Metabolic Syndrome and Autoimmune Diabetes: Action LADA 3
Por:
Hawa, MI, Thivolet, C, Mauricio, D, Alemanno, I, Cipponeri, E, Collier, D, Hunter, S, Buzzetti, R, de Leiva, A, Pozzilli, P, Leslie, RDG
Publicada:
1 ene 2009
Resumen:
OBJECTIVE - The purpose of this study was to estimate whether prevalence of metabolic syndrome in adult European diabetic patients is associated with type of diabetes.
RESEARCH DESIGN AND METHODS - A Consecutive series Of patients attending hospital-based diabetes clinics were assessed for the frequency of metabolic syndrome and compared with population-based control subjects is part of the Action LADA study. In total, 2,011 subjects (aged 30-70 years) were studied, including 1,247 patients with recent-onset type 2 diabetes Without glutamic acid decarboxylase autoantibodies (GADAs), 117 non-insulin-requiring patients with GADAs who had not received insulin therapy for at least 6 months after diagnosis (designated latent autoimmune diabetes of adults [LADA]), 288 type 1 diabetic patients, and 359 normal subjects.
RESULTS - Frequency of metabolic syndrome was significantly different in patients with type 1 diabetes (31.9%) and LADA (41.9%) (P = 0,015) and fit both conditions was less frequent than in type 2 diabetic Patients (88.8%) (P < 0.0001 for each). Eliminating glucose as a variable, the prevalence of metabolic syndrome was similar in patients with autoimmune diabetes (type 1 diabetes and/or LADA) (17.3%) and control subjects (23.7%) but remained more (common in type 2 diabetic patients (47.8%) (P = 0.001 for all groups). in both type 1 diabetic patients and those with LADA, individual components of metabolic syndrome were similar but less common than in type 2 diabetic patients (P < 0.0001 for each).
CONCLUSIONS - The prevalence of metabolic syndrome is significantly higher in type 2 diabetic patients than in patients with LADA or adults with type 1 diabetes. Excluding glucose as it variable, metabolic syndrome is not more prevalent in Patients with autoimmune diabetes than in control subjects. Metabolic syndrome is not a characteristic of autoimmune diabetes.
Filiaciones:
Hawa, MI:
Inst Cell & Mol Sci, London, England
Thivolet, C:
Hop Edouard Herriot, Dept Endocrinol, Lyon, France
Mauricio, D:
Hosp Santa Creu & Sant Pau, Dept Endocrinol & Nutr, Barcelona, Spain
Alemanno, I:
Inst Cell & Mol Sci, London, England
Cipponeri, E:
Inst Cell & Mol Sci, London, England
Collier, D:
Inst Cell & Mol Sci, London, England
Hunter, S:
Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland
Buzzetti, R:
Univ Roma La Sapienza, Dept Clin Sci, Rome, Italy
de Leiva, A:
Hosp Santa Creu & Sant Pau, Dept Endocrinol & Nutr, Barcelona, Spain
Pozzilli, P:
Inst Cell & Mol Sci, London, England
Univ Campus Biomed, Dept Endocrinol & Diabet, Rome, Italy
Leslie, RDG:
Inst Cell & Mol Sci, London, England
Hybrid Gold, Green Published
|