Evaluation of occult hepatitis B infection in tissue donors: a multicenter analysis in Spain
Por:
Ibanez, JS, Serrat, AV, Pillado, TS, Aierbe, CR, Montoro, RV, Benito, JC, Lopez, MP, Paneque, SF, Lopez, EV, Lorenzo, MJM, Romero, MG, Castellanos, AC, Oliveras, SS
Publicada:
1 dic 2019
Resumen:
Traditionally, when antibody to the Hepatitis B core antigen (anti-HBc) and antibody to the Hepatitis B surface antigen (anti-HBs) are positive, the donor is considered suitable. However, the literature contains cases with this profile and circulating hepatitis B virus DNA. The aim of the study is to analyze the incidence of occult hepatitis B virus infection (OBI). Retrospective data were evaluated for deceased tissue donors in ten Tissue Establishments (Spain) during 2017. The data included demographic data and the serological markers for hepatitis B that each tissue establishment performed. A total number of 1933 tissue donors were evaluated. A total of 180 donors were excluded: 6 (0.3%) with Hepatitis B surface antigen (HBs positive), and 174 in which DNA testing was not performed. Anti-HBc was positive in 175 donors (10%), in which anti-HBs was negative in 30 (17.1%) and positive in 145 (82.9%). In total, 27 donors with DNA positive (1.5%) were found, of which 3 of 117 donors (1.7%) showed anti-HBc negative and anti-HBs positive (> 10 IU/ml), 4 of 30 donors (13.3%) showed anti-HBc positive and antiHBs negative and 20 of 145 donors (13.8%) showed both anti-HBc and anti-HBs positive. The highest probability of finding DNA occurs when anti-HBc is positive, regardless of the presence of anti-HBs. In our study, the probability of OBI was 1.5%. The classic concept that when anti-HBc and anti-HBs are positive (even with a titer of over 100 IU/ml) the donor can be accepted should, therefore, be reconsidered, and DNA testing should be mandatory.
Filiaciones:
Ibanez, JS:
A Coruna Univ Hosp, Cryobiol Unit, Tissue Estab, Complejo Hosp Univ A Coruna, Ave Xubias 84, La Coruna 15006, Spain
Serrat, AV:
Banc Sang & Teixits, Tissue Estab, Barcelona, Spain
Pillado, TS:
A Coruna Univ Hosp, Clin Epidemiol & Biostat Res Grp, Inst Invest Biomed A Coruna, La Coruna, Spain
Aierbe, CR:
Ctr Vasco Transfus Tejidos Humanos, Tissue Estab, Galdakao, Spain
Montoro, RV:
Ctr Transfus Tejidos & Celulas, Cordoba, Spain
Benito, JC:
Balear Isl Inst Hlth Res IdISBa, Tissue Estab, Balear Isl Blood & Tissue Bank Fdn FBSTIB, Cell Therapy & Tissue Engn Grp TERCIT, Palma De Mallorca, Spain
Lopez, MP:
Ctr Comunitario Sangre & Tejidos Principado Astur, Tissue Estab, Oviedo, Spain
Paneque, SF:
Ctr Transfus Tejidos & Celulas, Tissue Estab, Malaga, Spain
Lopez, EV:
Fdn Clin San Francisco, Tissue Estab, Estab Tejidos Humanos, Leon, Spain
Lorenzo, MJM:
Banco Sangre & Tejidos Arago, Tissue Estab, Zaragoza, Spain
Romero, MG:
Hosp Clin San Carlos, Tissue Estab, Madrid, Spain
Castellanos, AC:
A Coruna Univ Hosp, Dept Microbiol, La Coruna, Spain
Oliveras, SS:
Banc Sang & Teixits, Transfus Safety Lab, Barcelona, Spain
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