Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
Por:
Gretarsdottir, S, Baas, AF, Thorleifsson, G, Holm, H, den Heijer, M, de Vries, JPPM, Kranendonk, SE, Zeebregts, CJAM, van Sterkenburg, SM, Geelkerken, RH, van Rij, AM, Williams, MJA, Boll, APM, Kostic, JP, Jonasdottir, A, Jonasdottir, A, Walters, GB, Masson, G, Sulem, P, Saemundsdottir, J, Mouy, M, Magnusson, KP, Tromp, G, Elmore, JR, Sakalihasan, N, Limet, R, Defraigne, JO, Ferrell, RE, Ronkainen, A, Ruigrok, YM, Wijmenga, C, Grobbee, DE, Shah, SH, Granger, CB, Quyyumi, AA, Vaccarino, V, Patel, RS, Zafari, AM, Levey, AI, Austin, H, Girelli, D, Pignatti, PF, Olivieri, O, Martinelli, N, Malerba, G, Trabetti, E, Becker, LC, Becker, DM, Reilly, MP, Rader, DJ, Mueller, T, Dieplinger, B, Haltmayer, M, Urbonavicius, S, Lindblad, B, Gottsater, A, Gaetani, E, Pola, R, Wells, P, Rodger, M, Forgie, M, Langlois, N, Corral, J, Vicente, V, Fontcuberta, J, Espana, F, Grarup, N, Jorgensen, T, Witte, DR, Hansen, T, Pedersen, O, Aben, KK, de Graaf, J, Holewijn, S, Folkersen, L, Franco-Cereceda, A, Eriksson, P, Collier, DA, Stefansson, H, Steinthorsdottir, V, Rafnar, T, Valdimarsson, EM, Magnadottir, HB, Sveinbjornsdottir, S, Olafsson, I, Magnusson, MK, Palmason, R, Haraldsdottir, V, Andersen, K, Onundarson, PT, Thorgeirsson, G, Kiemeney, LA, Powell, JT, Carey, DJ, Kuivaniemi, H, Lindholt, JS, Jones, GT, Kong, A, Blankensteijn, JD, Matthiasson, SE, Thorsteinsdottir, U, Stefansson, K
Publicada:
1 ago 2010
Resumen:
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
Filiaciones:
Gretarsdottir, S:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Baas, AF:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Thorleifsson, G:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Holm, H:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
den Heijer, M:
Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Dept Endocrinol, NL-6525 ED Nijmegen, Netherlands
de Vries, JPPM:
St Antonius Hosp, Dept Vasc Surg, Nieuwegein, Netherlands
Kranendonk, SE:
TweeSteden Hosp Tilburg, Dept Surg, Tilburg, Netherlands
Zeebregts, CJAM:
Univ Med Ctr Groningen, Dept Surg, NL-9713 AV Groningen, Netherlands
van Sterkenburg, SM:
Locat Rijnstate, Alysis Zorggroep, Div Vasc Surg, Dept Surg, Arnhem, Netherlands
Geelkerken, RH:
Med Spectrum Twente, Dept Surg, Enschede, Netherlands
van Rij, AM:
Univ Otago, Dunedin Sch Med, Dept Surg, Dunedin, New Zealand
Williams, MJA:
Univ Otago, Dunedin Sch Med, Dept Med, Dunedin, New Zealand
Boll, APM:
Canisius Wilhelmina Hosp Nijmegen, Dept Surg, Nijmegen, Netherlands
Kostic, JP:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Jonasdottir, A:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Jonasdottir, A:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Walters, GB:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Masson, G:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Sulem, P:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Saemundsdottir, J:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Mouy, M:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Magnusson, KP:
Univ Akureyri, Borgir Vid Nordurslod, Akureyri, Iceland
Tromp, G:
Weis Ctr Res, Geisinger Clin, Weis Ctr Res, Danville, PA 17822 USA
Elmore, JR:
Weis Ctr Res, Geisinger Clin, Dept Vasc Surg, Danville, PA 17822 USA
Sakalihasan, N:
Univ Liege, Liege, Belgium
Limet, R:
Univ Liege, Liege, Belgium
Defraigne, JO:
Univ Liege, Liege, Belgium
Ferrell, RE:
Univ Pittsburgh, Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15260 USA
Ronkainen, A:
Kuopio Univ Hosp, Dept Neurosurg, SF-70210 Kuopio, Finland
Ruigrok, YM:
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, Netherlands
Wijmenga, C:
Univ Med Ctr Groningen, Dept Genet, NL-9713 AV Groningen, Netherlands
Univ Groningen, Groningen, Netherlands
Grobbee, DE:
Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Shah, SH:
Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USA
Granger, CB:
Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27710 USA
Quyyumi, AA:
Emory Univ, Sch Med, Atlanta, GA USA
Vaccarino, V:
Emory Univ, Sch Med, Atlanta, GA USA
Patel, RS:
Emory Univ, Sch Med, Atlanta, GA USA
Cardiff Univ, Cardiff, S Glam, Wales
Zafari, AM:
Emory Univ, Sch Med, Atlanta, GA USA
Atlanta Vet Affairs Med Ctr, Decatur, GA USA
Levey, AI:
Emory Univ, Sch Med, Atlanta, GA USA
Austin, H:
Emory Univ, Sch Publ Hlth, Atlanta, GA USA
Girelli, D:
Univ Verona, Dept Med, Sect Internal Med, I-37100 Verona, Italy
Pignatti, PF:
Univ Verona, Dept Life & Reprod Sci, Sect Biol & Genet, I-37100 Verona, Italy
Olivieri, O:
Univ Verona, Dept Med, Sect Internal Med, I-37100 Verona, Italy
Martinelli, N:
Univ Verona, Dept Med, Sect Internal Med, I-37100 Verona, Italy
Malerba, G:
Univ Verona, Dept Life & Reprod Sci, Sect Biol & Genet, I-37100 Verona, Italy
Trabetti, E:
Univ Verona, Dept Life & Reprod Sci, Sect Biol & Genet, I-37100 Verona, Italy
Becker, LC:
Johns Hopkins Univ, Sch Med, Johns Hopkins GeneSTAR Res Program, Baltimore, MD USA
Becker, DM:
Johns Hopkins Univ, Sch Med, Johns Hopkins GeneSTAR Res Program, Baltimore, MD USA
Reilly, MP:
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Rader, DJ:
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Mueller, T:
Konventhosp Barmherzige Brueder, Dept Lab Med, Linz, Austria
Dieplinger, B:
Konventhosp Barmherzige Brueder, Dept Lab Med, Linz, Austria
Haltmayer, M:
Konventhosp Barmherzige Brueder, Dept Lab Med, Linz, Austria
Urbonavicius, S:
Viborg Hosp, Vasc Res Unit, Viborg, Denmark
Lindblad, B:
Skaane Univ Hosp, Vasc Ctr, Malmo, Sweden
Gottsater, A:
Skaane Univ Hosp, Vasc Ctr, Malmo, Sweden
Gaetani, E:
Catholic Univ, Lab Vasc Biol & Genet, A Gemelli Univ Hosp, Sch Med,Dept Med, Rome, Italy
Pola, R:
Catholic Univ, Lab Vasc Biol & Genet, A Gemelli Univ Hosp, Sch Med,Dept Med, Rome, Italy
Tufts Univ, Sch Med, Dept Med, Div Cardiovasc Res,Caritas St Elizabeths Med Ctr, Boston, MA 02111 USA
Wells, P:
Ottawa Hosp, Dept Med, Ottawa, ON, Canada
Rodger, M:
Ottawa Hosp, Div Hematol, Ottawa, ON, Canada
Forgie, M:
Univ Ottawa, Fac Med, Ottawa, ON, Canada
Langlois, N:
Ottawa Hosp Res Inst, Ottawa, ON, Canada
Corral, J:
Univ Murcia, Dept Med, Ctr Reg Hemodonac, Murcia, Spain
Vicente, V:
Univ Murcia, Dept Med, Ctr Reg Hemodonac, Murcia, Spain
Fontcuberta, J:
Santa Creu & St Pau Hosp, Hemostasia & Thrombosis Unit, Barcelona, Spain
Espana, F:
Hosp La Fe, Res Ctr, E-46009 Valencia, Spain
Grarup, N:
Hagedorn Res Inst, Gentofte, Denmark
Jorgensen, T:
Glostrup Cty Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Univ Copenhagen, Fac Hlth Sci, DK-1168 Copenhagen, Denmark
Witte, DR:
Steno Diabet Ctr, DK-2820 Gentofte, Denmark
Hansen, T:
Hagedorn Res Inst, Gentofte, Denmark
Univ So Denmark, Odense, Denmark
Pedersen, O:
Hagedorn Res Inst, Gentofte, Denmark
Univ Copenhagen, Inst Biomed Sci, DK-1168 Copenhagen, Denmark
Aben, KK:
Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands
Comprehens Canc Ctr E, Nijmegen, Netherlands
Radboud Univ Nijmegen, Dept Gen Internal Med, Med Ctr, NL-6525 ED Nijmegen, Netherlands
Folkersen, L:
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Atherosclerosis Res Unit, Stockholm, Sweden
Franco-Cereceda, A:
Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Cardiothorac Surg Unit, Stockholm, Sweden
Eriksson, P:
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Atherosclerosis Res Unit, Stockholm, Sweden
Collier, DA:
Kings Coll London, Div Psychol Med & Social Genet, London WC2R 2LS, England
Kings Coll London, Dev Psychiat Ctr, Inst Psychiat, London WC2R 2LS, England
Stefansson, H:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Steinthorsdottir, V:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Rafnar, T:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Valdimarsson, EM:
Landspitali Univ Hosp, Reykjavik, Iceland
Magnadottir, HB:
Upper Valley Neurol Neurosurg, Lebanon, NH USA
Sveinbjornsdottir, S:
Landspitali Univ Hosp, Reykjavik, Iceland
Olafsson, I:
Landspitali Univ Hosp, Reykjavik, Iceland
Magnusson, MK:
Landspitali Univ Hosp, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Palmason, R:
Landspitali Univ Hosp, Reykjavik, Iceland
Haraldsdottir, V:
Landspitali Univ Hosp, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Andersen, K:
Landspitali Univ Hosp, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Onundarson, PT:
Landspitali Univ Hosp, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Thorgeirsson, G:
Landspitali Univ Hosp, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Kiemeney, LA:
Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands
Powell, JT:
Imperial Coll Charing Cross, London, England
Carey, DJ:
Weis Ctr Res, Geisinger Clin, Weis Ctr Res, Danville, PA 17822 USA
Kuivaniemi, H:
Weis Ctr Res, Geisinger Clin, Weis Ctr Res, Danville, PA 17822 USA
Lindholt, JS:
Viborg Hosp, Vasc Res Unit, Viborg, Denmark
Jones, GT:
Univ Otago, Dunedin Sch Med, Dept Surg, Dunedin, New Zealand
Kong, A:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Blankensteijn, JD:
VU Med Ctr Amsterdam, Div Surg, Amsterdam, Netherlands
Radboud Univ Nijmegen, Med Ctr, Dept Vasc Surg, NL-6525 ED Nijmegen, Netherlands
Matthiasson, SE:
Univ Iceland, Fac Med, Reykjavik, Iceland
Thorsteinsdottir, U:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Stefansson, K:
DeCODE Genet, Populat Genom, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Green Accepted
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