The MAPT H1 Haplotype Is a Risk Factor for Alzheimer's Disease in APOE epsilon 4 Non-carriers
Por:
Sanchez-Juan, P, Moreno, S, de Rojaso, I, Hernandez, I, Valero, S, Alegret, M, Montrreal, L, Gonzalez, PG, Lage, C, Lopez-Garcia, S, Rodriiguez-Rodriguez, E, Orellana, A, Tarraga, L, Boada, M, Ruiz, A, Abdelnour, C, Aguilera, N, Alarcon, E, Alegret, M, Boada, M, Buendia, M, Canabate, P, de Rojas, I, Diego, S, Espinosa, A, Gailhajenet, A, Gonzalez, PG, Gil, S, Guitart, M, Hernandez, I, Ibarria, M, Lafuente, A, Martin, E, Mauleon, A, Monte-Rubio, G, Montrreal, L, Moreno-Grau, S, Moreno, M, Orellana, A, Ortega, G, Pancho, A, Peleja, E, Perez-Cordon, A, Preckler, S, Rodriguez-Gomez, O, Rosende-Roca, M, Ruiz, A, Ruiz, S, Sanabria, A, Santos-Santos, MA, Sotolongo-Grau, O, Tarraga, L, Valero, S, Vargas, L, Quintela, I, Real, LM, Carracedo, A, Maronas, O, Corbaton, A, Martinez, MT, Serrano-Rios, M, Perez, AG, Saez, ME, Macias, J, Pineda, JA, Adarmes-Gomez, AD, Buiza-Rueda, D, Carrillo, F, Carrion-Claro, M, Gomez-Garre, P, Jesus, S, Espinosa, MAL, Macias, D, Mir, P, Perinan-Tocino, T, Blesa, R, Bullido, MJ, Calero, M, Clarimon, J, Fortea, J, Frank-Garcia, A, Lage, C, Lleo, A, Lopez-Garcia, S, Montes, AM, Medina, M, Tur, JP, Ripoll, GP, Rabano, A, Rodriguez-Rodriguez, E, Sanchez-Juan, P, Sastre, I, Alarcon-Martin, E, Marquie, M, Cruz-Gamero, JM, Royo, JL, Alvarez, I, Diez-Fairen, M, Pastor, P, Alvarez, V, Martinez, C, Menendez-Gonzalez, M, Amer-Ferrer, G, Antequera, M, Antunez, C, Legaz, A, Manzanares, S, Marin-Munoz, J, Martinez, B, Martinez, V, Vicente, MP, Vivancos, L, Baquero, M, Burguera, JA, Bernal, M, Franco, E, Marin, M, Rodrigo, S, del Ser, T, Pastor, AB, Madrona, SG, Garcia-Ribas, G, Casajeros, MJ, de Pancorbo, MM, Garcia-Alberca, JM, Hevilla, S, Marin, T, de Munain, AL, Alvarez, PML, Iriarte, MM, Molinuevo, JL, de Asua, DR, Diaz, RSD
Publicada:
4 dic 2019
Resumen:
An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently with AD. In a previous study, we showed that an SNP tagging this haplotype (rs1800547) was associated with AD risk in a large population from the Dementia Genetics Spanish Consortium (DEGESCO) including 4435 cases and 6147 controls. The association was mainly driven by individuals that were non-carriers of the APOE epsilon 4 allele. Our aim was to replicate our previous findings in an independent sample of 4124 AD cases and 3290 controls from Spain (GR@ACE project) and to analyze the effect of the H1 sub-haplotype structure on the risk of AD. The H1 haplotype was associated with AD risk (OR = 1.12; p = 0.0025). Stratification analysis showed that this association was mainly driven by the APOE epsilon 4 non-carriers (OR = 1.15; p = 0.0022). Pooled analysis of both Spanish datasets (n = 17,996) showed that the highest AD risk related to the MAPT H1/H2 haplotype was in those individuals that were the oldest [third tertile (>77 years)] and did not carry APOE epsilon 4 allele (p = 0.001). We did not find a significant association between H1 sub-haplotypes and AD. H1c was nominally associated but lost statistical significance after adjusting by population sub-structure. Our results are consistent with the hypothesis that genetic variants linked to the MAPT H1/H2 are tracking a genuine risk allele for AD. The fact that this association is stronger in APOE epsilon 4 non-carriers partially explains previous controversial results and might be related to a slower alternative causal pathway less dependent on brain amyloid load.
Filiaciones:
Sanchez-Juan, P:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, IDIVAL, Serv Neurol, Univ Hosp Marques de Valdecilla, Santander, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, IDIVAL, Neurol Serv, Santander, Spain
Moreno, S:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
de Rojaso, I:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Hernandez, I:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Valero, S:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Alegret, M:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Montrreal, L:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Gonzalez, PG:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Lage, C:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, IDIVAL, Serv Neurol, Univ Hosp Marques de Valdecilla, Santander, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, IDIVAL, Neurol Serv, Santander, Spain
Lopez-Garcia, S:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, IDIVAL, Serv Neurol, Univ Hosp Marques de Valdecilla, Santander, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, IDIVAL, Neurol Serv, Santander, Spain
Rodriiguez-Rodriguez, E:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, IDIVAL, Serv Neurol, Univ Hosp Marques de Valdecilla, Santander, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Orellana, A:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Tarraga, L:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Boada, M:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Ruiz, A:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Abdelnour, C:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Aguilera, N:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Alarcon, E:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Alegret, M:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Boada, M:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Buendia, M:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Canabate, P:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
de Rojas, I:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Diego, S:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Espinosa, A:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Gailhajenet, A:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Gonzalez, PG:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Gil, S:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Guitart, M:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Hernandez, I:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Ibarria, M:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Lafuente, A:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Martin, E:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Mauleon, A:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Monte-Rubio, G:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Montrreal, L:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Moreno-Grau, S:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Moreno, M:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Orellana, A:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Ortega, G:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Pancho, A:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Peleja, E:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Perez-Cordon, A:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Preckler, S:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Rodriguez-Gomez, O:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Rosende-Roca, M:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Ruiz, A:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Ruiz, S:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Sanabria, A:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Santos-Santos, MA:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Sotolongo-Grau, O:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Tarraga, L:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Valero, S:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Vargas, L:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Quintela, I:
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Real, LM:
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Carracedo, A:
Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Grp Med Xenom, Santiago, Spain
IDIS, CIBERER, Fdn Publ Galega Med Xenom, Santiago, Spain
Maronas, O:
Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Grp Med Xenom, Santiago, Spain
Corbaton, A:
Hosp Clin San Carlos, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
Martinez, MT:
Hosp Clin San Carlos, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Serrano-Rios, M:
Hosp Clin San Carlos, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
Perez, AG:
Ctr Andaluz Estudios Bioinformat, Seville, Spain
Saez, ME:
Ctr Andaluz Estudios Bioinformat, Seville, Spain
Macias, J:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Pineda, JA:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Adarmes-Gomez, AD:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Buiza-Rueda, D:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Carrillo, F:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Carrion-Claro, M:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Gomez-Garre, P:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Jesus, S:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Espinosa, MAL:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Macias, D:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Mir, P:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Perinan-Tocino, T:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio,Inst Biomed Sevilla, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Blesa, R:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, St Pau Memory Unit,Neurol Dept, Barcelona, Spain
Bullido, MJ:
Inst Invest Sanitaria Hosp la Paz, Madrid, Spain
Calero, M:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
CIEN Fdn, Queen Sofia Fdn, Alzheimer Ctr, Madrid, Spain
Inst Salud Carlos III, Madrid, Spain
Clarimon, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, St Pau Memory Unit,Neurol Dept, Barcelona, Spain
Fortea, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, St Pau Memory Unit,Neurol Dept, Barcelona, Spain
Frank-Garcia, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Inst Invest Sanitaria Hosp la Paz, Madrid, Spain
Hosp Univ La Paz UAM, Neurol Serv, Madrid, Spain
Lage, C:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, IDIVAL, Serv Neurol, Univ Hosp Marques de Valdecilla, Santander, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, IDIVAL, Neurol Serv, Santander, Spain
Lleo, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, St Pau Memory Unit,Neurol Dept, Barcelona, Spain
Lopez-Garcia, S:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, IDIVAL, Serv Neurol, Univ Hosp Marques de Valdecilla, Santander, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, IDIVAL, Neurol Serv, Santander, Spain
Montes, AM:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain
Hosp Univ La Paz UAM, Neurol Serv, Madrid, Spain
Medina, M:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Inst Invest Sanitaria Hosp la Paz, Madrid, Spain
Tur, JP:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
CSIC, Inst Biomed Valencia, Unitat Genet Mol, Valencia, Spain
Inst Invest Sanitaria La Fe, Unidad Mixta Neurol & Genet, Valencia, Spain
Ripoll, GP:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Inst Recerca Biomed Lleida, Lleida, Spain
Rabano, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
CIEN Fdn, Queen Sofia Fdn, Alzheimer Ctr, Madrid, Spain
BT CIEN, Madrid, Spain
Rodriguez-Rodriguez, E:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, IDIVAL, Neurol Serv, Santander, Spain
Sanchez-Juan, P:
Minist Econ & Competitiveness, Natl Inst Hlth Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, IDIVAL, Serv Neurol, Univ Hosp Marques de Valdecilla, Santander, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, IDIVAL, Neurol Serv, Santander, Spain
Sastre, I:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain
Alarcon-Martin, E:
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Marquie, M:
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Cruz-Gamero, JM:
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Royo, JL:
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Alvarez, I:
Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Univ Barcelona, Sch Med, Hosp Univ Mutua de Terrassa, Memory Disorders Unit,Dept Neurol, Barcelona, Spain
Diez-Fairen, M:
Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Univ Barcelona, Sch Med, Hosp Univ Mutua de Terrassa, Memory Disorders Unit,Dept Neurol, Barcelona, Spain
Pastor, P:
Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Univ Barcelona, Sch Med, Hosp Univ Mutua de Terrassa, Memory Disorders Unit,Dept Neurol, Barcelona, Spain
Alvarez, V:
Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain
Inst Invest Biosanit Principado Asturias, Oviedo, Spain
Martinez, C:
Inst Invest Biosanit Principado Asturias, Oviedo, Spain
Hosp Cabuenes, Serv Neurol, Gijon, Spain
Menendez-Gonzalez, M:
Inst Invest Biosanit Principado Asturias, Oviedo, Spain
Hosp Univ Cent Asturias, Serv Neurol, Oviedo, Spain
Amer-Ferrer, G:
Hosp Univ Son Espases, Dept Neurol, Palma De Mallorca, Spain
Antequera, M:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Antunez, C:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Legaz, A:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Manzanares, S:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Fdn Formac & Invest Sanitarias Reg Murcia, Murcia, Spain
Marin-Munoz, J:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Martinez, B:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Martinez, V:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Vicente, MP:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Vivancos, L:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Baquero, M:
Hosp Univ & Politecn La Fe, Serv Neurol, Valencia, Spain
Burguera, JA:
Hosp Univ & Politecn La Fe, Serv Neurol, Valencia, Spain
Bernal, M:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
Franco, E:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
Marin, M:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
Rodrigo, S:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
del Ser, T:
Inst Invest Sanitaria Hosp la Paz, Madrid, Spain
Pastor, AB:
CIEN Fdn, Queen Sofia Fdn, Alzheimer Ctr, Madrid, Spain
Madrona, SG:
Inst Salud Carlos III, Madrid, Spain
Garcia-Ribas, G:
Inst Salud Carlos III, Madrid, Spain
Casajeros, MJ:
Hosp Univ Ramon y Cajal, Madrid, Spain
de Pancorbo, MM:
Univ Basque Country, UPV EHU, Ctr Invest Lascaray, BIOMICs, Leioa, Spain
Garcia-Alberca, JM:
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Hevilla, S:
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Marin, T:
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
de Munain, AL:
Hosp Donostia San Sebastian, Donostia San Sebastian, Spain
Alvarez, PML:
Fdn CITA Alzheimer, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Spain
Iriarte, MM:
Navarrabiomed, Pamplona, Spain
Molinuevo, JL:
Fundacio Pasqua Maragall, Barcelonasseta Brain Res Ctr, Barcelona, Spain
de Asua, DR:
Hosp Univ La Princesa, Madrid, Spain
Diaz, RSD:
Hosp Clin Barcelona, Barcelona, Spain
Green Published, gold
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