Maturity onset diabetes of the young and pregnancy
Por:
Colom, C, Corcoy, R
Publicada:
1 ago 2010
Resumen:
Three and a half decades after the clinical description of "Maturity Onset Diabetes of the Young" (MODY), and despite its low prevalence, important knowledge has been gathered concerning its genetic basis, molecular pathways, clinical phenotypes and pharmacogenetic issues. This knowledge has proved to be important not only for the attention of subjects carrying a mutation but also for the insight provided in Type 2 diabetes mellitus.
In recent years, a shift from the term "MODY" to "monogenic diabetes" has taken place, the latter term being a better and more comprehensive descriptor. We stick to the "old" term because information on other types of monogenic diabetes and pregnancy is scarce. In this review we perform an overview of the entity, the prevalence rates reported in women with gestational diabetes mellitus and the specific impact of each type on pregnancy outcome. (C) 2010 Elsevier Ltd. All rights reserved.
Filiaciones:
Colom, C:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Serv Endocrinol & Nutr, Barcelona 08025, Spain
Corcoy, R:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Serv Endocrinol & Nutr, Barcelona 08025, Spain
Inst Salud Carlos III, CIBER Bioengn Biomat & Nanotechnol, Madrid, Spain
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