Aging in bipolar disorder: Cognitive performance and clinical factors based on an adulthood-lifespan perspective
Por:
Montejo, L, Sole, B, Jimenez, E, Borras, R, Clougher, D, Reinares, M, Portella, MJ, Martinez-Aran, A, Vieta, E, Bonnin, CD, Torrent, C
Publicada:
1 sep 2022
Ahead of Print:
1 jun 2022
Resumen:
Background: The evolution of cognitive performance throughout the lifespan in bipolar disorder (BD) is understudied. This cross-sectional study aims to describe the cognitive performance across age groups. Methods: A sample of 654 participants was recruited for this study (BD = 432 and healthy controls -HC- =222). Three subgroups, divided according to age range (18 to 35, 36 to 49, and >= 50 years old) were analyzed after administering a comprehensive neuropsychological battery including six cognitive domains. Demographic, clinical, and psychosocial functioning data were also analyzed. Generalized linear models (GLM) with age, diagnostic group, and age x group as main effects were carried out to examine their potential association on cognitive domains. Subsequently, a GLM in the BD sample was conducted to analyze interactions of several clinical variables by age on each cognitive domain.Results: Main effects of diagnostic group and age were found in all cognitive domains. Significant group x age effect interaction was found for attention domain (p = 0.02) demonstrating a worse cognitive evolution across age in BD, driven by older age, but not in HC. Significant interaction effects of higher number of manic episodes and older age were also found in attention and verbal memory. Older age was also associated with a longer duration of illness, higher number of episodes, more somatic comorbidities, and poorer psychosocial functioning.Conclusions: These results suggest that older age was associated with a selective cognitive decline in BD in the attentional domain. These findings highlight the importance of developing interventions targeting cognitive dysfunction throughout the BD adulthood lifespan.
Filiaciones:
Montejo, L:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Sole, B:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Jimenez, E:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Borras, R:
Hosp Clin Barcelona, Inst Neurosci, IDIBAPS, CIBERSAM, Barcelona, Spain
Clougher, D:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Reinares, M:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Inst Neurosci, IDIBAPS, CIBERSAM, Barcelona, Spain
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Inst Invest Biomed St Pau IIBSANT PAU, Psychiat Dept, Barcelona, Catalonia, Spain
Portella, MJ:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Inst Neurosci, IDIBAPS, CIBERSAM, Barcelona, Spain
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Inst Invest Biomed St Pau IIBSANT PAU, Psychiat Dept, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, C Villarroel 170,12-0, Barcelona 08036, Spain
Martinez-Aran, A:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, C Villarroel 170,12-0, Barcelona 08036, Spain
Vieta, E:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Inst Invest Biomed St Pau IIBSANT PAU, Psychiat Dept, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, C Villarroel 170,12-0, Barcelona 08036, Spain
Bonnin, CD:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Inst Invest Biomed St Pau IIBSANT PAU, Psychiat Dept, Barcelona, Catalonia, Spain
Torrent, C:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
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