Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21
Por:
Scandurra, M, Mian, M, Greiner, TC, Rancoita, PMV, De Campos, CP, Chan, WC, Vose, JM, Chigrinova, E, Inghirami, G, Chiappella, A, Baldini, L, Ponzoni, M, Ferreri, AJM, Franceschetti, S, Gaidano, G, Montes-Moreno, S, Piris, MA, Facchetti, F, Tucci, A, Nomdedeu, JF, Lazure, T, Lambotte, O, Uccella, S, Pinotti, G, Pruneri, G, Martinelli, G, Young, KH, Tibiletti, MG, Rinaldi, A, Zucca, E, Kwee, I, Bertoni, F
Publicada:
1 nov 2010
Resumen:
P>Despite recent therapeutic improvements, the clinical course of diffuse large B-cell lymphoma (DLBCL) still differs considerably among patients. We conducted this retrospective multi-centre study to evaluate the impact of genomic aberrations detected using a high-density genome wide-single nucleotide polymorphism-based array on clinical outcome in a population of DLBCL patients treated with R-CHOP-21 (rituximab, cyclophosphamide, doxorubicine, vincristine and prednisone repeated every 21 d). 166 DNA samples were analysed using the GeneChip Human Mapping 250K NspI. Genomic anomalies were analysed regarding their impact on the clinical course of 124 patients treated with R-CHOP-21. Unsupervised clustering was performed to identify genetically related subgroups of patients with different clinical outcomes. Twenty recurrent genetic lesions showed an impact on the clinical course. Loss of genomic material at 8p23.1 showed the strongest statistical significance and was associated with additional aberrations, such as 17p- and 15q-. Unsupervised clustering identified five DLBCL clusters with distinct genetic profiles, clinical characteristics and outcomes. Genetic features and clusters, associated with a different outcome in patients treated with R-CHOP, have been identified by arrayCGH.
Filiaciones:
Scandurra, M:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Mian, M:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Azienda Osped S Maurizio, Div Haematol, Bolzano, Italy
Greiner, TC:
Univ Nebraska, Dept Pathol & Microbiol, Omaha, NE 68182 USA
Rancoita, PMV:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Ist Dalle Molle Studi Sullintelligenza Artificial, Manno, Switzerland
De Campos, CP:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Ist Dalle Molle Studi Sullintelligenza Artificial, Manno, Switzerland
Chan, WC:
Univ Nebraska, Dept Pathol & Microbiol, Omaha, NE 68182 USA
Vose, JM:
Univ Nebraska, Dept Pathol & Microbiol, Omaha, NE 68182 USA
Chigrinova, E:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Inghirami, G:
Univ Turin, Dept Pathol, Turin, Italy
Univ Turin, CeRMS, Turin, Italy
Chiappella, A:
AOU San Giovanni Battista, Haematol Sect 2, Dept Haematol & Oncol, Turin, Italy
Baldini, L:
Univ Milan, Osped Maggiore Policlin MaRe, IRCCS, UO Ematol CTMO 1,Dipartimento Sci Med, Milan, Italy
Ponzoni, M:
Ist Sci San Raffaele, Pathol Unit, Milan, Italy
Unit Lymphoid Malignancies, Milan, Italy
Ferreri, AJM:
Ist Sci San Raffaele, Pathol Unit, Milan, Italy
Unit Lymphoid Malignancies, Milan, Italy
Franceschetti, S:
Amedeo Avogadro Univ Eastern Piedmont, Div Haematol, Dept Clin & Expt Med, Novara, Italy
Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy
Gaidano, G:
Amedeo Avogadro Univ Eastern Piedmont, Div Haematol, Dept Clin & Expt Med, Novara, Italy
Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy
Montes-Moreno, S:
Ctr Nacl Invest Oncol, Programa Patol Mol, Madrid, Spain
Piris, MA:
Ctr Nacl Invest Oncol, Programa Patol Mol, Madrid, Spain
Facchetti, F:
Univ Brescia, Dept Pathol, Serv Anat Patol 1, Brescia, Italy
Spedali Civil Brescia, Div Haematol, I-25125 Brescia, Italy
Tucci, A:
Univ Brescia, Dept Pathol, Serv Anat Patol 1, Brescia, Italy
Spedali Civil Brescia, Div Haematol, I-25125 Brescia, Italy
Nomdedeu, JF:
Univ Autonoma Barcelona, Dept Haematol, Hosp Santa Creu i St Pau, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Hematol Lab, Hosp Santa Creu i St Pau, E-08193 Barcelona, Spain
Lazure, T:
Univ Hosp Bicetre, AP HP, Dept Internal Med, Le Kremlin Bicetre, France
Univ Hosp Bicetre, AP HP, Dept Pathol, Le Kremlin Bicetre, France
Lambotte, O:
Univ Hosp Bicetre, AP HP, Dept Internal Med, Le Kremlin Bicetre, France
Univ Hosp Bicetre, AP HP, Dept Pathol, Le Kremlin Bicetre, France
Uccella, S:
Univ Insubria, Osped Circolo, Anat Pathol Unit, Varese, Italy
Univ Insubria, Osped Circolo, Dept Oncol, Varese, Italy
Pinotti, G:
Univ Insubria, Osped Circolo, Anat Pathol Unit, Varese, Italy
Univ Insubria, Osped Circolo, Dept Oncol, Varese, Italy
Pruneri, G:
European Inst Oncol, Div Pathol & Lab Med, Milan, Italy
European Inst Oncol, Div Haematol, Milan, Italy
Martinelli, G:
European Inst Oncol, Div Pathol & Lab Med, Milan, Italy
European Inst Oncol, Div Haematol, Milan, Italy
Young, KH:
Univ Wisconsin, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI USA
Tibiletti, MG:
Univ Insubria, Osped Circolo, Anat Pathol Unit, Varese, Italy
Univ Insubria, Osped Circolo, Dept Oncol, Varese, Italy
Rinaldi, A:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Zucca, E:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Kwee, I:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Ist Dalle Molle Studi Sullintelligenza Artificial, Manno, Switzerland
Bertoni, F:
Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland
Open Access
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