Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
Por:
Dohner, H, Estey, EH, Amadori, S, Appelbaum, FR, Buchner, T, Burnett, AK, Dombret, H, Fenaux, P, Grimwade, D, Larson, RA, Lo-Coco, F, Naoe, T, Niederwieser, D, Ossenkoppele, GJ, Sanz, MA, Sierra, J, Tallman, MS, Lowenberg, B, Bloomfield, CD
Publicada:
21 ene 2010
Resumen:
In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. (Blood. 2010; 115: 453-474)
Filiaciones:
Dohner, H:
Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany
Estey, EH:
Seattle Canc Ctr Alliance, Seattle, WA USA
Amadori, S:
Tor Vergata Univ Hosp, Dept Hematol, Rome, Italy
Appelbaum, FR:
Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Buchner, T:
Univ Munster, Dept Hematol Oncol, Munster, Germany
Burnett, AK:
Cardiff Univ, Dept Haematol, Cardiff CF4 4XN, S Glam, Wales
Dombret, H:
Hop St Louis, AP HP, Inst Univ Hematol, Paris, France
Fenaux, P:
Hop Avicenne, Serv Hematol Clin, F-93009 Bobigny, France
Grimwade, D:
Guys Kings & St Thomas Sch Med, Dept Med & Mol Genet, London, England
Larson, RA:
Univ Chicago, Dept Med, Chicago, IL 60637 USA
Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA
Lo-Coco, F:
Univ Tor Vergata, Dept Biopathol, Rome, Italy
Ctr Europeo Ric Cervello, Santa Lucia Fdn, Rome, Italy
Naoe, T:
Nagoya Univ Hosp, Dept Hematol, Showa Ku, Nagoya, Aichi, Japan
Niederwieser, D:
Univ Leipzig, Dept Hematol Oncol & Hemostasis, Leipzig, Germany
Ossenkoppele, GJ:
Vrije Univ Amsterdam, Med Ctr, Dept Haematol, Amsterdam, Netherlands
Sanz, MA:
Univ Hosp La Fe, Hematol & Bone Marrow Transplant Unit, Valencia, Spain
Sierra, J:
Hosp Santa Creu & Sant Pau, Dept Clin Hematol, Barcelona, Spain
Tallman, MS:
Northwestern Univ, Div Hematol Oncol, Feinberg Sch Med, Chicago, IL 60611 USA
Lowenberg, B:
Erasmus Univ, Med Ctr, Dept Hematol, Rotterdam, Netherlands
Bloomfield, CD:
Ohio State Univ, Ctr Comprehens Canc, Arthur G James Canc Hosp, Columbus, OH 43210 USA
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