Genetic damage in chronic renal failure patients is associated with the glomerular filtration rate index
Por:
Sandoval, SB, Stoyanova, E, Coll, E, Pastor, S, Reyes, J, Andres, E, Ballarin, J, Xamena, N, Marcos, R
Publicada:
1 nov 2010
Resumen:
Chronic renal failure (CRF) patients are considered to present genomic instability and, as a consequence, elevated levels of genetic damage. An open question is whether this damage is related to the stage of the pathology. To determine the background levels of genetic damage, a large population of 258 Caucasian adults (201 CRF patients and 57 controls) was analysed using the micronucleus (MN) assay. The frequency of MN in CRF patients was significantly higher than in controls and correlated with the progression of the disease, according to the glomerular filtration rate. In addition, a significant association was observed between genetic damage and serum creatinine levels. Genetic damage, measured as frequency of MN, increases when renal function decreases. The fact that an increased level of MN is already observed in patients' Stage 2 seems to indicate a genetic predisposition on these patients. Nevertheless, part of the observed damage can be attributed to the uraemic state itself.
Filiaciones:
Sandoval, SB:
Univ Autonoma Barcelona, Grp Mutagenesi, Dept Genet & Microbiol, Bellaterra 08193, Cerdanyola Vall, Spain
Stoyanova, E:
Univ Autonoma Barcelona, Grp Mutagenesi, Dept Genet & Microbiol, Bellaterra 08193, Cerdanyola Vall, Spain
Coll, E:
Fundacio Puigvert, Dept Dialisis, Barcelona 08025, Spain
Pastor, S:
Univ Autonoma Barcelona, Grp Mutagenesi, Dept Genet & Microbiol, Bellaterra 08193, Cerdanyola Vall, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ, Madrid, Spain
Reyes, J:
Fundacio Puigvert, Dept Dialisis, Barcelona 08025, Spain
Andres, E:
Fundacio Puigvert, Dept Dialisis, Barcelona 08025, Spain
Ballarin, J:
Fundacio Puigvert, Dept Dialisis, Barcelona 08025, Spain
Xamena, N:
Univ Autonoma Barcelona, Grp Mutagenesi, Dept Genet & Microbiol, Bellaterra 08193, Cerdanyola Vall, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ, Madrid, Spain
Marcos, R:
Univ Autonoma Barcelona, Grp Mutagenesi, Dept Genet & Microbiol, Bellaterra 08193, Cerdanyola Vall, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ, Madrid, Spain
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