Novel genes and sex differences in COVID-19 severity
Por:
Cruz, R, Diz-de Almeida, S, de Heredia, ML, Quintela, I, Ceballos, FC, Lorenzo-Salazar, GM, Gonzalez-Montelongo, R, Gago-Dominguez, M, Porras, MS, Castano, JAT, Nevado, J, Aguado, JM, Aguilar, C, Aguilera-Albesa, S, Almadana, V, Almoguera, B, Alvarez, N, Andreu-Bernabeu, A, Arana-Arri, E, Arango, C, Arranz, MJ, Artiga, MJ, Baptista-Rosas, RC, Barreda-Sanchez, M, Belhassen-Garcia, M, Bezerra, JF, Bezerra, MAC, Boix-Palop, L, Brion, M, Brugada, R, Bustos, M, Calderon, EJ, Carbonell, C, Castano, L, Castelao, JE, Conde-Vicente, R, Cordero-Lorenzana, ML, Cortes-Sanchez, JL, Corton, M, Darnaude, MT, De Martino-Rodriguez, A, del Campo-Perez, V, de Bustamante, AD, Dominguez-Garrido, E, Luchessi, AD, Eiros, R, Sanabria, GME, Carmen Farinas, M, Fernandez-Robelo, U, Fernandez-Rodriguez, A, Fernandez-Villa, T, Gil-Fournier, B, Gomez-Arrue, J, Alvarez, BG, de Quiros, FGB, Gonzalez-Penas, J, Gutierrez-Bautista, JF, Herrero, MJ, Herrero-Gonzalez, A, Jimenez-Sousa, MA, Lattig, MC, Borja, AL, Lopez-Rodriguez, R, Mancebo, E, Martin-Lopez, C, Martin, V, Martinez-Nieto, O, Martinez-Lopez, I, Martinez-Resendez, MF, Martinez-Perez, A, Mazzeu, JF, Macias, EM, Minguez, P, Cuerda, VM, Silbiger, VN, Oliveira, SF, Ortega-Paino, E, Parellada, M, Paz-Artal, E, Santos, NPC, Perez-Matute, P, Perez, P, Perez-Tomas, ME, Perucho, T, Pinsach-Abuin, ML, Pompa-Mera, EN, Porras-Hurtado, GL, Pujol, A, Leon, SR, Resino, S, Fernandes, MR, Rodriguez-Ruiz, E, Rodriguez-Artalejo, F, Rodriguez-Garcia, JA, Cabello, FR, Ruiz-Hornillos, J, Ryan, P, Soria, JM, Souto, JC, Tamayo, E, Tamayo-Velasco, A, Taracido-Fernandez, JC, Teper, A, Torres-Tobar, L, Urioste, M, Valencia-Ramos, J, Yanez, Z, Zarate, R, Nakanishi, T, Pigazzini, S, Degenhardt, F, Butler-Laporte, G, Maya-Miles, D, Bujanda, L, Bouysran, Y, Palom, A, Ellinghaus, D, Martinez-Bueno, M, Rolker, S, Amitrano, S, Roade, L, Fava, F, Spinner, CD, Prati, D, Bernardo, D, Garcia, F, Darcis, G, Fernandez-Cadenas, I, Holter, JC, Banales, JM, Frithiof, R, Duga, S, Asselta, R, Pereira, AC, Romero-Gomez, M, Nafria-Jimenez, B, Hov, JR, Migeotte, I, Renieri, A, Planas, AM, Ludwig, KU, Buti, M, Rahmouni, S, Alarcon-Riquelme, ME, Schulte, EC, Franke, A, Karlsen, TH, Valenti, L, Zeberg, H, Richards, B, Ganna, A, Boada, M, de Rojas, I, Ruiz, A, Sanchez-Juan, P, Real, LM, Guillen-Navarro, E, Ayuso, C, Gonzalez-Neira, A, Riancho, JA, Rojas-Martinez, A, Flores, C, Lapunzina, P, Carracedo, A
Publicada:
15 nov 2022
Ahead of Print:
1 jun 2022
Resumen:
Here, we describe the results of a genome-wide study conducted in 11939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P<5x10(-8)) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P= 1.3x10(-22) and P= 8.1x10(-12), respectively), and for variants in 9q21.32 near TLE1 only among females (P= 4.4x10(-8)). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P= 2.7x10(-8)) and ARHGAP33 (P= 1.3x10(-8)), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P=4.1x10(-8)). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or >= 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
Filiaciones:
Cruz, R:
Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN, Santiago De Compostela 15706, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Inst Invest Sanitaria Santiago IDIS, Santiago De Compostela 15706, Spain
Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cronic, Santiago De Compostela 15782, Spain
Diz-de Almeida, S:
Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cronic, Santiago De Compostela 15782, Spain
de Heredia, ML:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Quintela, I:
Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN, Santiago De Compostela 15706, Spain
Ceballos, FC:
Inst Salud Carlos III ISCIII, Ctr Nacl Microbiol CNM, Unidad Infecc Viral & Inmun, Madrid 28220, Spain
Lorenzo-Salazar, GM:
Inst Tecnol & Energias Renovables, Genom Div, Santa Cruz De Tenerife 38600, Spain
Gonzalez-Montelongo, R:
Inst Tecnol & Energias Renovables, Genom Div, Santa Cruz De Tenerife 38600, Spain
Gago-Dominguez, M:
Inst Invest Sanitaria Santiago IDIS, Santiago De Compostela 15706, Spain
Fdn Publ Galegade Med Xenom, Sistema Galegode Saude SERGAS, Santiago De Compostela 15706, Spain
Porras, MS:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Hosp Univ La Paz IDIPAZ, Inst Genet Med & Mol INGEMM, Madrid 28046, Spain
Castano, JAT:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Hosp Univ La Paz IDIPAZ, Inst Genet Med & Mol INGEMM, Madrid 28046, Spain
ERN, ITHACA, European Reference Network, Amsterdam, Netherlands
Nevado, J:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Hosp Univ La Paz IDIPAZ, Inst Genet Med & Mol INGEMM, Madrid 28046, Spain
ERN, ITHACA, European Reference Network, Amsterdam, Netherlands
Aguado, JM:
Hosp Univ 12 Octubre, Inst Invest Sanitaria Hosp 12 Octubre imas12, Unit Infect Dis, Madrid 28041, Spain
Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI RD16 0016 00, Madrid 28029, Spain
Univ Complutense, Sch Med, Madrid 28040, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CI, Madrid 28029, Spain
Aguilar, C:
Hosp Gen Santa Barbara Soria, Soria 42005, Spain
Aguilera-Albesa, S:
Navarra Hlth Serv Hosp, Dept Pediat, Pediat Neurol Unit, Pamplona 31008, Spain
NavarraBioMed Res Grp, Navarra Hlth Serv, Pamplona 31008, Spain
Almadana, V:
Hosp Univ Virgen Macarena, Neumol, Seville 41009, Spain
Almoguera, B:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS,Dept Genet & Genom, Madrid 28040, Spain
Alvarez, N:
Spanish Natl Canc Res Ctr, Human Genotyping CEGEN Unit, Madrid 28029, Spain
Andreu-Bernabeu, A:
Univ Complutense, Sch Med, Madrid 28040, Spain
Hosp Gen Univ Gregorio Maranon IiSGM, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain
Arana-Arri, E:
Biocruces Bizkai HRI, Baracaldo 48903, Bizkaia, Spain
Cruces Univ Hosp, Osakidetza, Baracaldo 48903, Bizkaia, Spain
Arango, C:
Univ Complutense, Sch Med, Madrid 28040, Spain
Hosp Gen Univ Gregorio Maranon IiSGM, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Mental Hlth CIBERSAM, Madrid 28029, Spain
Arranz, MJ:
Fdn Docencia I Recerca Mutua Terrassa, Terrassa 08221, Spain
Artiga, MJ:
Spanish Natl Canc Res Ctr, CNIO Biobank, Madrid 28029, Spain
Baptista-Rosas, RC:
Hosp Gen Occidente Seguro Social, Zapopan 45170, Jalisco, Mexico
Univ Guadalajara, Ctr Univ Tonala, Tonala 45425, Jalisco, Mexico
Univ Guadalajara, Ctr Invest Multidisciplinario Salud, Tonala 45425, Jalisco, Mexico
Barreda-Sanchez, M:
Inst Murciano Invest Biosanitaria IMIB Arrixaca, Murcia, Spain
Univ Catolica San Antonio Murcia UCAM, Murcia 30120, Spain
Belhassen-Garcia, M:
Hosp Univ Salamanca IBSAL, Serv Med Interna, Unidad Enfermedades Infecciosas, Salamanca 37007, Spain
Univ Salamanca, Salamanca 37007, Spain
Bezerra, JF:
Escola Tecn Saude, Lab Vigilancia Mol Aplicada, BR-68515000 Brasilia, Para, Brazil
Bezerra, MAC:
Univ Fed Pernambuco, Genet Postgrad Program, BR-50670907 Recife, PE, Brazil
Boix-Palop, L:
Hosp Univ Mutua Terrassa, Terrassa 08221, Spain
Brion, M:
Inst Invest Sanitaria Santiago IDIS, Xenet Cardiovasc, Santiago De Compostela 15706, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid 28029, Spain
Brugada, R:
Inst Salud Carlos III, Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid 28029, Spain
Inst Invest Biomed Girona IDIBGI, Cardiovasc Genet Ctr, Girona 17190, Spain
Univ Girona, Sch Med, Med Sci Dept, Girona 17190, Spain
Hosp Josep Trueta, Cardiol Serv, Girona 17190, Spain
Bustos, M:
Univ Seville, Virgen Rocio Univ Hosp, Consejo Super Invest Cient CSIC, Inst Biomed Seville IBiS, Seville 41013, Spain
Calderon, EJ:
Univ Seville, Hosp Univ Virgen Rocio, Dept Med, Seville 41013, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Epidemiol & Publ Hlth CIBE, Madrid 28029, Spain
Inst Biomed Sevilla, Seville 41013, Spain
Carbonell, C:
Univ Salamanca, Salamanca 37007, Spain
Hosp Univ Salamanca IBSAL, Serv Med Interna, Salamanca 37007, Spain
Castano, L:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Biocruces Bizkai HRI, Baracaldo 48903, Bizkaia, Spain
Cruces Univ Hosp, Osakidetza, Baracaldo 48903, Bizkaia, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Diabet & Metab Associated, Madrid 28029, Spain
Univ Basque Country, UPV EHU, Bizkaia 48903, Spain
Castelao, JE:
Inst Invest Sanitaria Galicia Sur, Xerencia Xest Integrada Vigo Serv Galego Saude, Oncol & Genet Unit, Vigo 36312, Spain
Conde-Vicente, R:
Hosp Univ Rio Hortega, Valladolid 47012, Spain
Cordero-Lorenzana, ML:
Complejo Hosp Univ A Coruna CHUAC, Sistema Galego Saude SERGAS, Serv Med Intens, La Coruna 15009, Spain
Cortes-Sanchez, JL:
Tecnol Monterrey, Monterrey 64718, Mexico
Otto Von Guericke Univ, Dept Micrograv & Translat Regenerat Med, D-39106 Magdeburg, Germany
Corton, M:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS,Dept Genet & Genom, Madrid 28040, Spain
Darnaude, MT:
Hosp Univ Mostoles, Unidad Genet, Madrid 28935, Spain
De Martino-Rodriguez, A:
Inst Aragones Ciencias Salud IACS, Zaragoza 50009, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain
del Campo-Perez, V:
Inst Invest Sanitaria Galicia Sur, Xerencia Xest Integrada Vigo Serv Galego Saude, Prevent Med Dept, Vigo 36312, Spain
de Bustamante, AD:
Hosp Univ Mostoles, Unidad Genet, Madrid 28935, Spain
Dominguez-Garrido, E:
Fdn Rioja Salud, Unidad Diagnost Mol, La Rioja 26006, Spain
Luchessi, AD:
Univ Fed Rio Grande do Norte, Dept Anal Clin & Toxicol, BR-59012570 Natal, RN, Brazil
Eiros, R:
Hosp Univ Salamanca IBSAL, Serv Cardiol, Salamanca 37007, Spain
Sanabria, GME:
Univ Nacl Caaguazu, Inst Reg Invest Salud, HH36 J3Q, Caaguazu, Paraguay
Carmen Farinas, M:
IDIVAL, Cantabria 39008, Spain
Univ Cantabria, Cantabria 39008, Spain
Hosp UM Valdecilla, Cantabria 39008, Spain
Fernandez-Robelo, U:
Complejo Hosp Univ A Coruna CHUAC, Urgencias Hosp, Sistema Galego Saude SERGAS, La Coruna 15009, Spain
Fernandez-Rodriguez, A:
Inst Salud Carlos III ISCIII, Ctr Nacl Microbiol CNM, Unidad Infecc Viral & Inmun, Madrid 28220, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CI, Madrid 28029, Spain
Fernandez-Villa, T:
Univ Leon, Inst Biomed IBIOMED, Grp Invest Interacc Gen Ambiente & Salud GIIGAS, Leon 24071, Spain
Gil-Fournier, B:
Hosp Univ Getafe, Serv Genet, Madrid 28905, Spain
Gomez-Arrue, J:
Inst Aragones Ciencias Salud IACS, Zaragoza 50009, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain
Alvarez, BG:
Inst Aragones Ciencias Salud IACS, Zaragoza 50009, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain
de Quiros, FGB:
Minist Salud Ciudad Buenos Aires, C1425EFD, Buenos Aires, DF, Argentina
Gonzalez-Penas, J:
Univ Complutense, Sch Med, Madrid 28040, Spain
Hosp Gen Univ Gregorio Maranon IiSGM, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Mental Hlth CIBERSAM, Madrid 28029, Spain
Gutierrez-Bautista, JF:
Hosp Univ Virgen Nieves, Serv Anal Clin & Inmunol, Granada 18014, Spain
Herrero, MJ:
IIS La Fe, Plataforma Farmacogenet, Valencia 46026, Spain
Univ Valencia, Dept Farmacol, Valencia 4610, Spain
Herrero-Gonzalez, A:
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS,Data Anal Dept, Madrid 28040, Spain
Jimenez-Sousa, MA:
Inst Salud Carlos III ISCIII, Ctr Nacl Microbiol CNM, Unidad Infecc Viral & Inmun, Madrid 28220, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CI, Madrid 28029, Spain
Lattig, MC:
Univ Los Andes, Fac Ciencias, Bogota 111711, Colombia
SIGEN Alianza Univ Los Andes, Fdn Santa Fe Bogota, Bogota 111711, Colombia
Borja, AL:
Hosp Gen Segovia, Med Intens, Segovia 40002, Spain
Lopez-Rodriguez, R:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS,Dept Genet & Genom, Madrid 28040, Spain
Mancebo, E:
Hosp Univ 12 Octubre, Dept Immunol, Madrid 28041, Spain
Inst Invest Sanitaria Hosp 12 Octubre imas12, Transplant Immunol & Immunodeficiencies Grp, Madrid 28041, Spain
Martin-Lopez, C:
Hosp Gen Segovia, Med Intens, Segovia 40002, Spain
Martin, V:
Inst Salud Carlos III, Ctr Biomed Network Res Epidemiol & Publ Hlth CIBE, Madrid 28029, Spain
Univ Leon, Inst Biomed IBIOMED, Leon 24071, Spain
Martinez-Nieto, O:
SIGEN Alianza Univ Los Andes, Fdn Santa Fe Bogota, Bogota 111711, Colombia
Fdn Santa Fe Bogota, Dept Pathol & Labs, Bogota 111711, Colombia
Martinez-Lopez, I:
Unidad Genet & Genom Islas Baleares, Islas Baleares 07120, Spain
Hosp Univ Son Espases, Unidad Diagnost Mol & Genet Clin, Islas Baleares 07120, Spain
Martinez-Resendez, MF:
Tecnol Monterrey, Monterrey 64718, Mexico
Martinez-Perez, A:
Hosp Santa Creu & Sant Pau, Res Inst, IIB St Pau, Genom Complex Dis Unit, Barcelona 08041, Spain
Mazzeu, JF:
Univ Brasilia, Fac Med, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Programa Pos Grad Ciencias Med, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Programa Pos Grad Ciencias Saude, BR-70910900 Brasilia, DF, Brazil
Macias, EM:
Hosp El Bierzo, Unidad Cuidados Intens, Leon 24404, Spain
Minguez, P:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS,Dept Genet & Genom, Madrid 28040, Spain
Cuerda, VM:
Hosp Univ Mostoles, Med Interna, Madrid 28935, Spain
Univ Francisco Vitoria, Madrid 28223, Spain
Silbiger, VN:
Univ Fed Rio Grande do Norte, Dept Anal Clin & Toxicol, BR-59012570 Natal, RN, Brazil
Oliveira, SF:
Univ Brasilia, Fac Med, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Programa Pos Grad Ciencias Med, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Programa Pos Grad Biol Anim, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Programa Pos Grad Profiss Ensino Biol, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Programa Pos Grad Profiss Ensino Biol UnB, BR-70910900 Brasilia, DF, Brazil
Ortega-Paino, E:
Spanish Natl Canc Res Ctr, CNIO Biobank, Madrid 28029, Spain
Parellada, M:
Univ Complutense, Sch Med, Madrid 28040, Spain
Hosp Gen Univ Gregorio Maranon IiSGM, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Mental Hlth CIBERSAM, Madrid 28029, Spain
Paz-Artal, E:
Hosp Univ 12 Octubre, Dept Immunol, Madrid 28041, Spain
Inst Invest Sanitaria Hosp 12 Octubre imas12, Transplant Immunol & Immunodeficiencies Grp, Madrid 28041, Spain
Univ Complutense Madrid, Dept Immunol Ophthalmol & ENT, Madrid 28040, Spain
Santos, NPC:
Univ Fed Para, Nucl Pesquisas Oncol, BR-66075110 Belem, Para, Brazil
Perez-Matute, P:
Ctr Biomed Res La Rioja CIBIR, Infect Dis Microbiota & Metab Unit, Logrono 26006, Spain
Perez, P:
Inditex, La Coruna 15141, Spain
Perez-Tomas, ME:
Inst Murciano Invest Biosanitaria IMIB Arrixaca, Murcia, Spain
Perucho, T:
GENYCA, Madrid 28220, Spain
Pinsach-Abuin, ML:
Inst Salud Carlos III, Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid 28029, Spain
Inst Invest Biomed Girona IDIBGI, Cardiovasc Genet Ctr, Girona 17190, Spain
Pompa-Mera, EN:
Ctr Med Nacl Siglo XXI, Inst Mexicano Seguro Social IMSS, Unidad Invest Med Enfermedades Infecciosas & Para, Mexico City 02990, DF, Mexico
Porras-Hurtado, GL:
Clin Comfamiliar Risaralda, Pereira 660003, Colombia
Pujol, A:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Bellvitge Biomed Res Inst IDIBELL, Neurometab Dis Lab, Lhospitalet De Llobregat 08908, Spain
Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain
Leon, SR:
Hosp Univ Getafe, Serv Genet, Madrid 28905, Spain
Resino, S:
Inst Salud Carlos III ISCIII, Ctr Nacl Microbiol CNM, Unidad Infecc Viral & Inmun, Madrid 28220, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CI, Madrid 28029, Spain
Fernandes, MR:
Univ Fed Para, Nucl Pesquisas Oncol, BR-66075110 Belem, Para, Brazil
Hosp Ophir Loyola, Dept Ensino & Pesquisa, BR-66063240 Belem, Para, Brazil
Rodriguez-Ruiz, E:
Inst Invest Sanitaria Santiago IDIS, Santiago De Compostela 15706, Spain
Hosp Clin Univ Santiago CHUS, Sistema Galego Saude SERGAS, Unidad Cuidados Intens, Santiago De Compostela 15706, Spain
Rodriguez-Artalejo, F:
Inst Salud Carlos III, Ctr Biomed Network Res Epidemiol & Publ Hlth CIBE, Madrid 28029, Spain
Univ Autonoma Madrid, Sch Med, Dept Prevent Med & Publ Hlth, Madrid 28049, Spain
IdiPaz Inst Invest Sanitaria Hosp Univ La Paz, Madrid 28046, Spain
UAM, CSIC, CEI, IMDEA Food Inst, Madrid 28049, Spain
Rodriguez-Garcia, JA:
Complejo Asistencial Univ Leon, Leon 24071, Spain
Cabello, FR:
Hosp Univ Virgen Nieves, Serv Anal Clin & Inmunol, Granada 18014, Spain
Inst Invest Biosanitaria Granada ibs Granada, Granada 18012, Spain
Univ Granada, Dept Bioquim Biol Mol & Inmunol 3, Granada 18071, Spain
Ruiz-Hornillos, J:
Hosp Infanta Elena, Allergy Unit, Madrid 28342, Spain
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS, Madrid 28040, Spain
Univ Francisco Vitoria, Fac Med, Madrid 28223, Spain
Ryan, P:
Hosp Univ Infanta Leonor, Madrid 28031, Spain
Univ Complutense Madrid, Madrid 28040, Spain
Gregorio Maranon Hlth Res Inst IiSGM, Madrid 28007, Spain
Soria, JM:
Hosp Santa Creu & Sant Pau, Res Inst, IIB St Pau, Genom Complex Dis Unit, Barcelona 08041, Spain
Souto, JC:
Hosp Santa Creu & Sant Pau, IIB St Pau, Haemostasis & Thrombosis Unit, Barcelona 08041, Spain
Tamayo, E:
Hosp Clin Univ Valladolid, Serv Anestesiol & Reanimac, Valladolid 47003, Spain
Univ Valladolid, Dept Cirugia, Valladolid 47005, Spain
Tamayo-Velasco, A:
Hosp Clin Univ Valladolid, Serv Hematol & Hemoterapia, Valladolid 47003, Spain
Taracido-Fernandez, JC:
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS,Data Anal Dept, Madrid 28040, Spain
Teper, A:
Hosp Ninos Dr Ricardo Gutierrez, C1425EFD, Buenos Aires, DF, Argentina
Torres-Tobar, L:
Fdn Univ Ciencias Salud, Bogota 113827, Colombia
Urioste, M:
Spanish Natl Canc Res Ctr, Familial Canc Clin Unit, Madrid 28029, Spain
Valencia-Ramos, J:
Univ Hosp Burgos, Burgos 09006, Spain
Yanez, Z:
Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080002, Colombia
Zarate, R:
Ctr Para Desarrollo Invest Cient, Asuncion 1255, Paraguay
Nakanishi, T:
Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland
McGill Univ, Dept Human Genet, Montreal, PQ H3A 0G4, Canada
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto 6068501, Japan
Japan Soc Promot Sci, Tokyo 1020083, Japan
Pigazzini, S:
Univ Milano Bicocca, I-20126 Milan, Italy
Univ Helsinki, Inst Mol Med Finland, Helsinki 00014, Finland
Degenhardt, F:
Univ Kiel, Inst Clin Mol Biol, D-24118 Kiel, Germany
Univ Hosp Schleswig Holstein, Campus Kiel, D-24118 Kiel, Germany
Butler-Laporte, G:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ H3A 0G4, Canada
Maya-Miles, D:
Univ Seville, Virgen Rocio Univ Hosp, Inst Biomed Seville, Digest Dis Unit, Seville 41103, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Hepat & Digest Dis CIBEREH, Madrid 28029, Spain
Bujanda, L:
Inst Salud Carlos III, Ctr Biomed Network Res Hepat & Digest Dis CIBEREH, Madrid 28029, Spain
Univ Basque Country, UPV EHU, Donostia Univ Hosp, Biodonostia Hlth Res Inst,Dept Liver & Gastrointe, San Sebastian 20014, Spain
Bouysran, Y:
Univ Libre Bruxelles, Hop Erasme, Ctr Genet Humaine, B-1070 Brussels, Belgium
Palom, A:
Hosp Univ Vall dHebron, Vall dHebron Barcelona Hosp Campus, Dept Internal Med, Liver Unit, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona 08193, Spain
Vall dHebron Inst Recerca VHIR, Liver Dis, Barcelona 08035, Spain
Ellinghaus, D:
Univ Copenhagen, Novo Nordisk Fdn, Ctr Prot Res, Fac Hlth & Med Sci,Dis Syst Biol, DK-2200 Copenhagen, Denmark
Martinez-Bueno, M:
Univ Granada, Pfizer, Andalusian Reg Govt, GENYO,Ctr Genom & Oncol Res, Granada 18016, Spain
Rolker, S:
Univ Bonn, Univ Hosp Bonn, Med Fac, Inst Human Genet, D-53127 Bonn, Germany
Amitrano, S:
Azienda Osped Univ Senese, Genet Med, I-53100 Siena, Italy
Roade, L:
Inst Salud Carlos III, Ctr Biomed Network Res Hepat & Digest Dis CIBEREH, Madrid 28029, Spain
Hosp Univ Vall dHebron, Vall dHebron Barcelona Hosp Campus, Dept Internal Med, Liver Unit, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona 08193, Spain
Fava, F:
Azienda Osped Univ Senese, Genet Med, I-53100 Siena, Italy
Univ Siena, Med Genet, I-53100 Siena, Italy
Univ Siena, Med Biotech Hub, I-53100 Siena, Italy
Univ Siena, Competence Ctr, Dept Med Biotechnol, I-53100 Siena, Italy
Spinner, CD:
Tech Univ Munich, Univ Hosp Rechts Isar, Sch Med, Dept Internal Med 2, D-80333 Munich, Germany
Prati, D:
Univ Milan, Fdn IRCCS CaGranda Osped Maggiore Policlin, Dept Transfus Med & Hematol, I-20126 Milan, Italy
Bernardo, D:
Inst Salud Carlos III, Ctr Biomed Network Res Hepat & Digest Dis CIBEREH, Madrid 28029, Spain
Univ Valladolid, CSIC, Inst Biomed & Genet Mol IBGM, Unidad Excelencia,Mucosal Immunol Lab, Valladolid 47005, Spain
Garcia, F:
Hosp Univ Clin San Cecilio, Granada 18016, Spain
Inst Invest Ibs, Granada 18012, Spain
Darcis, G:
Univ Liege, GIGA Inst, B-4000 Liege, Belgium
Liege Univ Hosp, CHU Liege, B-4000 Liege, Belgium
Fernandez-Cadenas, I:
Biomed Res Inst St Pau IIB St Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Holter, JC:
Oslo Univ Hosp, Dept Microbiol, N-0424 Oslo, Norway
Univ Oslo, Inst Clin Med, N-0424 Oslo, Norway
Banales, JM:
Inst Salud Carlos III, Ctr Biomed Network Res Hepat & Digest Dis CIBEREH, Madrid 28029, Spain
Univ Basque Country, UPV EHU, Donostia Univ Hosp, Ikerbasque,Biodonostia Hlth Res Inst,Dept Liver &, San Sebastian 20014, Spain
Frithiof, R:
Uppsala Univ, Dept Surg Sci Anaesthesiol & Intens Care Med, S-75105 Uppsala, Sweden
Duga, S:
Humanitas Univ, Dept Biomed Sci, I-20089 Milan, Italy
IRCCS Humanitas Res Hosp, I-20089 Milan, Italy
Asselta, R:
Humanitas Univ, Dept Biomed Sci, I-20089 Milan, Italy
IRCCS Humanitas Res Hosp, I-20089 Milan, Italy
Pereira, AC:
Univ Sao Paulo, Med Sch, Heart Inst InCor, BR-05508070 Sao Paulo, Brazil
Romero-Gomez, M:
Univ Seville, Virgen Rocio Univ Hosp, Inst Biomed Seville, Digest Dis Unit, Seville 41103, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Hepat & Digest Dis CIBEREH, Madrid 28029, Spain
Nafria-Jimenez, B:
Osakidetza Basque Hlth Serv, Donostialdea Integrated Hlth Org, Clin Biochem Dept, San Sebastian 20006, Spain
Hov, JR:
Univ Oslo, Inst Clin Med, N-0424 Oslo, Norway
Oslo Univ Hosp, Norwegian PSC Res Ctr, N-0424 Oslo, Norway
Oslo Univ Hosp, Dept Transplantat Med, Sect Gastroenterol, N-0424 Oslo, Norway
Oslo Univ Hosp, Res Inst Internal Med, N-0424 Oslo, Norway
Migeotte, I:
Univ Libre Bruxelles, Hop Erasme, Ctr Genet Humaine, B-1070 Brussels, Belgium
Fonds Rech Sci FNRS, B-1000 Brussels, Belgium
Renieri, A:
Azienda Osped Univ Senese, Genet Med, I-53100 Siena, Italy
Univ Siena, Med Genet, I-53100 Siena, Italy
Univ Siena, Med Biotech Hub, I-53100 Siena, Italy
Univ Siena, Competence Ctr, Dept Med Biotechnol, I-53100 Siena, Italy
Planas, AM:
Natl Spanish Res Council CSIC, Inst Biomed Res Barcelona IIBB, Barcelona 08028, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona 08036, Spain
Ludwig, KU:
Univ Bonn, Univ Hosp Bonn, Med Fac, Inst Human Genet, D-53127 Bonn, Germany
Buti, M:
Inst Salud Carlos III, Ctr Biomed Network Res Hepat & Digest Dis CIBEREH, Madrid 28029, Spain
Hosp Univ Vall dHebron, Vall dHebron Barcelona Hosp Campus, Dept Internal Med, Liver Unit, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona 08193, Spain
Rahmouni, S:
Univ Liege, GIGA Inst, B-4000 Liege, Belgium
Alarcon-Riquelme, ME:
Univ Granada, Pfizer, Andalusian Reg Govt, GENYO,Ctr Genom & Oncol Res, Granada 18016, Spain
Karolinska Inst, Inst Environm Med, S-17165 Solna, Sweden
Schulte, EC:
Tech Univ Munich, Helmholtz Zentrum Munchen, Inst Virol, D-85764 Munich, Germany
LMU Munich Univ, Univ Hosp, Inst Psychiat Phenom & Genom, D-80539 Munich, Germany
LMU Munich Univ, Univ Hosp, Dept Psychiat, D-80539 Munich, Germany
Franke, A:
Univ Kiel, Inst Clin Mol Biol, D-24118 Kiel, Germany
Univ Hosp Schleswig Holstein, Campus Kiel, D-24118 Kiel, Germany
Karlsen, TH:
Univ Oslo, Inst Clin Med, N-0424 Oslo, Norway
Oslo Univ Hosp, Norwegian PSC Res Ctr, N-0424 Oslo, Norway
Oslo Univ Hosp, Dept Transplantat Med, Sect Gastroenterol, N-0424 Oslo, Norway
Oslo Univ Hosp, Res Inst Internal Med, N-0318 Oslo, Norway
Valenti, L:
Univ Milan, Dept Pathopgysiol & Transplantat, I-20126 Milan, Italy
Fdn IRCCS CaGranda Osped Maggiore Policlin, Dept Transfus Med & Hematol, Precis Med, I-20122 Milan, Italy
Zeberg, H:
Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Richards, B:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
McGill Univ, Dept Human Genet Epidemiol Biostat & Occupat Hlth, Montreal, PQ H3A 0G4, Canada
Kings Coll London, Dept Twin Res, London WC2R 2LS, England
Ganna, A:
Univ Helsinki, Inst Mol Med Finland, Helsinki 00014, Finland
Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02114 USA
Boada, M:
Univ Int Catalunya, ACE Alzheimer Ctr Barcelona, Res Ctr, Barcelona 80828, Spain
Univ Int Catalunya, ACE Alzheimer Ctr Barcelona, Memory Clin, Barcelona 08028, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Neurodegenerat Dis CIBERNE, Madrid 28029, Spain
de Rojas, I:
Univ Int Catalunya, ACE Alzheimer Ctr Barcelona, Res Ctr, Barcelona 80828, Spain
Univ Int Catalunya, ACE Alzheimer Ctr Barcelona, Memory Clin, Barcelona 08028, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Neurodegenerat Dis CIBERNE, Madrid 28029, Spain
Ruiz, A:
Univ Int Catalunya, ACE Alzheimer Ctr Barcelona, Res Ctr, Barcelona 80828, Spain
Univ Int Catalunya, ACE Alzheimer Ctr Barcelona, Memory Clin, Barcelona 08028, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Neurodegenerat Dis CIBERNE, Madrid 28029, Spain
Sanchez-Juan, P:
CIEN Fdn, Queen Sofia Fdn, Alzheimer Ctr, Madrid 28031, Spain
Real, LM:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville 41014, Spain
Guillen-Navarro, E:
Inst Murciano Invest Biosanitaria IMIB Arrixaca, Murcia, Spain
Hosp Clin Univ Virgen Arrixaca, Serv Murciano Salud, Serv Pediat, Secc Genet Med, Murcia 30120, Spain
Univ Murcia UMU, Fac Med, Dept Cirugia Pediat Obstet & Ginecol, Murcia 30100, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Grp Clin Vinculado, Madrid 28029, Spain
Ayuso, C:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Univ Autonoma Madrid, Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria, UAM,FJD,IIS,Dept Genet & Genom, Madrid 28040, Spain
Gonzalez-Neira, A:
Spanish Natl Canc Res Ctr, Human Genotyping CEGEN Unit, Madrid 28029, Spain
Riancho, JA:
IDIVAL, Cantabria 39008, Spain
Univ Cantabria, Cantabria 39008, Spain
Hosp UM Valdecilla, Cantabria 39008, Spain
Rojas-Martinez, A:
Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey 64718, Mexico
Flores, C:
Inst Tecnol & Energias Renovables, Genom Div, Santa Cruz De Tenerife 38600, Spain
Univ Int Catalunya, ACE Alzheimer Ctr Barcelona, Res Ctr, Barcelona 80828, Spain
Hosp Univ NS Candelaria, Res Unit, Santa Cruz De Tenerife 38010, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Resp Dis CIBERES, Madrid 28029, Spain
Univ Fernando Pessoa, Fac Ciencias Salud, Las Palmas Gran Canaria 35450, Spain
Lapunzina, P:
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Hosp Univ La Paz IDIPAZ, Inst Genet Med & Mol INGEMM, Madrid 28046, Spain
ERN, ITHACA, European Reference Network, Amsterdam, Netherlands
Carracedo, A:
Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN, Santiago De Compostela 15706, Spain
Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid 28029, Spain
Inst Invest Sanitaria Santiago IDIS, Santiago De Compostela 15706, Spain
Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cronic, Santiago De Compostela 15782, Spain
Fdn Publ Galegade Med Xenom, Sistema Galegode Saude SERGAS, Santiago De Compostela 15706, Spain
hybrid, Green Published, Hybrid Gold, Green
|