Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction
Por:
Antoniou, AC, Beesley, J, McGuffog, L, Sinilnikova, OM, Healey, S, Neuhausen, SL, Ding, YC, Rebbeck, TR, Weitzel, JN, Lynch, HT, Isaacs, C, Ganz, PA, Tomlinson, G, Olopade, OI, Couch, FJ, Wang, XS, Lindor, NM, Pankratz, VS, Radice, P, Manoukian, S, Peissel, B, Zaffaroni, D, Barile, M, Viel, A, Allavena, A, Dall'Olio, V, Peterlongo, P, Szabo, CI, Zikan, M, Claes, K, Poppe, B, Foretova, L, Mai, PL, Greene, MH, Rennert, G, Lejbkowicz, F, Glendon, G, Ozcelik, H, Andrulis, IL, Thomassen, M, Gerdes, AM, Sunde, L, Cruger, D, Jensen, UB, Caligo, M, Friedman, E, Kaufman, B, Laitman, Y, Milgrom, R, Dubrovsky, M, Cohen, S, Borg, A, Jernstrom, H, Lindblom, A, Rantala, J, Stenmark-Askmalm, M, Melin, B, Nathanson, K, Domchek, S, Jakubowska, A, Lubinski, J, Huzarski, T, Osorio, A, Lasa, A, Duran, M, Tejada, MI, Godino, J, Benitez, J, Hamann, U, Kriege, M, Hoogerbrugge, N, van der Luijt, RB, van Asperen, CJ, Devilee, P, Meijers-Heijboer, EJ, Blok, MJ, Aalfs, CM, Hogervorst, F, Rookus, M, Cook, M, Oliver, C, Frost, D, Conroy, D, Evans, DG, Lalloo, F, Pichert, G, Davidson, R, Cole, T, Cook, J, Paterson, J, Hodgson, S, Morrison, PJ, Porteous, ME, Walker, L, Kennedy, MJ, Dorkins, H, Peock, S, Godwin, AK, Stoppa-Lyonnet, D, de Pauw, A, Mazoyer, S, Bonadona, V, Lasset, C, Dreyfus, H, Leroux, D, Hardouin, A, Berthet, P, Faivre, L, Loustalot, C, Noguchi, T, Sobol, H, Rouleau, E, Nogues, C, Frenay, M, Venat-Bouvet, L, Hopper, JL, Daly, MB, Terry, MB, John, EM, Buys, SS, Yassin, Y, Miron, A, Goldgar, D, Singer, CF, Dressler, AC, Gschwantler-Kaulich, D, Pfeiler, G, Hansen, TVO, Jnson, L, Agnarsson, BA, Kirchhoff, T, Offit, K, Devlin, V, Dutra-Clarke, A, Piedmonte, M, Rodriguez, GC, Wakeley, K, Boggess, JF, Basil, J, Schwartz, PE, Blank, SV, Toland, AE, Montagna, M, Casella, C, Imyanitov, E, Tihomirova, L, Blanco, I, Lazaro, C, Ramus, SJ, Sucheston, L, Karlan, BY, Gross, J, Schmutzler, R, Wappenschmidt, B, Engel, C, Meindl, A, Lochmann, M, Arnold, N, Heidemann, S, Varon-Mateeva, R, Niederacher, D, Sutter, C, Deissler, H, Gadzicki, D, Preisler-Adams, S, Kast, K, Schonbuchner, I, Caldes, T, de la Hoya, M, Aittomaki, K, Nevanlinna, H, Simard, J, Spurdle, AB, Holland, H, Chen, XQ, Platte, R, Chenevix-Trench, G, Easton, DF
Publicada:
1 dic 2010
Resumen:
The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. We evaluated the associations of 3 additional single nucleotide polymorphisms (SNPs), rs4973768 in SLC4A7/NEK10, rs6504950 in STXBP4/COX11, and rs10941679 at 5p12, and reanalyzed the previous associations using additional carriers in a sample of 12,525 BRCA1 and 7,409 BRCA2 carriers. Additionally, we investigated potential interactions between SNPs and assessed the implications for risk prediction. The minor alleles of rs4973768 and rs10941679 were associated with increased breast cancer risk for BRCA2 carriers (per-allele HR - 1.10, 95% CI: 1.03-1.18, P - 0.006 and HR - 1.09, 95% CI: 1.01-1.19, P = 0.03, respectively). Neither SNP was associated with breast cancer risk for BRCA1 carriers, and rs6504950 was not associated with breast cancer for either BRCA1 or BRCA2 carriers. Of the 9 polymorphisms investigated, 7 were associated with breast cancer for BRCA2 carriers (FGFR2, TOX3, MAP3K1, LSP1, 2q35, SLC4A7, 5p12, P 7 = 10 x (11) - 0.03), but only TOX3 and 2q35 were associated with the risk for BRCA1 carriers (P = 0.0049, 0.03, respectively). All risk-associated polymorphisms appear to interact multiplicatively on breast cancer risk for mutation carriers. Based on the joint genotype distribution of the 7 risk-associated SNPs in BRCA2 mutation carriers, the 5% of BRCA2 carriers at highest risk (i.e., between 95th and 100th percentiles) were predicted to have a probability between 80% and 96% of developing breast cancer by age 80, compared with 42%
Filiaciones:
Antoniou, AC:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Beesley, J:
Queensland Inst Med Res, Brisbane, Qld, Australia
McGuffog, L:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Sinilnikova, OM:
Univ Lyon 1, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Ctr Hosp, F-69365 Lyon, France
Healey, S:
Queensland Inst Med Res, Brisbane, Qld, Australia
Neuhausen, SL:
Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA
Ding, YC:
Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA
Rebbeck, TR:
Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Weitzel, JN:
City Hope Natl Med Ctr, Duarte, CA 91010 USA
Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA
Lynch, HT:
Creighton Univ, Omaha, NE 68178 USA
Ganz, PA:
Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA
Tomlinson, G:
Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA
Olopade, OI:
Univ Chicago, Med Ctr, Chicago, IL 60637 USA
Couch, FJ:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Wang, XS:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Lindor, NM:
Mayo Clin, Dept Med Genet, Rochester, MN USA
Pankratz, VS:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Radice, P:
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Fdn IRCCS Ist Nazl Tumori INT, Unit Genet Susceptibil Canc, Dept Expt Oncol & Mol Med, Milan, Italy
Manoukian, S:
Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Peissel, B:
Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Zaffaroni, D:
Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Barile, M:
IEO, Div Canc Prevent & Genet, Milan, Italy
Viel, A:
IRCCS, CRO, Div Expt Oncol 1, Aviano, PN, Italy
Allavena, A:
Univ Turin, Dept Genet Biol & Biochem, Turin, Italy
Dall'Olio, V:
Cogentech, Consortium Genom Technol, Milan, Italy
Peterlongo, P:
Fdn IRCCS Ist Nazl Tumori INT, Unit Genet Susceptibil Canc, Dept Expt Oncol & Mol Med, Milan, Italy
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Szabo, CI:
Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN USA
Zikan, M:
Charles Univ Prague, Fac Med 1, Dept Biochem & Expt Oncol, Prague, Czech Republic
Claes, K:
Ghent Univ Hosp, Ctr Med Genet, B-9000 Ghent, Belgium
Poppe, B:
Ghent Univ Hosp, Ctr Med Genet, B-9000 Ghent, Belgium
Foretova, L:
Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
Mai, PL:
US Natl Canc Inst, Clin Genet Branch, Rockville, MD USA
Greene, MH:
US Natl Canc Inst, Clin Genet Branch, Rockville, MD USA
Rennert, G:
Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
Technion Israel Inst Technol, Carmel Med Ctr, Haifa, Israel
Lejbkowicz, F:
Technion Israel Inst Technol, Carmel Med Ctr, Haifa, Israel
Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
Glendon, G:
OCGN, Toronto, ON, Canada
Ozcelik, H:
Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada
Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Samuel Lunenfeld Res Inst, New York, NY 10029 USA
Andrulis, IL:
Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada
OCGN, Toronto, ON, Canada
Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Samuel Lunenfeld Res Inst, New York, NY 10029 USA
Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
Thomassen, M:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Gerdes, AM:
Rigshosp, Dept Clin Genet, Odense, Denmark
Sunde, L:
Aalborg Hosp, Dept Clin Genet, Aalborg, Denmark
Cruger, D:
Vejle Hosp, Dept Clin Genet, Velje, Denmark
Jensen, UB:
Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark
Caligo, M:
Univ Pisa, Div Surg Mol & Ultrastruct Pathol, Dept Oncol, Pisa, Italy
Pisa Univ Hosp, Pisa, Italy
Friedman, E:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Kaufman, B:
Sheba Med Ctr, Inst Oncol, Tel Hashomer, Israel
Laitman, Y:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Milgrom, R:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Dubrovsky, M:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Cohen, S:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Borg, A:
Lund Univ, Dept Oncol, Lund, Sweden
Jernstrom, H:
Lund Univ, Dept Oncol, Lund, Sweden
Lindblom, A:
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
Rantala, J:
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
Stenmark-Askmalm, M:
Linkoping Univ, Dept Oncol, Linkoping, Sweden
Melin, B:
Umea Univ, Dept Radiat Sci, Umea, Sweden
Nathanson, K:
Univ Penn, Philadelphia, PA 19104 USA
Domchek, S:
Univ Penn, Philadelphia, PA 19104 USA
Jakubowska, A:
Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland
Lubinski, J:
Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland
Huzarski, T:
Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland
Osorio, A:
Spanish Natl Canc Res Ctr, Human Genet Grp, Human Canc Genet Programme, Madrid, Spain
Lasa, A:
Hosp Santa Creu & Sant Pau, Genet Serv, Barcelona, Spain
Duran, M:
Univ Valladolid, Inst Biol & Mol Genet, IBGM UVA, Valladolid, Spain
Tejada, MI:
Cruces Hosp Barakaldo, Mol Genet Lab, Dept Biochem, Bizkaia, Spain
Godino, J:
Univ Lozano Blesa, Hosp Clin, Oncol Serv, Zaragoza, Spain
Benitez, J:
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Genotyping Unit, Madrid, Spain
Hamann, U:
Deutsch Krebsforschungszentrum, Mol Genet Breast Canc, D-6900 Heidelberg, Germany
Kriege, M:
Daniel Denhoed Canc Ctr, Erasmus MC, Dept Med Oncol, Family Canc Clin, Rotterdam, Netherlands
Hoogerbrugge, N:
Radboud Univ Nijmegen, Nijmegen Med Ctr, Hereditary Canc Clin, NL-6525 ED Nijmegen, Netherlands
van der Luijt, RB:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
van Asperen, CJ:
Leiden Univ, Med Ctr, Dept Clin Genet, Leiden, Netherlands
Devilee, P:
Leiden Univ, Dept Human Genet, Med Ctr, Dept Pathol, NL-2300 RA Leiden, Netherlands
Meijers-Heijboer, EJ:
Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Blok, MJ:
Univ Med Ctr, Dept Genet & Cell Biol, Maastricht, Netherlands
Aalfs, CM:
Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands
Hogervorst, F:
Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
Rookus, M:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Cook, M:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Oliver, C:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Frost, D:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Conroy, D:
Univ Cambridge, Dept Oncol, Cambridge, England
Evans, DG:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Lalloo, F:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Pichert, G:
Guys & St Thomas NHS Fdn Trust, London, England
Davidson, R:
Ferguson Smith Ctr Clin Genet, Glasgow, Lanark, Scotland
Cole, T:
Birmingham Womens Hosp Healthcare NHS Trust, W Midlands Reg Genet Serv, Birmingham, W Midlands, England
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
Paterson, J:
Addenbrookes Hosp, Dept Clin Genet, E Anglian Reg Genet Serv, Cambridge, England
Hodgson, S:
Univ London, Dept Clin Genet, St Georges Hosp, London, England
Morrison, PJ:
Belfast City Hosp, Northern Ireland Reg Genet Ctr, Belfast BT9 7AD, Antrim, North Ireland
Porteous, ME:
Western Gen Hosp, SE Scotland Reg Genet Serv, Edinburgh EH4 2XU, Midlothian, Scotland
Walker, L:
Churchill Hosp, Oxford Reg Genet Serv, Oxford OX3 7LJ, England
Kennedy, MJ:
St James Hosp, Canc Genet Program, Hope Directorate, Dublin, Ireland
Dorkins, H:
Kennedy Galton Ctr, NW Thames Reg Genet Serv, Harrow, Middx, England
Peock, S:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Godwin, AK:
Fox Chase Canc Ctr, Dept Med Oncol, Womens Canc Program, Philadelphia, PA 19111 USA
Stoppa-Lyonnet, D:
Univ Paris 05, INSERM, U509, Serv Genet Oncol,Inst Curie, Paris, France
de Pauw, A:
Univ Paris 05, INSERM, U509, Serv Genet Oncol,Inst Curie, Paris, France
Mazoyer, S:
Univ Lyon 1, CNRS, Ctr Leon Berard, Equipe Labellisee LIGUE 2008,UMR5201, F-69365 Lyon, France
Bonadona, V:
Univ Lyon 1, CNRS, UMR5558, F-69365 Lyon, France
Ctr Leon Berard, Unite Prevent & Epidemiol Genet, F-69373 Lyon, France
Lasset, C:
Ctr Leon Berard, Unite Prevent & Epidemiol Genet, F-69373 Lyon, France
Univ Lyon 1, CNRS, UMR5558, F-69365 Lyon, France
Dreyfus, H:
CHU Grenoble, Dept Genet, F-38043 Grenoble, France
Univ Grenoble, Inst Albert Bonniot, Grenoble, France
Leroux, D:
Univ Grenoble, Inst Albert Bonniot, Grenoble, France
CHU Grenoble, Dept Genet, F-38043 Grenoble, France
Hardouin, A:
Ctr Francois Baclesse, F-14021 Caen, France
Berthet, P:
Ctr Francois Baclesse, F-14021 Caen, France
Faivre, L:
Ctr Lutte Canc Georges Francois Leclerc, Dijon, France
Ctr Hosp Univ Dijon, Ctr Genet, Dijon, France
Loustalot, C:
Ctr Lutte Canc Georges Francois Leclerc, Dijon, France
Noguchi, T:
INSERM, Inst Paoli Calmettes, UMR599, Dept Oncol Genet, F-13258 Marseille, France
Sobol, H:
INSERM, Inst Paoli Calmettes, UMR599, Dept Oncol Genet, F-13258 Marseille, France
Rouleau, E:
Ctr Rene Huguenin, INSERM, U735, St Cloud, France
Frenay, M:
Ctr Antoine Lacassagne, F-06054 Nice, France
Venat-Bouvet, L:
Ctr Hosp Univ Limoges, Dept Oncol, Limoges, France
Hopper, JL:
Univ Melbourne, Melbourne, Vic, Australia
Daly, MB:
Fox Chase Canc Ctr, Dept Med Oncol, Womens Canc Program, Philadelphia, PA 19111 USA
Terry, MB:
Columbia Univ, New York, NY USA
John, EM:
Stanford Univ, Sch Med, Stanford, CA 94305 USA
Canc Prevent Inst Calif, Fremont, CA USA
No Calif Canc Ctr, Fremont, CA USA
Buys, SS:
Univ Utah, Hlth Sci Ctr, Huntsman Canc Inst, Salt Lake City, UT USA
Yassin, Y:
Dana Farber Canc Inst, Boston, MA 02115 USA
Miron, A:
Dana Farber Canc Inst, Boston, MA 02115 USA
Goldgar, D:
Univ Utah, Dept Dermatol, Salt Lake City, UT USA
Singer, CF:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Dressler, AC:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Gschwantler-Kaulich, D:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Pfeiler, G:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Hansen, TVO:
Univ Copenhagen, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark
Jnson, L:
Univ Copenhagen, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark
Agnarsson, BA:
Univ Hosp, Dept Pathol, Reykjavik, Iceland
Univ Iceland, Sch Med, Reykjavik, Iceland
Kirchhoff, T:
Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA
Offit, K:
Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA
Devlin, V:
Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA
Dutra-Clarke, A:
Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA
Piedmonte, M:
Roswell Pk Canc Inst, GOG Stat & Data Ctr, Buffalo, NY 14263 USA
Rodriguez, GC:
NorthShore Univ Hlth Syst, Evanston NW Healthcare, Evanston, IL USA
Wakeley, K:
Tufts Univ, New England Med Ctr, Boston, MA 02111 USA
Boggess, JF:
Univ N Carolina, Chapel Hill, NC USA
Basil, J:
St Elizabeth Hosp, Edgewood, KY USA
Schwartz, PE:
Yale Univ, Sch Med, New Haven, CT USA
Blank, SV:
NYU, Sch Med, New York, NY USA
Toland, AE:
Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med & Mol Virol, Div Human Canc Genet, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Dept Immunol & Med Genet, Div Human Canc Genet, Columbus, OH 43210 USA
Montagna, M:
IRCCS, Ist Oncol Veneto, Immunol & Mol Oncol Unit, Padua, Italy
Casella, C:
IRCCS, Ist Oncol Veneto, Immunol & Mol Oncol Unit, Padua, Italy
Imyanitov, E:
NN Petrov Inst Oncol, St Petersburg, Russia
Tihomirova, L:
Latvian Biomed Res & Study Ctr, Riga, Latvia
Blanco, I:
Catalan Inst Oncol IDIBELL, Hereditary Canc Program, Barcelona, Spain
Lazaro, C:
Catalan Inst Oncol IDIBELL, Hereditary Canc Program, Barcelona, Spain
Ramus, SJ:
Univ London Imperial Coll Sci Technol & Med, Gynaecol Oncol Unit, UCL EGA Inst Womens Hlth, London, England
Sucheston, L:
Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA
Karlan, BY:
Cedars Sinai Med Ctr, Womens Canc Res Inst, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA
Gross, J:
Cedars Sinai Med Ctr, Womens Canc Res Inst, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA
Schmutzler, R:
Univ Cologne, CIO, Cologne, Germany
Univ Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Wappenschmidt, B:
Univ Cologne, CIO, Cologne, Germany
Univ Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Engel, C:
Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany
Meindl, A:
Tech Univ Munich, Klinikum Rechts Isar, Dept Obstet & Gynaecol, Div Tumor Genet, D-8000 Munich, Germany
Lochmann, M:
Tech Univ Munich, Klinikum Rechts Isar, Dept Obstet & Gynaecol, Div Tumor Genet, D-8000 Munich, Germany
Arnold, N:
Univ Kiel, Dept Obstet & Gynaecol, Univ Hosp Schleswig Holstein, Kiel, Germany
Heidemann, S:
Univ Kiel, Inst Human Genet, Univ Hosp Schleswig Holstein, Kiel, Germany
Varon-Mateeva, R:
Campus Virchow Klinikum, Charite Berlin, Inst Human Genet, Berlin, Germany
Niederacher, D:
Univ Dusseldorf, Dept Obstet & Gynaecol, Div Mol Genet, Univ Hosp Dusseldorf, Dusseldorf, Germany
Sutter, C:
Univ Heidelberg, Inst Human Genet, Div Mol Diagnost, Heidelberg, Germany
Deissler, H:
Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany
Gadzicki, D:
Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany
Preisler-Adams, S:
Univ Hosp Muenster, Inst Human Genet, Munster, Germany
Kast, K:
Tech Univ Dresden, Dept Obstet & Gynaecol, Univ Hosp Carl Gustav Carus, Dresden, Germany
Schonbuchner, I:
Univ Wurzburg, Inst Human Genet, Div Med Genet, Wurzburg, Germany
Caldes, T:
Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain
de la Hoya, M:
Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain
Aittomaki, K:
Univ Helsinki, Cent Hosp, Dept Clin Genet, Helsinki, Finland
Nevanlinna, H:
Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland
Simard, J:
Univ Laval, Quebec City, PQ, Canada
Ctr Hosp Univ Quebec, Canada Res Chair Oncogenet, Canc Genom Lab, Quebec City, PQ, Canada
Spurdle, AB:
Familial Breast Canc Peter MacCallum Canc Ctr, Kathleen Cuningham Consortium Res, Melbourne, Vic, Australia
Queensland Inst Med Res, Brisbane, Qld, Australia
Holland, H:
Queensland Inst Med Res, Brisbane, Qld, Australia
Familial Breast Canc Peter MacCallum Canc Ctr, Kathleen Cuningham Consortium Res, Melbourne, Vic, Australia
Chen, XQ:
Queensland Inst Med Res, Brisbane, Qld, Australia
Familial Breast Canc Peter MacCallum Canc Ctr, Kathleen Cuningham Consortium Res, Melbourne, Vic, Australia
Easton, DF:
Univ Chicago, Med Ctr, Chicago, IL 60637 USA
Green Accepted, Bronze
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