Matched unrelated donor stem cell transplant in 131 patients with follicular lymphoma: an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
Por:
Avivi, I, Montoto, S, Canals, C, Maertens, J, Al-Ali, H, Mufti, GJ, Finke, J, Schattenberg, A, Fanin, R, Cornelissen, JJ, Vernant, JP, Russell, N, Beguin, Y, Thomson, K, Verdonck, LF, Kobbe, G, Tilly, H, Socie, G, Sureda, A
Publicada:
1 dic 2009
Resumen:
P>Matched unrelated donor stem cell transplantation (MUD-SCT) provides the only curative option for patients with follicular lymphoma (FL) who fail conventional therapies and do not have a sibling donor. The purpose of this study was to analyse the outcome of patients with FL treated with MUD-SCT included in the European Group for Blood and Marrow Transplantation registry. 131 patients treated with reduced-intensity conditioning (RIC, n = 87) or conventional myeloablative (CONV, n = 44) MUD-SCT between 2000 and 2005 were included. Median time from diagnosis to MUD-SCT was 47 months and the median number of previous therapeutic regimens was 4 (previous autograft: 47%). RIC recipients were significantly older, with a longer interval from diagnosis to MUD-SCT and had failed a previous autograft more frequently than CONV recipients. Non-relapse mortality (NRM) was 24% and 30% at 100-d and 1-year, respectively. After a median follow-up of 36 months, 17% of the patients developed disease progression, the 3-year progression-free survival (PFS) being 47%. Three-year overall survival (OS) for the whole series was 51%. On multivariate analysis, RIC regimens were associated with at lower NRM and a significantly longer PFS and OS. This retrospective study demonstrated that MUD-SCT results, even in heavily pre-treated populations, in a meaningful PFS and OS.
Filiaciones:
Avivi, I:
Rambam Med Ctr, Dept Hematol & Bone Marrow Transplantat, IL-31096 Haifa, Israel
Technion Israel Inst Technol, Haifa, Israel
Montoto, S:
St Bartholomews Hosp, London, England
Canals, C:
Technion Israel Inst Technol, Haifa, Israel
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Maertens, J:
Univ Hosp Gasthuisberg, B-3000 Leuven, Belgium
Al-Ali, H:
Univ Hosp Leipzig, Leipzig, Germany
Mufti, GJ:
GKT Sch Med, London, England
Finke, J:
Univ Freiburg, Freiburg, Germany
Schattenberg, A:
Radboud Univ Nijmegen, Nijmegen Med Ctr, NL-6525 ED Nijmegen, Netherlands
Fanin, R:
Univ Hosp, Udine, Italy
Cornelissen, JJ:
Erasmus MC, Daniel Hoed Canc Ctr, Rotterdam, Netherlands
Vernant, JP:
Grp Hosp Pitie Salpetriere, Paris, France
Russell, N:
City Hosp Nottingham, Nottingham, England
Beguin, Y:
Univ Liege, Liege, Belgium
Thomson, K:
Univ Coll London Hosp, London, England
Verdonck, LF:
Univ Med Ctr, Utrecht, Netherlands
Kobbe, G:
Univ Dusseldorf, Dusseldorf, Germany
Tilly, H:
Ctr Henri Becquerel, F-76038 Rouen, France
Socie, G:
Hop St Louis, Paris, France
Sureda, A:
Technion Israel Inst Technol, Haifa, Israel
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Bronze
|