Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets


Por: Badimon, L, Padro, T, Arderiu, G, Vilahur, G, Borrell-Pages, M, Suades, R

Publicada: 1 nov 2022 Ahead of Print: 1 ago 2022
Resumen:
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular bioactive cargoes and play essential roles in intercellular communication and, hence, a multifaceted role in health and disease. The present review offers a glimpse into the current state and up-to-date concepts on EV field. It also covers their association with several cardiovascular risk factors and ischemic conditions, being subclinical atherosclerosis of utmost relevance for prevention. Interestingly, we show that EVs hold promise as prognostic and diagnostic as well as predictive markers of ASCVD in the precision medicine era. We then report on the role of EVs in atherothrombosis, disentangling the mechanisms involved in the initiation, progression, and complication of atherosclerosis and showing their direct effect in the context of arterial thrombosis. Finally, their potential use for therapeutic intervention is highlighted.

Filiaciones:
Badimon, L:
 Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain

 CIBERCV Inst Salud Carlos III, Madrid, Spain

 UAB, Cardiovasc Res Chair, Barcelona, Spain

Padro, T:
 Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain

 CIBERCV Inst Salud Carlos III, Madrid, Spain

Arderiu, G:
 Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain

 CIBERCV Inst Salud Carlos III, Madrid, Spain

Vilahur, G:
 Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain

 CIBERCV Inst Salud Carlos III, Madrid, Spain

Borrell-Pages, M:
 Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain

 CIBERCV Inst Salud Carlos III, Madrid, Spain

Suades, R:
 Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain

 CIBERCV Inst Salud Carlos III, Madrid, Spain
ISSN: 01052896
Editorial
WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, Dinamarca
Tipo de documento: Review
Volumen: 312 Número: 1
Páginas: 6-19
WOS Id: 000842843400001
ID de PubMed: 35996799
imagen Green Published, hybrid

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