Rheumatoid Arthritis Does Not Share Most of the Newly Identified Systemic Lupus Erythematosus Genetic Factors
Por:
Suarez-Gestal, M, Calaza, M, Dieguez-Gonzalez, R, Perez-Pampin, E, Pablos, JL, Navarro, F, Narvaez, J, Marenco, JL, Herrero-Beaumont, G, Fernandez-Gutierrez, B, Lamas, JR, de la Serna, AR, Ortiz, AM, Carreno, L, Canete, JD, Caliz, R, Blanco, FJ, Balsa, A, Gomez-Reino, JJ, Gonzalez, A
Publicada:
1 sep 2009
Resumen:
Objective. Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as HLA, PTPN22, STAT4, and 6q23. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility.
Methods. A characteristic single-nucleotide polymorphism (SNP) in each of 9 genetic factors, 1TGAM (rs1143679), C8orf13-BLK (rs13277113), TYK2 (rs2304256), 1q25.1 (rs10798269), PXK (rs6445975), KIAA1542 (rs4963128), MECP2 (rs17435), BANK1 (rs17266594), and LY9 (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in STAT4 was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti-cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis).
Results. No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta-analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the C8orf13-BLK locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; P = 0.003).
Conclusion. None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.
Filiaciones:
Pablos, JL:
Hosp 12 Octubre, E-28041 Madrid, Spain
Navarro, F:
Hosp Univ Virgen Macarena, Seville, Spain
Narvaez, J:
Hosp Univ Bellvitge, Barcelona, Spain
Marenco, JL:
Hosp Univ Valme, Seville, Spain
Herrero-Beaumont, G:
Fdn Jimenez Diaz, E-28040 Madrid, Spain
Fernandez-Gutierrez, B:
Hosp Clin San Carlos, Madrid, Spain
Lamas, JR:
Hosp Clin San Carlos, Madrid, Spain
de la Serna, AR:
Hosp Santa Crue & St Pau, Barcelona, Spain
Ortiz, AM:
Hosp Univ Princesa, Madrid, Spain
Carreno, L:
Hosp Univ Gregorio Maranon, Madrid, Spain
Canete, JD:
Hosp Clin Barcelona, Barcelona, Spain
Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain
Caliz, R:
Hosp Univ Virgen Nieves, Granada, Spain
Blanco, FJ:
Hosp Univ Juan Canalejo, Coruna, Spain
Balsa, A:
Hosp La Paz, Madrid, Spain
Gomez-Reino, JJ:
Univ Santiago de Compostela, Santiago De Compostela, Spain
Gonzalez, A:
Univ Santiago, Hosp Clin, Lab Invest 10, Santiago De Compostela 15706, Spain
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