IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis
Por:
Checa, MA, Alonso-Coello, P, Sola, I, Robles, A, Carreras, R, Balasch, J
Publicada:
1 may 2009
Resumen:
To assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders.
Systematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data.
Ten randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62-0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64-0.91) than standard in vitro fertilization/intracytoplasmic sperm injection.
In women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified.
Filiaciones:
Checa, MA:
Autonomous Univ Barcelona, Hosp Univ Mar, Dept Obstet & Gynecol, Barcelona 08003, Spain
Alonso-Coello, P:
Autonomous Univ Barcelona, Hosp Santa Cruz & Sant Pau, Serv Epidemiol Clin & Salud Publ, Ctr Cochrane Iberoamer, Barcelona 08003, Spain
CIBERESP, Barcelona, Spain
Sola, I:
Autonomous Univ Barcelona, Hosp Santa Cruz & Sant Pau, Serv Epidemiol Clin & Salud Publ, Ctr Cochrane Iberoamer, Barcelona 08003, Spain
Robles, A:
Autonomous Univ Barcelona, Hosp Univ Mar, Dept Obstet & Gynecol, Barcelona 08003, Spain
Carreras, R:
Autonomous Univ Barcelona, Hosp Univ Mar, Dept Obstet & Gynecol, Barcelona 08003, Spain
Balasch, J:
Univ Barcelona, Fac Med, Inst Clin Gynecol Obstet & Neonatol,Hosp Clin, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona 7, Spain
Green Published
|