Prospective Study of the Frequency of Hepatic Hemangiomas in Infants with Multiple Cutaneous Infantile Hemangiomas
Por:
Horii, KA, Drolet, BA, Frieden, IJ, Baselga, E, Chamlin, SL, Haggstrom, AN, Holland, KE, Mancini, AJ, McCuaig, CC, Metry, DW, Morel, KD, Newell, BD, Nopper, AJ, Powell, J, Garzon, MC
Publicada:
1 may 2011
Resumen:
Multiple cutaneous infantile hemangiomas have been associated with hepatic hemangiomas. Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. The aim of this study was to determine the frequency with which hepatic hemangiomas occur in infants with five or more cutaneous infantile hemangiomas compared to those with one to four cutaneous infantile hemangiomas and to characterize the clinical features of these hepatic hemangiomas. A multicenter prospective study of children with cutaneous infantile hemangiomas was conducted at pediatric dermatology clinics at Hemangioma Investigator Groups sites in the United States, Canada, and Spain between October 2005 and December 2008. Data were collected, and abdominal ultrasonography was performed on infants younger than 6 months old with five or more cutaneous infantile hemangiomas and those with one to four cutaneous infantile hemangiomas. Twenty-four (16%) of the 151 infants with five or more cutaneous infantile hemangiomas had hepatic hemangiomas identified on abdominal ultrasound, versus none of the infants with fewer than five (p = 0.003). Two of the 24 infants with hepatic hemangiomas received treatment specifically for their hepatic hemangiomas. Infants with five or more cutaneous infantile hemangiomas have a statistically significantly greater frequency of hepatic hemangiomas than those with fewer than 5. These findings support the recommendation of five or more cutaneous infantile hemangiomas as a threshold for screening infants younger than 6 months old for hepatic hemangiomas but also demonstrate that the large majority of these infants with hepatic hemangiomas do not require treatment.
Filiaciones:
Horii, KA:
Childrens Mercy Hosp & Clin, Dermatol Sect, Kansas City, MO 64108 USA
Drolet, BA:
Med Coll Wisconsin, Dept Dermatol, Milwaukee, WI 53226 USA
Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA
Frieden, IJ:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Baselga, E:
Hosp Santa Creu & Sant Pau, Dept Dermatol, Barcelona, Spain
Chamlin, SL:
Northwestern Univ, Childrens Mem Hosp, Dept Pediat, Feinberg Sch Med, Chicago, IL 60614 USA
Northwestern Univ, Childrens Mem Hosp, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60614 USA
Haggstrom, AN:
Indiana Univ, Dept Dermatol, Indianapolis, IN 46204 USA
Indiana Univ, Dept Pediat, Indianapolis, IN 46204 USA
Holland, KE:
Med Coll Wisconsin, Dept Dermatol, Milwaukee, WI 53226 USA
Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA
Mancini, AJ:
Northwestern Univ, Childrens Mem Hosp, Dept Pediat, Feinberg Sch Med, Chicago, IL 60614 USA
Northwestern Univ, Childrens Mem Hosp, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60614 USA
McCuaig, CC:
Univ Montreal, Div Dermatol Pediat, St Justine Hosp, Montreal, PQ, Canada
Metry, DW:
Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA
Morel, KD:
Columbia Univ, Dept Dermatol, New York, NY 10027 USA
Columbia Univ, Dept Pediat, New York, NY 10027 USA
Newell, BD:
Childrens Mercy Hosp & Clin, Dermatol Sect, Kansas City, MO 64108 USA
Nopper, AJ:
Childrens Mercy Hosp & Clin, Dermatol Sect, Kansas City, MO 64108 USA
Powell, J:
Univ Montreal, Div Dermatol Pediat, St Justine Hosp, Montreal, PQ, Canada
Garzon, MC:
Columbia Univ, Dept Dermatol, New York, NY 10027 USA
Columbia Univ, Dept Pediat, New York, NY 10027 USA
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