Handling and reporting of transurethral resection specimens of the bladder in Europe: a web-based survey by the European Network of Uropathology (ENUP)
Por:
Lopez-Beltran, A, Algaba, F, Berney, DM, Boccon-Gibod, L, Camparo, P, Griffiths, D, Mikuz, G, Montironi, R, Varma, M, Egevad, L
Publicada:
1 mar 2011
Resumen:
Aims:
To collect of information about European practices on handling and reporting of transurethral resection specimens of the bladder.
Methods and results:
The European Network of Uropathology is a communication network that includes 335 pathology laboratories in 15 western European countries. A web-based questionnaire was answered by 52.2% of members. Some routines were adopted by a majority: formalin fixation (92.5%), separate containers for tumour and resection base (72%) and embedding of the entire specimen (60%). Cancer along/in adipose tissue would be reported as pT3a by 19.5% and non-invasive urothelial carcinoma in prostatic ducts/glands as pT4a by 16.1%. Papillary urothelial neoplasia of low malignant potential is recognized by 72.6% but rarely reported. Immunohistochemistry is rarely or sometimes used for diagnosing bladder cancer by 91.7%, and the most frequently used markers are CK20 (76.9%), CK7 (66.7%) and Ki67 (38.8%). Only 24.8% report prognostic markers, with Ki67 (84.4%) and p53 (64.4%) being most common. Only 50.9% use the International Society of Urological Pathology 1998/World Health Organization (WHO) 2004 grading system, followed by WHO 1973 (43.4%) and WHO 1999 (31.4%).
Conclusions:
There is still variability in routine practice and a need for standardization of methodologies. These results may be helpful when judging what recommendations are reasonable to issue.
Filiaciones:
Lopez-Beltran, A:
Univ Cordoba, Fac Med, Anat Pathol Unit, Sch Med, E-14004 Cordoba, Spain
Algaba, F:
Autonomous Univ Barcelona, Dept Pathol, Fdn Puigvert, Barcelona, Spain
Berney, DM:
Queen Mary Univ London, Dept Mol Oncol & Imaging, Inst Canc, London, England
Boccon-Gibod, L:
Univ Paris 06, Hop Armand Trousseau, AP HP, Dept Pathol, Paris, France
Camparo, P:
Hop Foch, Serv Anat & Cytol Pathol, Paris, France
Griffiths, D:
Univ Wales Hosp, Dept Pathol, Cardiff CF4 4XW, S Glam, Wales
Mikuz, G:
Med Univ, Inst Pathol, Innsbruck, Austria
Montironi, R:
Polytech Univ Marche Reg, Sch Med, Inst Pathol Anat & Histopathol, Ancona, Italy
Varma, M:
Univ Wales Hosp, Dept Pathol, Cardiff CF4 4XW, S Glam, Wales
Egevad, L:
Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden
Open Access
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