Protein scaffolds in human clinics
Por:
Cano-Garrido, O, Serna, N, Unzueta, U, Parlad, E, Mangues, R, Villaverde, A, Vazquez, E
Publicada:
1 dic 2022
Resumen:
Fundamental clinical areas such as drug delivery and regenerative medicine require biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers. Among the wide set of emerging biomaterials, polypeptides offer enticing properties over alternative polymers, including full biocompatibility, biodegradability, precise interactivity, structural stability and conformational and functional versatility, all of them tunable by conventional protein engineering. However, proteins from non-human sources elicit immunotoxicities that might bottleneck further development and narrow their clinical applicability. In this context, selecting human proteins or developing humanized protein versions as building blocks is a strict demand to design nonimmunogenic protein materials. We review here the expanding catalogue of human or humanized proteins tailored to execute different levels of scaffolding functions and how they can be engineered as self-assembling materials in form of oligomers, polymers or complex networks. In particular, we emphasize those that are under clinical development, revising their fields of applicability and how they have been adapted to offer, apart from mere mechanical support, highly refined functions and precise molecular interactions.
Filiaciones:
Cano-Garrido, O:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Barcelona 08193, Spain
Serna, N:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Barcelona 08193, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Barcelona 08193, Spain
Univ Autonoma Barcelona, Barcelona 08193, Spain
Unzueta, U:
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Barcelona 08193, Spain
Univ Auto noma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona 08193, Spain
Biomed Res Inst St Pau IIB St Pau, Barcelona 08025, Spain
Josep Carreras Leukaemia Res Inst, Barcelona 08916, Spain
Parlad, E:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Barcelona 08193, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Barcelona 08193, Spain
Josep Carreras Leukaemia Res Inst, Barcelona 08916, Spain
Mangues, R:
Biomed Res Inst St Pau IIB St Pau, Barcelona 08025, Spain
Josep Carreras Leukaemia Res Inst, Barcelona 08916, Spain
Villaverde, A:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Barcelona 08193, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Barcelona 08193, Spain
Univ Auto noma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona 08193, Spain
Vazquez, E:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Barcelona 08193, Spain
hybrid, Green Published
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