Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients
Por:
Sol, J, Colas-Campas, L, Mauri-Capdevila, G, Molina-Seguin, J, Galo-Licona, JD, Torres-Querol, C, Aymerich, N, Ois, A, Roquer, J, Tur, S, Garcia-Carreira, MD, Marti-Fabregas, J, Cruz-Culebras, A, Segura, T, Pamplona, R, Portero-Otin, M, Arque, G, Jove, M, Purroy, F
Publicada:
1 dic 2022
Ahead of Print:
1 jul 2022
Resumen:
Transient ischemic attacks (TIAs) before an acute ischemic stroke (AIS) could induce ischemic tolerance (IT) phenomena. with an endogenous neuroprotective role (Ischemic preconditioning. IPC). A consecutive prospective cohort of patients with AIS were recruited from 8 different hospitals. Participants were classified by those with non-previous recent TIA vs. previous TIA (within seven days. TIA <= 7d). A total of 541 AIS patients were recruited. 40 (7.4%). of them had previous TIA <= 7d. In line with IPC. patients with TIA <= 7d showed: 1) a significantly less severe stroke at admission by NIHSS score. 2) a better outcome at 7-90 days follow-up and reduced infarct volumes. 3) a specific upregulated metabolomics/lipidomic profile composed of diverse lipid categories. Effectively. IPC activates an additional adaptive response on increasing circulation levels of structural and bioactive lipids to facilitate functional recovery after AIS which may support biochemical machinery for neuronal survival. Furthermore. previous TIA before AIS seems to facilitate the production of anti-inflammatory mediators that contribute to a better immune response. Thus. the IT phenomena contributes to a better adaptation of further ischemia. Our study provides first-time evidence of a metabolomics/lipidomic signature related to the development of stroke tolerance in AIS patients induced by recent TIA.
Filiaciones:
Sol, J:
Lleida Univ Lleida Biomed Res Inst UdL IRBLleida, Expt Med Dept, Lleida, Spain
Inst Catala Salut ICS, Atencio Primaria, Lleida, Spain
Fundacio Inst Univ Recerca Atencio Primaria Salut, Res Support Unit Lleida, Lleida, Spain
Colas-Campas, L:
UdL, Inst Recerca Biomed Lleida, Clin Neurosci Grp, Lleida, Spain
Mauri-Capdevila, G:
UdL, Inst Recerca Biomed Lleida, Clin Neurosci Grp, Lleida, Spain
Hosp Univ Arnau de Vilanova Lleida, Dept Neurol, Stroke Unit, Lleida, Spain
Molina-Seguin, J:
UdL, Inst Recerca Biomed Lleida, Clin Neurosci Grp, Lleida, Spain
Galo-Licona, JD:
Lleida Univ Lleida Biomed Res Inst UdL IRBLleida, Expt Med Dept, Lleida, Spain
Torres-Querol, C:
UdL, Inst Recerca Biomed Lleida, Clin Neurosci Grp, Lleida, Spain
Aymerich, N:
Complejo Hosp Navarra, Pamplona, Spain
Ois, A:
Hosp Mar, Barcelona, Spain
Roquer, J:
Hosp Mar, Barcelona, Spain
Tur, S:
Son Espases Hosp, Palma De Mallorca, Spain
Garcia-Carreira, MD:
Corp Sanitaria Parc Tauli, Sabadell, Spain
Marti-Fabregas, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Cruz-Culebras, A:
Hosp Univ Ramon y Cajal, Madrid, Spain
Segura, T:
Complejo Hosp Univ Albacete, Albacete, Spain
Pamplona, R:
Lleida Univ Lleida Biomed Res Inst UdL IRBLleida, Expt Med Dept, Lleida, Spain
Portero-Otin, M:
Lleida Univ Lleida Biomed Res Inst UdL IRBLleida, Expt Med Dept, Lleida, Spain
Arque, G:
UdL, Inst Recerca Biomed Lleida, Clin Neurosci Grp, Lleida, Spain
Jove, M:
Lleida Univ Lleida Biomed Res Inst UdL IRBLleida, Expt Med Dept, Lleida, Spain
Purroy, F:
UdL, Inst Recerca Biomed Lleida, Clin Neurosci Grp, Lleida, Spain
Hosp Univ Arnau de Vilanova Lleida, Dept Neurol, Stroke Unit, Lleida, Spain
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