Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study
Por:
Safont, G, Corripio, I, Escarti, MJ, Portella, MJ, Perez, V, Ferrer, M, Camacho, V, Sauras, RB, Alonso, A, Grasa, EM, Arranz, B, San, L, Duenas, R, Carrio, I, Alvarez, E
Publicada:
1 jul 2011
Resumen:
The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n=14) and without (n=23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups. (C) 2011 Elsevier B.V. All rights reserved.
Filiaciones:
Safont, G:
Univ Barcelona UB, Dept Psychiat, Hosp Univ Mutua Terrassa, Barcelona 08221, Spain
Corripio, I:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Santa Creu & St Pau, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08025, Spain
Escarti, MJ:
Univ Valencia, Dept Psychiat, Hosp Clin, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Valencia 46010, Spain
Portella, MJ:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Santa Creu & St Pau, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08025, Spain
Perez, V:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Santa Creu & St Pau, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08025, Spain
Ferrer, M:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Univ Vall dHebron, Barcelona 08035, Spain
Camacho, V:
Hosp Santa Creu & Sant Pau, Dept Nucl Med, Barcelona 08025, Spain
Sauras, RB:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Santa Creu & St Pau, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08025, Spain
Alonso, A:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Santa Creu & St Pau, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08025, Spain
Grasa, EM:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Santa Creu & St Pau, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08025, Spain
Arranz, B:
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Barcelona, Spain
San, L:
Univ Barcelona UB, Hosp St Joan Deu, Dept Child & Adolescent Psychiat, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08950, Spain
Duenas, R:
Unidad Hosp Psiquiatr Penitenciaria, Barcelona 08830, Spain
Carrio, I:
Hosp Santa Creu & Sant Pau, Dept Nucl Med, Barcelona 08025, Spain
Alvarez, E:
Univ Autonoma Barcelona UAB, Dept Psychiat, Hosp Santa Creu & St Pau, Ctr Invest Biomed Red Salud Mental,CIBERSAM, Barcelona 08025, Spain
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