Efficacy and safety of pallidal stimulation in primary dystonia: results of the Spanish multicentric study
Por:
Valldeoriola, F, Regidor, I, Minguez-Castellanos, A, Lezcano, E, Garcia-Ruiz, P, Rojo, A, Salvador, A, Castro, A, Grandas, F, Kulisevsky, J, Marti, MJ, Martinez-Martin, P, Relova, L, Rumia, J, Camara, A, Burguera, JA, Linazasoro, G, de Val, JL, Obeso, J, Rodriguez-Oroz, MC, Tolosa, E
Publicada:
10 ene 2010
Resumen:
Background: Dystonia is a complex clinical syndrome originated by a wide range of aetiologies. The diagnosis of dystonia is made after the evaluation of aetiological, phenomenological and genetic factors.(1) Medications, except in patients with dopa-responsive dystonia, are of limited efficacy. Botulinum toxin injections are not applicable to patients with generalised dystonia, since many muscular groups contribute to disability.(2) Clinical studies in children and adults with primary generalised dystonia (PGD) have reported beneficial effects of bilateral GPi deep brain stimulation (DBS) in both motor symptoms and disability produced by dystonia(3-5) as well as a favourable impact of DBS in the health-related quality of life (HRQoL).(6) Some clinical aspects of GPi stimulation in primary dystonia still remain controversial such as the influence of disease duration or age at onset in determining the postoperative clinical outcome.
Results: The authors report the results of a multicentric study designed to assess the tolerability and clinical effects of bilateral pallidal DBS on motor impairment, functional disability, quality of life, pain and mood in patients with medically refractory primary generalised or segmental dystonia.
Filiaciones:
Valldeoriola, F:
Univ Barcelona, Hosp Clin, E-08036 Barcelona, Spain
Regidor, I:
Hosp Ramon & Cajal, E-28034 Madrid, Spain
Minguez-Castellanos, A:
Hosp Univ Virgen Nieves, Granada, Spain
Lezcano, E:
Hosp Cruces, Baracaldo, Spain
Garcia-Ruiz, P:
Fdn Jimenez Diaz, E-28040 Madrid, Spain
Rojo, A:
Hosp Mutua Terrassa, Terrassa, Spain
Salvador, A:
Hosp Clin, Valencia, Spain
Castro, A:
Univ Hosp, Santiago De Compostela, Spain
Grandas, F:
Hosp Gen Gregorio Maranon, Madrid, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Marti, MJ:
Univ Barcelona, Hosp Clin, E-08036 Barcelona, Spain
Martinez-Martin, P:
Inst Salud Carlos III, CIBERNED, Inst Nacl Epidemiol, Madrid, Spain
Relova, L:
Univ Hosp, Santiago De Compostela, Spain
Rumia, J:
Univ Barcelona, Hosp Clin, E-08036 Barcelona, Spain
Camara, A:
Univ Barcelona, Hosp Clin, E-08036 Barcelona, Spain
Burguera, JA:
Hosp La Fe, E-46009 Valencia, Spain
Linazasoro, G:
Clin Donosti, San Sebastian, Spain
de Val, JL:
Hosp Clin, Zaragoza, Spain
Obeso, J:
Univ Navarra Clin, Madrid, Spain
Rodriguez-Oroz, MC:
Univ Navarra Clin, Madrid, Spain
Tolosa, E:
Univ Barcelona, Hosp Clin, E-08036 Barcelona, Spain
Open Access
|