Are birth weight predictors in diabetic pregnancy the same in boys and girls?
Por:
Sojo, L, Garcia-Patterson, A, Maria, MA, Martin, E, Ubeda, J, Adelantado, JM, de Leiva, A, Corcoy, R
Publicada:
1 nov 2010
Resumen:
Objectives To study the predictors of abnormal fetal growth in diabetic pregnancy analyzing the role of fetal sex
Study design Observational retrospective study was carried out in a University hospital We studied 2833 newborns of diabetic mothers who attended the Diabetes and Pregnancy Clinic and delivered in the center between 1/1/1982 and 31/12/2006 (2370 born to women with gestational diabetes mellitus 391 to women with type I diabetes mellitus (DM) and 72 to women with type 2 DM) Logistic regression analyses were performed with a backward method to predict large for gestational age (LGA) small for gestational age (SGA) and macrosomic newborns using relevant variables and their interaction with fetal sex We have used as potential predictors of abnormal birth weight maternal prepregnancy age weight height and body mass index prior pregnancy prior macrosomia smoking habit weight increase during pregnancy hypertension gestational age at delivery twin pregnancy fetal sex diabetes type third trimester HbA1c and interaction of fetal sex with all these variables
Results Variables predictive of LGA SGA and macrosomia were as formerly described Moreover some predictors of abnormal growth displayed an interaction with fetal sex In LGA prediction male sex displayed a positive interaction with delivery week prior gestation diabetes type and twin pregnancy and a negative one with weight Increase In SGA prediction male sex displayed a positive interaction with delivery week and diabetes type In macrosorma prediction male sex displayed a negative interaction with weight Increase
Conclusions In this cohort of diabetic pregnancies some predictors of abnormal birth weight display interaction with fetal sex In general associations were more favorable to female fetuses (C) 2010 Elsevier Ireland Ltd All rights reserved
Filiaciones:
Sojo, L:
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Garcia-Patterson, A:
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Maria, MA:
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Martin, E:
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Ubeda, J:
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Adelantado, JM:
Hosp Santa Creu & Sant Pau, Dept Gynecol & Obstet, Barcelona, Spain
de Leiva, A:
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Inst Salud Carlos III, CIBER Bioengn Biomat & Nanotechnol, Madrid, Spain
Corcoy, R:
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Inst Salud Carlos III, CIBER Bioengn Biomat & Nanotechnol, Madrid, Spain
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