European guideline (EuroGuiDerm) on atopic eczema: part I - systemic therapy
Por:
Wollenberg, A, Kinberger, M, Arents, B, Aszodi, N, Valle, GA, Barbarot, S, Bieber, T, Brough, HA, Pinton, PC, Christen-Zach, S, Deleuran, M, Dittmann, M, Dressler, C, Fink-Wagner, AH, Fosse, N, Gaspar, K, Gerbens, L, Gieler, U, Girolomoni, G, Gregoriou, S, Mortz, CG, Nast, A, Nygaard, U, Redding, M, Rehbinder, EM, Ring, J, Rossi, M, Serra-Baldrich, E, Simon, D, Szalai, ZZ, Szepietowski, JC, Torrelo, A, Werfel, T, Flohr, C
Publicada:
1 sep 2022
Resumen:
The evidence- and consensus-based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were held between December 2020 and July 2021. Twenty-nine experts (including clinicians and patient representatives) from 12 European countries participated. This first part of the guideline includes general information on its scope and purpose, the health questions covered, target users and a methods section. It also provides guidance on which patients should be treated with systemic therapies, as well as recommendations and detailed information on each systemic drug. The systemic treatment options discussed in the guideline comprise conventional immunosuppressive drugs (azathioprine, ciclosporin, glucocorticosteroids, methotrexate and mycophenolate mofetil), biologics (dupilumab, lebrikizumab, nemolizumab, omalizumab and tralokinumab) and janus kinase inhibitors (abrocitinib, baricitinib and upadacitinib). Part two of the guideline will address avoidance of provocation factors, dietary interventions, immunotherapy, complementary medicine, educational interventions, occupational and psychodermatological aspects, patient perspective and considerations for paediatric, adolescent, pregnant and breastfeeding patients.
Filiaciones:
Wollenberg, A:
Ludwig Maximilians Univ Munchen, Dept Dermatol & Allergy, Munich, Germany
Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Dept Dermatol, Brussels, Belgium
Kinberger, M:
Charite Univ Med Berlin, Div Evidence Based Med dEBM, Dept Dermatol Venereol & Allergol, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Arents, B:
European Federat Allergy & Airways Dis Patients A, Brussels, Belgium
Aszodi, N:
Ludwig Maximilians Univ Munchen, Dept Dermatol & Allergy, Munich, Germany
Valle, GA:
Charite Univ Med Berlin, Div Evidence Based Med dEBM, Dept Dermatol Venereol & Allergol, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Barbarot, S:
Nantes Univ, Dept Dermatol, INRAE, CHU Nantes,UMR 1280 PhAN, Nantes, France
Bieber, T:
Univ Hosp Bonn, Dept Dermatol & Allergy, Bonn, Germany
Brough, HA:
Guys & St Thomas NHS Fdn Trust, Childrens Allergy Serv, Evelina London Childrens Hosp, London, England
Kings Coll London, Sch Life Course Sci, Dept Women & Childrens Hlth, London, England
Pinton, PC:
Univ Brescia, Dermatol Dept, Brescia, Italy
Christen-Zach, S:
Univ Hosp Lausanne, Lausanne, Switzerland
Deleuran, M:
Aarhus Univ Hosp, Aarhus, Denmark
Dittmann, M:
Charite Univ Med Berlin, Div Evidence Based Med dEBM, Dept Dermatol Venereol & Allergol, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Dressler, C:
Charite Univ Med Berlin, Div Evidence Based Med dEBM, Dept Dermatol Venereol & Allergol, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Fink-Wagner, AH:
Global Allergy & Airways Dis Patient Platform GAA, Vienna, Austria
Fosse, N:
Univ Hosp Basel, Dept Dermatol, Basel, Switzerland
Gaspar, K:
Univ Debrecen, Dept Dermatol, Debrecen, Hungary
Gerbens, L:
Amsterdam UMC Univ Med Ctr, Dept Dermatol, Amsterdam, Netherlands
Gieler, U:
Univ Giessen, Dept Dermatol, Giessen, Germany
Girolomoni, G:
Univ Verona, Dept Med, Dermatol & Venereol Sect, Verona, Italy
Gregoriou, S:
Natl & Kapodistrian Univ Athens, Fac Med, Athens, Greece
Mortz, CG:
Univ Southern Denmark, Odense Univ Hosp, Dept Dermatol, Odense, Denmark
Univ Southern Denmark, Odense Univ Hosp, Allergy Ctr, Odense, Denmark
Nast, A:
Charite Univ Med Berlin, Div Evidence Based Med dEBM, Dept Dermatol Venereol & Allergol, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Nygaard, U:
Aarhus Univ Hosp, Dept Dermatovenerol, Aarhus, Denmark
Redding, M:
Eczema Outreach Support UK, Linlithgow, Scotland
Rehbinder, EM:
Oslo Univ Hosp, Dermatol Dept, Oslo, Norway
Ring, J:
Tech Univ Munich, Dept Dermatol Allergol Biederstein, Munich, Germany
Rossi, M:
Spedali Civili Hosp Brescia, Dermatol Unit, Brescia, Italy
Serra-Baldrich, E:
Hosp Santa Creu & Sant Pau, Dermatol, Barcelona, Spain
Simon, D:
Univ Bern, Bern Univ Hosp, Dept Dermatol, Inselspital, Bern, Switzerland
Szalai, ZZ:
Heim Pal Natl Childrens Inst Budapest, Pediat Dermatol Unit, Budapest, Hungary
Szepietowski, JC:
Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland
Torrelo, A:
Hosp Infantil Nino Jesus, Madrid, Spain
Werfel, T:
Hannover Med Sch, Hannover, Germany
Flohr, C:
Kings Coll London, St Johns Inst Dermatol, London, England
Guys & St Thomas NHS Fdn Trust, London, England
Green Published, Hybrid Gold, Green
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