Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain
Por:
Requena, S, Caballero, E, Lozano, AB, Rios-Villegas, MJ, Benito, R, Rojo, S, Cabezas, T, Macia, MD, Nieto, MD, Soriano, V, de Mendoza, C, Rodriguez, C, Vera, M, del Romero, J, Ocete, MD, Caballero, E, Aguilera, A, Amengual, MJ, Cervantes, M, Benito, R, Algarate, S, de Lejarazu, RO, Rojo, S, Eiros, JM, Ramos, C, Garcia-Costa, J, Calderon, E, Rios-Villegas, MJ, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Ramos, JM, Gimeno, A, Sanchez, V, Gomez-Hernando, C, Echeverria, MJ, Cilla, G, Perez-Trallero, E, Fernandez-Pereira, L, Niubo, J, Margall, N, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Sauca, M, Perez, S, Morano, L, Raya, C, Praetorius, AG, Cifuentes, C, Penaranda, M, Nieto, MC, Montejo, JM, Roc, L, Martinez-Sapina, A, Viciana, I, Lozano, AB, Perez-Camacho, I, Fernandez-Fuertes, E, Fernandez, JM, Cabezas, T, Bermejo, IG, Gaspar, G, Gorgolas, M, Vegas, C, Blas, J, Tellez, R, Perez, L, Valeiro, M, Aldamiz, T, Garcia, F, Suarez, A, Rodriguez-Avial, I, Barreiro, P, Soriano, V, Gomez-Gallego, F, Corral, O, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, de Mendoza, C
Publicada:
15 nov 2019
Resumen:
Background: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all dually infected patients living in Spain.
Methods: We identified retrospectively all persons coinfected with HIV-1 recorded at the Spanish HIV-2 registry. Dual infection had been confirmed using PCR in plasma and/or cells, and/or using discriminatory serological tests.
Results: From a total of 373 individuals with HIV-2 recorded at the Spanish registry, 34 (9.1%) were coinfected with HIV-1. Compared with HIV-2 monoinfected persons, dually infected patients were more often male (67.6%), presented with lower median CD4(+) cell counts (204 cells/mu l), and had developed more frequently AIDS events (26.5%). Although 61.7% came from West Africa, 6 (17.6%) were native Spaniards. HIV-1 non-B subtypes were recognized in 75% of coinfected patients, being the most prevalent CRF02_AG. At baseline, 45% of dually infected patients had undetectable plasma HIV-2 RNA. After a median follow-up of 32 (13-48) months on antiretroviral therapy, dually infected patients achieved undetectable viremia in 85% for HIV-1, in 80% for HIV-2; and in 70% for both viruses. Median CD4(+) cell counts reached up to 418 cells/mu l.
Conclusion: Roughly 9% of individuals with HIV-2 infection living in Spain are coinfected with HIV-1. Overall, 70% of dually infected patients achieved viral suppression for both viruses under antiretroviral therapy. Given the relatively large population of West Africans living in Spain and the continuous migration flow from HIV-2 endemic areas, HIV-1/HIV-2 coinfection should always be excluded at first diagnosis in all HIV-seroreactive persons. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.
Filiaciones:
Requena, S:
Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Caballero, E:
Hosp Valle De Hebron, Barcelona, Spain
Lozano, AB:
Hosp Poniente, Almeria, Spain
Rios-Villegas, MJ:
Hosp Virgen Macarena, Seville, Spain
Benito, R:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Rojo, S:
Hosp Clin Univ, Valladolid, Spain
Cabezas, T:
Complejo Hosp Torrecardenas, Almeria, Spain
Macia, MD:
Hosp Univ Son Espases, Mallorca, Spain
Hosp Son Espases, Palma De Mallorca, Spain
Nieto, MD:
Hosp Univ Basurto, Bilbao, Spain
Soriano, V:
UNIR Hlth Sci Sch & Med Ctr, Madrid, Spain
UNIR Hlth Sci Sch, Madrid, Spain
de Mendoza, C:
Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain
Univ CEU San Pablo, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Rodriguez, C:
Ctr Sanitario Sandoval, Madrid, Spain
Vera, M:
Ctr Sanitario Sandoval, Madrid, Spain
del Romero, J:
Ctr Sanitario Sandoval, Madrid, Spain
Ocete, MD:
Hosp Gen Univ, Valencia, Spain
Caballero, E:
Hosp Valle De Hebron, Barcelona, Spain
Aguilera, A:
Hosp Conxo CHUS, Santiago, Spain
Amengual, MJ:
Corp Sanitaria Parc Tauli, Barcelona, Spain
Cervantes, M:
Corp Sanitaria Parc Tauli, Barcelona, Spain
Benito, R:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Algarate, S:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
de Lejarazu, RO:
Hosp Clin Univ, Valladolid, Spain
Rojo, S:
Hosp Clin Univ, Valladolid, Spain
Eiros, JM:
Hosp Rio Hortega, Valladolid, Spain
Ramos, C:
Hosp Rio Hortega, Valladolid, Spain
Garcia-Costa, J:
Hosp Cristal Pinor, Orense, Spain
Calderon, E:
Hosp Virgen del Rocio, Seville, Spain
CIBER Epidemiol & Salud Publ, Madrid, Spain
Rios-Villegas, MJ:
Hosp Virgen Macarena, Seville, Spain
Trigo, M:
Complejo Hosp, Pontevedra, Spain
Diz, J:
Complejo Hosp, Pontevedra, Spain
Garcia-Campello, M:
Complejo Hosp, Pontevedra, Spain
Rodriguez-Iglesias, M:
Hosp Univ Puerta del Mar, Cadiz, Spain
Hernandez-Betancor, A:
Hosp Insular Univ, Las Palmas Gran Canaria, Spain
Ramos, JM:
Hosp Univ, Alicante, Spain
Gimeno, A:
Hosp Univ, Alicante, Spain
Sanchez, V:
Hosp Gen, Elche, Spain
Gomez-Hernando, C:
Complejo Hosp Virgen de la Salud, Toledo, Spain
Echeverria, MJ:
Hosp Donostia, San Sebastian, Spain
Cilla, G:
Hosp Donostia, San Sebastian, Spain
Perez-Trallero, E:
Hosp Donostia, San Sebastian, Spain
Fernandez-Pereira, L:
Hosp San Pedro de Alcantara, Caceres, Spain
Niubo, J:
Ciudad Sanitaria Bellvitge, Barcelona, Spain
Margall, N:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Hernandez, M:
Hosp Univ La Laguna, Tenerife, Spain
Lopez-Lirola, AM:
Hosp Univ La Laguna, Tenerife, Spain
Gomez-Sirvent, JL:
Hosp Univ La Laguna, Tenerife, Spain
Force, L:
Hosp Gen, Mataro, Spain
Sauca, M:
Hosp Gen, Mataro, Spain
Perez, S:
Hosp Meixoeiro, Vigo, Spain
Morano, L:
Hosp Meixoeiro, Vigo, Spain
Raya, C:
Hosp Bierzo, Ponferrada, Spain
Praetorius, AG:
Hosp Univ, Guadalajara, Spain
Cifuentes, C:
Hosp Son Espases, Palma De Mallorca, Spain
Penaranda, M:
Hosp Son Espases, Palma De Mallorca, Spain
Nieto, MC:
Hosp Basurto, Bilbao, Spain
Montejo, JM:
Hosp Cruces, Bilbao, Spain
Roc, L:
Hosp Miguel Servet, Zaragoza, Spain
Martinez-Sapina, A:
Hosp Miguel Servet, Zaragoza, Spain
Viciana, I:
Hosp Virgen de la Victoria, Malaga, Spain
Lozano, AB:
Hosp Poniente, Almeria, Spain
Perez-Camacho, I:
Hosp Poniente, Almeria, Spain
Fernandez-Fuertes, E:
Hosp Poniente, Almeria, Spain
Fernandez, JM:
Hosp Poniente, Almeria, Spain
Cabezas, T:
Complejo Hosp Torrecardenas, Almeria, Spain
Bermejo, IG:
Hosp Univ Getafe, Madrid, Spain
Gaspar, G:
Hosp Univ Getafe, Madrid, Spain
Gorgolas, M:
Fdn Jimenez Diaz, Madrid, Spain
Vegas, C:
Fdn Jimenez Diaz, Madrid, Spain
Blas, J:
Fdn Jimenez Diaz, Madrid, Spain
Tellez, R:
Fdn Jimenez Diaz, Madrid, Spain
Perez, L:
Hosp Gregorio Maranon, Madrid, Spain
Valeiro, M:
Hosp Gregorio Maranon, Madrid, Spain
Aldamiz, T:
Hosp Gregorio Maranon, Madrid, Spain
Garcia, F:
Hosp Clin Univ, Granada, Spain
Suarez, A:
Hosp Clin San Carlos, Madrid, Spain
Rodriguez-Avial, I:
Hosp Clin San Carlos, Madrid, Spain
Barreiro, P:
Hosp Univ La Paz, Madrid, Spain
Soriano, V:
UNIR Hlth Sci Sch & Med Ctr, Madrid, Spain
UNIR Hlth Sci Sch, Madrid, Spain
Gomez-Gallego, F:
UNIR Hlth Sci Sch, Madrid, Spain
Corral, O:
UNIR Hlth Sci Sch, Madrid, Spain
Requena, S:
Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Benitez-Gutierrez, L:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Cuervas-Mons, V:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
de Mendoza, C:
Puerta de Hierro Univ Hosp & Res Inst, Madrid, Spain
Univ CEU San Pablo, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Bronze
|