CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy
Por:
Perez-Garcia, A, Brunet, S, Berlanga, JJ, Tormo, M, Nomdedeu, J, Guardia, R, Ribera, JM, Heras, I, Llorente, A, Hoyos, M, Esteve, J, Besalduch, J, Bueno, J, Sierra, J, Gallardo, D
Publicada:
1 mar 2009
Resumen:
The recently described single-nucleotide polymorphism CT60, located in the 3'-untranslated region of the CTLA4 (cytotoxic T-lymphocyte antigen 4) gene, has been associated with susceptibility to several autoimmune diseases and has also been shown to be involved in immune responses following allogeneic stem cell transplantation (SCT). However, the contribution of the CTLA4 genotype to the control of minimal residual disease in patients with acute myeloid leukemia (AML) has yet to be explored. We investigated the association between the CTLA4 CT60 A/G genotype and the incidence of leukemic relapse in 143 adult patients with AML in first complete remission after the same chemotherapy protocol (CETLAM LAM'03). The CT60 AA genotype was associated with a higher rate of leukemic relapse (56.4 vs 35.6%, P = 0.004; hazard ratio (HR) 2.64, 95% confidence interval (CI) 1.36-5.14) and lower overall survival at 3 years (39.4 vs 68.4%, P 0.004; HR 2.80, 95% CI 1.39-5.64). This is the first study to report an association between polymorphisms at CTLA-4 and AML relapse.
Filiaciones:
Perez-Garcia, A:
Inst Catala Oncol, Dept Hematol, Girona, Hospitalet & Ba, Spain
Brunet, S:
Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
Berlanga, JJ:
Inst Catala Oncol, Dept Hematol, Girona, Hospitalet & Ba, Spain
Tormo, M:
Hosp Clin, Dept Hematol, Valencia, Spain
Nomdedeu, J:
Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
Guardia, R:
Inst Catala Oncol, Dept Hematol, Girona, Hospitalet & Ba, Spain
Ribera, JM:
Inst Catala Oncol, Dept Hematol, Girona, Hospitalet & Ba, Spain
Heras, I:
Hosp Morales Meseguer, Dept Hematol, Murcia, Spain
Llorente, A:
Hosp Joan 23, Dept Hematol, Tarragona, Spain
Hoyos, M:
Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
Esteve, J:
Hosp Clin Barcelona, Dept Hematol, Barcelona, Spain
Besalduch, J:
Hosp Son Dureta, Dept Hematol, Palma de Mallorca, Spain
Bueno, J:
Hosp Vall Hebro, Dept Hematol, Barcelona, Spain
Sierra, J:
Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
Gallardo, D:
Inst Catala Oncol, Dept Hematol, Girona, Hospitalet & Ba, Spain
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