Efficacy and safety of nucleoside reverse transcriptase inhibitor-sparing salvage therapy for multidrug-resistant HIV-1 infection based on new-class and new-generation antiretrovirals
Por:
Imaz, A, Llibre, JM, Mora, M, Mateo, G, Camacho, A, Blanco, JR, Curran, A, Santos, JR, Caballero, E, Bravo, I, Gaya, F, Domingo, P, Rivero, A, Falco, V, Clotet, B, Ribera, E
Publicada:
1 feb 2011
Resumen:
The advent of new antiretrovirals has expanded the therapeutic options for multiple drug-resistant HIV-1 infection. The role of recycled nucleoside reverse transcriptase inhibitors (NRTIs) in this scenario remains uncertain.
Observational study of 122 consecutive patients with prior triple-class failure and multidrug-resistant HIV infection who started a salvage regimen with at least three of the new antiretrovirals darunavir, etravirine, raltegravir and maraviroc. Virological, immunological and clinical outcomes were compared according to the inclusion or not of NRTIs in the regimen, after 48 weeks of follow-up.
All patients received at least two and 65% received three fully active drugs in the salvage regimen. In 63 patients recycled NRTIs were added to new drugs (NRTI-containing group) and 59 patients did not receive NRTIs (NRTI-sparing group). Both groups were comparable at baseline regarding the number of prior failures, resistance profile, CD4 cell count and HIV plasma viral load. The rates of HIV-1 RNA suppression below 50 copies/mL at week 48 (intent-to-treat analysis) were similar in the two groups: 46/59 [78%, 95% confidence interval (CI) 67%-88%] in the NRTI-sparing group and 49/63 (78%, 95% CI 67%-88%) in the NRTI-containing group. No significant differences were found in CD4 cell count increases. Drug-related adverse events leading to drug discontinuations only occurred in the NRTI-containing group (5 of 63, NRTI-related in 3 cases).
The addition of NRTIs with reduced activity, according to genotypic resistance tests, does not seem to improve the efficacy of salvage regimens containing three of the new antiretrovirals in patients with multidrug-resistant HIV-1 infection.
Filiaciones:
Imaz, A:
Hosp Univ Vall dHebron, Dept Infect Dis, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Llibre, JM:
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain
Mora, M:
Hosp Univ La Paz, Dept Internal Med, Infect Dis Unit, Madrid, Spain
Mateo, G:
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Spain
Camacho, A:
Hosp Univ Reina Sofia, Dept Internal Med, Infect Dis Unit, Cordoba, Spain
Blanco, JR:
Hosp San Pedro CIBIR, Infect Dis Area, Logrono, Spain
Curran, A:
Hosp Univ Vall dHebron, Dept Infect Dis, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Santos, JR:
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain
Caballero, E:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Microbiol, E-08193 Barcelona, Spain
Bravo, I:
Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain
Gaya, F:
Hosp Univ La Paz, Secc Biostadist, Madrid, Spain
Domingo, P:
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Spain
Rivero, A:
Hosp Univ Reina Sofia, Dept Internal Med, Infect Dis Unit, Cordoba, Spain
Falco, V:
Hosp Univ Vall dHebron, Dept Infect Dis, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Clotet, B:
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Irsicaixa Fdn, Barcelona, Spain
Ribera, E:
Hosp Univ Vall dHebron, Dept Infect Dis, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain
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