The Prognosis of Noncutaneous, Nonlymphomatous Malignancy After Heart Transplantation: Data From the Spanish Post-Heart Transplant Tumour Registry
Por:
Crespo-Leiro, MG, Alonso-Pulpon, LA, Villa-Arranz, A, Brossa-Loidi, V, Almenar-Bonet, L, Gonzalez-Vilchez, F, Delgado-Jimenez, JF, Manito-Lorite, N, Diaz-Molina, B, Rabago, G, Arizon-del Prado, JM, Romero-Rodriguez, N, Brossa, V, Blasco-Peiro, T, Pascual-Figal, D, de la Fuente-Galan, L, Muniz-Garcia, J
Publicada:
1 oct 2010
Resumen:
Introduction. Malignancy is a major complication in the management of solid organ transplant patients. Skin cancers show a better prognosis than other neoplasms, but not all others are equal: Ideally, patient management must take into account the natural history of each type of cancer in relation to the transplanted organs. We sought to determine the prognosis of various groups of noncutaneous nonlymphomatous (NCNL) cancers after heart transplantation (HT).
Methods. We retrospectively analyzed the records of the Spanish Post-Heart-Transplant Tumour Registry, which collects data on posttransplant tumors in all patients who have undergone HT in Spain since 1984. Data were included in the study up to December 2008. We considered only the first NCNL post-HT tumors.
Results. Of 4359 patients, 375 developed an NCNL cancer. The most frequent were cancers of the lung (11 = 97; 25.9%); gastrointestinal tract (n = 52; 13.9%); prostate gland (n = 47; 12.5%; 14.0% of men), bladder (n = 32; 8.5%), liver (n = 14; 3.7%), and pharynx (n = 14; 3.7%), as well as Kaposi's sarcoma (n = 11; 2.9%). The corresponding Kaplan-Meier survival curves differed significantly (P < .0001; log-rank test), with respective survival rates of 47%, 72%, 91%, 73%, 36%, 64%, and 73% at 1 year versus 26%, 62%, 89%, 56%, 21%, 64%, and 73% at 2 years; and 15%, 51%, 77%, 42%, 21%, 64%, and 52% at 5 years post-diagnosis, respectively.
Conclusion. Mortality among HT patients with post-HT NCNL solid organ cancers was highest for cancers of the liver or lung (79%-85% at 5 years), and lowest for prostate cancer (23%).
Filiaciones:
Crespo-Leiro, MG:
H A Coruna, Serv Cardiol, La Coruna, Spain
Alonso-Pulpon, LA:
H Puerta Hierro, Serv Cardiol, Madrid, Spain
Villa-Arranz, A:
H Gregorio Maranon, Serv Cardiol, Madrid, Spain
Brossa-Loidi, V:
H St Pau I St Creu, Serv Cardiol, Barcelona, Spain
Almenar-Bonet, L:
H La Fe, Serv Cardiol, Valencia, Spain
Gonzalez-Vilchez, F:
H Valdecilla, Serv Cardiol, Santander, Spain
Delgado-Jimenez, JF:
H 12 Octubre, Serv Cardiol, Madrid, Spain
Manito-Lorite, N:
H Bellvitge, Serv Cardiol, Barcelona, Spain
Diaz-Molina, B:
H Cent Asturias, Serv Cardiol, Oviedo, Spain
Rabago, G:
C Navarra, Serv Cardiol, Pamplona, Spain
Arizon-del Prado, JM:
H Reina Sofia, Serv Cardiol, Cordoba, Spain
Romero-Rodriguez, N:
H Virgen del Rocio, Serv Cardiol, Seville, Spain
Brossa, V:
H Clin I Prov, Serv Cardiol, Barcelona, Spain
Blasco-Peiro, T:
H Miguel Servet, Serv Cardiol, Zaragoza, Spain
Pascual-Figal, D:
H Virgen de la Arrixaca, Serv Cardiol, Murcia, Spain
de la Fuente-Galan, L:
H Valladolid, Serv Cardiol, Valladolid, Spain
Muniz-Garcia, J:
Univ A Coruna, Inst Univ Ciencias Salud, La Coruna, Spain
Open Access
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