Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
Por:
Gao, YX, Wang, T, Yu, XH, Zhao, HS, Zeng, P, Ferrari, R, Hernandez, DG, Nails, MA, Rohrers, JD, Ramasamys, A, Kwok, JBJ, Dobson-Stone, C, Brooks, WS, Schofield, PR, Halliday, GM, Hodges, JR, Piguet, O, Bartley, L, Thompson, E, Haan, E, Hernandez, I, Ruiz, A, Boada, M, Borronils, B, Padovani, A, Cruchaga, C, Cairns, NJ, Benussi, L, Binetti, G, Ghidoni, R, Forloni, G, Albani, D, Galimberti, D, Fenoglio, C, Serpente, M, Scarpini, E, Clarim, J, Lie, A, Blesa, R, Waldo, ML, Nilsson, K, Nilsson, C, Mackenzie, IRA, Hsiung, GYR, Mann, DMA, Grafman, J, Morris, CM, Attems, J, Griffiths, TD, McKeith, IG, Thomas, AJ, Pietrini, P, Huey, ED, Wassermann, EM, Baborie, A, Jaros, E, Tierney, MC, Pastor, P, Razquin, C, Ortega-Cubero, S, Alonso, E, Perneczky, R, Diehl-Schmid, J, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, St George-Hyslop, P, Rossi, G, Tagliavini, F, Giacconen, G, Rowe, JB, Schlachetzki, JCM, Uphill, J, Collinge, J, Mead, S, Danek, A, Van Deerlin, VM, Grossman, M, Trojanowski, JQ, van der Zee, J, Cruts, M, Van Broeckhoven, C, Cappa, SF, Leber, I, Hannequin, D, Golfier, V, Vercelletto, M, Brice, A, Nacmias, B, Sorbi, S, Bagnoli, S, Piaceri, I, Nielsen, JE, Hjermind, LE, Riemenschneider, M, Mayhaus, M, Ibach, B, Gasparoni, G, Pichler, S, Gu, W, Rossor, MN, Fox, NC, Warren, JD, Spillantini, MG, Morris, HR, Rizzu, P, Heutink, P, Snowden, JS, Rollinson, S, Richardson, A, Gerhard, A, Bruni, AC, Maletta, R, Frangipane, F, Cupidi, C, Bernardi, L, Anfossi, M, Gallo, M, Conidi, ME, Smirne, N, Rademakers, R, Baker, M, Dickson, DW, Graff-Radford, NR, Petersen, RC, Knopman, D, Josephs, KA, Boeve, BF, Parisi, JE, Seeley, WW, Miller, BL, Karydas, AM, Rosen, H, van Swieten, JC, Dopper, EGP, Seelaar, H, Pijnenburg, YAL, Scheltens, P, Logroscino, G, Capozzo, R, Novelli, V, Puca, AA, Franceschi, M, Postiglione, A, Milan, G, Sorrentino, P, Kristiansen, M, Huei-Hsin, G, Graff, CC, Pasquier, F, Rollin, A, Deramecourt, V, Lebouvier, T, Ferrucci, L, Pickering-Brown, S, Singleton, AB, Hardy, J, Momeni, P
Publicada:
22 jul 2020
Resumen:
We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n=similar to 38,000 for LTL and similar to 81,000 for ALS in the European population; n=similar to 23,000 for LTL and similar to 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93-1.31, p=0.274) in the European population and 0.75 (95% CI 0.53-1.07, p=0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population.
Filiaciones:
Gao, YX:
Xuzhou Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Xuzhou 221004, Jiangsu, Peoples R China
Wang, T:
Xuzhou Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Xuzhou 221004, Jiangsu, Peoples R China
Yu, XH:
Xuzhou Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Xuzhou 221004, Jiangsu, Peoples R China
Zhao, HS:
Xuzhou Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Xuzhou 221004, Jiangsu, Peoples R China
Xuzhou Med Univ, Ctr Med Stat & Data Anal, Sch Publ Hlth, Xuzhou 221004, Jiangsu, Peoples R China
Zeng, P:
Xuzhou Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Xuzhou 221004, Jiangsu, Peoples R China
Xuzhou Med Univ, Ctr Med Stat & Data Anal, Sch Publ Hlth, Xuzhou 221004, Jiangsu, Peoples R China
Ferrari, R:
UCL, Dept Mol Neurosci, Russell Sq House,9-12 Russell Sq House, London WC1B 5EH, England
Hernandez, DG:
NIA, Lab Neurogenet, NIH, Bldg 35,Room 1A215,35 Convent Dr, Bethesda, MD 20892 USA
UCL, Inst Neurol, Reta Lila Weston Res Labs, Dept Mol Neurosci, Queen Sq, London WC1N 3BG, England
Nails, MA:
NIA, Lab Neurogenet, NIH, Bldg 35,Room 1A215,35 Convent Dr, Bethesda, MD 20892 USA
Rohrers, JD:
UCL, Inst Neurol, Reta Lila Weston Res Labs, Dept Mol Neurosci, Queen Sq, London WC1N 3BG, England
UCL, Dementia Res Ctr, Dept Neurodegenerat Dis, Inst Neurol, Queen Sq, London WC1N 3BG, England
Ramasamys, A:
UCL, Inst Neurol, Reta Lila Weston Res Labs, Dept Mol Neurosci, Queen Sq, London WC1N 3BG, England
Guys Hosp, Dept Med & Mol Genet, Kings Coll London Tower Wing, London SE1 9RT, England
Univ Oxford, Jenner Inst, Roosevelt Dr, Oxford OX3 7BQ, England
Kwok, JBJ:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW 2052, Australia
Dobson-Stone, C:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW 2052, Australia
Brooks, WS:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Univ New South Wales, Prince Wales Clin Sch, Sydney, NSW 2052, Australia
Schofield, PR:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Halliday, GM:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Hodges, JR:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Piguet, O:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Bartley, L:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Thompson, E:
Womens & Childrens Hosp, SA Pathol, South Australian Clin Genet Serv, Adelaide, SA 5006, Australia
Univ Adelaide, Dept Paediat, Adelaide, SA 5000, Australia
Haan, E:
Womens & Childrens Hosp, SA Pathol, South Australian Clin Genet Serv, Adelaide, SA 5006, Australia
Univ Adelaide, Dept Paediat, Adelaide, SA 5000, Australia
Hernandez, I:
Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain
Inst Catala Neurociencies Aplicades, Fundacio ACE, Memory Clin, Barcelona, Spain
Ruiz, A:
Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain
Inst Catala Neurociencies Aplicades, Fundacio ACE, Memory Clin, Barcelona, Spain
Boada, M:
Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain
Inst Catala Neurociencies Aplicades, Fundacio ACE, Memory Clin, Barcelona, Spain
Borronils, B:
Univ Brescia, Neurol Clin, Brescia, Italy
Padovani, A:
Univ Brescia, Neurol Clin, Brescia, Italy
Cruchaga, C:
Washington Univ, Dept Psychiat, St Louis, MO USA
Washington Univ, Sch Med, Hope Ctr, St Louis, MO USA
Cairns, NJ:
Washington Univ, Sch Med, Hope Ctr, St Louis, MO USA
Washington Univ, Dept Pathol & Immunol, St Louis, MO 63110 USA
Benussi, L:
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy
Binetti, G:
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, MAC Memory Clin, Brescia, Italy
Ghidoni, R:
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy
Forloni, G:
IRCCS Ist Ric Farmacol Mario Negri, Biol Neurodegenerat Disorders, Milan, Italy
Albani, D:
IRCCS Ist Ric Farmacol Mario Negri, Biol Neurodegenerat Disorders, Milan, Italy
Galimberti, D:
Univ Milan, Milan, Italy
Fdn Ca Granda, IRCCS Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy
Fenoglio, C:
Univ Milan, Milan, Italy
Fdn Ca Granda, IRCCS Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy
Serpente, M:
Univ Milan, Milan, Italy
Fdn Ca Granda, IRCCS Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy
Scarpini, E:
Univ Milan, Milan, Italy
Clarim, J:
Fdn Ca Granda, IRCCS Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Lie, A:
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Blesa, R:
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Waldo, ML:
Lund Univ, Unit Geriatr Psychiat, Dept Clin Sci, Lund, Sweden
Nilsson, K:
Lund Univ, Unit Geriatr Psychiat, Dept Clin Sci, Lund, Sweden
Nilsson, C:
Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Lund, Sweden
Mackenzie, IRA:
Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
Hsiung, GYR:
Univ British Columbia, Div Neurol, Vancouver, BC, Canada
Mann, DMA:
Univ Manchester, Salford Royal Hosp, Inst Brain Behav & Mental Hlth, Stott Lane, Salford M6 8HD, Lancs, England
Grafman, J:
Northwestern Univ, Dept Phys Med & Rehabil, Feinberg Sch Med, Rehabil Inst Chicago, Chicago, IL 60611 USA
Northwestern Univ, Dept Psychiat, Feinberg Sch Med, Rehabil Inst Chicago, Chicago, IL 60611 USA
Northwestern Univ, Dept Cognit Neurol, Feinberg Sch Med, Rehabil Inst Chicago, Chicago, IL 60611 USA
Northwestern Univ, Alzheimers Dis Ctr, Feinberg Sch Med, Rehabil Inst Chicago, Chicago, IL 60611 USA
Northwestern Univ, Dept Psychol, Weinberg Coll Arts & Sci, Chicago, IL 60611 USA
Morris, CM:
Newcastle Univ, Inst Ageing, Newcastle Brain Tissue Resource, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Inst Ageing, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Attems, J:
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Inst Ageing, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Griffiths, TD:
Newcastle Univ, Med Sch, Inst Neurosci, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
McKeith, IG:
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Inst Ageing, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Thomas, AJ:
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Inst Ageing, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Pietrini, P:
IMT Sch Adv Studies, Lucca, Lucca, Italy
Huey, ED:
Columbia Univ, Taub Inst, Dept Psychiat, 630 West 168th St, New York, NY 10032 USA
Columbia Univ, Taub Inst, Dept Neurol, 630 West 168th St, New York, NY 10032 USA
Wassermann, EM:
NINDS, Behav Neurol Unit, NIH, 10 Ctr DR MSC 1440, Bethesda, MD 20892 USA
Baborie, A:
Univ Alberta Edmonton, Walter Mackenzie Hlth Sci Ctr, Dept Lab Med & Pathol, 8440-112 St, Edmonton, AB T6G 2B7, Canada
Jaros, E:
Newcastle Univ, Inst Ageing & Hlth, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Tierney, MC:
NINDS, Behav Neurol Unit, NIH, 10 Ctr DR MSC 1440, Bethesda, MD 20892 USA
Pastor, P:
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Univ Navarra, Ctr Appl Med Res, Div Neurosci, Neurogenet Lab, Pamplona, Spain
Univ Navarra, Clin Univ Navarra, Dept Neurol, Sch Med, Pamplona, Spain
Razquin, C:
Univ Navarra, Ctr Appl Med Res, Div Neurosci, Neurogenet Lab, Pamplona, Spain
Ortega-Cubero, S:
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Univ Navarra, Ctr Appl Med Res, Div Neurosci, Neurogenet Lab, Pamplona, Spain
Alonso, E:
Univ Navarra, Ctr Appl Med Res, Div Neurosci, Neurogenet Lab, Pamplona, Spain
Perneczky, R:
Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London W6 8RP, England
West London Mental Hlth Trust, West London Cognit Disorders Treatment & Res Unit, London TW8 8DS, England
Diehl-Schmid, J:
Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany
Alexopoulos, P:
Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany
Kurz, A:
Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany
Rainero, I:
Univ Torino, Dept Neurosci, Neurol 1, Turin, Italy
AO Citta Salute & Sci Torino, Turin, Italy
Rubino, E:
Univ Torino, Dept Neurosci, Neurol 1, Turin, Italy
AO Citta Salute & Sci Torino, Turin, Italy
Pinessi, L:
Univ Torino, Dept Neurosci, Neurol 1, Turin, Italy
AO Citta Salute & Sci Torino, Turin, Italy
Rogaeva, E:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, 60 Leonard St, Toronto, ON M5T 258, Canada
St George-Hyslop, P:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, 60 Leonard St, Toronto, ON M5T 258, Canada
Univ Cambridge, Cambridge Inst Med Res, Dept Clin Neurosci, Hills Rd, Cambridge CB2 0XY, England
Rossi, G:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol 5, I-20133 Milan, Italy
Tagliavini, F:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol 5, I-20133 Milan, Italy
Giacconen, G:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol 5, I-20133 Milan, Italy
Rowe, JB:
Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0SZ, England
MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England
Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England
Schlachetzki, JCM:
Univ Calif San Diego, Dept Cellular & Mol Med, 9500 Gilman Dr, La Jolla, CA 92093 USA
Uphill, J:
UCL, Dept Neurodegenerat Dis, MRC, Inst Neurol,Pr Unit, Queen Sq House,Queen Sq, London WC1N 36G, England
Collinge, J:
UCL, Dept Neurodegenerat Dis, MRC, Inst Neurol,Pr Unit, Queen Sq House,Queen Sq, London WC1N 36G, England
Mead, S:
UCL, Dept Neurodegenerat Dis, MRC, Inst Neurol,Pr Unit, Queen Sq House,Queen Sq, London WC1N 36G, England
Danek, A:
Ludwig Maximilians Univ Munchen, Neurol Klin & Poliklin, Munich, Germany
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Van Deerlin, VM:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
Grossman, M:
Univ Penn, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Penn, Penn Frontotemporal Degenerat Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA
Trojanowski, JQ:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
van der Zee, J:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Cruts, M:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Van Broeckhoven, C:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Cappa, SF:
Univ Vita Salute San Raffaele, Dept Clin Neurosci, Neurorehabil Unit, Milan, Italy
Ist Sci San Raffaele, Milan, Italy
Leber, I:
INSERM, UMR S975, CRICM, F-75013 Paris, France
Univ Paris 06, UPMC, UMR S975, F-75013 Paris, France
CNRS, UMR 7225, F-75013 Paris, France
Hannequin, D:
Rouen Univ Hosp, Serv Neurol, CNR, U1079,INSERM,MAJ, Rouen, France
Golfier, V:
CH St Brieuc, Serv Neurol, St Brieuc, France
Vercelletto, M:
CHU Nantes, Serv Neurol, Nantes, France
Brice, A:
INSERM, UMR S975, CRICM, F-75013 Paris, France
Univ Paris 06, UPMC, UMR S975, F-75013 Paris, France
CNRS, UMR 7225, F-75013 Paris, France
Hop La Pitie Salpetriere, AP HP, Ctr References Demences Rares, Dept Neurol, F-75013 Paris, France
Nacmias, B:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Sorbi, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
IRCCS Don Carlo Gnocchi Firenze, Florence, Italy
Bagnoli, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Piaceri, I:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Nielsen, JE:
Copenhagen Univ Hosp, Rigshosp, Danish Dementia Res Ctr, Dept Neurol,Neurogenet Clin, Copenhagen, Denmark
Hjermind, LE:
Copenhagen Univ Hosp, Rigshosp, Danish Dementia Res Ctr, Dept Neurol,Neurogenet Clin, Copenhagen, Denmark
Univ Copenhagen, Panum Inst, Dept Cellular & Mol Med, Sect Neurogenet, Copenhagen, Denmark
Riemenschneider, M:
Saarland Univ Hosp, Dept Psychiat & Psychotherapy, Kirrberger Str 1,Bld 90, D-66421 Homburg, Germany
Saarland Univ Hosp, Lab Neurogenet, Kirrberger Str 1,Bld 90, D-66421 Homburg, Germany
Mayhaus, M:
Saarland Univ Hosp, Lab Neurogenet, Kirrberger Str 1,Bld 90, D-66421 Homburg, Germany
Ibach, B:
Univ Regensburg, Dept Psychiat Psychotherapy & Psychosomat, Univ Str 84, D-93053 Regensburg, Germany
Gasparoni, G:
Saarland Univ Hosp, Lab Neurogenet, Kirrberger Str 1,Bld 90, D-66421 Homburg, Germany
Pichler, S:
Saarland Univ Hosp, Lab Neurogenet, Kirrberger Str 1,Bld 90, D-66421 Homburg, Germany
Gu, W:
Saarland Univ Hosp, Lab Neurogenet, Kirrberger Str 1,Bld 90, D-66421 Homburg, Germany
Univ Luxembourg, Luxembourg Ctr Syst Biomed LCSB, 7 Ave Hauts Fourneaux, L-4362 Esch Sur Alzette, Luxembourg
Rossor, MN:
UCL, Dementia Res Ctr, Dept Neurodegenerat Dis, Inst Neurol, Queen Sq, London WC1N 3BG, England
Fox, NC:
UCL, Dementia Res Ctr, Dept Neurodegenerat Dis, Inst Neurol, Queen Sq, London WC1N 3BG, England
Warren, JD:
UCL, Dementia Res Ctr, Dept Neurodegenerat Dis, Inst Neurol, Queen Sq, London WC1N 3BG, England
Spillantini, MG:
Univ Cambridge, John Van Geest Brain Repair Ctr, Dept Clin Neurosci, Forvie Site,Robinson Way, Cambridge CB2 0PY, England
Morris, HR:
UCL, Dept Mol Neurosci, Russell Sq House,9-12 Russell Sq House, London WC1B 5EH, England
Rizzu, P:
German Ctr Neurodegenerat Dis Tubingen, Otfried Muellerstr 23, D-72076 Tubingen, Germany
Heutink, P:
German Ctr Neurodegenerat Dis Tubingen, Otfried Muellerstr 23, D-72076 Tubingen, Germany
Snowden, JS:
Univ Manchester, Fac Med & Human Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
Rollinson, S:
Univ Manchester, Fac Med & Human Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
Richardson, A:
Univ Manchester, Salford Royal Fdn Trust, Fac Med & Human Sci, Manchester, Lancs, England
Gerhard, A:
Univ Manchester, Inst Brain Behav & Mental Hlth, 27 Palatine Rd, Manchester M20 3LJ, Lancs, England
Bruni, AC:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Maletta, R:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Frangipane, F:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Cupidi, C:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Bernardi, L:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Anfossi, M:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Gallo, M:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Conidi, ME:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Smirne, N:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Rademakers, R:
Mayo Clin, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Baker, M:
Mayo Clin, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Dickson, DW:
Mayo Clin, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Graff-Radford, NR:
Mayo Clin, Dept Neurol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Petersen, RC:
Mayo Clin Rochester, Dept Neurol, 2001st St SW, Rochester, MN 55904 USA
Knopman, D:
Mayo Clin Rochester, Dept Neurol, 2001st St SW, Rochester, MN 55904 USA
Josephs, KA:
Mayo Clin Rochester, Dept Neurol, 2001st St SW, Rochester, MN 55904 USA
Boeve, BF:
Mayo Clin Rochester, Dept Neurol, 2001st St SW, Rochester, MN 55904 USA
Parisi, JE:
Mayo Clin Rochester, Dept Pathol, 2001st St SW, Rochester, MN 55904 USA
Seeley, WW:
Univ Calif San Francisco, Dept Neurol, Box 1207, San Francisco, CA 94143 USA
Miller, BL:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94158 USA
Karydas, AM:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94158 USA
Rosen, H:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94158 USA
van Swieten, JC:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Vrije Univ Amsterdam, Dept Med Genet, Med Ctr, Amsterdam, Netherlands
Dopper, EGP:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Seelaar, H:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Pijnenburg, YAL:
Vrije Univ Amsterdam, Alzheimer Ctr, Med Ctr, Amsterdam, Netherlands
Vrije Univ Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
Scheltens, P:
Vrije Univ Amsterdam, Alzheimer Ctr, Med Ctr, Amsterdam, Netherlands
Vrije Univ Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
Logroscino, G:
Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy
Capozzo, R:
Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy
Novelli, V:
Fdn Policlin Univ A Gemelli, Med Genet Unit, Rome, Italy
Puca, AA:
IRCCS Multimed, Cardiovasc Res Unit, Milan, Italy
Univ Salerno, Dept Med & Surg, Baronissi, SA, Italy
Franceschi, M:
IRCCS Multimed, Neurol Dept, Milan, Italy
Postiglione, A:
Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy
Milan, G:
ASL Napoli 1 Ctr, Geriatr Ctr Frullone, Naples, Italy
Sorrentino, P:
ASL Napoli 1 Ctr, Geriatr Ctr Frullone, Naples, Italy
Kristiansen, M:
UCL, Inst Child Hlth ICH, UCL Genom, London, England
Huei-Hsin, G:
Karolinska Inst, Dept NVS, Alzheimer Res Ctr, Novum, S-14157 Stockholm, Sweden
Karolinska Univ Hosp, Dept Geriatr Med, Genet Unit, M51, S-14186 Stockholm, Sweden
Graff, CC:
Karolinska Inst, Dept NVS, Alzheimer Res Ctr, Novum, S-14157 Stockholm, Sweden
Karolinska Univ Hosp, Dept Geriatr Med, Genet Unit, M51, S-14186 Stockholm, Sweden
Pasquier, F:
Univ Lille, Inserm 1171, DISTALZ, CHU, F-59000 Lille, France
Rollin, A:
Univ Lille, Inserm 1171, DISTALZ, CHU, F-59000 Lille, France
Deramecourt, V:
Univ Lille, Inserm 1171, DISTALZ, CHU, F-59000 Lille, France
Lebouvier, T:
Univ Lille, Inserm 1171, DISTALZ, CHU, F-59000 Lille, France
Ferrucci, L:
NIA, Clin Res Branch, Baltimore, MD 21224 USA
Pickering-Brown, S:
Univ Manchester, Fac Med & Human Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
Singleton, AB:
NIA, Lab Neurogenet, NIH, Bldg 35,Room 1A215,35 Convent Dr, Bethesda, MD 20892 USA
Hardy, J:
UCL, Dept Mol Neurosci, Russell Sq House,9-12 Russell Sq House, London WC1B 5EH, England
Momeni, P:
Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lab Neurogenet, 4th St, Lubbock, TX 79430 USA
NIA, NIH, 3001 S Hanover St,NM 531, Baltimore, MD 21230 USA.
Green Published, gold
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