Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey
Por:
Frederiksen, KS, Nielsen, TR, Appollonio, I, Andersen, BB, Riverol, M, Boada, M, Ceccaldi, M, Dubois, B, Engelborghs, S, Frolich, L, Hausner, L, Gabelle, A, Gabryelewicz, T, Grimmer, T, Hanseeuw, B, Hort, J, Hugon, J, Jelic, V, Koivisto, A, Kramberger, MG, Lebouvier, T, Lleo, A, de Mendonca, A, Nobili, F, Ousset, PJ, Perneczky, R, Rikkert, MO, Robinson, D, Rouaud, O, Sanchez, E, Santana, I, Scarmeas, N, Sheardova, K, Sloan, S, Spiru, L, Stefanova, E, Traykov, L, Yener, G, Waldemar, G
Publicada:
1 feb 2021
Ahead of Print:
1 sep 2020
Resumen:
Objectives Mild cognitive impairment (MCI) is associated with an increased risk of further cognitive decline, partly depending on demographics and biomarker status. The aim of the present study was to survey the clinical practices of physicians in terms of biomarker counseling, management, and follow-up in European expert centers diagnosing patients with MCI. Methods An online email survey was distributed to physicians affiliated with European Alzheimer's disease Consortium centers (Northern Europe: 10 centers; Eastern and Central Europe: 9 centers; and Southern Europe: 15 centers) with questions on attitudes toward biomarkers and biomarker counseling in MCI and dementia. This included postbiomarker counseling and the process of diagnostic disclosure of MCI, as well as treatment and follow-up in MCI. Results The response rate for the survey was 80.9% (34 of 42 centers) across 20 countries. A large majority of physicians had access to biomarkers and found them useful. Pre- and postbiomarker counseling varied across centers, as did practices for referral to support groups and advice on preventive strategies. Less than half reported discussing driving and advance care planning with patients with MCI. Conclusions The variability in clinical practices across centers calls for better biomarker counseling and better training to improve communication skills. Future initiatives should address the importance of communicating preventive strategies and advance planning.
Filiaciones:
Frederiksen, KS:
Univ Copenhagen, Danish Dementia Res Ctr, Dept Neurol, Rigshosp, Copenhagen, Denmark
Nielsen, TR:
Univ Copenhagen, Danish Dementia Res Ctr, Dept Neurol, Rigshosp, Copenhagen, Denmark
Appollonio, I:
Univ Milano Bicocca, Sch Med & Surg, Milan, Italy
Univ Milano Bicocca, Milan Ctr Neurosci NeuroMI, Milan, Italy
Andersen, BB:
Univ Copenhagen, Danish Dementia Res Ctr, Dept Neurol, Rigshosp, Copenhagen, Denmark
Riverol, M:
Univ Navarra, Clin Univ Navarra, Dept Neurol, Madrid, Spain
Boada, M:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain
Univ Int Catalunya, Memory Clin, Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Inst Salud Carlos III, Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Ceccaldi, M:
CHU Timone, APHM, Dept Neurol & Neuropsychol, Marseille, France
Aix Marseille Univ, INSERM, Inst Neurosci Syst, Marseille, France
Dubois, B:
Salpetriere Univ Hosp, Alzheimer Res Ctr IM2A, Paris, France
Sorbonne Univ, Salpetriere Univ Hosp, AP HP, Dept Neurol, Paris, France
Engelborghs, S:
Inst Born Bunge, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium
Univ Antwerp, Antwerp, Belgium
UZ Brussel, Dept Neurol, Brussels, Belgium
UZ Brussel, Ctr Neurosci, Brussels, Belgium
Vrije Univ Brussel VUB, Brussels, Belgium
Frolich, L:
Heidelberg Univ, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany
Hausner, L:
Heidelberg Univ, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany
Gabelle, A:
Univ Montpellier, Memory Resources & Res Ctr, Dept Neurol, Gui Chauliac Hosp,Montpellier Univ Hosp, Montpellier, France
Gabryelewicz, T:
Mossakowski Med Res Ctr PAN, Dept Neurodegenerat Disorders, Warsaw, Poland
Grimmer, T:
Tech Univ Munich, Sch Med, Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, Munich, Germany
Hanseeuw, B:
Catholic Univ Louvain, Inst Neurosci, Dept Neurol, Clin Univ St Luc, Brussels, Belgium
Hort, J:
Charles Univ Prague, Memory Clin, Dept Neurol, Fac Med 2,Motol Univ Hosp, Prague, Czech Republic
Hugon, J:
Univ Paris, Lariboisiere Hosp Paris, Ctr Cognit Neurol, Paris, France
Jelic, V:
Karolinska Univ Hosp Huddinge, Clin Cognit Disorders, Theme Aging, Stockholm, Sweden
Koivisto, A:
Univ Eastern Finland, Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland
Univ Helsinki, Helsinki Univ Hosp, Dept Neurosci & Geriatr, Helsinki, Finland
Kramberger, MG:
Univ Med Ctr Ljubljana, Ctr Cognit Impairments, Ljubljana, Slovenia
Lebouvier, T:
Lille 2 Univ Hlth & Law, Pole Neurol, Lille, France
Lleo, A:
Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain
de Mendonca, A:
Univ Lisbon, Fac Med, Lisbon, Portugal
Nobili, F:
Univ Genoa, Dept Neurosci, DINOGMI, Genoa, Italy
IRCCS Osped Policlin San Martino, Genoa, Italy
Ousset, PJ:
Toulouse Univ Hosp, Clin Res Ctr, Memory Clin, Toulouse, France
Perneczky, R:
Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
German Ctr Neurodegenerat Disorders DZNE, Munich, Germany
Munich Cluster Syst Neurol SyNergy, Munich, Germany
Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol AGE Res Unit, London, England
Rikkert, MO:
Radboud Univ Nijmegen, Radboudumc Alzheimer Ctr, Dept Geriatr, Med Ctr, Nijmegen, Netherlands
Robinson, D:
St James Hosp, Memory Clin, Dublin, Ireland
Rouaud, O:
Vaud Univ Hosp, Leenaards Memory Ctr, Dept Clin Neurosci, Lausanne, Switzerland
Sanchez, E:
Hosp Univ Ramon & Cajal, Serv Geriatria, Madrid, Spain
Santana, I:
Ctr Hosp & Univ Coimbra, Neurol Dept, Coimbra, Portugal
Univ Coimbra, Fac Med, Coimbra, Portugal
Scarmeas, N:
Natl & Kapodistrian Univ Athens, Aiginition Univ Hosp, Dept Neurol 1, Athens, Greece
Columbia Univ, Dept Neurol, Med Ctr, New York, NY USA
Sheardova, K:
St Annes Univ Hosp, Memory Ctr ICRC, Int Clin Res Ctr, Brno, Czech Republic
Sloan, S:
Ninewells Hosp, Neuroprogress Disorders & Dementia Network, Dundee, Scotland
Spiru, L:
Carol Davila Univ Med & Pharm, Geriatr Gerontol & Old Age Psychiat Alzheimer Uni, Clin Dept, Bucharest, Romania
Ana Aslan Int Fdn, Excellence Memory Clin & Longev Med, Bucharest, Romania
Stefanova, E:
Univ Belgrade, Fac Med, Clin Ctr Serbia, Neurol Clin, Belgrade, Serbia
Traykov, L:
UH Alexandrovska, Dept Neurol, Sofia, Bulgaria
Yener, G:
Dokuz Eylul Univ, Dept Neurosci, Med Sch, Izmir, Turkey
Dokuz Eylul Univ, Dept Neurol, Med Sch, Izmir, Turkey
Waldemar, G:
Univ Copenhagen, Danish Dementia Res Ctr, Dept Neurol, Rigshosp, Copenhagen, Denmark
Green Published
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