Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain


Por: Requena, S, Caballero, E, Lozano, AB, Rios-Villegas, MJ, Benito, R, Rojo, S, Cabezas, T, Macia, MD, Nieto, MD, Soriano, V, de Mendoza, C, Rodriguez, C, Vera, M, del Romero, J, Ocete, MD, Caballero, E, Aguilera, A, Amengual, MJ, Cervantes, M, Benito, R, Algarate, S, de Lejarazu, RO, Rojo, S, Eiros, JM, Ramos, C, Garcia-Costa, J, Calderon, E, Rios-Villegas, MJ, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Ramos, JM, Gimeno, A, Sanchez, V, Gomez-Hernando, C, Echeverria, MJ, Cilla, G, Perez-Trallero, E, Fernandez-Pereira, L, Niubo, J, Margall, N, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Sauca, M, Perez, S, Morano, L, Raya, C, Praetorius, AG, Cifuentes, C, Penaranda, M, Nieto, MC, Montejo, JM, Roc, L, Martinez-Sapina, A, Viciana, I, Lozano, AB, Perez-Camacho, I, Fernandez-Fuertes, E, Fernandez, JM, Cabezas, T, Bermejo, IG, Gaspar, G, Gorgolas, M, Vegas, C, Blas, J, Tellez, R, Perez, L, Valeiro, M, Aldamiz, T, Garcia, F, Suarez, A, Rodriguez-Avial, I, Barreiro, P, Soriano, V, Gomez-Gallego, F, Corral, O, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, de Mendoza, C

Publicada: 15 nov 2019
Resumen:
Background: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all dually infected patients living in Spain. Methods: We identified retrospectively all persons coinfected with HIV-1 recorded at the Spanish HIV-2 registry. Dual infection had been confirmed using PCR in plasma and/or cells, and/or using discriminatory serological tests. Results: From a total of 373 individuals with HIV-2 recorded at the Spanish registry, 34 (9.1%) were coinfected with HIV-1. Compared with HIV-2 monoinfected persons, dually infected patients were more often male (67.6%), presented with lower median CD4(+) cell counts (204 cells/mu l), and had developed more frequently AIDS events (26.5%). Although 61.7% came from West Africa, 6 (17.6%) were native Spaniards. HIV-1 non-B subtypes were recognized in 75% of coinfected patients, being the most prevalent CRF02_AG. At baseline, 45% of dually infected patients had undetectable plasma HIV-2 RNA. After a median follow-up of 32 (13-48) months on antiretroviral therapy, dually infected patients achieved undetectable viremia in 85% for HIV-1, in 80% for HIV-2; and in 70% for both viruses. Median CD4(+) cell counts reached up to 418 cells/mu l. Conclusion: Roughly 9% of individuals with HIV-2 infection living in Spain are coinfected with HIV-1. Overall, 70% of dually infected patients achieved viral suppression for both viruses under antiretroviral therapy. Given the relatively large population of West Africans living in Spain and the continuous migration flow from HIV-2 endemic areas, HIV-1/HIV-2 coinfection should always be excluded at first diagnosis in all HIV-seroreactive persons. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.

Filiaciones:
Requena, S:
 Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain

 IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain

Caballero, E:
 Hosp Valle De Hebron, Barcelona, Spain

Lozano, AB:
 Hosp Poniente, Almeria, Spain

Rios-Villegas, MJ:
 Hosp Virgen Macarena, Seville, Spain

Benito, R:
 Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

Rojo, S:
 Hosp Clin Univ, Valladolid, Spain

Cabezas, T:
 Complejo Hosp Torrecardenas, Almeria, Spain

Macia, MD:
 Hosp Univ Son Espases, Mallorca, Spain

 Hosp Son Espases, Palma De Mallorca, Spain

Nieto, MD:
 Hosp Univ Basurto, Bilbao, Spain

Soriano, V:
 UNIR Hlth Sci Sch & Med Ctr, Madrid, Spain

 UNIR Hlth Sci Sch, Madrid, Spain

de Mendoza, C:
 Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain

 Univ CEU San Pablo, Madrid, Spain

 IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain

Rodriguez, C:
 Ctr Sanitario Sandoval, Madrid, Spain

Vera, M:
 Ctr Sanitario Sandoval, Madrid, Spain

del Romero, J:
 Ctr Sanitario Sandoval, Madrid, Spain

Ocete, MD:
 Hosp Gen Univ, Valencia, Spain

Caballero, E:
 Hosp Valle De Hebron, Barcelona, Spain

Aguilera, A:
 Hosp Conxo CHUS, Santiago, Spain

Amengual, MJ:
 Corp Sanitaria Parc Tauli, Barcelona, Spain

Cervantes, M:
 Corp Sanitaria Parc Tauli, Barcelona, Spain

Benito, R:
 Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

Algarate, S:
 Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

de Lejarazu, RO:
 Hosp Clin Univ, Valladolid, Spain

Rojo, S:
 Hosp Clin Univ, Valladolid, Spain

Eiros, JM:
 Hosp Rio Hortega, Valladolid, Spain

Ramos, C:
 Hosp Rio Hortega, Valladolid, Spain

Garcia-Costa, J:
 Hosp Cristal Pinor, Orense, Spain

Calderon, E:
 Hosp Virgen del Rocio, Seville, Spain

 CIBER Epidemiol & Salud Publ, Madrid, Spain

Rios-Villegas, MJ:
 Hosp Virgen Macarena, Seville, Spain

Trigo, M:
 Complejo Hosp, Pontevedra, Spain

Diz, J:
 Complejo Hosp, Pontevedra, Spain

Garcia-Campello, M:
 Complejo Hosp, Pontevedra, Spain

Rodriguez-Iglesias, M:
 Hosp Univ Puerta del Mar, Cadiz, Spain

Hernandez-Betancor, A:
 Hosp Insular Univ, Las Palmas Gran Canaria, Spain

Ramos, JM:
 Hosp Univ, Alicante, Spain

Gimeno, A:
 Hosp Univ, Alicante, Spain

Sanchez, V:
 Hosp Gen, Elche, Spain

Gomez-Hernando, C:
 Complejo Hosp Virgen de la Salud, Toledo, Spain

Echeverria, MJ:
 Hosp Donostia, San Sebastian, Spain

Cilla, G:
 Hosp Donostia, San Sebastian, Spain

Perez-Trallero, E:
 Hosp Donostia, San Sebastian, Spain

Fernandez-Pereira, L:
 Hosp San Pedro de Alcantara, Caceres, Spain

Niubo, J:
 Ciudad Sanitaria Bellvitge, Barcelona, Spain

Margall, N:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Hernandez, M:
 Hosp Univ La Laguna, Tenerife, Spain

Lopez-Lirola, AM:
 Hosp Univ La Laguna, Tenerife, Spain

Gomez-Sirvent, JL:
 Hosp Univ La Laguna, Tenerife, Spain

Force, L:
 Hosp Gen, Mataro, Spain

Sauca, M:
 Hosp Gen, Mataro, Spain

Perez, S:
 Hosp Meixoeiro, Vigo, Spain

Morano, L:
 Hosp Meixoeiro, Vigo, Spain

Raya, C:
 Hosp Bierzo, Ponferrada, Spain

Praetorius, AG:
 Hosp Univ, Guadalajara, Spain

Cifuentes, C:
 Hosp Son Espases, Palma De Mallorca, Spain

Penaranda, M:
 Hosp Son Espases, Palma De Mallorca, Spain

Nieto, MC:
 Hosp Basurto, Bilbao, Spain

Montejo, JM:
 Hosp Cruces, Bilbao, Spain

Roc, L:
 Hosp Miguel Servet, Zaragoza, Spain

Martinez-Sapina, A:
 Hosp Miguel Servet, Zaragoza, Spain

Viciana, I:
 Hosp Virgen de la Victoria, Malaga, Spain

Lozano, AB:
 Hosp Poniente, Almeria, Spain

Perez-Camacho, I:
 Hosp Poniente, Almeria, Spain

Fernandez-Fuertes, E:
 Hosp Poniente, Almeria, Spain

Fernandez, JM:
 Hosp Poniente, Almeria, Spain

Cabezas, T:
 Complejo Hosp Torrecardenas, Almeria, Spain

Bermejo, IG:
 Hosp Univ Getafe, Madrid, Spain

Gaspar, G:
 Hosp Univ Getafe, Madrid, Spain

Gorgolas, M:
 Fdn Jimenez Diaz, Madrid, Spain

Vegas, C:
 Fdn Jimenez Diaz, Madrid, Spain

Blas, J:
 Fdn Jimenez Diaz, Madrid, Spain

Tellez, R:
 Fdn Jimenez Diaz, Madrid, Spain

Perez, L:
 Hosp Gregorio Maranon, Madrid, Spain

Valeiro, M:
 Hosp Gregorio Maranon, Madrid, Spain

Aldamiz, T:
 Hosp Gregorio Maranon, Madrid, Spain

Garcia, F:
 Hosp Clin Univ, Granada, Spain

Suarez, A:
 Hosp Clin San Carlos, Madrid, Spain

Rodriguez-Avial, I:
 Hosp Clin San Carlos, Madrid, Spain

Barreiro, P:
 Hosp Univ La Paz, Madrid, Spain

Soriano, V:
 UNIR Hlth Sci Sch & Med Ctr, Madrid, Spain

 UNIR Hlth Sci Sch, Madrid, Spain

Gomez-Gallego, F:
 UNIR Hlth Sci Sch, Madrid, Spain

Corral, O:
 UNIR Hlth Sci Sch, Madrid, Spain

Requena, S:
 Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain

 IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain

Benitez-Gutierrez, L:
 IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain

Cuervas-Mons, V:
 IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain

de Mendoza, C:
 Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain

 Univ CEU San Pablo, Madrid, Spain

 IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
ISSN: 02699370





AIDS
Editorial
LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 33 Número: 14
Páginas: 2167-2172
WOS Id: 000509678600006
ID de PubMed: 31373918
imagen Bronze

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