A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids


Por: Ramdas, S, Judd, J, Graham, SE, Kanoni, S, Wang, YX, Surakka, I, Wenz, B, Clarke, SL, Chesi, A, Wells, A, Bhatti, KF, Vedantam, S, Winkler, TW, Locke, AE, Marouli, E, Zajac, GJM, Wu, KHH, Ntalla, I, Hui, Q, Klarin, D, Hilliard, AT, Wang, ZY, Xue, C, Thorleifsson, G, Helgadottir, A, Gudbjartsson, DF, Holm, H, Olafsson, I, Hwang, MY, Han, S, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B, Rasheed, H, Havulinna, AS, Veturi, Y, Pacheco, JA, Rosenthal, EA, Lingren, T, Feng, QP, Kullo, IJ, Narita, A, Takayama, J, Martin, HC, Hunt, KA, Trivedi, B, Haessler, J, Giulianini, F, Bradford, Y, Miller, JE, Campbell, A, Lin, K, Millwood, IY, Rasheed, A, Hindy, G, Faul, JD, Zhao, W, Weir, DR, Turman, C, Huang, HY, Graff, M, Choudhury, A, Sengupta, D, Mahajan, A, Brown, MR, Zhang, WH, Yu, KT, Schmidt, EM, Pandit, A, Gustafsson, S, Yin, XY, Luan, JA, Zhao, JH, Matsuda, F, Jang, HM, Yoon, K, Medina-Gomez, C, Pitsillides, A, Hottenga, JJ, Wood, AR, Ji, YJ, Gao, ZS, Haworth, S, Mitchell, RE, Chai, JF, Aadahl, M, Bjerregaard, AA, Yao, J, Manichaikul, A, Lee, WJ, Hsiung, CA, Warren, HR, Ramirez, J, Bork-Jensen, J, Karhus, LL, Goel, A, Sabater-Lleal, M, Noordam, R, Mauro, P, Matteo, F, McDaid, AF, Marques-Vidal, P, Wielscher, M, Trompet, S, Sattar, N, Mollehave, LT, Munz, M, Zeng, LY, Huang, JF, Yang, B, Poveda, A, Kurbasic, A, Schonherr, S, Forer, L, Scholz, M, Galesloot, TE, Bradfield, JP, Ruotsalainen, SE, Daw, EW, Zmuda, JM, Mitchell, JS, Fuchsberger, C, Christensen, H, Brody, JA, Le, P, Feitosa, MF, Wojczynski, MK, Hemerich, D, Preuss, M, Mangino, M, Christofidou, P, Verweij, N, Benjamins, JW, Engmann, J, Noah, TL, Verma, A, Slieker, RC, Lo, KS, Zilhao, NR, Kleber, ME, Delgado, GE, Huo, SF, Ikeda, DD, Iha, H, Yang, J, Liu, J, Demirkan, A, Leonard, HL, Marten, J, Emmel, C, Schmidt, B, Smyth, LJ, Canadas-Garre, M, Wang, CL, Nakatochi, M, Wong, A, Hutri-Kahonen, N, Sim, XL, Xia, R, Huerta-Chagoya, A, Fernandez-Lopez, JC, Lyssenko, V, Nongmaithem, SS, Sankareswaran, A, Irvin, MR, Oldmeadow, C, Kim, HN, Ryu, S, Timmers, PRHJ, Arbeeva, L, Dorajoo, R, Lange, LA, Prasad, G, Lores-Motta, L, Pauper, M, Long, JR, Li, XH, Theusch, E, Takeuchi, F, Spracklen, CN, Loukola, A, Bollepalli, S, Warner, SC, Wang, YX, Wei, WB, Nutile, T, Ruggiero, D, Sung, YJ, Chen, SF, Liu, FC, Yang, JY, Kentistou, KA, Banas, B, Morgan, A, Meidtner, K, Bielak, LF, Smith, JA, Hebbar, P, Farmaki, AE, Hofer, E, Lin, MX, Concas, MP, Vaccargiu, S, van der Most, PJ, Pitkanen, N, Cade, BE, van der Laan, SW, Chitrala, KN, Weiss, S, Bentley, AR, Doumatey, AP, Adeyemo, AA, Lee, JY, Petersen, ERB, Nielsen, AA, Choi, HS, Nethander, M, Freitag-Wolf, S, Southam, L, Rayner, NW, Wang, CA, Lin, SY, Wang, JS, Couture, C, Lyytikainen, LP, Nikus, K, Cuellar-Partida, G, Vestergaard, H, Hidalgo, B, Giannakopoulou, O, Cai, QY, Obura, MO, van Setten, J, He, KY, Tang, H, Terzikhan, N, Shin, JH, Jackson, RD, Reiner, AP, Martin, LW, Chen, ZM, Li, LM, Kawaguchi, T, Thiery, J, Bis, JC, Launer, LJ, Li, HX, Nalls, MA, Raitakari, OT, Ichihara, S, Wild, SH, Nelson, CP, Campbell, H, Jager, S, Nabika, T, Al-Mulla, F, Niinikoski, H, Braund, PS, Kolcic, I, Kovacs, P, Giardoglou, T, Katsuya, T, de Kleijn, D, de Borst, GJ, Kim, EK, Adams, HHH, Ikram, MA, Zhu, XF, Asselbergs, FW, Kraaijeveld, AO, Beulens, JWJ, Shu, XO, Rallidis, LS, Pedersen, O, Hansen, T, Mitchell, P, Hewitt, AW, Kahonen, M, Perusse, L, Bouchard, C, Tonjes, A, Chen, YDI, Pennell, CE, Mori, TA, Lieb, W, Franke, A, Ohlsson, C, Mellstrom, D, Cho, YS, Lee, H, Yuan, JM, Koh, WP, Rhee, SY, Woo, JT, Heid, IM, Stark, KJ, Zimmermann, ME, Volzke, H, Homuth, G, Evans, MK, Zonderman, AB, Polasek, O, Pasterkamp, G, Hoefer, IE, Redline, S, Pahkala, K, Oldehinkel, AJ, Snieder, H, Biino, G, Schmidt, R, Schmidt, H, Bandinelli, S, Dedoussis, G, Thanaraj, TA, Peyser, PA, Kato, N, Schulze, MB, Girotto, G, Boger, CA, Jung, B, Joshi, PK, Bennett, DA, De Jager, PL, Lu, XF, Mamakou, V, Brown, M, Caulfield, MJ, Munroe, PB, Guo, XQ, Ciullo, M, Jonas, JB, Samani, NJ, Kaprio, J, Pajukanta, P, Tusie-Luna, T, Aguilar-Salinas, CA, Adair, LS, Bechayda, SA, de Silva, HJ, Wickremasinghe, AR, Krauss, RM, Wu, JY, Zheng, W, den Hollander, AI, Bharadwaj, D, Correa, A, Wilson, JG, Lind, L, Heng, CK, Nelson, AE, Golightly, YM, Wilson, JF, Penninx, B, Kim, HL, Attia, J, Scott, RJ, Rao, DC, Arnett, DK, Walker, M, Scott, LJ, Koistinen, HA, Chandak, GR, Mercader, JM, Villalpando, CG, Orozco, L, Fornage, M, Tai, ES, van Dam, RM, Lehtimaki, T, Chaturvedi, N, Yokota, M, Liu, JJ, Reilly, DF, McKnight, AJ, Kee, F, Jockel, KH, McCarthy, MI, Palmer, CNA, Vitart, V, Hayward, C, Simonsick, E, van Duijn, CM, Jin, ZB, Lu, F, Hishigaki, H, Lin, X, Marz, W, Gudnason, V, Tardif, JC, Lettre, G, Hart, LMT, Elders, PJM, Rader, DJ, Damrauer, SM, Kumari, M, Kivimaki, M, van der Harst, P, Spector, TD, Loos, RJF, Province, MA, Parra, EJ, Cruz, M, Psaty, BM, Brandslund, I, Pramstaller, PP, Rotimi, CN, Christensen, K, Ripatti, S, Widen, E, Hakonarson, H, Grant, SFA, Kiemeney, L, de Graaf, J, Loeffler, M, Kronenberg, F, Gu, DF, Erdmann, J, Schunkert, H, Franks, PW, Linneberg, A, Jukema, JW, Khera, AV, Mannikko, M, Jarvelin, MR, Kutalik, Z, Francesco, C, Mook-Kanamori, DO, van Dijk, KW, Watkins, H, Strachan, DP, Grarup, N, Sever, P, Poulter, N, Sheu, WHH, Rotter, JI, Dantoft, TM, Karpe, F, Neville, MJ, Timpson, NJ, Cheng, CY, Wong, TY, Khor, CC, Li, HT, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, AT, Pedersen, NL, Magnusson, PKE, Boomsma, DI, de Geus, EJC, Cupples, LA, van Meurs, JBJ, Ikram, A, Ghanbari, M, Gordon-Larsen, P, Huang, W, Kim, YJ, Tabara, Y, Wareham, NJ, Langenberg, C, Zeggini, E, Tuomilehto, J, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, JC, Kooner, JS, de Vries, PS, Morrison, AC, Hazelhurst, S, Ramsay, M, North, KE, Daviglus, M, Kraft, P, Martin, NG, Whitfield, JB, Abbas, S, Saleheen, D, Walters, RG, Holmes, MV, Black, C, Smith, BH, Baras, A, Justice, AE, Buring, JE, Ridker, PM, Chasman, DI, Kooperberg, C, Tamiya, G, Yamamoto, M, van Heel, DA, Trembath, RC, Wei, WQ, Jarvik, GP, Namjou, B, Hayes, MG, Ritchie, MD, Jousilahti, P, Salomaa, V, Hveem, K, Asvold, BO, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Kim, BJ, Thorsteinsdottir, U, Stefansson, K, Zhang, JF, Chen, YE, Ho, YL, Lynch, JA, Tsao, PS, Chang, KM, Cho, K, O'Donnell, CJ, Gaziano, JM, Wilson, P, Mohlke, KL, Frayling, TM, Hirschhorn, JN, Kathiresan, S, Boehnke, M, Grant, S, Natarajan, P, Sun, YV, Morris, AP, Deloukas, P, Peloso, G, Assimes, TL, Willer, CJ, Zhu, X, Brown, CD
Publicada: 4 ago 2022 Ahead of Print: 1 ago 2022
Resumen:
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
Filiaciones:
Ramdas, S:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
Judd, J:
 Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
Graham, SE:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA
Kanoni, S:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England
Wang, YX:
 Boston Univ, Dept Biostat, Sch Publ Hlth, 801 Massachusetts Ave, Boston, MA 02118 USA
Surakka, I:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA
Wenz, B:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
Clarke, SL:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA
Chesi, A:
 Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA
Wells, A:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
Bhatti, KF:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England
Vedantam, S:
 Boston Childrens Hosp, Endocrinol, Boston, MA 02115 USA

 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA
Winkler, TW:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
Locke, AE:
 Washington Univ, McDonnell Genome Inst, St Louis, MO 63108 USA

 Washington Univ, Dept Med, St Louis, MO 63108 USA
Marouli, E:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England
Zajac, GJM:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Wu, KHH:
 Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA
Ntalla, I:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England
Hui, Q:
 Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA USA

 Atlanta VA Hlth Care Syst, Decatur, GA USA
Klarin, D:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 Malcolm Randall VA Med Ctr, Gainesville, FL USA

 Univ Florida, Coll Med, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA
Hilliard, AT:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA
Wang, ZY:
 Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA USA

 Atlanta VA Hlth Care Syst, Decatur, GA USA
Xue, C:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA
Thorleifsson, G:
 Amgen Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland
Helgadottir, A:
 Amgen Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland
Gudbjartsson, DF:
 Amgen Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland

 Univ Iceland, Sch Engn & Nat Sci, IS-102 Reykjavik, Iceland
Holm, H:
 Amgen Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland
Olafsson, I:
 Landspitali Natl Univ Hosp Iceland, Dept Clin Biochem, IS-101 Reykjavik, Iceland
Hwang, MY:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Chungbuk, South Korea
Han, S:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Chungbuk, South Korea
Akiyama, M:
 RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan

 Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan
Sakaue, S:
 Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan

 Univ Tokyo, Lab Stat Anal, RIKEN Ctr Integrat Med Sci, Tokyo, Japan

 Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan
Terao, C:
 RIKEN Ctr Integrat Med Sci, Lab Stat & Translat Genet, Yokohama, Kanagawa, Japan
Kanai, M:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan

 Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA
Zhou, W:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

 Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Brumpton, B:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway

 Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Oakfield House, Bristol BS8 2BN, Avon, England

 Trondheim Reg & Univ Hosp, Clin Med, St Olavs Hosp, Trondheim, Norway
Rasheed, H:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway

 Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Oakfield House, Bristol BS8 2BN, Avon, England

 Univ Oslo, Div Med & Lab Sci, Oslo, Norway
Havulinna, AS:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland

 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Veturi, Y:
 Univ Penn, Perelman Sch Med, Inst Biomed Informat, Dept Genet, Philadelphia, PA 19104 USA
Pacheco, JA:
 Northwestern Univ, Ctr Genet Med, Feinberg Sch Med, Chicago, IL 60611 USA
Rosenthal, EA:
 Univ Washington, Dept Med Med Genet, Seattle, WA 98195 USA
Lingren, T:
 Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA
Feng, QP:
 Vanderbilt Univ Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN USA
Kullo, IJ:
 Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA

 Mayo Clin, Gonda Vasc Ctr, Rochester, MN USA
Narita, A:
 Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi 9808573, Japan
Takayama, J:
 Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi 9808573, Japan
Martin, HC:
 Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Hunt, KA:
 Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England
Trivedi, B:
 Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England
Haessler, J:
 Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
Giulianini, F:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA
Bradford, Y:
 Univ Penn, Perelman Sch Med, Inst Biomed Informat, Dept Genet, Philadelphia, PA 19104 USA
Miller, JE:
 Univ Penn, Perelman Sch Med, Inst Biomed Informat, Dept Genet, Philadelphia, PA 19104 USA
Campbell, A:
 Univ Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, Inst Genet & Canc, Edinburgh EH4 2XU, Midlothian, Scotland

 Univ Edinburgh, Usher Inst, Nine Edinburgh Bioquarter,9 Little France Rd, Edinburgh EH16 4UX, Midlothian, Scotland
Lin, K:
 Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
Millwood, IY:
 Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
Rasheed, A:
 Ctr Noncommunicable Dis, Karachi, SD, Pakistan

 Faisalabad Inst Cardiol, Faislabad, Pakistan
Hindy, G:
 Qatar Univ, Dept Populat Med, QU Hlth, Coll Med, Doha, Qatar
Faul, JD:
 Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI 48104 USA
Zhao, W:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
Weir, DR:
 Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI 48104 USA
Turman, C:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA
Huang, HY:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA
Graff, M:
 Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA
Choudhury, A:
 Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa
Sengupta, D:
 Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa
Mahajan, A:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England
Brown, MR:
 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Dept Epidemiol, Houston, TX 77030 USA
Zhang, WH:
 Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London W2 1PG, England

 London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Harrow UB1 3HW, Middx, England

 Imperial Coll London, Imperial Coll Healthcare NHS Trust, London W12 0HS, England
Yu, KT:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Schmidt, EM:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Pandit, A:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Gustafsson, S:
 Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden
Yin, XY:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Luan, JA:
 Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge CB2 0QQ, England
Zhao, JH:
 Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Strangeways Res Lab, Cambridge CB1 8RN, England
Matsuda, F:
 Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan
Jang, HM:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Chungbuk, South Korea
Yoon, K:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Chungbuk, South Korea
Medina-Gomez, C:
 Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands
Pitsillides, A:
 Boston Univ, Dept Biostat, Sch Publ Hlth, 801 Massachusetts Ave, Boston, MA 02118 USA
Hottenga, JJ:
 Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

 Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
Wood, AR:
 Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter EX2 5DW, Devon, England
Ji, YJ:
 Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter EX2 5DW, Devon, England
Gao, ZS:
 Nanjing Univ Chinese Med, Dept Clin Acupuncture & Moxibust, Nanjing 210029, Jiangsu, Peoples R China

 Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany
Haworth, S:
 Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Oakfield House, Bristol BS8 2BN, Avon, England

 Univ Bristol, Bristol Dent Sch, Lower Maudlin St, Bristol BS1 2LY, Avon, England
Mitchell, RE:
 Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Oakfield House, Bristol BS8 2BN, Avon, England

 Univ Bristol, Bristol Med Sch, Bristol BS8 2BN, Avon, England
Chai, JF:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

 Natl Univ Hlth Syst, Singapore 117549, Singapore
Aadahl, M:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

 Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
Bjerregaard, AA:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark
Yao, J:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat,LABioMed, Torrance, CA 90502 USA
Manichaikul, A:
 Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22903 USA
Lee, WJ:
 Taichung Vet Gen Hosp, Dept Med Res, 1650,Sec 4,Taiwan Blvd, Taichung 40705, Taiwan
Hsiung, CA:
 Natl Hlth Res Inst, Inst Populat Hlth Sci, 35 Keyan Rd, Zhunan Town 350, Miaoli County, Taiwan
Warren, HR:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London EC1M 6BQ, England
Ramirez, J:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England
Bork-Jensen, J:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
Karhus, LL:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark
Goel, A:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

 Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX3 9DU, England
Sabater-Lleal, M:
 St Pau Biomed Res Inst IIB St Pau, Unit Genom Complex Dis, Barcelona, Spain

 Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Med,Cardiovasc Med Unit, Stockholm, Sweden
Noordam, R:
 Leiden Univ Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands
Mauro, P:
 CNR, Ist Ric Genet & Biomed, Rome, Italy
Matteo, F:
 CNR, Ist Ric Genet & Biomed, Rome, Italy

 Univ Sassari, Dipartimento Sci Biomed, Sardinia, Italy
McDaid, AF:
 Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Rte Berne 113, CH-1010 Lausanne, Switzerland

 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland
Marques-Vidal, P:
 Lausanne Univ Hosp, Dept Med, Internal Med, Rue Bugnon 46, CH-1011 Lausanne, Switzerland

 Univ Lausanne, Rue Bugnon 46, CH-1011 Lausanne, Switzerland
Wielscher, M:
 Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London W2 1PG, England
Trompet, S:
 Leiden Univ Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands
Sattar, N:
 BHF Glasgow Cardiovasc Res Ctr, Fac Med, Glasgow, Lanark, Scotland
Mollehave, LT:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark
Munz, M:
 Univ Lubeck, Inst Cardiogenet, DZHK German Res Ctr Cardiovasc Res, Univ Heart Ctr Lubeck,Partner Site Hamburg Lubeck, Lubeck, Germany

 Charite Univ Med Berlin, Berlin, Germany

 Free Univ Berlin, Berlin, Germany

 Humboldt Univ, Berlin, Germany
Zeng, LY:
 Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany

 Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
Huang, JF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing 100037, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China
Yang, B:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing 100037, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China
Poveda, A:
 Lund Univ, Lund Univ Diabet Ctr, Malmo, Sweden
Kurbasic, A:
 Lund Univ, Lund Univ Diabet Ctr, Malmo, Sweden
Schonherr, S:
 Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria

 German Chron Kidney Dis Study, Innsbruck, Austria
Forer, L:
 Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria

 German Chron Kidney Dis Study, Innsbruck, Austria
Scholz, M:
 Univ Leipzig, Inst Med Informat Stat & Epidemiol, Haertelstr 16-18, D-04107 Leipzig, Germany

 Univ Leipzig, LIFE Res Ctr Civilizat Dis, Philipp Rosenthal Str 27, D-04103 Leipzig, Germany
Galesloot, TE:
 Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands
Bradfield, JP:
 Quantinuum Res LLC, Wayne, PA 19087 USA
Ruotsalainen, SE:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland
Daw, EW:
 Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany

 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
Zmuda, JM:
 Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15232 USA
Mitchell, JS:
 Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Via Galvani 31, I-39100 Bolzano, Italy
Fuchsberger, C:
 Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Via Galvani 31, I-39100 Bolzano, Italy
Christensen, H:
 Lillebaelt Hosp, Dept Clin Biochem, Vejle, Denmark
Brody, JA:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA
Le, P:
 Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON L5L 1C6, Canada

 Univ Toronto, Dept Comp Sci, Toronto, ON M5S 2E4, Canada
Feitosa, MF:
 Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany

 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
Wojczynski, MK:
 Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany

 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
Hemerich, D:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
Preuss, M:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
Mangino, M:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

 Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England
Christofidou, P:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Verweij, N:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands
Benjamins, JW:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands
Engmann, J:
 UCL, Inst Cardiovasc Sci, Gower St, London WC1E 6BT, England

 UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England
Noah, TL:
 Univ Penn, Dept Surg, Philadelphia, PA 19104 USA
Verma, A:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
Slieker, RC:
 Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam Publ Hlth Res Inst, NL-1081 HV Amsterdam, Netherlands

 Leiden Univ Med Ctr, Dept Cell & Chem Biol, NL-2333 ZA Leiden, Netherlands
Lo, KS:
 Univ Montreal, Montreal Heart Inst, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada
Zilhao, NR:
 Iceland Heart Assoc, IS-201 Kopavogur, Iceland
Kleber, ME:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68163 Mannheim, Germany

 MVZ Humangenet Mannheim GmbH, SYNLAB, D-68163 Mannheim, Germany
Delgado, GE:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68163 Mannheim, Germany
Huo, SF:
 Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China
Ikeda, DD:
 Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan
Iha, H:
 Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan
Yang, J:
 Westlake Univ, Sch Life Sci, Hangzhou 310024, Zhejiang, Peoples R China

 Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA

 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL USA
Liu, J:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands

 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore
Demirkan, A:
 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands

 Univ Surrey, Dept Clin & Expt Res, Sect Stat Multiomics, Guildford, Surrey, England
Leonard, HL:
 NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

 Data Tecn Int, Glen Echo, MD USA
Marten, J:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland
Emmel, C:
 Univ Duisburg Essen, Inst Med Informat Biometrie & Epidemiol, Essen, Germany
Schmidt, B:
 Univ Duisburg Essen, Inst Med Informat Biometrie & Epidemiol, Essen, Germany
Smyth, LJ:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland
Canadas-Garre, M:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

 Pfizer Univ Granada Andalusian Reg Govt, Ctr Genom & Oncol Res, GENYO, Genom Oncol Area, Granada, Spain

 Hosp Univ Virgen de las Nieves, Hematol Dept, Granada, Spain

 Inst Invest Biosanitaria Granada IbsGRANADA, Granada, Spain
Wang, CL:
 Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China

 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore
Nakatochi, M:
 Nagoya Univ, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, Grad Sch Med, Nagoya, Aichi 4618673, Japan
Wong, A:
 Univ Alabama Birmingham, Sch Publ Hlth, Epidemiol, Birmingham, AL 35294 USA
Hutri-Kahonen, N:
 Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Skills Training & Simulat, Tampere, Finland
Sim, XL:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

 Natl Univ Hlth Syst, Singapore 117549, Singapore
Xia, R:
 Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, McGovern Med Sch, Houston, TX 77030 USA
Huerta-Chagoya, A:
 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, CONACYT, Ciudad De Mexico, Mexico
Fernandez-Lopez, JC:
 Inst Nacl Med Genom, Dept Genom Computac, Ciudad De Mexico, Mexico
Lyssenko, V:
 Lund Univ, Lund Univ Diabet Ctr, Malmo, Sweden

 Univ Bergen, Ctr Diabet Res, Bergen, Norway
Nongmaithem, SS:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad, Telangana, India
Sankareswaran, A:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad, Telangana, India

 CSIR Human Resource Dev Ctr, Acad Sci & Innovat Res AcSIR, New Delhi, India
Irvin, MR:
 Univ Alabama Birmingham, Sch Publ Hlth, Epidemiol, Birmingham, AL 35294 USA
Oldmeadow, C:
 Hunter Med Res Inst, Newcastle, NSW, Australia
Kim, HN:
 Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul 03181, South Korea

 Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul 06355, South Korea
Ryu, S:
 Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul 04514, South Korea

 Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul 03181, South Korea
Timmers, PRHJ:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland
Arbeeva, L:
 Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA
Dorajoo, R:
 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

 Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore 169857, Singapore
Lange, LA:
 Univ Colorado, Dept Med, Div Biomed Informat & Personalized Med, Anschutz Med Campus, Aurora, CO 80045 USA
Prasad, G:
 CSIR Human Resource Dev Ctr, Acad Sci & Innovat Res AcSIR, New Delhi, India

 CSIR Inst Genom & Integrat Biol, Genom & Mol Med Unit, New Delhi 110020, India
Lores-Motta, L:
 Radboud Univ Nijmegen, Dept Ophthalmol, Med Ctr, NL-6525 EX Nijmegen, Netherlands

 Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, NL-6525 EX Nijmegen, Netherlands
Pauper, M:
 Radboud Univ Nijmegen, Dept Ophthalmol, Med Ctr, NL-6525 EX Nijmegen, Netherlands

 Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, NL-6525 EX Nijmegen, Netherlands
Long, JR:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA
Li, XH:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat,LABioMed, Torrance, CA 90502 USA
Theusch, E:
 Univ Calif San Francisco, Dept Pediat, Oakland, CA 94609 USA
Takeuchi, F:
 Natl Ctr Global Hlth & Med, Tokyo 1628655, Japan
Spracklen, CN:
 Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

 Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA 01003 USA
Loukola, A:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland
Bollepalli, S:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland
Warner, SC:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England
Wang, YX:
 Capital Med Univ, Beijing Inst Ophthalmol,Beijing Ophthalmol & Visu, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, 17 Hougou Lane, Beijing 100005, Peoples R China
Wei, WB:
 Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China
Nutile, T:
 Adriano Buzzati Traverso CNR, Inst Genet & Biophys, Naples, Italy
Ruggiero, D:
 Adriano Buzzati Traverso CNR, Inst Genet & Biophys, Naples, Italy

 IRCCS Neuromed, Pozzilli, Isernia, Italy
Sung, YJ:
 Washington Univ, Div Biostat, Sch Med, St Louis, MO 63110 USA
Chen, SF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing 100037, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China
Liu, FC:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing 100037, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China
Yang, JY:
 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA

 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL USA
Kentistou, KA:
 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland
Banas, B:
 Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany
Morgan, A:
 Inst Maternal & Child Hlth IRCCS, I-34127 Trieste, Italy
Meidtner, K:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Munich, Germany
Bielak, LF:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
Smith, JA:
 Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI 48104 USA

 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
Hebbar, P:
 Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait
Farmaki, AE:
 Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece

 UCL, Dept Populat Sci & Expt Med, London, England
Hofer, E:
 Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria

 Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria
Lin, MX:
 Massachusetts Gen Hosp Canc Ctr, Charlestown, MA 02129 USA
Concas, MP:
 Inst Maternal & Child Hlth IRCCS, I-34127 Trieste, Italy
Vaccargiu, S:
 UOS Sassari, Natl Res Council Italy, Inst Genet & Biomed Res, Sassari, Italy
van der Most, PJ:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epide Miol, NL-9700 RB Groningen, Netherlands
Pitkanen, N:
 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

 Univ Turku, Ctr Populat Hlth Res, Turku, Finland

 Turku Univ Hosp, Turku, Finland
Cade, BE:
 Brigham & Womens Hosp, Sleep Med & Circadian Disorders, Boston, MA 02115 USA

 Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA
van der Laan, SW:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands
Chitrala, KN:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH,Biomed Res Ctr, NIH 251 Bayview Blvd, Baltimore, MD 21224 USA

 Temple Univ, Fels Canc Inst Personalized Med, Lewis Katz Sch Med, Philadelphia, PA USA
Weiss, S:
 Univ Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany

 Univ Med Greifswald, Greifswald, Germany
Bentley, AR:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, 12 South Dr,Room 4047, Bethesda, MD 20892 USA
Doumatey, AP:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, 12 South Dr,Room 4047, Bethesda, MD 20892 USA
Adeyemo, AA:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, 12 South Dr,Room 4047, Bethesda, MD 20892 USA
Lee, JY:
 Oneomics Co Ltd, Soonchunhyang Mirai Med Ctr, 2F,173 Buheuyng Ro, Bucheon Si 14585, Gyeonggi Do, South Korea
Petersen, ERB:
 Hosp Southern Jutland, Dept Clin Biochem & Immunol, Kresten Philipsens Vej 15, DK-6200 Aabenraa, Denmark
Nielsen, AA:
 Lillebaelt Hosp, Dept Clin Biochem, Kolding, Denmark
Choi, HS:
 Hallym Univ, Dept Biomed Sci, Chunchon 24252, Gangwon, South Korea
Nethander, M:
 Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden

 Univ Gothenburg, Sahlgrenska Acad, Bioinformat Core Facil, Gothenburg, Sweden
Freitag-Wolf, S:
 Univ Kiel, Inst Med Informat & Stat, Kiel, Germany
Southam, L:
 Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

 Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany
Rayner, NW:
 Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

 Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

 Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany

 Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
Wang, CA:
 Univ Newcastle, Fac Med & Hlth, Sch Med & Publ Hlth, Newcastle, NSW 2308, Australia
Lin, SY:
 Taichung Vet Gen Hosp, Ctr Geriatr & Gerontol, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

 Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

 Natl Def Med Ctr, Sch Med, Taipei, Taiwan
Wang, JS:
 Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

 Natl Yang Ming Univ, Sch Med, Dept Med, Taipei, Taiwan
Couture, C:
 Univ Laval, Dept Kinesiol, Quebec City, PQ, Canada
Lyytikainen, LP:
 Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33014, Finland
Nikus, K:
 Tampere Univ Hosp, Heart Ctr, Dept Car Diol, Tampere 33521, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiol, Tampere 33014, Finland
Cuellar-Partida, G:
 Univ Queensland, Translat Res Inst, Diamantina Inst, Kent St, Brisbane, Qld 4102, Australia
Vestergaard, H:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

 Bornholms Hosp, Dept Med, Ronne, Denmark
Hidalgo, B:
 Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA
Giannakopoulou, O:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England
Cai, QY:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA
Obura, MO:
 Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam Publ Hlth Res Inst, NL-1081 HV Amsterdam, Netherlands
van Setten, J:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Cardiol, Utrecht, Netherlands
He, KY:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
Tang, H:
 Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
Terzikhan, N:
 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands
Shin, JH:
 Hallym Univ, Dept Biomed Sci, Chunchon 24252, Gangwon, South Korea
Jackson, RD:
 Ohio State Univ, Div Endricinol, Columbus, OH 43210 USA
Reiner, AP:
 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
Martin, LW:
 George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20037 USA
Chen, ZM:
 Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
Li, LM:
 Peking Univ, Sch Publ Hlth, Dept Epidemiol, Hlth Sci Ctr, Beijing, Peoples R China
Kawaguchi, T:
 Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan
Thiery, J:
 Univ Leipzig, LIFE Res Ctr Civilizat Dis, Philipp Rosenthal Str 27, D-04103 Leipzig, Germany

 Univ Hosp Leipzig, Inst Lab Med, Paul List Str 13-15, D-04103 Leipzig, Germany
Bis, JC:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA
Launer, LJ:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Baltimore, MD 20892 USA
Li, HX:
 Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China
Nalls, MA:
 NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

 Data Tecn Int, Glen Echo, MD USA
Raitakari, OT:
 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

 Univ Turku, Ctr Populat Hlth Res, Turku, Finland

 Turku Univ Hosp, Turku, Finland

 Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland
Ichihara, S:
 Jichi Med Univ, Dept Environm & Prevent Med, Sch Med, Shimotsuke, Tochigi 3290498, Japan
Wild, SH:
 Univ Edinburgh, Ctr Populat Hlth Sci, Usher Inst, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland
Nelson, CP:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England
Campbell, H:
 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland
Jager, S:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Munich, Germany
Nabika, T:
 Shimane Univ, Dept Funct Pathol, Sch Med, Izumo, Shimane 6938501, Japan
Al-Mulla, F:
 Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait
Niinikoski, H:
 Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland

 Univ Turku, Turku, Finland

 Univ Turku, Dept Physiol, Turku, Finland
Braund, PS:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England
Kolcic, I:
 Univ Split, Fac Med, Soltanska 2, Split 21000, Croatia
Kovacs, P:
 Univ Leipzig Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, Liebigstr 21, D-04103 Leipzig, Germany
Giardoglou, T:
 Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece
Katsuya, T:
 Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Suita, Osaka 5650871, Japan

 Osaka Univ, Dept Geriatr & Gen Med, Grad Sch Med, Suita, Osaka 5650871, Japan
de Kleijn, D:
 Univ Utrecht, Univ Med Ctr Utrecht, Dept Vasc Surg, Div Surg Specialties, Utrecht, Netherlands
de Borst, GJ:
 Univ Utrecht, Univ Med Ctr Utrecht, Dept Vasc Surg, Div Surg Specialties, Utrecht, Netherlands
Kim, EK:
 Yonsei Univ, Dept Ophthalmol, Corneal Dystrophy Res Inst, Coll Med, Seoul 03722, South Korea
Adams, HHH:
 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, Rotterdam, Netherlands
Ikram, MA:
 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands
Zhu, XF:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
Asselbergs, FW:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Cardiol, Utrecht, Netherlands
Kraaijeveld, AO:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Cardiol, Utrecht, Netherlands
Beulens, JWJ:
 Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam Publ Hlth Res Inst, NL-1081 HV Amsterdam, Netherlands

 Univ Med Ceslrntre Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 CG Utrecht, Netherlands
Shu, XO:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA
Rallidis, LS:
 Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Dept Cardiol 2, Athens, Greece
Pedersen, O:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
Hansen, T:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
Mitchell, P:
 Univ Sydney, Ctr Vis Res, Dept Ophthalmol, Hawkesbury Rd, Sydney, NSW 2145, Australia

 Univ Sydney, Westmead Inst, Hawkesbury Rd, Sydney, NSW 2145, Australia
Hewitt, AW:
 Univ Tasmania, Sch Med, Menzies Inst Med Res, Liverpool St, Hobart, Tas 7000, Australia

 Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic 3002, Australia
Kahonen, M:
 Tampere Univ Hosp, Dept Clin Physiol, Tampere 33521, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere 33014, Finland
Perusse, L:
 Univ Laval, Dept Kinesiol, Quebec City, PQ, Canada

 Inst Nutr & Funct Foods INAF, Ctr Nutr Sante & Soc NUTRISS, Quebec City, PQ, Canada
Bouchard, C:
 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA
Tonjes, A:
 Univ Leipzig Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, Liebigstr 21, D-04103 Leipzig, Germany
Chen, YDI:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat,LABioMed, Torrance, CA 90502 USA
Pennell, CE:
 Univ Newcastle, Fac Med & Hlth, Sch Med & Publ Hlth, Newcastle, NSW 2308, Australia
Mori, TA:
 Univ Western Australia, Med Sch, Discipline Internal Med, Perth, WA, Australia
Lieb, W:
 Univ Kiel, Inst Epidemiol, Kiel, Germany
Franke, A:
 Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
Ohlsson, C:
 Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden

 Sahlgrens Univ Hosp, Dept Drug Treatment, Gothenburg, Sweden
Mellstrom, D:
 Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden

 Univ Gothenburg, Sahlgrenska Acad, Inst Med, Geriatr Med, Gothenburg, Sweden
Cho, YS:
 Hallym Univ, Dept Biomed Sci, Chunchon 24252, Gangwon, South Korea
Lee, H:
 Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea
Yuan, JM:
 Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15232 USA

 Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA 15232 USA
Koh, WP:
 Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Programme, Singapore 117545, Singapore

 ASTAR, Singapore Inst Clin Sci, Singapore 117609, Singapore
Rhee, SY:
 Kyung Hee Univ, Dept Endocrinol & Metab, Sch Med, Seoul 02447, South Korea
Woo, JT:
 Kyung Hee Univ, Dept Endocrinol & Metab, Sch Med, Seoul 02447, South Korea
Heid, IM:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
Stark, KJ:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
Zimmermann, ME:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
Volzke, H:
 Univ Med Greifswald, Inst Community Med, Greifswald, Germany
Homuth, G:
 Univ Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany

 Univ Med Greifswald, Greifswald, Germany
Evans, MK:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Baltimore, MD 20892 USA
Zonderman, AB:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Baltimore, MD 20892 USA
Polasek, O:
 Univ Split, Fac Med, Soltanska 2, Split 21000, Croatia

 Algebra Univ Coll, Ilica 242, Zagreb, Croatia
Pasterkamp, G:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands
Hoefer, IE:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands
Redline, S:
 Brigham & Womens Hosp, Sleep Med & Circadian Disorders, Boston, MA 02115 USA

 Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA
Pahkala, K:
 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

 Univ Turku, Ctr Populat Hlth Res, Turku, Finland

 Turku Univ Hosp, Turku, Finland

 Univ Turku, Paavo Nurmi Ctr, Dept Phys Act & Hlth, Sports & Exercise Med Unit, Turku, Finland
Oldehinkel, AJ:
 Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9700 RB Groningen, Netherlands
Snieder, H:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epide Miol, NL-9700 RB Groningen, Netherlands
Biino, G:
 Natl Res Council Italy, Inst Mol Genet, Pavia, Italy
Schmidt, R:
 Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria
Schmidt, H:
 Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Graz, Austria
Bandinelli, S:
 Toscana Ctr, Local Hlth Unit, Florence, Italy
Dedoussis, G:
 Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece
Thanaraj, TA:
 Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait
Peyser, PA:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
Kato, N:
 Natl Ctr Global Hlth & Med, Tokyo 1628655, Japan
Schulze, MB:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Munich, Germany

 Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany
Girotto, G:
 Inst Maternal & Child Hlth IRCCS, I-34127 Trieste, Italy

 Univ Trieste, Dept Med Surg & Hlth Sci, Str Fiume 447, I-34149 Trieste, Italy
Boger, CA:
 Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

 Traunstein Hosp, Dept Nephrol Diabetol Rheumatol, Traunstein, Germany

 KfH Kidney Ctr Traunstein, Traunstein, Germany
Jung, B:
 Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

 Traunstein Hosp, Dept Nephrol Diabetol Rheumatol, Traunstein, Germany

 KfH Kidney Ctr Traunstein, Traunstein, Germany
Joshi, PK:
 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland
Bennett, DA:
 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA

 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL USA
De Jager, PL:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 Columbia Univ Med Ctr, Ctr Translat & Syst Neuroimmunol, Dept Neurol, New York, NY USA
Lu, XF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing 100037, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China
Mamakou, V:
 Natl & Kapodistrian Univ Athens, Med Sch, 75 M Assias St, Athens 11527, Greece

 Dromokaiteio Psychiat Hosp, Athens 12461, Greece
Brown, M:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Dept Epidemiol, Houston, TX 77030 USA

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London EC1M 6BQ, England
Caulfield, MJ:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London EC1M 6BQ, England
Munroe, PB:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London EC1M 6BQ, England
Guo, XQ:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat,LABioMed, Torrance, CA 90502 USA
Ciullo, M:
 Adriano Buzzati Traverso CNR, Inst Genet & Biophys, Naples, Italy

 IRCCS Neuromed, Pozzilli, Isernia, Italy
Jonas, JB:
 Capital Med Univ, Beijing Inst Ophthalmol,Beijing Ophthalmol & Visu, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, 17 Hougou Lane, Beijing 100005, Peoples R China

 Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, D-68167 Mannheim, Germany

 Inst Mol & Clin Ophthalmol, Basel, Switzerland

 Privatpraxis Prof Jonas & Dr Panda Jonas, Heidelberg, Germany
Samani, NJ:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England
Kaprio, J:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland
Pajukanta, P:
 Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
Tusie-Luna, T:
 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City 14080, DF, Mexico

 Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
Aguilar-Salinas, CA:
 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metabol, Mexico City 14080, DF, Mexico

 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Direcc Nutr, Mexico City, DF, Mexico

 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Estudios Enfermedades Metab, Mexico City, DF, Mexico
Adair, LS:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA

 Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27516 USA
Bechayda, SA:
 Univ San Carlos, USC Off Populat Studies Fdn, Cebu 6000, Philippines

 Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu 6000, Philippines
de Silva, HJ:
 Univ Kelaniya, Fac Med, Dept Med, Ragama 11010, Sri Lanka
Wickremasinghe, AR:
 Univ Kelaniya, Fac Med, Dept Publ Hlth, Ragama 11010, Sri Lanka
Krauss, RM:
 Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
Wu, JY:
 Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Zheng, W:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA
den Hollander, AI:
 Radboud Univ Nijmegen, Dept Ophthalmol, Med Ctr, NL-6525 EX Nijmegen, Netherlands

 Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, NL-6525 EX Nijmegen, Netherlands
Bharadwaj, D:
 CSIR Human Resource Dev Ctr, Acad Sci & Innovat Res AcSIR, New Delhi, India

 Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi 110067, India
Correa, A:
 Univ Mississippi Med Ctr, Dept Med, Jackson, MS 39216 USA
Wilson, JG:
 Univ Mississippi Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA
Lind, L:
 Uppsala Univ, Dept Med Sci, Uppsala, Sweden
Heng, CK:
 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore

 Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore, Singapore
Nelson, AE:
 Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA

 Univ N Carolina, Dept Med, Chapel Hill, NC USA
Golightly, YM:
 Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

 Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA

 Univ N Carolina, Injury Prevent Res Ctr, Chapel Hill, NC USA

 Univ N Carolina, Div Phys Therapy, Chapel Hill, NC USA
Wilson, JF:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland
Penninx, B:
 Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
Kim, HL:
 Ewha Womans Univ, Coll Med, Dept Biochem, Seoul 07804, South Korea
Attia, J:
 Hunter Med Res Inst, Newcastle, NSW, Australia

 Univ Newcastle, Fac Med & Hlth, Sch Med & Publ Hlth, Newcastle, NSW 2308, Australia
Scott, RJ:
 Hunter Med Res Inst, Newcastle, NSW, Australia

 Univ Newcastle, Fac Med & Hlth, Sch Med & Publ Hlth, Newcastle, NSW 2308, Australia
Rao, DC:
 Washington Univ, Div Biostat, Sch Med, St Louis, MO 63110 USA
Arnett, DK:
 Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
Walker, M:
 Newcastle Univ, Med Sch, Inst Cellular Med Diabet, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
Scott, LJ:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Koistinen, HA:
 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

 Univ Helsinki, POB 340,Haartmaninkatu 4, Helsinki 00029, Finland

 Helsinki Univ Hosp, Dept Med, POB 340,Haartmaninkatu 4, Helsinki 00029, Finland

 Minerva Fdn Inst Med Ical Res, Helsinki 00290, Finland
Chandak, GR:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad, Telangana, India

 CSIR Human Resource Dev Ctr, Acad Sci & Innovat Res AcSIR, New Delhi, India

 JSS Acad Higher Educ & Res, Mysuru, India
Mercader, JM:
 Broad Inst MIT & Harvard, Program Metab, Cambridge, MA 02142 USA

 Broad Inst MIT & Harvard, Program Med, Cambridge, MA 02142 USA

 Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

 Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA USA

 Harvard Med Sch, Boston, MA 02115 USA
Villalpando, CG:
 Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico

 Ctr Estudios Diabet, Cuernavaca, Morelos, Mexico
Orozco, L:
 Inst Nacl Med Genom, Mexico City, DF, Mexico
Fornage, M:
 Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, McGovern Med Sch, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA
Tai, ES:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

 Natl Univ Hlth Syst, Singapore 117549, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119228, Singapore

 Natl Univ Hlth Syst, Singapore 119228, Singapore
van Dam, RM:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

 Natl Univ Hlth Syst, Singapore 117549, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119228, Singapore

 Natl Univ Hlth Syst, Singapore 119228, Singapore
Lehtimaki, T:
 Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33014, Finland
Chaturvedi, N:
 UCL, MRC Unit Lifelong Hlth & Ageing, 1-19 Torrington Pl, London WC1E 7HB, England
Yokota, M:
 Kurume Univ, Sch Med, Kurume, Fukuoka 8300011, Japan
Liu, JJ:
 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore
Reilly, DF:
 Merck Sharp & Dohme Corp, Genet, Kenilworth, NJ 07033 USA
McKnight, AJ:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland
Kee, F:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland
Jockel, KH:
 Univ Duisburg Essen, Inst Med Informat Biometrie & Epidemiol, Essen, Germany
McCarthy, MI:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

 Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
Palmer, CNA:
 Univ Dundee, Ninwells Hosp & Med Sch, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland
Vitart, V:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland
Hayward, C:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland
Simonsick, E:
 NIA, Intramural Res Program, 3001 S Hanover St, Baltimore, MD 21225 USA
van Duijn, CM:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands
Jin, ZB:
 Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China

 Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China
Lu, F:
 Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China
Hishigaki, H:
 Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan
Lin, X:
 Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China
Marz, W:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68163 Mannheim, Germany

 Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany

 Synlab Holding Deutschland GmbH, Synlab Acad, Augsburg, Germany

 Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria
Gudnason, V:
 Iceland Heart Assoc, IS-201 Kopavogur, Iceland

 Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland
Tardif, JC:
 Univ Montreal, Montreal Heart Inst, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada
Lettre, G:
 Univ Montreal, Montreal Heart Inst, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada
Hart, LMT:
 Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam Publ Hlth Res Inst, NL-1081 HV Amsterdam, Netherlands

 Leiden Univ Med Ctr, Dept Cell & Chem Biol, NL-2333 ZA Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Biomed Data Sci, Sect Mol Epidemiol, NL-2333 ZA Leiden, Netherlands
Elders, PJM:
 Amsterdam UMC, Dept Gen Practice & Elderly Care, Amsterdam Publ Hlth Res Inst, NL-1081 HV Amsterdam, Netherlands
Rader, DJ:
 Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

 Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Damrauer, SM:
 Univ Penn, Dept Surg, Philadelphia, PA 19104 USA

 Corporal Michael Crescenz VA Med Ctr, Philadelphia, PA 19104 USA
Kumari, M:
 Univ Essex, Inst Social & Econ Res, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England
Kivimaki, M:
 UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England
van der Harst, P:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands
Spector, TD:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Loos, RJF:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA
Province, MA:
 Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany

 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
Parra, EJ:
 Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON L5L 1C6, Canada
Cruz, M:
 Ctr Med Nacl Siglo XXI, Hosp Especialidades, Inst Mexicano Seguro Social, Unidad Invest Med Bioquim, Mexico City, DF, Mexico
Psaty, BM:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

 Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA
Brandslund, I:
 Lillebaelt Hosp, Dept Clin Biochem, Vejle, Denmark

 Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark
Pramstaller, PP:
 Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Via Galvani 31, I-39100 Bolzano, Italy
Rotimi, CN:
 NHGRI, 16Ctr Res Genom & Global Hlth, NIH, 12 South Dr,Room 4047, Bethesda, MD 20892 USA
Christensen, K:
 Univ Southern Denmark, Danish Aging Res Ctr, Odense C, Denmark
Ripatti, S:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland

 Univ Helsinki, Fac Med, Dept Publ Hlth, Helsinki, Finland

 Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
Widen, E:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland
Hakonarson, H:
 Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

 Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
Grant, SFA:
 Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

 Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

 Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA
Kiemeney, L:
 Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands
de Graaf, J:
 Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands
Loeffler, M:
 Univ Leipzig, Inst Med Informat Stat & Epidemiol, Haertelstr 16-18, D-04107 Leipzig, Germany

 Univ Leipzig, LIFE Res Ctr Civilizat Dis, Philipp Rosenthal Str 27, D-04103 Leipzig, Germany
Kronenberg, F:
 Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria

 German Chron Kidney Dis Study, Innsbruck, Austria
Gu, DF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing 100037, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China

 Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China
Erdmann, J:
 Univ Lubeck, Inst Cardiogenet, DZHK German Res Ctr Cardiovasc Res, Univ Heart Ctr Lubeck,Partner Site Hamburg Lubeck, Lubeck, Germany

 Charite Univ Med Berlin, Berlin, Germany

 Free Univ Berlin, Berlin, Germany

 Humboldt Univ, Berlin, Germany
Schunkert, H:
 Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany

 Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
Franks, PW:
 Lund Univ, Lund Univ Diabet Ctr, Malmo, Sweden
Linneberg, A:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

 Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
Jukema, JW:
 Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands

 Netherlands Heart Inst, Utrecht, Netherlands
Khera, AV:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 Harvard Med Sch, Div Cardiol, Dept Med, Massachusetts Gen Hosp, Boston, MA 02115 USA

 Harvard Med Sch, Dept Med, Boston, MA 02115 USA

 Univ Oulu, Fac Med, Infrastruct Populat Studies, Northern Finland Birth Cohorts, Oulu, Finland
Mannikko, M:
 Univ Oulu, Fac Med, Infrastruct Populat Studies, Northern Finland Birth Cohorts, Oulu, Finland
Jarvelin, MR:
 Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London W2 1PG, England

 Univ Oulu, Fac Med, Ctr Life Course Hlth Res, Oulu, Finland

 Univ Oulu, Bioctr Oulu, Oulu, Finland
Kutalik, Z:
 Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Rte Berne 113, CH-1010 Lausanne, Switzerland

 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland
Francesco, C:
 Italian Natl Council Res IRGB CNR, Inst Genet & Biomed Res, Cagliari, Italy

 Univ Sassari, Sassari, Italy
Mook-Kanamori, DO:
 Leiden Univ Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands
van Dijk, KW:
 Leiden Univ Med Ctr, Dept Internal Med, Div Endocrinol, Leiden, Netherlands

 Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands
Watkins, H:
 Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX3 9DU, England

 St Pau Biomed Res Inst IIB St Pau, Unit Genom Complex Dis, Barcelona, Spain
Strachan, DP:
 St Georges Univ London, Populat Hlth Res Inst, London SW17 0RE, England
Grarup, N:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
Sever, P:
 Imperial Coll London, Natl Heart & Lung Inst, London W2 1PG, England
Poulter, N:
 Imperial Coll London, Sch Publ Hlth, London W12 7RH, England
Sheu, WHH:
 Taichung Vet Gen Hosp, 1650,Sec 4,Taiwan Blvd, Taichung 40705, Taiwan

 Taipei Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, 201,Sec 2,Shipai Rd, Taipei 112201, Taiwan
Rotter, JI:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat,LABioMed, Torrance, CA 90502 USA
Dantoft, TM:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark
Karpe, F:
 Univ Oxford, Churchill Hosp, OCDEM, Oxford OX3 7LE, England

 Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England
Neville, MJ:
 Univ Oxford, Churchill Hosp, OCDEM, Oxford OX3 7LE, England

 Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England
Timpson, NJ:
 Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Oakfield House, Bristol BS8 2BN, Avon, England

 Univ Bristol, Bristol Med Sch, Bristol BS8 2BN, Avon, England
Cheng, CY:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore 168751, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore
Wong, TY:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore 168751, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore
Khor, CC:
 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore
Li, HT:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Data Sci, Singapore 168751, Singapore
Sabanayagam, C:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore 168751, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore
Peters, A:
 Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany

 German Ctr Diabet Res DZD, Neuherberg, Germany
Gieger, C:
 Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 German Ctr Diabet Res DZD, Neuherberg, Germany
Hattersley, AT:
 Univ Exeter, Univ Exeter Med Sch, Exeter EX2 5DW, Devon, England
Pedersen, NL:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Magnusson, PKE:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Boomsma, DI:
 Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
de Geus, EJC:
 Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
Cupples, LA:
 Boston Univ, Dept Biostat, Sch Publ Hlth, 801 Massachusetts Ave, Boston, MA 02118 USA

 NHLBI, Framingham Heart Study, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
van Meurs, JBJ:
 Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands

 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands
Ikram, A:
 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands
Ghanbari, M:
 Univ Med Ctr, Depart Ment Epidemiol, Erasmus MC, Rotterdam, Netherlands

 Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Razavi Khorasan, Iran
Gordon-Larsen, P:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA

 Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27516 USA
Huang, W:
 Chinese Natl Human Genome Ctr Shanghai, Dept Genet, Shanghai Most Key Lab Hlth & Dis Genom, Shanghai 201203, Peoples R China
Kim, YJ:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Chungbuk, South Korea
Tabara, Y:
 Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan
Wareham, NJ:
 Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge CB2 0QQ, England
Langenberg, C:
 Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge CB2 0QQ, England
Zeggini, E:
 Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

 Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany

 Tech Univ Munich TUM, TUM Sch Med, Munich, Germany

 TUM Sch Med, Klinikum Rechts Isar, Munich, Germany
Tuomilehto, J:
 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

 Univ Helsinki, Fac Med, Dept Publ Hlth, Helsinki, Finland

 King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia
Kuusisto, J:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

 Kuopio Univ Hosp, Kuopio, Finland
Laakso, M:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

 Kuopio Univ Hosp, Kuopio, Finland
Ingelsson, E:
 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

 Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden

 Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

 Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA
Abecasis, G:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

 Regeneron Pharmaceut, Tarrytown, NY USA
Chambers, JC:
 Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London W2 1PG, England

 London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Harrow UB1 3HW, Middx, England

 Imperial Coll London, Imperial Coll Healthcare NHS Trust, London W12 0HS, England

 Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 308232, Singapore
Kooner, JS:
 London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Harrow UB1 3HW, Middx, England

 Imperial Coll London, Imperial Coll Healthcare NHS Trust, London W12 0HS, England

 Imperial Coll London, Natl Heart & Lung Inst, London W2 1PG, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England
de Vries, PS:
 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Dept Epidemiol, Houston, TX 77030 USA
Morrison, AC:
 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Dept Epidemiol, Houston, TX 77030 USA
Hazelhurst, S:
 Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa

 Univ Witwatersrand, Sch Elect & Informat Engn, Johannesburg, South Africa
Ramsay, M:
 Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa
North, KE:
 Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA
Daviglus, M:
 Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA
Kraft, P:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA

 Harvard TH Chan Sch Publ Hlth, Dept Biostat, 677 Huntington Ave, Boston, MA 02115 USA
Martin, NG:
 QIMR Berghofer Med Res Inst, 300 Herston Rd, Brisbane, Qld 4006, Australia
Whitfield, JB:
 QIMR Berghofer Med Res Inst, 300 Herston Rd, Brisbane, Qld 4006, Australia
Abbas, S:
 Ctr Noncommunicable Dis, Karachi, SD, Pakistan

 Faisalabad Inst Cardiol, Faislabad, Pakistan
Saleheen, D:
 Ctr Noncommunicable Dis, Karachi, SD, Pakistan

 Faisalabad Inst Cardiol, Faislabad, Pakistan

 Columbia Univ, Dept Med, Irving Med Ctr, New York, NY USA

 Columbia Univ, Dept Cardiol, Irving Med Ctr, New York, NY USA
Walters, RG:
 Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Big Data Inst, Oxford OX3 7LF, England
Holmes, MV:
 Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England
Black, C:
 Univ Aberdeen, Aberdeen Ctr Hlth Data Sci, Sch Med Med Sci & Nutr, 1 042 Polwarth Bldg, Aberdeen AB25 2ZD, Scotland
Smith, BH:
 Univ Dundee, Ninwells Hosp & Med Sch, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland
Baras, A:
 Regeneron Pharmaceut, Tarrytown, NY USA
Justice, AE:
 Geisinger Hlth, Biomed & Translat Informat, Danville, PA 17822 USA
Buring, JE:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

 Harvard Med Sch, Boston, MA 02115 USA
Ridker, PM:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

 Harvard Med Sch, Boston, MA 02115 USA
Chasman, DI:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

 Harvard Med Sch, Boston, MA 02115 USA
Kooperberg, C:
 Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
Tamiya, G:
 Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi 9808573, Japan
Yamamoto, M:
 Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi 9808573, Japan
van Heel, DA:
 Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England
Trembath, RC:
 Kings Coll London, Fac Life Sci & Med, Sch Basic & Med Biosci, London, England
Wei, WQ:
 Vanderbilt Univ Sch Med, Dept Biomed Informat, Nashville, TN USA
Jarvik, GP:
 Univ Washington, Dept Med Med Genet, Seattle, WA 98195 USA

 Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Namjou, B:
 Cincinnati Childrens Hosp Med Ctr CCHMC, Ctr Autoimmune Genom & Etiol, Cincinnati, OH USA
Hayes, MG:
 Northwestern Univ, Ctr Genet Med, Feinberg Sch Med, Chicago, IL 60611 USA

 Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA

 Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA
Ritchie, MD:
 Univ Penn, Perelman Sch Med, Inst Biomed Informat, Dept Genet, Philadelphia, PA 19104 USA
Jousilahti, P:
 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Salomaa, V:
 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Hveem, K:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway

 Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, NTNU, N-7600 Levanger, Norway

 Levanger Hosp, Nord Trondelag Hosp Trust, Dept Med, N-7600 Levanger, Norway
Asvold, BO:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway

 Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, NTNU, N-7600 Levanger, Norway

 Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olavs Hosp, Trondheim, Norway
Kubo, M:
 RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
Kamatani, Y:
 RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan

 Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Complex Trait Genom, Tokyo, Japan
Okada, Y:
 RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan

 Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan

 Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Stat Immunol, Osaka, Japan

 Osaka Univ, Inst Open & Transdisciplinary Res Initiat, Integrated Frontier Res Med Sci Div, Osaka, Japan
Murakami, Y:
 Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo, Japan
Kim, BJ:
 Natl Inst Hlth, Ctr Genome Sci, Div Genome Res, Chungcheongbuk Do, South Korea
Thorsteinsdottir, U:
 Amgen Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland

 Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland
Stefansson, K:
 Amgen Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland

 Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland
Zhang, JF:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA
Chen, YE:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA
Ho, YL:
 VA Boston Healthcare Syst, Boston, MA USA
Lynch, JA:
 VA Salt Lake City Hlth Care Syst, VA Informat & Comp Infrastruct, Salt Lake City, UT USA

 Univ Massachusetts, Boston, MA USA
Tsao, PS:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

 Stanford Univ, Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA
Chang, KM:
 Corporal Michael Crescenz VA Med Ctr, Philadelphia, PA 19104 USA

 Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Cho, K:
 VA Boston Healthcare Syst, Boston, MA USA

 Brigham Womens Hosp, Dept Med, Boston, MA USA
O'Donnell, CJ:
 VA Boston Healthcare Syst, Boston, MA USA

 Brigham Womens Hosp, Dept Med, Boston, MA USA
Gaziano, JM:
 VA Boston Healthcare Syst, Boston, MA USA

 Brigham Womens Hosp, Dept Med, Boston, MA USA
Wilson, P:
 Atlanta VA Hlth Care Syst, Decatur, GA USA

 Emory Univ, Div Cardiol, Sch Med, Atlanta, GA USA
Mohlke, KL:
 Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
Frayling, TM:
 Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter EX2 5DW, Devon, England
Hirschhorn, JN:
 Boston Childrens Hosp, Endocrinol, Boston, MA 02115 USA

 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

 Harvard Med Sch, Dept Genet, Boston, MA 02115 USA
Kathiresan, S:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 Massachusetts Gen Hosp, Dept Med, Ctr Genom Med, Boston, MA 02114 USA

 Harvard Med Sch, Dept Med, Boston, MA 02115 USA
Boehnke, M:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Grant, S:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

 Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

 Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

 Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA
Natarajan, P:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA

 Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA USA

 Harvard Med Sch, Div Cardiol, Dept Med, Massachusetts Gen Hosp, Boston, MA 02115 USA

 Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA

 Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
Sun, YV:
 Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA USA

 Atlanta VA Hlth Care Syst, Decatur, GA USA
Morris, AP:
 Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England
Deloukas, P:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England

 King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia
Peloso, G:
 Boston Univ, Dept Biostat, Sch Publ Hlth, 801 Massachusetts Ave, Boston, MA 02118 USA
Assimes, TL:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

 Stanford Univ, Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA
Willer, CJ:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA

 Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

 Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Zhu, X:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

 Penn State Univ, Dept Stat, University Pk, PA 16802 USA

 Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA

 Stanford Univ, Dept Stat, Stanford, CA 94305 USA
Brown, CD:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
ISSN: 00029297





AMERICAN JOURNAL OF HUMAN GENETICS
Editorial
CELL PRESS, 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 109 Número: 8
Páginas: 1366-1387
WOS Id: 000850681500003
ID de PubMed: 35931049
imagen Green Accepted, Green Submitted, Green Published

MÉTRICAS