Maternal glucose tolerance status influences the risk of macrosomia in male but not in female fetuses
Por:
Ricart, W, Lopez, J, Mozas, J, Pericot, A, Sancho, MA, Gonzalez, N, Balsells, M, Luna, R, Cortazar, A, Navarro, P, Ramirez, O, Flandez, B, Pallardo, LF, Hernandez, A, Ampudia, J, Fernandez-Real, JM, Hernandez-Aguado, I, Corcoy, R
Publicada:
1 ene 2009
Resumen:
Objective: To elucidate whether the risk of macrosomia, large for gestational age (LGA) and small for gestational age (SGA) is influenced by maternal body mass index and glucose tolerance differently in male and female fetuses.
Methods: A population study was conducted in 16 general hospitals from the Spanish National Health Service that included 9270 consecutive women with singleton pregnancies and without a former diagnosis of diabetes mellitus who delivered 4793 male and 4477 female newborns. Logistic regression analyses were performed to predict the effect of body mass index (BMI) category and glucose tolerance on macrosomia, large for gestational age newborns (LGA) and small for gestational age newborns (SGA) Separate analyses according to foetal sex were carried out for each outcome. The results were adjusted for maternal age, gestational age and pregnancy-induced hypertension.
Results: There were significant differences between males and females in the percentage of infants who had macrosomia, LGA or SGA. Maternal BMI category was positively associated with the risk of macrosomia and LGA in both male and female newborns. In addition, there was a negative association between maternal BMI and SGA that only reached significance in males. In contrast, gestational diabetes was only a predictor of macrosomia exclusively in male fetuses (OR 1.67, 95% CI 1.12 to 2.49)
Conclusions: There is sexual dimorphism in the risk of abnormal birth weight attributed to maternal glucose tolerance status. A closer surveillance of foetal growth might be warranted in pregnant women with abnormal glucose tolerance carrying a male fetus.
Filiaciones:
Ricart, W:
Hosp Univ Girona Dr Josep Trueta, Unit Diabet Endocrinol & Nutr, Girona 17007, Spain
Lopez, J:
Hosp Virgen Salud, Toledo, Spain
Mozas, J:
Hosp Univ Virgen Nieves, Granada, Spain
Pericot, A:
Hosp Clin Univ Barcelona, Barcelona, Spain
Sancho, MA:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Gonzalez, N:
Hosp Univ Canarias, Tenerife, Spain
Balsells, M:
Hosp Mutua Terrassa, Terrassa, Spain
Luna, R:
Complejo Hosp Univ Xeral Cies Vigo, Vigo, Spain
Cortazar, A:
Hosp Cruces, Baracaldo, Spain
Navarro, P:
Hosp Gen Univ, Alicante, Spain
Ramirez, O:
Hosp Univ Maternoinfantil Canarias, Las Palmas Gran Canaria, Spain
Flandez, B:
Hosp Univ Getafe, Getafe, Spain
Pallardo, LF:
Hosp La Paz, Madrid, Spain
Hernandez, A:
Hosp Univ Dr Peset, Valencia, Spain
Ampudia, J:
Hosp Clin Valencia, Valencia, Spain
Fernandez-Real, JM:
Hosp Univ Girona Dr Josep Trueta, Unit Diabet Endocrinol & Nutr, Girona 17007, Spain
Hernandez-Aguado, I:
Hosp Univ Alicante, CIBER Epidemiol & Salud Publ, Alicante, Spain
Corcoy, R:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
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