Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
Por:
Jesus, S, Labrador-Espinosa, MA, Adarmes, AD, Mendel-Del Barrio, C, Martinez-Castrillo, JC, Alonso-Canovas, A, Alonso, PS, Novo-Ponte, S, Alonso-Losada, MG, Ariztegui, NL, Rodriguez, JCS, Morales, MI, Gaston, I, Bescos, FL, Ibarra, PC, Kulisevsky, J, Pagonabarraga, J, Pascual-Sedano, B, Martinez-Martin, P, Santos-Garcia, D, Mir, P
Publicada:
9 oct 2020
Resumen:
The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 +/- 9.09 years, 59.87% men) and 179 CS (mean age 60.84 +/- 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.
Filiaciones:
Jesus, S:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla,Hosp Univ Virgen Rocio,CSIC, Av Manuel Siurot S-N, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Labrador-Espinosa, MA:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla,Hosp Univ Virgen Rocio,CSIC, Av Manuel Siurot S-N, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Adarmes, AD:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla,Hosp Univ Virgen Rocio,CSIC, Av Manuel Siurot S-N, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Mendel-Del Barrio, C:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla,Hosp Univ Virgen Rocio,CSIC, Av Manuel Siurot S-N, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Martinez-Castrillo, JC:
Hosp Univ Ramon y Cajal, Madrid, Spain
Alonso-Canovas, A:
Hosp Univ Ramon y Cajal, Madrid, Spain
Alonso, PS:
Hosp Univ Puerta Hierro, Madrid, Spain
Novo-Ponte, S:
Hosp Univ Puerta Hierro, Madrid, Spain
Alonso-Losada, MG:
Complejo Hosp Univ Vigo, Hosp Meixoeiro, Vigo, Spain
Ariztegui, NL:
Complejo Hosp Toledo, Toledo, Spain
Rodriguez, JCS:
Complejo Hosp Toledo, Toledo, Spain
Morales, MI:
Complejo Hosp Toledo, Toledo, Spain
Gaston, I:
Complejo Hosp Navarra, Navarra, Spain
Bescos, FL:
Complejo Hosp Navarra, Navarra, Spain
Ibarra, PC:
Complejo Hosp Navarra, Navarra, Spain
Kulisevsky, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Unidad Trastornos Movimiento, Serv Neurol, Barcelona, Spain
Pagonabarraga, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Unidad Trastornos Movimiento, Serv Neurol, Barcelona, Spain
Pascual-Sedano, B:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Unidad Trastornos Movimiento, Serv Neurol, Barcelona, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Martinez-Martin, P:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid, Spain
Santos-Garcia, D:
Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain
Mir, P:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla,Hosp Univ Virgen Rocio,CSIC, Av Manuel Siurot S-N, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Gold, Green Published
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