Immune response to the 23-valent polysaccharide pneumococcal vaccine after the 7-valent conjugate vaccine in allogeneic stem cell transplant recipients: Results from the EBMT IDWP01 trial
Por:
Cordonnier, C, Labopin, M, Chesnel, V, Ribaud, P, De La Camara, R, Martino, R, Ullmann, AJ, Parkkali, T, Locasciulli, A, Yakouben, K, Pauksens, K, Bonnet, E, Einsele, H, Niederwieser, D, Apperley, J, Ljungman, P
Publicada:
24 mar 2010
Resumen:
The current recommendations for active immunization after stem cell transplant (SCT) include 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7) from 3 months after transplant, followed by a 23-valent polysaccharide pneumococcal vaccine (PPV23). However, until now, the immune response to PPV23 after PCV7 has not been assessed after SCT. In the EBMT IDWP01 trial, 101 patients received 1 dose of PPV23 at 12 or 18 months, both after 3 doses of PCV7. The efficacy of PPV23 was assessed 1 month later and at 24 months after transplant by the pneumococcal serotype 1 and 5 antibody levels. Serotype 1 and 5 are not included in PCV7. Although the geometric mean concentrations were significantly higher 1 month after PPV23, for both antigens, the response rates (>= 0.15 mu g/mL), in the range of 68-94%, were not different between groups independent of the assessment date. One PPV23 dose after 3 PCV7 doses, already known to increase the response to PCV7, also extends the serotype coverage given 12 or 18 months after transplant. (C) 2010 Elsevier Ltd. All rights reserved.
Filiaciones:
Cordonnier, C:
Henri Mondor Teaching Hosp, AP HP, Dept Hematol, F-94010 Creteil, France
Univ Paris 12, F-94010 Creteil, France
Labopin, M:
Univ Paris 06, EBMT Data & Study Off, UMR S 893, AP HP,INSERM,St Antoine Teaching Hosp,Grp 14, F-75571 Paris, France
Chesnel, V:
Univ Paris 06, EBMT Data & Study Off, UMR S 893, AP HP,INSERM,St Antoine Teaching Hosp,Grp 14, F-75571 Paris, France
Ribaud, P:
St Louis Teaching Hosp, Hematol & Bone Marrow Transplant Dept, AP HP, Paris, France
Univ Paris 07, Paris, France
De La Camara, R:
Princesa Teaching Hosp, Dept Hematol, Madrid, Spain
Martino, R:
St Pau Teaching Hosp, Dept Hematol, Barcelona, Spain
Ullmann, AJ:
Johannes Gutenberg Univ Mainz, Univ Med, Mainz, Germany
Parkkali, T:
Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland
Locasciulli, A:
San Camillo Teaching Hosp, Rome, Italy
Yakouben, K:
Robert Debre Teaching Hosp, Dept Hematol, Paris, France
Pauksens, K:
Univ Uppsala Hosp, Div Infect Dis, Uppsala, Sweden
Bonnet, E:
Wyeth Pharmaceut Med Dept, F-92301 Puteaux Paris La Def, France
Einsele, H:
Univ Hosp, Dept Internal Med, Wurzburg, Germany
Niederwieser, D:
Univ Hosp, Div Internal Med 2, Leipzig, Germany
Apperley, J:
Hammersmith Teaching Hosp, Dept Haematol, London, England
Ljungman, P:
Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden
Karolinska Inst, Stockholm, Sweden
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