Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers
Por:
Jansen, RE, van der Lee, SJ, Gomez-Fonseca, D, de Rojas, I, Dalmasso, MC, Grenier-Boley, B, Zettergren, A, Mishra, A, Ali, M, Andrade, V, Bellenguez, C, Kleineidam, L, Kucukali, F, Sung, YJ, Tesi, N, Vromen, EM, Wightman, DP, Alcolea, D, Alegret, M, Alvarez, I, Amouyel, P, Athanasiu, L, Bahrami, S, Bailly, H, Belbin, O, Bergh, S, Bertram, L, Biessels, GJ, Blennow, K, Blesa, R, Boada, M, Boland, A, Buerger, K, Carracedo, A, Cervera-Carles, L, Chene, G, Claassen, JAHR, Debette, S, Deleuze, JF, de Deyn, PP, Diehl-Schmid, J, Djurovic, S, Dols-Icardo, O, Dufouil, C, Duron, E, Duzel, E, Fladby, T, Fortea, J, Frolich, L, Garcia-Gonzalez, P, Garcia-Martinez, M, Giegling, I, Goldhardt, O, Gobom, J, Grimmer, T, Haapasalo, A, Hampel, H, Hanon, O, Hausner, L, Heilmann-Heimbach, S, Helisalmi, S, Heneka, MT, Hernandez, I, Herukka, SK, Holstege, H, Jarholm, J, Kern, S, Knapskog, AB, Koivisto, AM, Kornhuber, J, Kuulasmaa, T, Lage, C, Laske, C, Leinonen, V, Lewczuk, P, Lleo, A, de Munain, AL, Lopez-Garcia, S, Maier, W, Marquie, M, Mol, MO, Montrreal, L, Moreno, F, Moreno-Grau, S, Nicolas, G, Nothen, MM, Orellana, A, Palhaugen, L, Papma, JM, Pasquier, F, Perneczky, R, Peters, O, Pijnenburg, YAL, Popp, J, Posthuma, D, Pozueta, A, Priller, J, Puerta, R, Quintela, I, Ramakers, I, Rodriguez-Rodriguez, E, Rujescu, D, Saltvedt, I, Sanchez-Juan, P, Scheltens, P, Scherbaum, N, Schmid, M, Schneider, A, Selbaek, G, Selnes, P, Shadrin, A, Skoog, I, Soininen, H, Tarraga, L, Teipel, S, Tijms, B, Tsolaki, M, Van Broeckhoven, C, Van Dongen, J, van Swieten, JC, Vandenberghe, R, Vidal, JS, Visser, PJ, Vogelgsang, J, Waern, M, Wagner, M, Wiltfang, J, Wittens, MMJ, Zetterberg, H, Zulaica, M, van Duijn, CM, Bjerke, M, Engelborghs, S, Jessen, F, Teunissen, CE, Pastor, P, Hiltunen, M, Ingelsson, M, Andreassen, OA, Clarimon, J, Sleegers, K, Ruiz, A, Ramirez, A, Cruchaga, C, Lambert, JC, van der Flier, W
Publicada:
1 nov 2022
Ahead of Print:
1 sep 2022
Resumen:
Amyloid-beta 42 (A beta 42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for A beta 42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple A beta 42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.
Filiaciones:
Jansen, RE:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands
van der Lee, SJ:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC Locat VUmc, Human Genet, Amsterdam, Netherlands
Gomez-Fonseca, D:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Washington Univ, Sch Med, NeuroGen & Informat, St Louis, MO USA
Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO USA
de Rojas, I:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Dalmasso, MC:
Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany
Univ Cologne, Univ Hosp Cologne, Cologne, Germany
Natl Univ A Jauretche UNAJ, Hosp El Cruce, Neurosci & Complex Syst Unit ENyS, CONICET, Florencio Varela, Argentina
Grenier-Boley, B:
Univ Lille, Inst Pasteur Lille, U1167 RID AGE Labex DISTALZ Facteurs Risque & Det, CHU Lille, F-59000 Lille, France
Zettergren, A:
Univ Gothenburg, Sahlgrenska Acad, Neuropsychiat Epidemiol Unit,Ctr Ageing & Hlth AG, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Mishra, A:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Team VINTAGE, INSERM,UMR 1219, F-33000 Bordeaux, France
Ali, M:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Washington Univ, Sch Med, NeuroGen & Informat, St Louis, MO USA
Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO USA
Andrade, V:
Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany
Univ Cologne, Univ Hosp Cologne, Cologne, Germany
Univ Hosp Bonn, Med Fac, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Bellenguez, C:
Univ Lille, Inst Pasteur Lille, U1167 RID AGE Labex DISTALZ Facteurs Risque & Det, CHU Lille, F-59000 Lille, France
Kleineidam, L:
Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany
Univ Cologne, Univ Hosp Cologne, Cologne, Germany
Univ Hosp Bonn, Med Fac, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Kucukali, F:
VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Sung, YJ:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Washington Univ, Sch Med, NeuroGen & Informat, St Louis, MO USA
Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO USA
Tesi, N:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC Locat VUmc, Human Genet, Amsterdam, Netherlands
Vromen, EM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Wightman, DP:
Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands
Alcolea, D:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
Alegret, M:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Alvarez, I:
Hosp Univ Mutua Terrassa, Dept Neurol, Memory Disorders Unit, Terrassa, Spain
Fundacio Recerca Biomed & Social Mutua Terrassa, Terrassa, Spain
Amouyel, P:
Univ Lille, Inst Pasteur Lille, U1167 RID AGE Labex DISTALZ Facteurs Risque & Det, CHU Lille, F-59000 Lille, France
Athanasiu, L:
Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway
Div Mental Hlth, Oslo, Norway
Bahrami, S:
Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway
Div Mental Hlth, Oslo, Norway
Bailly, H:
Univ Paris Cite, Maladie Alzheimer, EA4468, F-75013 Paris, France
Belbin, O:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
Bergh, S:
Innlandet Hosp Trust, Res Ctr Age Related Funct Decline & Dis, Brumunddal, Norway
Vestfold Hosp Trust, Norwegian Natl Ctr Ageing & Hlth, Tonsberg, Norway
Bertram, L:
Univ Lubeck, Lubeck Interdisciplinary Platform Genome Analyt, Lubeck, Germany
Biessels, GJ:
UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands
Blennow, K:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Blesa, R:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
Boada, M:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Boland, A:
Univ Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, F-91057 Evry, France
Buerger, K:
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Ludwig Maximilians Univ Munchen, Inst Stroke & Dementia Res ISD, Univ Hosp, Munich, Germany
Carracedo, A:
Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Grp Med Xenom, Santiago De Compostela, Spain
Fdn Publ Galega Med Xenom CIBERER IDIS, Santiago De Compostela, Spain
Cervera-Carles, L:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
Chene, G:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Team VINTAGE, INSERM,UMR 1219, F-33000 Bordeaux, France
CHU Bordeaux, Dept Neurol, F-33000 Bordeaux, France
Claassen, JAHR:
Radboud Univ Nijmegen Med Ctr, Radboudumc Alzheimer Ctr, Dept Geriatr, Nijmegen, Netherlands
Donders Ctr Med Neurosci, Nijmegen, Netherlands
Debette, S:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Team VINTAGE, INSERM,UMR 1219, F-33000 Bordeaux, France
CHU Bordeaux, Dept Neurol, F-33000 Bordeaux, France
Boston Univ, Sch Med, Dept Neurol, Boston, MA USA
Deleuze, JF:
Univ Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, F-91057 Evry, France
de Deyn, PP:
Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands
Univ Med Ctr Groningen, Alzheimer Ctr Groningen, Groningen, Netherlands
Diehl-Schmid, J:
Tech Univ Munich, Ctr Cognit Disorders, Sch Med,Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, Munich, Germany
Kbo Inn Salzach Hosp, Wasserburg, Germany
Djurovic, S:
Oslo Univ Hosp, Dept Med Genet, Oslo, Norway
Univ Bergen, NORMENT Ctr, Dept Clin Sci, Bergen, Norway
Dols-Icardo, O:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
Dufouil, C:
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Team VINTAGE, INSERM,UMR 1219, F-33000 Bordeaux, France
Ctr Hosp Univ CHU Bordeaux, Pole Sante Publ, Bordeaux, France
Duron, E:
Univ Paris Saclay, Inserm 1178 MOODS, Paris, France
Duzel, E:
German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany
Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany
Fladby, T:
Univ Oslo, Inst Clin Med, Oslo, Norway
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
Fortea, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
Frolich, L:
Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Heidelberg, Germany
Garcia-Gonzalez, P:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Garcia-Martinez, M:
Univ Cantabria, Cognit Impairment Unit, Neurol Serv,Inst Res Marques de Valdecilla IDIVAL, Marques de Valdecilla Univ Hosp, Santander, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Giegling, I:
Med Univ Vienna, Dept Psychiat & Psychotherapy, Div Gen Psychiat, Vienna, Austria
Goldhardt, O:
Tech Univ Munich, Ctr Cognit Disorders, Sch Med,Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, Munich, Germany
Gobom, J:
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Grimmer, T:
Tech Univ Munich, Ctr Cognit Disorders, Sch Med,Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, Munich, Germany
Haapasalo, A:
Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland
Hampel, H:
Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Alzheimer Precis Med APM, Paris, France
Eisai Inc, Neurol Business Grp, 100 Tice Blvd, Woodcliff Lake, NJ 07677 USA
Hanon, O:
Univ Paris Cite, Maladie Alzheimer, EA4468, F-75013 Paris, France
Hop Broca, AP HP, Serv Geriatr, Ctr Memoire Ressources & Rech Ile France Broca, F-75013 Paris, France
Hausner, L:
Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Heidelberg, Germany
Heilmann-Heimbach, S:
Univ Bonn, Sch Med, Inst Human Genet, D-53127 Bonn, Germany
Univ Hosp Bonn, D-53127 Bonn, Germany
Helisalmi, S:
Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland
Heneka, MT:
Univ Hosp Bonn, Med Fac, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Hernandez, I:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Herukka, SK:
Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland
Holstege, H:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC Locat VUmc, Human Genet, Amsterdam, Netherlands
Jarholm, J:
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
Kern, S:
Univ Gothenburg, Sahlgrenska Acad, Neuropsychiat Epidemiol Unit,Ctr Ageing & Hlth AG, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Sahlgrens Univ Hosp, Psychiat Cognit & Old Age Psychiat Clin, Reg Vastra Gotaland, Gothenburg, Sweden
Knapskog, AB:
Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway
Koivisto, AM:
Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland
Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
Kornhuber, J:
Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany
Kuulasmaa, T:
Univ Eastern Finland, Bioinformat Ctr, Inst Biomed, Kuopio, Finland
Lage, C:
Univ Cantabria, Cognit Impairment Unit, Neurol Serv,Inst Res Marques de Valdecilla IDIVAL, Marques de Valdecilla Univ Hosp, Santander, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Calif San Francisco, Global Brain Hlth Inst GBHI, San Francisco, CA 94143 USA
Laske, C:
German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany
Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany
Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany
Leinonen, V:
Univ Eastern Finland, Inst Clin Med, Neurosurg, Kuopio, Finland
Kuopio Univ Hosp, Dept Neurosurg, Kuopio, Finland
Lewczuk, P:
Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany
Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland
Lleo, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
de Munain, AL:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Univ Donostia OSAKIDETZA, Donostia San Sebastian, Spain
Inst Biodonostia, San Sebastian, Spain
Univ Basque Country, San Sebastian, Spain
Lopez-Garcia, S:
Univ Cantabria, Cognit Impairment Unit, Neurol Serv,Inst Res Marques de Valdecilla IDIVAL, Marques de Valdecilla Univ Hosp, Santander, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Maier, W:
Univ Hosp Bonn, Med Fac, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Marquie, M:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Mol, MO:
Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Alzheimer Ctr Erasmus MC, Rotterdam, Netherlands
Montrreal, L:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Moreno, F:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Univ Donostia OSAKIDETZA, Donostia San Sebastian, Spain
Inst Biodonostia, San Sebastian, Spain
Moreno-Grau, S:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Nicolas, G:
Normandie Univ, Dept Genet, Inserm U1245, UNIROUEN, Rouen, France
Normandie Univ, Inserm U1245, UNIROUEN, CNR MAJ, Rouen, France
CHU Rouen, Rouen, France
Nothen, MM:
Univ Bonn, Sch Med, Inst Human Genet, D-53127 Bonn, Germany
Univ Hosp Bonn, D-53127 Bonn, Germany
Orellana, A:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Palhaugen, L:
Univ Oslo, Inst Clin Med, Oslo, Norway
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
Papma, JM:
Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Alzheimer Ctr Erasmus MC, Rotterdam, Netherlands
Pasquier, F:
Univ Lille, Inst Pasteur Lille, U1167 RID AGE Labex DISTALZ Facteurs Risque & Det, CHU Lille, F-59000 Lille, France
Perneczky, R:
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany
Munich Cluster Syst Neurol SyNergy Munich, Munich, Germany
Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England
Peters, O:
German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany
German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
Pijnenburg, YAL:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Popp, J:
Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland
Univ Zurich, Zurich, Switzerland
Univ Hosp Lausanne, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland
Posthuma, D:
Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands
Pozueta, A:
Univ Cantabria, Cognit Impairment Unit, Neurol Serv,Inst Res Marques de Valdecilla IDIVAL, Marques de Valdecilla Univ Hosp, Santander, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Priller, J:
German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
Charite, Dept Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany
Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, D-81675 Munich, Germany
Puerta, R:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Quintela, I:
Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Grp Med Xenom, Santiago De Compostela, Spain
Ramakers, I:
Maastricht Univ, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Rodriguez-Rodriguez, E:
Univ Cantabria, Cognit Impairment Unit, Neurol Serv,Inst Res Marques de Valdecilla IDIVAL, Marques de Valdecilla Univ Hosp, Santander, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Rujescu, D:
Med Univ Vienna, Dept Psychiat & Psychotherapy, Div Gen Psychiat, Vienna, Austria
Saltvedt, I:
Norwegian Univ Sci & Technol NTNU, Dept Neuromed & Movement Sci, Trondheim, Norway
Univ Hosp Trondheim, Dept Geriatr, St Olav Hosp, Trondheim, Norway
Sanchez-Juan, P:
Alzheimers Ctr Reina Sofia CIEN Fdn ISCIII, Madrid 28031, Spain
Scheltens, P:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Scherbaum, N:
Univ Duisburg Essen, LVR Hosp Essen, Med Fac, Dept Psychiat & Psychotherapy, Essen, Germany
Schmid, M:
Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany
Schneider, A:
Univ Hosp Bonn, Med Fac, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Selbaek, G:
Vestfold Hosp Trust, Norwegian Natl Ctr Ageing & Hlth, Tonsberg, Norway
Univ Oslo, Inst Clin Med, Oslo, Norway
Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway
Selnes, P:
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
Shadrin, A:
Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway
Div Mental Hlth, Oslo, Norway
Skoog, I:
Univ Gothenburg, Sahlgrenska Acad, Neuropsychiat Epidemiol Unit,Ctr Ageing & Hlth AG, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Sahlgrens Univ Hosp, Psychiat Cognit & Old Age Psychiat Clin, Reg Vastra Gotaland, Gothenburg, Sweden
Soininen, H:
Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland
Tarraga, L:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Teipel, S:
German Ctr Neurodegenerat Dis DZNE, Rostock, Germany
Rostock Univ Med Ctr, Dept Psychosomat Med, Gehlsheimer Str 20, D-18147 Rostock, Germany
Tijms, B:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Tsolaki, M:
Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Dept Neurol 1, Thessaloniki, Greece
Van Broeckhoven, C:
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
VIB, VIB Ctr Mol Neurol, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Van Dongen, J:
VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
van Swieten, JC:
Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Alzheimer Ctr Erasmus MC, Rotterdam, Netherlands
Vandenberghe, R:
Univ Hosp Leuven, Neurol, Leuven, Belgium
Leuven Brain Inst, Dept Neurosci, Lab Cognit Neurol, Leuven, Belgium
Vidal, JS:
Univ Paris Cite, Maladie Alzheimer, EA4468, F-75013 Paris, France
Visser, PJ:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Maastricht, Netherlands
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden
Vogelgsang, J:
Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
Harvard Med Sch, McLean Hosp, Dept Psychiat, Belmont, MA USA
Waern, M:
Univ Gothenburg, Sahlgrenska Acad, Neuropsychiat Epidemiol Unit,Ctr Ageing & Hlth AG, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Sahlgrens Univ Hosp, Psychosis Clin, Psychiat, Reg Vastra Gotaland, Gothenburg, Sweden
Wagner, M:
Univ Hosp Bonn, Med Fac, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Wiltfang, J:
Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
iBiMED, Med Sci Dept, Aveiro, Portugal
Wittens, MMJ:
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Vrije Univ Brussel, Ctr Neurosci C4N, Brussels, Belgium
Zetterberg, H:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
UCL Inst Neurol, Dept Neurodegenerat Dis, London, England
UK Dementia Res Inst UCL, London, England
Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China
Zulaica, M:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Univ Donostia OSAKIDETZA, Donostia San Sebastian, Spain
Inst Biodonostia, San Sebastian, Spain
van Duijn, CM:
ErasmusMC, Dept Epidemiol, Rotterdam, Netherlands
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Bjerke, M:
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Vrije Univ Brussel, Ctr Neurosci C4N, Brussels, Belgium
Univ Ziekenhuis Brussel, Lab Neurochem, Brussels, Belgium
Engelborghs, S:
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Vrije Univ Brussel, Ctr Neurosci C4N, Brussels, Belgium
Univ Ziekenhuis Brussel, Lab Neurochem, Brussels, Belgium
Univ Ziekenhuis Brussel, Dept Neurol, Brussels, Belgium
Jessen, F:
Univ Cologne, Univ Hosp Cologne, Cologne, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany
Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany
Teunissen, CE:
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Pastor, P:
Univ Hosp Germans Trias & Pujol, Dept Neurol, Unit Neurodegenerat Dis, Barcelona, Spain
Germans Trias & Pujol Res Inst IGTP Badalona, Barcelona, Spain
Hiltunen, M:
Univ Eastern Finland, Inst Biomed, Kuopio, Finland
Ingelsson, M:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Rudbeck Lab, Mol Geriatr, Uppsala, Sweden
Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada
Univ Toronto, Dept Med, Toronto, ON, Canada
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Andreassen, OA:
Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway
Div Mental Hlth, Oslo, Norway
Oslo Univ Hosp, Addict, N-0407 Oslo, Norway
Clarimon, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Inst Invest Biomed St Pau,Hosp St Pau, Barcelona, Spain
Sleegers, K:
VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Ruiz, A:
Univ Int Catalunya, Res Ctr, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Ramirez, A:
Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany
Univ Cologne, Univ Hosp Cologne, Cologne, Germany
Univ Hosp Bonn, Med Fac, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany
Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, Dept Psychiat, San Antonio, TX USA
Cruchaga, C:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Washington Univ, Sch Med, NeuroGen & Informat, St Louis, MO USA
Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO USA
Lambert, JC:
Univ Lille, Inst Pasteur Lille, U1167 RID AGE Labex DISTALZ Facteurs Risque & Det, CHU Lille, F-59000 Lille, France
van der Flier, W:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC Locat VUmc, Neurol, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Green Submitted, Green Published, hybrid, Hybrid Gold, Green
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