Differences in breast cancer risk after benign breast disease by type of screening diagnosis
Por:
Louro, J, Roman, M, Posso, M, Comerma, L, Vidal, C, Saladie, F, Alcantara, R, Sanchez, M, Quintana, MJ, del Riego, J, Ferrer, J, Penalva, L, Bargallo, X, Prieto, M, Sala, M, Castells, X
Publicada:
1 dic 2020
Ahead of Print:
3 oct 2020
Resumen:
Introduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens.
Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer.
Results: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24-3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57-2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09-9.08, and 3.35; 95%CI: 1.51-7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95-2.93, and 1.63; 95%CI: 1.32-2.02 for those diagnosed at incident and prevalent screens, respectively).
Conclusion: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis. (C) 2020 The Authors. Published by Elsevier Ltd.
Filiaciones:
Louro, J:
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Hosp Del Mar, Serv Epidemiol & Avaluacio, Passeig Maritim 25-29, Barcelona 08003, Spain
Univ Autonoma Barcelona UAB, Doctoral Programme Methodol Biomed Res & Publ Hlt, European Higher Educ Area EHEA, Dept Pediat Obstet & Gynecol Prevent Med & Publ H, Bellaterra, Barcelona, Spain
Roman, M:
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Hosp Del Mar, Serv Epidemiol & Avaluacio, Passeig Maritim 25-29, Barcelona 08003, Spain
Posso, M:
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Hosp Del Mar, Serv Epidemiol & Avaluacio, Passeig Maritim 25-29, Barcelona 08003, Spain
Comerma, L:
Hosp del Mar, Serv Patol, Barcelona, Spain
Vidal, C:
Catalan Inst Oncol ICO, Barcelona, Spain
Saladie, F:
Univ Rovira & Virgili, Inst Invest Sanit Pere Virgili, Hosp Univ St Joan Reus, Canc Epidemiol & Prevent Serv, Reus, Spain
Alcantara, R:
Hosp Del Mar, Serv Diagnost La Imatge, Barcelona, Spain
Sanchez, M:
Direct Gen Publ Hlth, Cantabria, Spain
Quintana, MJ:
Univ Hosp Santa Creu & St Pau, IIB St Pau, Dept Clin Epidemiol & Publ Hlth, Barcelona, Spain
CIBER Epidemiol & Publ Hlth CIBERESP, Barcelona, Spain
del Riego, J:
Parc Tauli Hosp Univ, UDIAT Ctr Diagnost, Dept Radiol, Womens Imaging, Sabadell, Barcelona, Spain
Ferrer, J:
Hosp Santa Caterina, Radiol Dept, Salt, Girona, Spain
Penalva, L:
Valles Oriental Breast Canc Early Detect Program, Granollers, Spain
Bargallo, X:
Hosp Clin Barcelona, Radiol Dept, Barcelona, Spain
Prieto, M:
Breast Canc Screening Program, Principality Of Asturias, Spain
Sala, M:
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Hosp Del Mar, Serv Epidemiol & Avaluacio, Passeig Maritim 25-29, Barcelona 08003, Spain
Castells, X:
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Hosp Del Mar, Serv Epidemiol & Avaluacio, Passeig Maritim 25-29, Barcelona 08003, Spain
Gold, Green Published
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