Pilonidal sinus disease: an intergluteal localization of hidradenitis suppurativa/acne inversa: a cross-sectional study among 2465 patients
Por:
Benhadou, F, Van der Zee, HH, Pascual, JC, Rigopoulos, D, Katoulis, A, Liakou, AI, Daxhelet, M, Romanelli, M, Iannone, M, Kinyo, A, Nikolakis, G, Zouboulis, CC, Dessinioti, C, Zisimou, C, Antoniou, C, Alavi, A, Mintoff, D, Aquilina, S, Matusiak, L, Szepietowski, JC, Sinclair, R, Husein-ElAhmed, H, von Laffert, M, Revuz, J, Danby, B, Puig, L, Theut Riis, P, Jemec, GBE, van Straalen, K, Wigny, KMGJ, del Marmol, V, Guillem, P
Publicada:
1 dic 2019
Resumen:
Background Hidradenitis suppurativa (HS), also referred to as acne inversa, is a debilitating skin disease characterized by inflammatory nodules, chronic abscesses and tunnels (fistulae and sinuses). The association with pilonidal sinus disease (PSD) is frequently reported but not well documented. Objectives To determine the prevalence and characteristics of inflammatory skin lesions located in the intergluteal fold (IGF) of patients with HS. Methods This was an international multicentre retrospective cross-sectional study based on data collection from a large cohort of patients with HS with and without histopathology. Results From a total of 2465 patients with HS included in the study, 661 (27%) reported lesions in the IGF. These patients were significantly more often smokers and had more severe HS. Of the 238 patients with an available clinical diagnosis, intergluteal-HS (IG-HS) was diagnosed in 52 patients (22%) and PSD was diagnosed in 186 patients (78%). IG-HS was associated with the localization of HS in the proximity of the IGF, including the buttocks, genitals and the anus. There was a possibility of misclassification bias in this study as a clinical/image-based diagnosis or histopathology of the IGF lesions was not always available. Conclusions The high prevalence of PSD suggests a strong link between both entities. Therefore, it may be useful to identify common pathophysiological mechanisms and develop common therapeutic strategies. What's already known about this topic?
The occurrence of pilonidal sinus disease has not been clearly reported among patients with hidradenitis suppurativa/acne inversa. What does this study add?
This is the first study that investigated the prevalence of pilonidal sinus disease among a large cohort of patients and identified the patient characteristics. Risk factors that might help to improve the management of patients were identified.
Filiaciones:
Benhadou, F:
Univ Libre Bruxelles, Erasme Hosp, Dept Dermatol, Brussels, Belgium
ResoVerneuil, Paris, France
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Van der Zee, HH:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Erasmus MC, Dept Dermatol, Rotterdam, Netherlands
Pascual, JC:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Erasmus MC, Dept Dermatol, Rotterdam, Netherlands
Rigopoulos, D:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Alicante Univ Gen Hosp, Alicante Inst Hlth & Biomed Res, ISABIAL FISABIO Fdn, Dept Dermatol, Alicante, Spain
Katoulis, A:
Univ Athens, Attikon Gen Univ Hosp, Dept Dermatol & Venereol 2, Athens, Greece
Liakou, AI:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Univ Athens, Attikon Gen Univ Hosp, Dept Dermatol & Venereol 2, Athens, Greece
Daxhelet, M:
Univ Libre Bruxelles, Erasme Hosp, Dept Dermatol, Brussels, Belgium
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Romanelli, M:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Univ Pisa, Dept Dermatol, Pisa, Italy
Iannone, M:
Univ Pisa, Dept Dermatol, Pisa, Italy
Kinyo, A:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Univ Pecs, Dept Dermatol Venereol & Oncodermatol, Pecs, Hungary
Nikolakis, G:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Dermatol, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Venereol, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Allergol, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Immunol, Dessau, Germany
Zouboulis, CC:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Dermatol, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Venereol, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Allergol, Dessau, Germany
Brandenburg Med Sch Theodore Fontane, Dessau Med Ctr, Dept Immunol, Dessau, Germany
Dessinioti, C:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Andreas Syggros Hosp, Dept Dermatol, Athens, Greece
Zisimou, C:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Andreas Syggros Hosp, Dept Dermatol, Athens, Greece
Antoniou, C:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Andreas Syggros Hosp, Dept Dermatol, Athens, Greece
Alavi, A:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
York Dermatol Ctr, Dept Dermatol, Richmond Hill, ON, Canada
Mintoff, D:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Sir Paul Boffa Hosp, Dept Dermatol, Floriana, Malta
Aquilina, S:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Sir Paul Boffa Hosp, Dept Dermatol, Floriana, Malta
Matusiak, L:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Wroclaw Med Univ, Dept Dermatol Allergol & Venereol, Wroclaw, Poland
Szepietowski, JC:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Wroclaw Med Univ, Dept Dermatol Allergol & Venereol, Wroclaw, Poland
Sinclair, R:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Univ Melbourne, Epworth Hosp, Dept Dermatol, Melbourne, Vic, Australia
Husein-ElAhmed, H:
Hosp Baza, Dept Dermatol, Granada, Spain
von Laffert, M:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Charite Univ Med Berlin, Inst Pathol, Berlin, Germany
Revuz, J:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Danby, B:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Geisel Sch Med Dartmouth, Dept Dermatol, Manchester, NH USA
Puig, L:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Autonomous Univ Barcelona, Hosp Santa Creu & St Pau, Barcelona, Spain
Theut Riis, P:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Univ Copenhagen, Fac Hlth Sci, Zealand Univ Hosp, Dept Dermatol, Copenhagen, Denmark
Jemec, GBE:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Univ Copenhagen, Fac Hlth Sci, Zealand Univ Hosp, Dept Dermatol, Copenhagen, Denmark
van Straalen, K:
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Erasmus MC, Dept Dermatol, Rotterdam, Netherlands
Wigny, KMGJ:
Erasmus MC, Dept Dermatol, Rotterdam, Netherlands
del Marmol, V:
Univ Libre Bruxelles, Erasme Hosp, Dept Dermatol, Brussels, Belgium
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Guillem, P:
ResoVerneuil, Paris, France
European Hidradenitis Suppurat Fdn eV, Dessau, Germany
Clin Val Ouest, Dept Surg, Ecully, France
Green Published
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