Predicting Impulse Control Disorders in Parkinson Disease through Incentive Biomarkers
Por:
Marin-Lahoz, J, Martinez-Horta, S, Pagonabarraga, J, Horta-Barba, A, Aracil-Bolanos, I, Bejr-kasem, H, Sampedro, F, Campolongo, A, Kulisevsky, J
Publicada:
1 dic 2022
Ahead of Print:
1 sep 2022
Resumen:
Objective: This study was undertaken to evaluate whether the feedback-related negativity (FRN)-a neurophysiological marker of incentive processing-can be used to predict the development of impulse control disorders (ICDs) in Parkinson disease (PD).
Methods: The longitudinal cohort consisted of consecutive nondemented PD patients with no ICD history. We recorded FRN signals while they performed a gambling task. We calculated the mean amplitude difference between losses and gains (FRNdiff) to be used as a predictor of future ICD development. We performed prospective biannual follow-up assessments for 30 months to detect incident ICDs. Finally, we evaluated how basal FRNdiff was associated with posterior development of ICDs using survival models.
Results: Between October 7, 2015 and December 16, 2016, we screened 120 patients. Among them, 94 patients performed the gambling and 92 completed the follow-up. Eighteen patients developed ICDs during follow-up, whereas 74 remained free of ICDs. Baseline FRNdiff was greater in patients who developed ICDs than in those who did not (-2.33 mu V vs -0.84 mu V, p = 0.001). No other significant baseline differences were found. The FRNdiff was significantly associated with ICD development in the survival models both when not adjusted (hazard ratio [HR] = 0.73, 95% confidence interval [CI] = 0.58-0.91, p = 0.006) and when controlling for dopamine replacement therapy, sex, and age (HR = 0.74, 95% CI = 0.55-0.97, p = 0.035). None of the impulsivity measures evaluated was related to ICD development.
Interpretation: Reward-processing differences measured by FRN signals precede ICD development in PD. This neurophysiological marker permits identification of patients with high risk of ICD development.
Filiaciones:
Marin-Lahoz, J:
Hosp Univ Miguel Servet, Dept Neurol, Paseo Isabel Catolica 1-3, Zaragoza 50009, Spain
Miguel Servet Univ Hosp, Dept Neurol, Zaragoza, Spain
IIS Aragon, Inst Hlth Res Aragon, Servet Neurosci Grp, Zaragoza, Spain
Barcelona Autonomous Univ, Dept Med, Barcelona, Spain
Martinez-Horta, S:
Barcelona Autonomous Univ, Dept Med, Barcelona, Spain
Sant Pau Hosp, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
Pagonabarraga, J:
Barcelona Autonomous Univ, Dept Med, Barcelona, Spain
Sant Pau Hosp, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
Horta-Barba, A:
Sant Pau Hosp, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
Aracil-Bolanos, I:
Barcelona Autonomous Univ, Dept Med, Barcelona, Spain
Sant Pau Hosp, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
Bejr-kasem, H:
Barcelona Autonomous Univ, Dept Med, Barcelona, Spain
Sant Pau Hosp, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
Sampedro, F:
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
Campolongo, A:
Sant Pau Hosp, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, C Mas Casanovas 90, Barcelona 08041, Spain
Barcelona Autonomous Univ, Dept Med, Barcelona, Spain
Sant Pau Hosp, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst Sant Pau, Movement Disorders Grp, Barcelona, Spain
CIBERNED, Network Res Ctr Neurodegenerat Dis, Madrid, Spain
hybrid, Hybrid Gold
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