Genetic testing for the clinician in prostate cancer
Por:
Lopez-Campos, F, Linares-Espinos, E, Pijoan, XM, Pardo, GS, Morgan, TM, Martinez-Ballesteros, C, Martinez-Salamanca, J, Counago, F
Publicada:
1 oct 2020
Ahead of Print:
1 oct 2020
Resumen:
Introduction Prostate cancer (PCa) is one of the most common cancers worldwide and a leading cause of cancer-related mortality. Although the diagnosis and treatment of prostate cancer has improved substantially in recent years, new molecular biomarkers are needed to further prolong survival and improve the quality of life in these patients. Areas covered This review analyzes the current evidence for prognostic and predictive molecular biomarkers that can be applied across different clinical scenarios, ranging from localized disease to metastatic castration-resistant PCa, with a particular emphasis on the biomarkers likely to become available in routine clinical practice in the near future. Expert opinion There is a growing need for molecular testing to identify the most indolent types of prostate cancer to help optimize treatment strategies and spare treatment in these patients when possible. Current trends in the treatment of prostate cancer underscore the unmet clinical need for biomarkers to improve decision-making in a challenging clinical setting.
Filiaciones:
Lopez-Campos, F:
Hosp Univ Ramon y Cajal, Radiat Oncol Dept, Madrid, Spain
Linares-Espinos, E:
Hosp Univ La Paz, Urol Dept, Madrid, Spain
Lyx Inst Urol, Urol Dept, Madrid, Spain
Francisco De Vitoria Univ, Urol Dept, Madrid, Spain
Pijoan, XM:
Hosp Univ Vall dHebron, Radiat Oncol Dept, Barcelona, Spain
Pardo, GS:
Hosp Santa Creu & Sant Pau, Radiat Oncol Dept, Barcelona, Spain
Morgan, TM:
Michigan Ctr Translat Pathol, Urol Dept, Ctr Comprehens Canc, Ctr Canc, Floor B1 Recept C, Ann Arbor, MI USA
Martinez-Ballesteros, C:
Lyx Inst Urol, Urol Dept, Madrid, Spain
Hosp Univ Puerta De Hierro Majadahonda, Urol Dept, Majadahonda 28222, Spain
Martinez-Salamanca, J:
Lyx Inst Urol, Urol Dept, Madrid, Spain
Francisco De Vitoria Univ, Urol Dept, Madrid, Spain
Hosp Univ Puerta De Hierro Majadahonda, Urol Dept, Majadahonda 28222, Spain
Counago, F:
Hosp Univ Quiron Salud Madrid, Radiat Oncol Dept, Madrid, Spain
Hosp La Luz, Madrid, Spain
Univ Europea Madrid, Madrid, Spain
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