Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+lymphocytopenia
Por:
Cervera, C, Fernandez-Aviles, F, de la Calle-Martin, O, Bosch, X, Rovira, M, Plana, M, Moreno, A, Garcia, F, Miro, JM, Martinez, A, Gallart, T, Carreras, E, Blade, J, Gatell, JM
Publicada:
1 jul 2011
Resumen:
A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total-body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA-identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow-up period. The patient did not develop infectious complications during the procedure. At 35 months of follow-up, his CD4+ T cell count was 1019 cells per microliter. Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.
Filiaciones:
Cervera, C:
Univ Barcelona, Infect Dis Serv, Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Fernandez-Aviles, F:
Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, BMT Unit, Barcelona, Spain
de la Calle-Martin, O:
Autonomous Univ Barcelona, Serv Immunol, Hosp Santa Creu & St Pau, Barcelona, Spain
Rovira, M:
Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, BMT Unit, Barcelona, Spain
Plana, M:
IDIBAPS, Retrovirol & Viral Immunopathol Lab, Barcelona, Spain
Moreno, A:
Univ Barcelona, Infect Dis Serv, Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Garcia, F:
Univ Barcelona, Infect Dis Serv, Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Miro, JM:
Univ Barcelona, Infect Dis Serv, Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Martinez, A:
IDIBAPS, Retrovirol & Viral Immunopathol Lab, Barcelona, Spain
Carreras, E:
Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, BMT Unit, Barcelona, Spain
Blade, J:
Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, BMT Unit, Barcelona, Spain
Gatell, JM:
Univ Barcelona, Infect Dis Serv, Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
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