Genome-Wide Studies in Ischaemic Stroke: Are Genetics Only Useful for Finding Genes?
Por:
Gallego-Fabrega, C, Muino, E, Carcel-Marquez, J, Llucia-Carol, L, Lledos, M, Martin-Campos, JM, Cullell, N, Fernandez-Cadenas, I
Publicada:
1 jun 2022
Resumen:
Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies may also be useful in other disciplines. Analysis of these data can be used to understand the biological mechanisms associated with stroke risk and stroke outcome, to determine the causality between stroke and other diseases without the need for expensive clinical trials, or to find potential drug targets with higher success rates than other strategies. In this review we will discuss several of the most relevant studies regarding the genetics of ischaemic stroke and the potential use of the data generated.
Filiaciones:
Gallego-Fabrega, C:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Muino, E:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Carcel-Marquez, J:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Llucia-Carol, L:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Inst Biomed Res Barcelona IIBB, Natl Spanish Res Council CSIC, Barcelona 08036, Spain
Univ Autonoma Barcelona, Dept Genet & Microbiol, Bellaterra 08193, Spain
Lledos, M:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Martin-Campos, JM:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Cullell, N:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Fernandez-Cadenas, I:
Inst Recerca Hosp Santa Creu I Sant Pau, Stroke Pharmacogenom & Genet Grp, Barcelona 08041, Spain
Fundacio MutuaTerrassa Docencia & Recerca, Stroke Pharmacogenom & Genet Grp, Terrassa 08221, Spain
gold, Green Published
|