Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012-2013
Por:
Alvarez, J, Godoy, P, Plans-Rubio, P, Camps, N, Carol, M, Carmona, G, Solano, R, Rius, C, Minguell, S, Barrabeig, I, Sala-Farre, MR, Rodriguez, R, Garcia-Cenoz, M, Munoz-Almagro, C, Dominguez, A
Publicada:
1 nov 2020
Resumen:
We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient's household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within <= 7 days, 8-14 days, 15-21 days, and >21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within <= 21 days after the primary patient's symptom onset, the treatment was 43.9% effective. Chemoprophylaxis started >14 days after primary patient's symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <= 14 days after primary patient's symptom onset.
Filiaciones:
Alvarez, J:
Agencia Salut Publ Catalunya, Barcelona, Spain
Godoy, P:
Agencia Salut Publ Catalunya, Barcelona, Spain
Inst Recerca Biomed Lleida, Lleida, Spain
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Plans-Rubio, P:
Agencia Salut Publ Catalunya, Barcelona, Spain
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Camps, N:
Agencia Salut Publ Catalunya, Barcelona, Spain
Carol, M:
Agencia Salut Publ Catalunya, Barcelona, Spain
Carmona, G:
Agencia Salut Publ Catalunya, Barcelona, Spain
Solano, R:
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Agencia Salut Publ Barcelona, Barcelona, Spain
Rius, C:
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Agencia Salut Publ Barcelona, Barcelona, Spain
Minguell, S:
Agencia Salut Publ Catalunya, Barcelona, Spain
Barrabeig, I:
Agencia Salut Publ Catalunya, Barcelona, Spain
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Sala-Farre, MR:
Agencia Salut Publ Catalunya, Barcelona, Spain
Rodriguez, R:
Agencia Salut Publ Catalunya, Barcelona, Spain
Garcia-Cenoz, M:
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Inst Salud Publ Navarra, Pamplona, Spain
Munoz-Almagro, C:
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Hosp St Joan Deu, Barcelona, Spain
Dominguez, A:
Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain
Univ Barcelona, Barcelona, Spain
gold, Green Published
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