Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta-analysis by the OCD Brain Imaging Consortium
Por:
Fouche, JP, Groenewold, NA, Sevenoaks, T, Heany, S, Lochner, C, Alonso, P, Batistuzzo, MC, Cardoner, N, Ching, CRK, de Wit, SJ, Gutman, B, Hoexter, MQ, Jahanshad, N, Kim, M, Kwon, JS, Mataix-Cols, D, Menchon, JM, Miguel, EC, Nakamae, T, Phillips, ML, Pujol, J, Sakai, Y, Yun, JY, Soriano-Mas, C, Thompson, PM, Yamada, K, Veltman, DJ, van den Heuvel, OA, Stein, DJ
Publicada:
1 oct 2022
Ahead of Print:
1 sep 2022
Resumen:
Objective Neuroimaging studies of obsessive-compulsive disorder (OCD) patients have highlighted the important role of deep gray matter structures. Less work has however focused on subcortical shape in OCD patients. Methods Here we pooled brain MRI scans from 412 OCD patients and 368 controls to perform a meta-analysis utilizing the ENIGMA-Shape protocol. In addition, we investigated modulating effects of medication status, comorbid anxiety or depression, and disease duration on subcortical shape. Results There was no significant difference in shape thickness or surface area between OCD patients and healthy controls. For the subgroup analyses, OCD patients with comorbid depression or anxiety had lower thickness of the hippocampus and caudate nucleus and higher thickness of the putamen and pallidum compared to controls. OCD patients with comorbid depression had lower shape surface area in the thalamus, caudate nucleus, putamen, hippocampus, and nucleus accumbens and higher shape surface area in the pallidum. OCD patients with comorbid anxiety had lower shape surface area in the putamen and the left caudate nucleus and higher shape surface area in the pallidum and the right caudate nucleus. Further, OCD patients on medication had lower shape thickness of the putamen, thalamus, and hippocampus and higher thickness of the pallidum and caudate nucleus, as well as lower shape surface area in the hippocampus and amygdala and higher surface area in the putamen, pallidum, and caudate nucleus compared to controls. There were no significant differences between OCD patients without co-morbid anxiety and/or depression and healthy controls on shape measures. In addition, there were also no significant differences between OCD patients not using medication and healthy controls. Conclusions The findings here are partly consistent with prior work on brain volumes in OCD, insofar as they emphasize that alterations in subcortical brain morphology are associated with comorbidity and medication status. Further work is needed to understand the biological processes contributing to subcortical shape.
Filiaciones:
Fouche, JP:
Univ Cape Town, Dept Psychiat, Cape Town, South Africa
Univ Cape Town, Neurosci Inst, Cape Town, South Africa
Groenewold, NA:
Univ Cape Town, Dept Psychiat, Cape Town, South Africa
Univ Cape Town, Neurosci Inst, Cape Town, South Africa
Sevenoaks, T:
Univ Cape Town, Dept Psychiat, Cape Town, South Africa
Univ Cape Town, Neurosci Inst, Cape Town, South Africa
Heany, S:
Univ Cape Town, Dept Psychiat, Cape Town, South Africa
Univ Cape Town, Neurosci Inst, Cape Town, South Africa
Lochner, C:
Stellenbosch Univ, Dept Psychiat, SAMRC Unit Risk & Resilience Mental Disorders, Stellenbosch, South Africa
Alonso, P:
Bellvitge Univ Hosp, Bellvitge Biomed Res Inst, IDIBELL, Dept Psychiat, Barcelona, Spain
Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain
Batistuzzo, MC:
Univ Sao Paulo, Dept & Inst Psychiat, Med Sch, Sao Paulo, Brazil
Pontifical Catholic Univ, Dept Methods & Tech Psychol, Sao Paulo, SP, Brazil
Cardoner, N:
Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IBB St Pau, St Pau Mental Hlth Grp, Barcelona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Barcelona, Spain
Ching, CRK:
USC, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Marina Del Rey, CA USA
de Wit, SJ:
Vrije Univ, Dept Psychiat, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ, Dept Anat & Neurosci, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands
Gutman, B:
IIT, Dept Biomed Engn, Chicago, IL 60616 USA
Hoexter, MQ:
Univ Sao Paulo, Dept & Inst Psychiat, Med Sch, Sao Paulo, Brazil
Jahanshad, N:
USC, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Marina Del Rey, CA USA
Kim, M:
Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea
Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea
Kwon, JS:
Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea
SNU MRC, Inst Human Behav Med, Seoul, South Korea
Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul, South Korea
Mataix-Cols, D:
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
Menchon, JM:
Bellvitge Univ Hosp, Bellvitge Biomed Res Inst, IDIBELL, Dept Psychiat, Barcelona, Spain
Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain
Miguel, EC:
Univ Sao Paulo, Dept & Inst Psychiat, Med Sch, Sao Paulo, Brazil
Nakamae, T:
Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kyoto, Japan
Phillips, ML:
Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA USA
Pujol, J:
Hosp del Mar, Radiol Dept, MRI Res Unit, Barcelona, Spain
Sakai, Y:
Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kyoto, Japan
ATR Brain Informat Commun Res Lab Grp, Kyoto, Japan
Yun, JY:
Seoul Natl Univ Hosp, Seoul, South Korea
Seoul Natl Univ, Coll Med, Yeongeon Student Support Ctr, Seoul, South Korea
Soriano-Mas, C:
Bellvitge Univ Hosp, Bellvitge Biomed Res Inst, IDIBELL, Dept Psychiat, Barcelona, Spain
Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona UB, Dept Social Psychol & Quantitat Psychol, Barcelona, Spain
Thompson, PM:
USC, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Marina Del Rey, CA USA
Yamada, K:
Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Radiol, Kyoto, Japan
Veltman, DJ:
Vrije Univ, Dept Psychiat, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ, Dept Anat & Neurosci, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands
van den Heuvel, OA:
Vrije Univ, Dept Psychiat, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ, Dept Anat & Neurosci, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands
Stein, DJ:
Univ Cape Town, Dept Psychiat, Cape Town, South Africa
Univ Cape Town, Neurosci Inst, Cape Town, South Africa
Stellenbosch Univ, Dept Psychiat, SAMRC Unit Risk & Resilience Mental Disorders, Stellenbosch, South Africa
Green Published, All Open Access; Green
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