut Int Drassanes, Barcelona, Spain
Caubet, I:
Espitau Vall dAran, Vielha, Spain
Claveria, I:
Hosp Univ Vall dHebron, Unitat Salut Int Drassanes, Barcelona, Spain
Sanfeliu, I:
Hosp Univ Parc Tauli, Sabadell, Spain
Molina, I:
Hosp Univ Vall dHebron, Barcelona, Spain
Blanch, J:
Hosp Residencia St Camil, Barcelona, Spain
Marti, JA:
Hosp Palamos, Palamos, Spain
Farre, J:
Hosp Univ Arnau Vilanova Lleida, Lleida, Spain
Gascon, J:
Univ Barcelona, Hosp Clin, Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain
Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain
Costa, J:
Hosp Univ Parc Tauli, Sabadell, Spain
Prat, JGI:
Hosp Univ Vall dHebron, Unitat Salut Int Drassanes, Barcelona, Spain
Fulquet, J:
Hosp Figueres, Figueres, Spain
Jove, JP:
AIE, Ctr Analit Terrassa, Catlab, Viladecavalls, Spain
Armengol, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Riera, JC:
ICS, ASSIR Girones Pla de lEstany, Girona, Spain
Villar, J:
Parc Salut Mar, Barcelona, Spain
Torrent, LS:
Hosp Gen Parc Sanitari St Joan de Deu St Boi de L, Barcelona, Spain
De La Torre, L:
Hosp Clin Barcelona, ISGlobal, Barcelona, Spain
Delgado, L:
Hosp Comarcal Alt Penedes, Vilafranca Del Penedes, Spain
Valerio, L:
ICS, Unitat Salut Int Metropolitana Nord, Barcelona, Spain
Montsant, L:
Hosp Cerdanya, Puigcerda, Spain
Basile, L:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Mayol, L:
Hosp Univ Girona Doctor Josep Trueta, Girona, Spain
Valls, ME:
Hosp Clin Barcelona, ISGlobal, Barcelona, Spain
Vives, MA:
Hosp Terrassa, Terrassa, Spain
Sauca, MG:
Hosp Mataro, Mataro, Spain
Coll, M:
Hosp Gen Granollers, Granollers, Spain
Pinazo, MJ:
Hosp Clin Barcelona, ISGlobal, Barcelona, Spain
Ferri, MJ:
Hosp Univ Dr Josep Trueta Girona, Girona, Spain
Vidal, MJ:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Villegas, ML:
Hosp Gen LHospitalet, Barcelona, Spain
Anquela, MAS:
PIUS Hosp Valls, Valls, Spain
Monsonis, M:
Hosp Maternoinfantil St Joan de Deu, Lhospitalet De Llobregat, Spain
Blasco, MP:
ICS, ASSIR Santa Coloma de Gramenet, Barcelona, Spain
Perez-Moreno, MO:
Hosp Verge Cinta Tortosa, Tortosa, Spain
Sabates, MC:
Hosp St Bernabe, Barcelona, Spain
Mendez, M:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Navarro, M:
Consorci Hosp Vic, Vic, Spain
Hosp Univ Parc Tauli, Sabadell, Spain
Urcola, M:
Hosp Santa Caterina, Girona, Spain
Lora, M:
Hosp Univ Dr Josep Trueta Girona, Girona, Spain
Navarro, M:
Consorci Hosp Vic, Vic, Spain
Hosp Univ Parc Tauli, Sabadell, Spain
Almirall, M:
Hosp Univ Arnau Vilanova Lleida, Lleida, Spain
Arasa, M:
ICS, ASSIR Terres de LEbre, Tortosa, Spain
Alaball, MV:
Hosp Palamos, ASSIR Baix Emporda, Palamos, Spain
Carulla, M:
Hosp St Pau & Santa Tecla, Tarragona, Spain
Jane, M:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Ribell-Bachs, M:
Hosp Gen Granollers, Granollers, Spain
Abella, M:
ICS, ASSIR Sabadell, Sabadell, Spain
Gallego, M:
Hosp Clin Barcelona, ISGlobal, Barcelona, Spain
Prat, N:
ICS, ASSIR Baix Llobregat, Cornella De Li, Spain
Rius, N:
Hosp Univ St Joan Reus, Reus, Spain
Bosh, NP:
Lab Referencia Catalunya, Prat De Llobregat, Spain
Garcia, P:
Hosp Comarcal Mora dEbre, Mora Debre, Spain
Araujo, P:
Hosp Terrassa, Terrassa, Spain
Sole, P:
Hosp Mataro, Mataro, Spain
Ciruela, P:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Villalobos, P:
Hosp Figueres, Figueres, Spain
Almirall, R:
ICS, ASSIR Izquierdo Barcelona Ciudad, Barcelona, Spain
Diaz, R:
ICS, ASSIR Mataro, Mataro, Spain
Puigarnau, R:
Hosp Mutua Terrassa, Terrassa, Spain
Serra, R:
ASSIR Girones Pla de LEstany, Girona, Spain
Diez, R:
Hosp Mataro, Mataro, Spain
Bosch, ST:
Hosp Univ Dr Josep Trueta Girona, Girona, Spain
Franch, S:
Hosp St Pau & Santa Tecla, Tarragona, Spain
Vega, S:
Hosp Figueres, Figueres, Spain
Mani, SG:
ICS, ASSIR Baix Llobregat Nord, Cornella De Li, Spain
Juncosa, T:
Hosp Maternoinfantil St Joan de Deu, Lhospitalet De Llobregat, Spain
Pineda, V:
Hosp Parc Tauli Sabadell, Sabadell, Spain
Fumado, V:
Hosp Maternoinfantil St Joan de Deu, Lhospitalet De Llobregat, Spain
Urquizu, X:
Hosp Mutua Terrassa, Terrassa, Spain
Green Published, gold
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