Hemostatic Proteins and Their Association With Hematoma Growth in Patients With Acute Intracerebral Hemorrhage
Por:
Marti-Fabregas, J, Borrell, M, Silva, Y, Delgado-Mederos, R, Martinez-Ramirez, S, de Juan-Delago, M, Tirado, I, Alejaldre, A, Marin, R, Marti-Vilalta, JL, Fontcuberta, J
Publicada:
1 dic 2010
Resumen:
Background and Purpose-We tested the hypothesis that proteins of hemostasia could be associated with hematoma growth (HG) in patients with acute intracerebral hemorrhage.
Methods-We prospectively studied patients with spontaneous supratentorial intracerebral hemorrhage within the first 6 hours after the onset of symptoms. HG was defined as an increase >33% in the volume of hematoma on CT obtained 24 to 72 hours after the onset of symptoms in comparison with the CT obtained at admission. We collected admission and follow-up blood samples. We measured fibrinogen, factor XIII, thrombin activatable fibrinolysis inhibitor, plasminogen activator inhibitor, plasminogen, alpha(2)-antiplasmin, tissue plasminogen activator, D-dimer, thrombomodulin, thrombin-antithrombin complex, and plasmin-antiplasmin complex.
Results-We included 90 patients with a mean age of 71 +/- 10.8 years; 61% were men. HG was observed in 35 (39%) of the patients. Mean baseline and follow-up protein measurements showed no difference between the groups with and without HG. The analysis of variance showed that factor XIII activity decreased in the non-HG group in the 24 to 72 hours sample, whereas it increased in the HG group (P=0.001).
Conclusion-Factor XIII was the only measured protein related to HG. The levels at the follow-up sample decreased in the non-HG group and increased in the HG group. Further studies are needed to confirm this association. (Stroke. 2010;41:2976-2978.)
Filiaciones:
Marti-Fabregas, J:
Hosp Santa Creu & Sant Pau, Serv Neurol, Dept Neurol, Barcelona 08025, Spain
Borrell, M:
Hosp Santa Creu & Sant Pau, Thrombosis & Hemostasia Unit, Barcelona 08025, Spain
Silva, Y:
Hosp Univ Dr Josep Trueta, Dept Neurol, Girona, Spain
Delgado-Mederos, R:
Hosp Santa Creu & Sant Pau, Serv Neurol, Dept Neurol, Barcelona 08025, Spain
Martinez-Ramirez, S:
Hosp Santa Creu & Sant Pau, Serv Neurol, Dept Neurol, Barcelona 08025, Spain
de Juan-Delago, M:
Hosp Santa Creu & Sant Pau, Neuroradiol Unit, Barcelona 08025, Spain
Tirado, I:
Hosp Santa Creu & Sant Pau, Thrombosis & Hemostasia Unit, Barcelona 08025, Spain
Alejaldre, A:
Hosp Santa Creu & Sant Pau, Serv Neurol, Dept Neurol, Barcelona 08025, Spain
Marin, R:
Hosp Santa Creu & Sant Pau, Serv Neurol, Dept Neurol, Barcelona 08025, Spain
Marti-Vilalta, JL:
Hosp Santa Creu & Sant Pau, Serv Neurol, Dept Neurol, Barcelona 08025, Spain
Fontcuberta, J:
Hosp Santa Creu & Sant Pau, Thrombosis & Hemostasia Unit, Barcelona 08025, Spain
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