State of the art in therapeutic drug monitoring
Por:
Fernandez, EL, Pares, L, Ajuria, I, Bandres, F, Castanyer, B, Campos, F, Farre, C, Pou, L, Queralto, JM, To-Figueras, J
Publicada:
1 abr 2010
Resumen:
Therapeutic drug monitoring (TDM) is a multidisciplinary activity. Because laboratory reports are part of the patient's chart, some clinical information is required. In order to guarantee quality and safety, an increasing number of TDM departments have implemented a quality management system. The aim of the present article is to review the three phases of TDM: the pre-analytical, analytical and post-analytical phases. In the pre-analytical phase, it is necessary to acquire a valid specimen collected at the specific time window. Analytical methods should be validated, assessing possible interfering substances. The objective of the post-analytical phase is the final report, which should include correct interpretation, as well as possible advice. Appropriate pharmacokinetic interpretation avoids unnecessary costs and leads to clinical benefits. Clin Chem Lab Med 2010;48:437-46.
Filiaciones:
Fernandez, EL:
Hosp V Alvarez Buylla, Serv Anal Clin, Mieres 33006, Asturias, Spain
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Pares, L:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Hosp Univ Doce de Octubre, Serv Bioquim Clin, Madrid, Spain
Ajuria, I:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Hosp Galdakao Usansolo, Serv Anal Clin, Galdakao, Vizcaya, Spain
Bandres, F:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Univ Complutense Madrid, Fac Med, Madrid, Spain
Castanyer, B:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Hosp Univ Son Dureta, Serv Anal Clin, Palma de Mallorca, Spain
Campos, F:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
UDIAT CD, Corp Sanit Parc Tauli, Serv Lab, Barcelona, Spain
Farre, C:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Hosp Univ St Joan de Deu, Serv Bioquim, Barcelona, Spain
Pou, L:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Hosp Univ Vall dHebron, Clin Labs, Barcelona, Spain
Queralto, JM:
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Hosp Santa Creu & Sant Pau, Serv Bioquim, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
To-Figueras, J:
Hosp V Alvarez Buylla, Serv Anal Clin, Mieres 33006, Asturias, Spain
Soc Espanola Quim Clin, Comis Monitorizac Farmacos & Toxicol Clin, Madrid, Spain
Hosp Clin Barcelona, Serv Bioquim Clin, Barcelona, Spain
|