Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets
Por:
Badimon, L, Padro, T, Arderiu, G, Vilahur, G, Borrell-Pages, M, Suades, R
Publicada:
1 nov 2022
Ahead of Print:
1 ago 2022
Resumen:
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular bioactive cargoes and play essential roles in intercellular communication and, hence, a multifaceted role in health and disease. The present review offers a glimpse into the current state and up-to-date concepts on EV field. It also covers their association with several cardiovascular risk factors and ischemic conditions, being subclinical atherosclerosis of utmost relevance for prevention. Interestingly, we show that EVs hold promise as prognostic and diagnostic as well as predictive markers of ASCVD in the precision medicine era. We then report on the role of EVs in atherothrombosis, disentangling the mechanisms involved in the initiation, progression, and complication of atherosclerosis and showing their direct effect in the context of arterial thrombosis. Finally, their potential use for therapeutic intervention is highlighted.
Filiaciones:
Badimon, L:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain
CIBERCV Inst Salud Carlos III, Madrid, Spain
UAB, Cardiovasc Res Chair, Barcelona, Spain
Padro, T:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain
CIBERCV Inst Salud Carlos III, Madrid, Spain
Arderiu, G:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain
CIBERCV Inst Salud Carlos III, Madrid, Spain
Vilahur, G:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain
CIBERCV Inst Salud Carlos III, Madrid, Spain
Borrell-Pages, M:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain
CIBERCV Inst Salud Carlos III, Madrid, Spain
Suades, R:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona, Spain
CIBERCV Inst Salud Carlos III, Madrid, Spain
Green Published, hybrid
|